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The role of BAF (mSWI/SNF) complexes in mammalian neural development

Journal Article published Sep 2014 in American Journal of Medical Genetics Part C: Seminars in Medical Genetics volume 166 issue 3 on pages 333 to 349

Research funded by National Institutes of Health (NS046789) | Howard Hughes Medical Institute

Authors: Esther Y. Son, Gerald R. Crabtree

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

Journal Article published 13 Jul 2015 in Proceedings of the National Academy of Sciences volume 112 issue 30 on pages E4017 to E4025

Research funded by National Institute of General Medical Sciences (GM05586, GM60635, GM092802, GM007753) | Howard Hughes Medical Institute (N/A, N/A, N/A)

Authors: Neil B. Blok, Dongyan Tan, Ray Yu-Ruei Wang, Pawel A. Penczek, David Baker, Frank DiMaio, Tom A. Rapoport, Thomas Walz

RNA-guided assembly of Rev-RRE nuclear export complexes

Journal Article published 27 Aug 2014 in eLife volume 3

Research funded by National Institute of General Medical Sciences (The HARC Center, P50GM82250, The HARC Center, P50GM82250) | Howard Hughes Medical Institute

Authors: Yun Bai, Akshay Tambe, Kaihong Zhou, Jennifer A Doudna

Counteracting suppression of CFTR and voltage-gated K+ channels by a bacterial pathogenic factor with the natural product tannic acid

Journal Article published 14 Oct 2014 in eLife volume 3

Research funded by National Institute of General Medical Sciences (GM55560, GM55560) | Howard Hughes Medical Institute

Authors: Yajamana Ramu, Yanping Xu, Hyeon-Gyu Shin, Zhe Lu

A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells

Journal Article published 27 Nov 2014 in eLife volume 3

Research funded by National Institute of General Medical Sciences (R01GM073898, GM031627, GM104556) | Howard Hughes Medical Institute

Authors: Marcella L Erb, James A Kraemer, Joanna K C Coker, Vorrapon Chaikeeratisak, Poochit Nonejuie, David A Agard, Joe Pogliano

Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

Journal Article published 12 Oct 2015 in eLife volume 4

Research funded by National Institute of General Medical Sciences (R37GM057260) | Howard Hughes Medical Institute | Stowers Institute for Medical Research | Ellison Medical Foundation | American Foundation for Aging Research

Authors: Kimberly C Tu, Li-Chun Cheng, Hanh TK Vu, Jeffrey J Lange, Sean A McKinney, Chris W Seidel, Alejandro Sánchez Alvarado

A novel GTP-binding protein–adaptor protein complex responsible for export of Vangl2 from the trans Golgi network

Journal Article published 8 Jan 2013 in eLife volume 2

Research funded by Howard Hughes Medical Institute

Authors: Yusong Guo, Giulia Zanetti, Randy Schekman

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

Journal Article published 20 Jul 2014 in eLife volume 3

Research funded by Howard Hughes Medical Institute | National Institute of General Medical Sciences (NIHGM43949, NIHGM43949)

Authors: Weiwei Wang, Matthew R Whorton, Roderick MacKinnon

Phosphatidic acid modulation of Kv channel voltage sensor function

Journal Article published 6 Oct 2014 in eLife volume 3

Research funded by Howard Hughes Medical Institute | National Institute of General Medical Sciences (GM43949, GM43949)

Authors: Richard K Hite, Joel A Butterwick, Roderick MacKinnon

Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

Journal Article published 25 May 2016 in eLife volume 5

Research funded by National Institute of General Medical Sciences (GM0627, GM033928, GM108751, GM62580) | Howard Hughes Medical Institute

Authors: Gurunathan Laxmikanthan, Chen Xu, Axel F Brilot, David Warren, Lindsay Steele, Nicole Seah, Wenjun Tong, Nikolaus Grigorieff, Arthur Landy, Gregory D Van Duyne

Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects

Journal Article published 23 Sep 2014 in eLife volume 3

Research funded by Jane Coffin Childs Memorial Fund for Medical Research (Postdoctoral fellowship, Postdoctoral fellowship) | National Institute of General Medical Sciences (R01 GM74108, R01 GM74108) | Howard Hughes Medical Institute (Investigator, Investigator) | G. Harold and Leila Y. Mathers Charitable Foundation

Authors: Ines A Drinnenberg, Dakota deYoung, Steven Henikoff, Harmit Singh Malik

Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1

Journal Article published 22 Jun 2015 in Proceedings of the National Academy of Sciences volume 112 issue 27 on pages 8320 to 8325

Research funded by National Institute of General Medical Sciences (R01GM086196, R01GM086196, R01GM085437, R01GM085437) | National Eye Institute (PN2EY016525, PN2EY016525) | Howard Hughes Medical Institute (none, none)

Authors: Ljiljana Milenkovic, Lucien E. Weiss, Joshua Yoon, Theodore L. Roth, YouRong S. Su, Steffen J. Sahl, Matthew P. Scott, W. E. Moerner

A conserved MCM single-stranded DNA binding element is essential for replication initiation

Journal Article published 1 Apr 2014 in eLife volume 3

Research funded by American Lebanese Syrian Associated Charities | National Institute of General Medical Sciences (R01GM098771, R01-GM52339, R01GM098771, R01-GM52339) | Cancer Center Support Grant, National Cancer Institute (5 P30 CA021765-32) | Howard Hughes Medical Institute | National Cancer Institute (5 P30 CA021765-32)

Authors: Clifford A Froelich, Sukhyun Kang, Leslie B Epling, Stephen P Bell, Eric J Enemark

Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid

Journal Article published 2 Jul 2015 in Proceedings of the National Academy of Sciences volume 112 issue 30 on pages 9166 to 9173

Research funded by National Institute of General Medical Sciences (1R01-GM099839-01, R01GM056006, R01GM067837, RC2GM092412, R01GM056006) | Division of Integrative Organismal Systems (IOS 0929226) | Howard Hughes Medical Institute (N/A) | Gordon and Betty Moore Foundation (GBMF3032)

Authors: Xiao-yu Zheng, Mian Zhou, Heejin Yoo, Jose L. Pruneda-Paz, Natalie Weaver Spivey, Steve A. Kay, Xinnian Dong

A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

Journal Article published 5 Aug 2014 in eLife volume 3

Research funded by National Science Foundation (MCB1054947, Predoctoral Fellowship, MCB1054947, Predoctoral Fellowship) | National Institute of General Medical Sciences (T32 GM008297, GM053163, GM098543, T32 GM008297, GM053163, GM098543) | Howard Hughes Medical Institute (HHMI, HHMI)

Authors: Pelin Ayaz, Sarah Munyoki, Elisabeth A Geyer, Felipe-Andrés Piedra, Emily S Vu, Raquel Bromberg, Zbyszek Otwinowski, Nick V Grishin, Chad A Brautigam, Luke M Rice

Super Spy variants implicate flexibility in chaperone action

Journal Article published 4 Feb 2014 in eLife volume 3

Research funded by Howard Hughes Medical Institute | Genome Canada | Western Economic Diversification of Canada | National Institute of General Medical Sciences (GM083107, GM084222, GM083107, GM084222) | Western Economic Diversification Canada

Authors: Shu Quan, Lili Wang, Evgeniy V Petrotchenko, Karl AT Makepeace, Scott Horowitz, Jianyi Yang, Yang Zhang, Christoph H Borchers, James CA Bardwell

Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

Journal Article published 15 Apr 2014 in eLife volume 3

Research funded by National Institutes of Health (NIH R37GM057260, NIH R37GM057260) | Howard Hughes Medical Institute (N/A, N/A) | Stowers Institute for Medical Research (N/A, N/A)

Authors: Carolyn E Adler, Chris W Seidel, Sean A McKinney, Alejandro Sánchez Alvarado

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans

Journal Article published 30 Dec 2014 in eLife volume 3

Research funded by American Cancer Society (121631-PF-12-088-01-RMC) | National Institute of General Medical Sciences (2T32GM008759-11, 5R01GM047869, R01GM059083) | Howard Hughes Medical Institute

Authors: Benjamin P Weaver, Rebecca Zabinsky, Yi M Weaver, Eui Seung Lee, Ding Xue, Min Han

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation

Journal Article published 19 Nov 2015 in eLife volume 4

Research funded by National Institute of General Medical Sciences (R01GM077581, R01GM80372, P50GM081892) | Howard Hughes Medical Institute (Early Investigator) | U.S. Department of Energy (DE-NA0002520)

Authors: Nicolás Peláez, Arnau Gavalda-Miralles, Bao Wang, Heliodoro Tejedor Navarro, Herman Gudjonson, Ilaria Rebay, Aaron R Dinner, Aggelos K Katsaggelos, Luís AN Amaral, Richard W Carthew

1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure

Journal Article published Jun 2016 in Journal of Molecular Biology volume 428 issue 11 on pages 2307 to 2316

Research funded by National Institute of Allergy and Infectious Diseases (AI064046) | National Institute of General Medical Sciences (GM091743, GM095558, GM109770, P41 GM103403) | Howard Hughes Medical Institute | National Institutes of Health (S10 RR029205)

Authors: Nadine M. Shaban, Ke Shi, Ming Li, Hideki Aihara, Reuben S. Harris