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Supplementary file 1. Previous proteomic studies of HIV-infected cells.

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Figure 1: Systems design schematics from: (A) Son et al. (2010); (B) Lau et al. (2010); (C) Fujiwara et al. (2011); and (D) Gjerlufsen et al. (2011).

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Figure 8—figure supplement 1. Buried surface analysis of crystal lattice pairs of IR and IGF1R kinase domains.

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Table 2. Table comparing enzymatic rates (Woodger et al., 2005; Sultemeyer et al., 1995; Heinhorst et al., 2006)

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Figure 2—figure supplement 2. Relationship between GE target and targets of other RNAP inhibitors.

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Figure 1—source data 1. Neuronal markers used in RNA-seq analysis and co-expression studies.

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Figure 1. Open access articles get more citations.

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Table 1: Comparing systems from Son et al. (2010), Lau et al. (2010), Fujiwara et al. (2011), Gjerlufsen et al. (2011), and this work based on our user requirements.

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Table 1. Ensemble refinement statistics for 20 datasets. Datasets were taken from the PDB or PDB_REDO and were re-refined using ensemble refinement and phenix.refine. The relaxation timeτxused, the resulting number of structures in the final ensemble andRworkandRfreevalues are given. The ensemble models yield improvedRfreevalues for all datasets, ranging in improvement from 0.3% to 4.9% with a mean improvement of 1.8%. The PDB accession numbers are as follows: 1KZK (Reiling et al., 2002), 3K0M (Fraser et al., 2009), 3K0N (Fraser et al., 2009), 2PC0 (Heaslet et al., 2007), 1UOY (Olsen et al., 2004), 3CA7 (Klein et al., 2008), 2R8Q (Wang et al., 2007), 3QL0 (Bhabha et al., 2011), 1X6P (Dunlop et al., 2005), 1F2F (Kimber et al., 2000), 3QL3 (Bhabha et al., 2011), 1YTT (Burling et al., 1996), 3GWH (Rodríguez et al., 2009), 1BV1 (Gajhede et al., 1996), 1IEP (Nagar et al., 2002), 2XFA (Singh et al., 2011), 3ODU (Wu et al., 2010), 1M52 (Nagar et al., 2002), 3CM8 (He et al., 2008) and 3RZE (Shimamura et al., 2011)

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