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Boron-based hybrids as novel scaffolds for the development of drugs with neuroprotective properties

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by Ministero dell’Istruzione, dell’Università e della Ricerca (FAR 2019)

Authors: Ivana Cacciatore | Hasan Turkez | Annalisa Di Rienzo | Michele Ciulla | Adil Mardinoglu | Antonio Di Stefano

Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

Research funded by Fundação de Amparo à Pesquisa do Estado de São Paulo (2013/07600-3,2015/19495-5,2015/50655-9)

Authors: Paul J. Koovits | Marco A. Dessoy | An Matheeussen | Louis Maes | Guy Caljon | Leonardo L. G. Ferreira | Rafael C. Chelucci | Simone Michelan-Duarte | Adriano D. Andricopulo | Simon Campbell | Jadel M. Kratz | Charles E. Mowbray | Luiz C. Dias

Novel irreversible peptidic inhibitors of transglutaminase 2

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Natural Sciences and Engineering Research Council of Canada (RGPIN-2019-05893) | Canadian Institutes of Health Research (PJT-162180)

Authors: Nicholas J. Cundy | Jane Arciszewski | Eric W. J. Gates | Sydney L. Acton | Kyle D. Passley | Ernest Awoonor-Williams | Elizabeth K. Boyd | Nancy Xu | Élise Pierson | Catalina Fernandez-Ansieta | Marie R. Albert | Nicole M. R. McNeil | Gautam Adhikary | Richard L. Eckert | Jeffrey W. Keillor

Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Ministry of Higher Education, Malaysia (203.CDADAH.6711955)

Authors: Yusuf Oloruntoyin Ayipo | Chien Fung Chong | Mohd Nizam Mordi

Contents list

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Profiling MAP kinase cysteines for targeted covalent inhibitor design

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Research funded by National Institutes of Health (R01CA256557) | National Institute of General Medical Sciences (R01GM098818)

Authors: Ruibin Liu | Neha Verma | Jack A. Henderson | Shaoqi Zhan | Jana Shen

Nitrile-containing pharmaceuticals: target, mechanism of action, and their SAR studies

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by National Natural Science Foundation of China (22071175)

Authors: Xi Wang | Yuanxun Wang | Xuemin Li | Zhenyang Yu | Chun Song | Yunfei Du

Mechanisms and inhibitors of nicotinamide N-methyltransferase

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Authors: Iredia D. Iyamu | Rong Huang

Discovery of dibenzylbutane lignan LCA derivatives as potent anti-inflammatory agents

JOURNAL ARTICLE published 2024 in RSC Medicinal Chemistry

Research funded by National Natural Science Foundation of China (21602250,82204347)

Authors: Zhen Wang | Juan Zhang | Conghao Gai | Jing Wang | Xiaobin Zhuo | Yan Song | Yan Zou | Peichao Zhang | Guige Hou | Qingguo Meng | Qingjie Zhao | Xiaoyun Chai

Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening

JOURNAL ARTICLE published 2024 in RSC Medicinal Chemistry

Research funded by H2020 Marie Skłodowska-Curie Actions (675899,860517) | Norges Forskningsråd (262695,274858)

Authors: Edward A. FitzGerald | Daniela Cederfelt | Bjarte Aarmo Lund | Nadine E. M. Myers | He Zhang | Doreen Dobritzsch | U. Helena Danielson

Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Engineering and Physical Sciences Research Council (EP/S035990/1)

Authors: Ross P. Thomas | Emma K. Grant | Eleanor R. Dickinson | Francesca Zappacosta | Lee J. Edwards | Michael M. Hann | David House | Nicholas C. O. Tomkinson | Jacob T. Bush

Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

Research funded by National Natural Science Foundation of China (81573313) | Graduate Research and Innovation Projects of Jiangsu Province (CXZZ13_0320)

Authors: Xiao-Bing Wang | Fu-Cheng Yin | Ming Huang | Neng Jiang | Jin-Shuai Lan | Ling-Yi Kong

Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Authors: Ingrid Allart-Simon | Aurélie Moniot | Nicolo Bisi | Miguel Ponce-Vargas | Sandra Audonnet | Marie Laronze-Cochard | Janos Sapi | Eric Hénon | Frédéric Velard | Stéphane Gérard

Phenylthiazoles with potent & optimum selectivity toward Clostridium difficile

JOURNAL ARTICLE published 2024 in RSC Medicinal Chemistry

Research funded by Science and Technology Development Fund (under grant number (43883))

Authors: Mahmoud M. Seif El-Din | Mohamed Hagras | Abdelrahman S. Mayhoub

Aptamer AS411 interacts with the KRAS promoter/hnRNP A1 complex and shows increased potency against drug-resistant lung cancer

JOURNAL ARTICLE published 2024 in RSC Medicinal Chemistry

Research funded by National Science and Technology Major Project (2017ZX09303013,2012CB720604) | National Natural Science Foundation of China (21778006)

Authors: Yuejie Zhu | Xiang Li | Qi Zhang | Xiantao Yang | Xudong Sun | Yi Pan | Xia Yuan | Yuan Ma | Bo Xu | Zhenjun Yang

New imidazo[2,1-b]thiazole-based aryl hydrazones: unravelling their synthesis and antiproliferative and apoptosis-inducing potential

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

Authors: Mohd Adil Shareef | Ganthala Parimala Devi | Sunitha Rani Routhu | C. Ganesh Kumar | Ahmed Kamal | Bathini Nagendra Babu

A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

Research funded by National Natural Science Foundation of China (21472242) | National Major Science and Technology Projects of China (2015ZX09102001) | State Key Laboratory of Natural Medicines (SKLNMZZCX201406)

Authors: Shaochi Wang | Xueqing Han | Yun Yang | Rui Chen | Zhaoyi Guo | Qihua Zhu | Yungen Xu

Dual functional therapeutics: mitigating bacterial infection and associated inflammation

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Department of Biotechnology, Ministry of Science and Technology, India (BT/PR31801/MED) | Science and Engineering Research Board (CRG/2020/003118)

Authors: Yash Acharya | Kashish Kumar Taneja | Jayanta Haldar

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JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Exploration of cytotoxic potential and tubulin polymerization inhibition activity of cis-stilbene-1,2,3-triazole congeners

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Authors: Darshana Bora | Khan Mehtab Samir | Anamika Sharma | Shrilekha Chilvery | Sapana Bansod | Stephy Elza John | Mursalim Ali Khan | Chandraiah Godugu | Nagula Shankaraiah