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Aza Diels–Alder Reactions of Nitriles, N,N-Dimethylhydrazones, and Oximino Ethers. Application in Formal [2 + 2 + 2] Cycloadditions for the Synthesis of Pyridines

Journal Article published Dec 2017 in The Journal of Organic Chemistry volume 82 issue 24 on pages 12975 to 12991

Research funded by Division of Chemistry (CHE-1111567, CHE-1464799) | Amgen Foundation | Japan Society for the Promotion of Science

Authors: Philip J. Hamzik, Anne-Sophie Goutierre, Takeo Sakai, Rick L. Danheiser

Evolution of protein phosphorylation across 18 fungal species

Journal Article published 13 Oct 2016 in Science volume 354 issue 6309 on pages 229 to 232

Research funded by Ellison Medical Foundation (AG-NS-0953-12) | Amgen Foundation | Mary Gates scholarship | National Science Foundation (1243710) | Human Frontier Science Program (CDA00069/2013) | European Research Council (ERC-2014-STG) | Rita Allen Foundation

Authors: R. A. Studer, R. A. Rodriguez-Mias, K. M. Haas, J. I. Hsu, C. Vieitez, C. Sole, D. L. Swaney, L. B. Stanford, I. Liachko, R. Bottcher, M. J. Dunham, E. de Nadal, F. Posas, P. Beltrao, J. Villen

Transition State Gauche Effects Control the Torquoselectivities of the Electrocyclizations of Chiral 1-Azatrienes

Journal Article published 16 Oct 2015 in The Journal of Organic Chemistry volume 80 issue 23 on pages 11888 to 11894

Research funded by Division of Chemistry (CHE-1351104) | Amgen Foundation | University of California, Los Angeles | National Institute of General Medical Sciences (GM-36700, GM-66055, T32 GM 008496)

Authors: Ashay Patel, Joseph R. Vella, Zhi-Xiong Ma, R. P. Hsung, K. N. Houk

Paths to health equity: Local area variation in progress toward eliminating breast cancer mortality disparities, 1990-2009

Journal Article published 23 Apr 2015 in Cancer volume 121 issue 16 on pages 2765 to 2774

Research funded by National Institutes of Health (1P20MD006881-02, 8U54MD007588) | Agency for Healthcare Research and Quality (K18HS022444) | Amgen Foundation (2014)

Authors: George Rust, Shun Zhang, Khusdeep Malhotra, Leroy Reese, Luceta McRoy, Peter Baltrus, Lee Caplan, Robert S. Levine

Relative abundance of fetuin- A in peritoneal dialysis effluent and its association with in situ formation of calciprotein particles: An observational pilot study

Journal Article published 23 Dec 2014 in Nephrology volume 20 issue 1 on pages 6 to 10

Research funded by Amgen Foundation | National Health and Medical Research Council | Jacquot Research Fellowship

Authors: Michael MX Cai, Belinda Wigg, Edward R Smith, Timothy D Hewitson, Lawrence P McMahon, Stephen G Holt

Restrictive lung disorder is common in patients with kidney failure and associates with protein-energy wasting, inflammation and cardiovascular disease

Journal Article published 27 Apr 2018 in PLOS ONE volume 13 issue 4 on page e0195585

Research funded by Baxter Healthcare Corporation | Amgen Foundation | Vetenskapsrådet | Martin Rind foundation | Njurfonden

Authors: Hideyuki Mukai, Pei Ming, Bengt Lindholm, Olof Heimbürger, Peter Barany, Björn Anderstam, Peter Stenvinkel, Abdul Rashid Qureshi

Editors: Ping-Hsun Wu

Psoriasis patients with psoriasis Area and Severity Index (PASI) 90 response achieve greater health-related quality-of-life improvements than those with PASI 75–89 response: results from two phase 3 studies of secukinumab

Journal Article published 7 Mar 2017 in Journal of Dermatological Treatment volume 28 issue 6 on pages 492 to 499

Research funded by Novartis Pharmaceuticals Corporation | Pfizer | AbbVie | Novartis | Lilly | Amgen Foundation | University of Connecticut | University of Alabama at Birmingham | Janssen Research and Development | Merck

Authors: Boni E. Elewski, Lluís Puig, Margaret Mordin, Isabelle Gilloteau, Bintu Sherif, Todd Fox, Ari Gnanasakthy, Charis Papavassilis, Bruce E. Strober

Magnesiate Addition/Ring-Expansion Strategy To Access the 6–7–6 Tricyclic Core of Hetisine-Type C20-Diterpenoid Alkaloids

Journal Article published 18 Aug 2017 in Organic Letters volume 19 issue 17 on pages 4632 to 4635

Research funded by Amgen Foundation | National Institute of General Medical Sciences (R01 GM084906) | Eli Lilly and Company | National Science Foundation

Authors: Jason J. Pflueger, Louis C. Morrill, Justine N. deGruyter, Melecio A. Perea, Richmond Sarpong

Correction to “Nickel-Catalyzed Asymmetric Reductive Cross-Coupling To Access 1,1-Diarylalkanes”

Journal Article published 11 Jun 2018 in Journal of the American Chemical Society volume 140 issue 24 on pages 7746 to 7746

Research funded by Amgen Foundation | Division of Graduate Education (DGE-1144469) | American Cancer Society (123594-RSG-13-010-01-CDD) | Shionogi | National Institute of General Medical Sciences (GM111805-01, R35GM118191-01) | Heritage Medical Research Institute

Authors: Kelsey E. Poremba, Nathaniel T. Kadunce, Naoyuki Suzuki, Alan H. Cherney, Sarah E. Reisman

Development of 2-Deoxy-2-[18F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo

Journal Article published 2 Jul 2015 in Journal of Medicinal Chemistry volume 58 issue 14 on pages 5538 to 5547

Research funded by Amgen Foundation | National Cancer Institute (R25T CA098010) | Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California

Authors: Nikolai M. Evdokimov, Peter M. Clark, Graciela Flores, Timothy Chai, Kym F. Faull, Michael E. Phelps, Owen N. Witte, Michael E. Jung

The impact of the combination of income and education on the incidence of coronary heart disease in the prospective Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study

Journal Article published Dec 2015 in BMC Public Health volume 15 issue 1

Research funded by National Institute of Neurological Disorders and Stroke (U01NS041588) | National Heart, Lung, and Blood Institute (R01 HL080477, R01 HL080477-06) | Amgen Foundation (K24 HL111154)

Authors: Marquita W. Lewis, Yulia Khodneva, Nicole Redmond, Raegan W. Durant, Suzanne E. Judd, Larrell L. Wilkinson, Virginia J. Howard, Monika M. Safford

Gender, low Kt/V, and mortality in Japanese hemodialysis patients: Opportunities for improvement through modifiable practices

Journal Article published 24 Feb 2014 in Hemodialysis International volume 18 issue 3 on pages 596 to 606

Research funded by AbbVie | Sanofi Renal | Fresenius Medical Care | WiNE Institute | Vifor Fresenius Medical Care Renal Pharma Ltd | The Japanese Society for Peritoneal Dialysis | Kyowa Hakko Kirin | Baxter Healthcare | Amgen Foundation | Shire | Janssen | Kidney Foundation of Canada | BHC Medical | Takeda Pharmaceuticals U.S.A. | Hexal | DGfN

Authors: Naoki Kimata, Angelo Karaboyas, Brian A. Bieber, Ronald L. Pisoni, Hal Morgenstern, Brenda W. Gillespie, Akira Saito, Tadao Akizawa, Shunichi Fukuhara, Bruce M. Robinson, Friedrich K. Port, Takashi Akiba

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort

Journal Article published Jul 2018 in Respiratory Medicine volume 140 on pages 87 to 93

Research funded by Novartis Pharmaceuticals Corporation | U.S. Department of Veterans Affairs | Pfizer | Equinox Health Clubs | Teva | Spiration | U.S. Department of Defense | Janssen/Johnson & Johnson | National Heart, Lung, and Blood Institute | Amgen Foundation | National Institutes of Health (HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C, HHSN268200900020C, R01HL122438, R01HL126838, T32HL007749, K24HL138188, K23HL133438, K08HL123940, HL118128) | COPD | AstraZeneca-MedImmune | Gilead Sciences | Sanofi-Regneron | Genentech/Roche | Quintiles | AstraZeneca | Cystic Fibrosis Foundation | MedImmune | Boehringer-Ingelheim | Amgen | Alpha-1 Foundation | Mylan | GlaxoSmithKline

Authors: Wassim W. Labaki, Meng Xia, Susan Murray, Jeffrey L. Curtis, R. Graham Barr, Surya P. Bhatt, Eugene R. Bleecker, Nadia N. Hansel, Christopher B. Cooper, Mark T. Dransfield, J. Michael Wells, Eric A. Hoffman, Richard E. Kanner, Robert Paine, Victor E. Ortega, Stephen P. Peters, Jerry A. Krishnan, Russell P. Bowler, David J. Couper, Prescott G. Woodruff, Fernando J. Martinez, Carlos H. Martinez, MeiLan K. Han

Counties eliminating racial disparities in colorectal cancer mortality

Journal Article published 11 Mar 2016 in Cancer volume 122 issue 11 on pages 1735 to 1748

Research funded by Amgen Foundation | Agency for Healthcare Research and Quality (K18HS022444) | National Institutes of Health (NIH)/National Institute on Minority Health and Health Disparities (NIMHD) Center of Excellence on Health Disparities (1P20MD006881-02) | NIH/NIMHD Research Centers in Minority Institutions Program (8U54MD007588) | NIH/NIMHD (P20MD000516)

Authors: George Rust, Shun Zhang, Zhongyuan Yu, Lee Caplan, Sanjay Jain, Turgay Ayer, Luceta McRoy, Robert S. Levine

Synthesis of Robust Surface-Charged Nanoparticles Based on Cyclopropenium Ions

Journal Article published 17 Apr 2015 in Macromolecules volume 48 issue 8 on pages 2519 to 2525

Research funded by Amgen Foundation | Division of Materials Research (DMR-1351293) | Army Research Office (W911NF-14-0137) | 3M | U.S. Army Materiel Command | American Chemical Society Petroleum Research Fund (54471-DNI7)

Authors: Kato L. Killops, Spencer D. Brucks, Kourtney L. Rutkowski, Jessica L. Freyer, Yivan Jiang, Erica R. Valdes, Luis M. Campos

JAK3-STAT pathway blocking benefits in experimental lupus nephritis

Journal Article published 8 Jun 2016 in Arthritis Research & Therapy volume 18 issue 1

Research funded by Instituto de Salud Carlos III (Sara Borrell, PI14/00762) | Amgen Foundation | Fundació la Marató de TV3 (144/U/2012) | Societat Catalana de Trasplantament

Authors: Èlia Ripoll, Laura de Ramon, Juliana Draibe, Ana Merino, Nuria Bolaños, Montse Goma, Josep M. Cruzado, Josep M. Grinyó, Juan Torras

Molecular insights into cortico-striatal miscommunications in Huntington's disease

Journal Article published Feb 2018 in Current Opinion in Neurobiology volume 48 on pages 79 to 89

Research funded by National Institutes of Health (R01-NS084298, U01-MH106008) | Hereditary Disease Foundation | Amgen Foundation

Authors: Matthew B Veldman, X William Yang

Access to innovative medicines for metastatic melanoma worldwide: Melanoma World Society and European Association of Dermato-oncology survey in 34 countries

Journal Article published Nov 2018 in European Journal of Cancer volume 104 on pages 201 to 209

Research funded by LEO | AbbVie Deutschland | Pfizer | EU Joint Programme – Neurodegenerative Disease Research | British Mycological Society | Fondation Sanofi Espoir | Philogen | Array BioPharma | Novartis Pharma | Amgen Foundation | Merck Sharp and Dohme | Genentech | Asofarma | Meso Scale Diagnostics | Provectus | Janssen Research and Development | Boehringer Ingelheim Fonds | Les Laboratories Pierre Fabre | Roche | Celgene | Merck | Bayer HealthCare | Oncosec | Regeneron Pharmaceuticals | Astellas Pharma US | GlaxoSmithKline | AstraZeneca Schweiz

Authors: L. Kandolf Sekulovic, J. Guo, S. Agarwala, A. Hauschild, G. McArthur, G. Cinat, A. Wainstein, C. Caglevic, P. Lorigan, H. Gogas, M. Alvarez, R. Duncombe, C. Lebbe, K. Peris, P. Rutkowski, A. Stratigos, A.-M. Forsea, L. De La Cruz Merino, M. Kukushkina, R. Dummer, C. Hoeller, C. Gorry, L. Bastholt, D. Herceg, B. Neyns, R. Vieira, P. Arenberger, M. Bylaite-Bucinskiene, N. Babovic, M. Banjin, K. Putnik, V. Todorovic, K. Kirov, J. Ocvirk, A. Zhukavets, A. Ymeri, I. Stojkovski, C. Garbe

Denosumab for treating periprosthetic osteolysis; study protocol for a randomized, double-blind, placebo-controlled trial

Journal Article published 23 Apr 2016 in BMC Musculoskeletal Disorders volume 17 issue 1

Research funded by The regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet | Amgen Foundation

Authors: Olof Sköldenberg, Agata Rysinska, Thomas Eisler, Mats Salemyr, Henrik Bodén, Olle Muren

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids

Journal Article published Dec 2017 in Immunity volume 47 issue 6 on pages 1182 to 1196.e10

Research funded by Asana Medical | Colton Center for Autoimmunity | UCB | Sanofi-Aventis Korea Company | National Institute of Diabetes and Digestive and Kidney Diseases (5R01DK099076-07, P01DK071176) | Pfizer | AbbVie | Nagao Memorial Fund | Prova Education | Ministry of Education, Culture, Sports, Science and Technology (T15K15152, A15H02511) | Lotte Research Promotion Grant | Ministry of Health, Labour and Welfare (201324001B) | National Institute of Allergy and Infectious Diseases (R21AI119728, R21AI124129) | State of Florida | National Heart, Lung, and Blood Institute (RO1HL125816) | Broad Medical Foundation (IBD-0389R) | Amgen Foundation | Crohn's and Colitis Foundation of America (422515, 3786, 26971) | GI Health Foundation | Genentech | Focus Medical Communications | TSRI Florida | Shire | Genova Diagnostics | Hospira | GSK Holding Americas | Gilead Foundation | Core Research for Evolutional Science and Technology (JPMJCR10J2) | Janssen | Mucosal Health Board | WebMD Health | Takeda Pharmaceuticals U.S.A. | Ferring Pharmaceuticals | Prometheus

Authors: Wei Cao, Hisako Kayama, Mei Lan Chen, Amber Delmas, Amy Sun, Sang Yong Kim, Erumbi S. Rangarajan, Kelly McKevitt, Amanda P. Beck, Cody B. Jackson, Gogce Crynen, Angelos Oikonomopoulos, Precious N. Lacey, Gustavo J. Martinez, Tina Izard, Robin G. Lorenz, Alex Rodriguez-Palacios, Fabio Cominelli, Maria T. Abreu, Daniel W. Hommes, Sergei B. Koralov, Kiyoshi Takeda, Mark S. Sundrud