Oxazolidinones as versatile scaffolds in medicinal chemistry

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by H2020 Marie Skłodowska-Curie Actions (101027065)

Authors: Guilherme Felipe Santos Fernandes | Cauê Benito Scarim | Seong-Heun Kim | Jingyue Wu | Daniele Castagnolo

Potential of covalently linked tamoxifen hybrids for cancer treatment: Recent update

JOURNAL ARTICLE published 2024 in RSC Medicinal Chemistry

Authors: Shagufta . | Irshad Ahmad | Donna J. Nelson | Maheen Imtiaz Hussain | Noora Ali Nasar

Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

Research funded by Medical Research Scotland (PHD-1046-2016)

Authors: Daniel J. Baillache | Asier Unciti-Broceta

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JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by National Institute of General Medical Sciences (1R15GM148956,S10OD028690) | Cystic Fibrosis Foundation (THOMPS2010)

Authors: Skye Travis | Keith D. Green | Nishad Thamban Chandrika | Allan H. Pang | Patrick A. Frantom | Oleg V. Tsodikov | Sylvie Garneau-Tsodikova | Matthew K. Thompson

The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by Engineering and Physical Sciences Research Council (EP/T01783X/1)

Authors: Samantha J. Bann | Ross D. Ballantine | Stephen A. Cochrane

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JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

The future of chemical probes is diversity

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Authors: Susanne Müller | Stephen Frye | Jonathan Baell

Expanding the structure–activity relationships of alkynyl diphenylurea scaffold as promising antibacterial agents

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Science and Technology Development Fund (43883)

Authors: Hanzada T. Nour El-Din | Mohamed M. Elsebaie | Nader S. Abutaleb | Ahmed M. Kotb | Ahmed S. Attia | Mohamed N. Seleem | Abdelrahman S. Mayhoub

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JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Kementerian Riset dan Teknologi/Badan Riset dan Inovasi Nasional (8245-ID)

Authors: Hendris Wongso | Maiko Ono | Tomoteru Yamasaki | Katsushi Kumata | Makoto Higuchi | Ming-Rong Zhang | Michael J. Fulham | Andrew Katsifis | Paul A. Keller

Human carboxylesterases and fluorescent probes to image their activity in live cells

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Authors: Anchal Singh | Mingze Gao | Michael W. Beck

Proline pre-conditioning of cell monolayers increases post-thaw recovery and viability by distinct mechanisms to other osmolytes

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by Wellcome Trust (105627/Z/14/Z) | H2020 European Research Council (638661,789182)

Authors: Trisha L. Bailey | Juan Ramon Hernandez-Fernaud | Matthew I. Gibson

De novo molecular drug design benchmarking

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by Natural Sciences and Engineering Research Council of Canada (510963,RGPIN-2017-05813)

Authors: Lauren L. Grant | Clarissa S. Sit

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JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Screening and optimization of phage display cyclic peptides against the WDR5 WBM site

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by National Natural Science Foundation of China (82173658,82373720)

Authors: Lingyu Song | Jiawen Cao | Lin Chen | Zhiyan Du | Naixia Zhang | Danyan Cao | Bing Xiong

Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by U.S. Department of Veterans Affairs (I01BX005188) | National Institutes of Health (R01CA264471) | American Cancer Society (RSG-12-092-01-CDD)

Authors: Khuchtumur Bum-Erdene | Mona K. Ghozayel | Mark J. Zhang | Giovanni Gonzalez-Gutierrez | Samy O. Meroueh

Exploring the potential of tamoxifen-based copper(ii) dichloride in breast cancer therapy

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Deutscher Akademischer Austauschdienst (57440919)

Authors: Aleksandr Kazimir | Benedikt Schwarze | Peter Lönnecke | Sanja Jelača | Sanja Mijatović | Danijela Maksimović-Ivanić | Evamarie Hey-Hawkins

Mitochondria-targeted biotin-conjugated BODIPYs for cancer imaging and therapy

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Department of Biotechnology, Ministry of Science and Technology, India (BT/PR28133/NER/95/1383/2018) | Department of Science and Technology, Ministry of Science and Technology, India (IF160502) | Indian Council of Medical Research (2021-11018-F1)

Authors: Dhiraj Dutta | Rajshree R. Nair | Kashmiri Neog | S. Asha Nair | Pranjal Gogoi

Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery

JOURNAL ARTICLE published 2024 in RSC Medicinal Chemistry

Research funded by China Postdoctoral Science Foundation (2022M711938) | Natural Science Foundation of Jiangsu Province (SBK2023041680) | National Natural Science Foundation of China (82173677,82211530493) | Ministry of Health and Welfare (HI22C2067)

Authors: Huinan Jia | Lide Hu | Jiwei Zhang | Xing Huang | Yuanmin Jiang | Guanyu Dong | Chuanfeng Liu | Xinyong Liu | Meehyein Kim | Peng Zhan