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American Association for Cancer Research
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Aggressive disease defined by cytogenetics is associated with cytokine dysregulation in CLL/SLL patients

Journal Article published Jan 2013 in Journal of Leukocyte Biology volume 93 issue 1 on pages 161 to 170

Research funded by Rush University Medical Center | Leukemia and Lymphoma Society (6044-08) | American Association for Cancer Research (07-10-19-CHRI) | National Blood Foundation/American Association of Blood Banks (031824) | National Institutes of Health | National Institute of Diabetes and Digestive and Kidney Diseases (DK074892) | Rubschlager Foundation | Coleman Foundation

Authors: Reem Karmali, Laura A. Paganessi, Robin R. Frank, Sucheta Jagan, Melissa L. Larson, Parameswaran Venugopal, Stephanie A. Gregory, Kent W. Christopherson

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

Journal Article published 25 Apr 2017 in The Journal of Experimental Medicine volume 214 issue 6 on pages 1711 to 1724

Research funded by National Institutes of Health (CA168611, CA155649, CA206105) | U.S. Department of Defense | Lustgarten Foundation | American Association for Cancer Research | Pancreatic Cancer Action Network | Hirshberg Foundation for Pancreatic Cancer Research | Irene and Bernard Schwartz Fellowship in Gastrointestinal Oncology

Authors: Donnele Daley, Vishnu R. Mani, Navyatha Mohan, Neha Akkad, Gautam S.D. Balasubramania Pandian, Shivraj Savadkar, Ki Buom Lee, Alejandro Torres-Hernandez, Berk Aykut, Brian Diskin, Wei Wang, Mohammad S. Farooq, Arif I. Mahmud, Gregor Werba, Eduardo J. Morales, Sarah Lall, Benjamin J. Wadowski, Amanda G. Rubin, Matthew E. Berman, Rajkishen Narayanan, Mautin Hundeyin, George Miller

Enhanced Tumor Selectivity of 5-Fluorouracil Using a Reactive Oxygen Species-Activated Prodrug Approach

Journal Article published 6 Dec 2018 in ACS Medicinal Chemistry Letters

Research funded by American Association for Cancer Research (00167155) | Samuel Waxman Cancer Research Foundation | National Institute of General Medical Sciences (R01GM099742) | Leukemia and Lymphoma Society

Authors: Yong Ai, Obinna N. Obianom, Meredith Kuser, Yue Li, Yan Shu, Fengtian Xue

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Journal Article published 28 Jan 2015 in Science Translational Medicine volume 7 issue 272 on pages 272ra12 to 272ra12

Research funded by American Association for Cancer Research (12-20-16-BERT) | Ministero dell’Istruzione, dell’Università e della Ricerca | Associazione Italiana per la Ricerca sul Cancro (14205, 11852) | European Regional Development Fund | Fondo per gli Investimenti della Ricerca di Base_Futuro in Ricercaq | Fondazione Piemontese per la Ricerca sul Cancro-ONLUS | State Budget of the Czech Republic-RECAMO (CZ.1.05/2.1.00/03.0101)

Authors: Eugenia R. Zanella, Francesco Galimi, Francesco Sassi, Giorgia Migliardi, Francesca Cottino, Simonetta M. Leto, Barbara Lupo, Jessica Erriquez, Claudio Isella, Paolo M. Comoglio, Enzo Medico, Sabine Tejpar, Eva Budinská, Livio Trusolino, Andrea Bertotti

AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

Journal Article published 1 Aug 2017 in Breast Cancer Research volume 19 issue 1

Research funded by American Association for Cancer Research (SU2C-AACR-IRG0911) | National Cancer Institute (R01 CA185086)

Authors: Sheheryar Kabraji, Xavier Solé, Ying Huang, Clyde Bango, Michaela Bowden, Aditya Bardia, Dennis Sgroi, Massimo Loda, Sridhar Ramaswamy

Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma

Journal Article published 16 Sep 2017 in Neuro-Oncology volume 20 issue 4 on pages 506 to 518

Research funded by Childhood Brain Tumor Foundation (CBTF) | Alex’s Lemonade Stand Pediatric Cancer Foundation (ALSF) | Alliance for Cancer Gene Therapy (ACGT, Inc) (R01AI067946) | Stand Up to Cancer–St Baldrick’s Pediatric Dream Team Translational Research (SU2C-AACR-DT1113) | American Association for Cancer Research (T32HL092332, T32GM088129) | National Institute of General Medical Sciences

Authors: Kevin Bielamowicz, Kristen Fousek, Tiara T Byrd, Hebatalla Samaha, Malini Mukherjee, Nikita Aware, Meng-Fen Wu, Jordan S Orange, Pavel Sumazin, Tsz-Kwong Man, Sujith K Joseph, Meenakshi Hegde, Nabil Ahmed

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway

Journal Article published 29 Aug 2017 in ACS Chemical Biology volume 12 issue 9 on pages 2436 to 2447

Research funded by American Association for Cancer Research | National Cancer Institute (CA096832) | St. Jude Children's Research Hospital | Astellas USA Foundation | James S. McDonnell Foundation | American Brain Tumor Association

Authors: Jamie R. Genthe, Jaeki Min, Dana M. Farmer, Anang A. Shelat, Jose A. Grenet, Wenwei Lin, David Finkelstein, Karen Vrijens, Taosheng Chen, R. Kiplin Guy, Wilson K. Clements, Martine F. Roussel

Oral delivery of anticancer drugs III: formulation using drug delivery systems

Journal Article published Jan 2013 in Drug Discovery Today volume 18 issue 1-2 on pages 99 to 104

Research funded by American Association for Cancer Research

Authors: Silvia Mazzaferro, Kawthar Bouchemal, Gilles Ponchel

Oral delivery of anticancer drugs II: the prodrug strategy

Journal Article published Jan 2013 in Drug Discovery Today volume 18 issue 1-2 on pages 93 to 98

Research funded by American Association for Cancer Research

Authors: Silvia Mazzaferro, Kawthar Bouchemal, Gilles Ponchel

Functional screen identifies kinases driving prostate cancer visceral and bone metastasis

Journal Article published 30 Nov 2015 in Proceedings of the National Academy of Sciences volume 113 issue 2 on pages E172 to E181

Research funded by National Cancer Institute (T32 CA009056, T32 CA00912) | California Institute of Regenerative Medicine (TG2-01169) | U.S. Department of Defense (W81XWH-14-1-0148) | American Association for Cancer Research (SU2C-AACR-DT0812) | Howard Hughes Medical Institute (PI)

Authors: Claire M. Faltermeier, Justin M. Drake, Peter M. Clark, Bryan A. Smith, Yang Zong, Carmen Volpe, Colleen Mathis, Colm Morrissey, Brandon Castor, Jiaoti Huang, Owen N. Witte

Gamma Delta T Cell Reconstitution Is Associated with Fewer Infections and Improved Event-Free Survival after Hematopoietic Stem Cell Transplantation for Pediatric Leukemia

Journal Article published Jan 2015 in Biology of Blood and Marrow Transplantation volume 21 issue 1 on pages 130 to 136

Research funded by National Institutes of Health (R56 AI091938) | American Association for Cancer Research | St. Baldrick's Foundation | Assisi Foundation of Memphis | Hartwell Foundation | American Lebanese Syrian Associated Charities

Authors: Ross Perko, Guolian Kang, Anusha Sunkara, Wing Leung, Paul G. Thomas, Mari H. Dallas

Oral delivery of anticancer drugs I: general considerations

Journal Article published Jan 2013 in Drug Discovery Today volume 18 issue 1-2 on pages 25 to 34

Research funded by American Association for Cancer Research

Authors: Silvia Mazzaferro, Kawthar Bouchemal, Gilles Ponchel

Na/K-ATPase signaling mediates miR-29b-3p regulation and cardiac fibrosis formation in mice with chronic kidney disease

Journal Article published 18 May 2018 in PLOS ONE volume 13 issue 5 on page e0197688

Research funded by National Heart, Lung, and Blood Institute (HL105649, HL137004) | National Institute of Diabetes and Digestive and Kidney Diseases (DK106666, F32DK104615) | American Association for Cancer Research (12SDG12050473) | David and Helen Boone Foundation Research Fund | The University of Toledo women and Philanthropy Genetic Analysis Instrumentation Center | The University of Toledo Medical Research Society

Authors: Christopher A. Drummond, Xiaoming Fan, Steven T. Haller, David J. Kennedy, Jiang Liu, Jiang Tian

Editors: Luis Eduardo M. Quintas

TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer

Journal Article published 28 Nov 2017 in Cancer Research volume 78 issue 2 on pages 489 to 500

Research funded by National Institute of General Medical Sciences (T32GM088129) | National Heart, Lung, and Blood Institute (5T32HL092332) | American Association for Cancer Research (SU2C-AACR-DT1113) | National Institutes of Health (AI036211, CA125123)

Authors: Tiara T. Byrd, Kristen Fousek, Antonella Pignata, Christopher Szot, Heba Samaha, Steven Seaman, Lacey Dobrolecki, Vita S. Salsman, Htoo Zarni Oo, Kevin Bielamowicz, Daniel Landi, Nino Rainusso, John Hicks, Suzanne Powell, Matthew L. Baker, Winfried S. Wels, Joachim Koch, Poul H. Sorensen, Benjamin Deneen, Matthew J. Ellis, Michael T. Lewis, Meenakshi Hegde, Bradley S. Fletcher, Brad St. Croix, Nabil Ahmed

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1–MAPK Interaction

Journal Article published 18 Jul 2017 in Cancer Research volume 77 issue 16 on pages 4328 to 4341

Research funded by National Institutes of Health (CA134514, CA130908, and CA193239, CA140550) | Pancreatic Cancer UK (P50 CA102701) | American Association for Cancer Research (10-60-25-TANG)

Authors: Xin Jin, Yunqian Pan, Liguo Wang, Tao Ma, Lizhi Zhang, Amy H. Tang, Daniel D. Billadeau, Heshui Wu, Haojie Huang

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

Journal Article published 6 Mar 2018 in The Journal of Experimental Medicine volume 215 issue 4 on pages 1091 to 1100

Research funded by Sidney Kimmel Foundation for Cancer Research (SKF-015-036) | Stand Up To Cancer | American Association for Cancer Research (SU2C-AACR-IRG-04-16) | National Institutes of Health (DP2AI136598, T32 CA082084, F99CA222711) | Cancer Institute, University of Pittsburgh (P30CA047904)

Authors: Ashley V. Menk, Nicole E. Scharping, Dayana B. Rivadeneira, Michael J. Calderon, McLane J. Watson, Deanna Dunstane, Simon C. Watkins, Greg M. Delgoffe

Trastuzumab-Resistant HER2+Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition

Journal Article published 28 Mar 2018 in Molecular Cancer Therapeutics volume 17 issue 5 on pages 921 to 930

Research funded by Susan G. Komen for the Cure (CCR12364491) | American Association for Cancer Research (12-30-18-YANG) | Breast cancer research foundation of alabama (N/A) | National Institutes of Health (P30 AI027767, P30 AR048311) | National Cancer Institute (P50 CA089019)

Authors: Monica E. Wielgos, Zhuo Zhang, Rajani Rajbhandari, Tiffiny S. Cooper, Ling Zeng, Andres Forero, Francisco J. Esteva, C. Kent Osborne, Rachel Schiff, Albert F. LoBuglio, Susan E. Nozell, Eddy S. Yang

Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer

Journal Article published Jul 2018 in American Journal of Physiology-Gastrointestinal and Liver Physiology volume 315 issue 1 on pages G27 to G35

Research funded by Michigan Institute for Clinical and Health Research | National Cancer Institute (T32-CA009676) | National Institutes of Health (R01CA151588, R01CA198074, P30CA46592, U01CA224145) | American Association for Cancer Research (13-70-25-LYSS, 17-20-01-LYSS) | The V Foundation (V2016-009) | Sidney Kimmel Foundation for Cancer Research (SKF-16-005)

Authors: Christopher J. Halbrook, Marina Pasca di Magliano, Costas A. Lyssiotis

Cancer Manipulation of Host Physiology: Lessons from Pancreatic Cancer

Journal Article published May 2017 in Trends in Molecular Medicine volume 23 issue 5 on pages 465 to 481

Research funded by Center for Metastasis Research Fellowship (Memorial Sloan Kettering Cancer Center | National Institutes of Health (CA168611, CA155649, CA206105) | U.S. Department of Defense | Lustgarten Foundation | American Association for Cancer Research | Hirshberg Foundation for Pancreatic Cancer Research

Authors: Constantinos P. Zambirinis, George Miller

PBRM1 loss is a late event during the development of cholangiocarcinoma

Journal Article published 22 Jun 2017 in Histopathology volume 71 issue 3 on pages 375 to 382

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (K08 DK107781) | American Association for Cancer Research | Joseph C. Monastra Foundation | Sol Goldman Pancreatic Cancer Research Center | Kaya Tuncer Career Development Award in Gastrointestinal Cancer Prevention | National Institutes of Health (P50 CA62924) | Buffone Family Gastrointestinal Cancer Research Fund | Sigma Beta Sorority | Associazione Italiana per la Ricerca sul Cancro (12182, P50 CA62924) | Rolfe Pancreatic Cancer Foundation | AGA-Bernard Lee Schwartz Foundation Research Scholar Award in Pancreatic Cancer | Sidney Kimmel Foundation for Cancer Research

Authors: Claudio Luchini, Scott A Robertson, Seung-Mo Hong, Matthäus Felsenstein, Robert A Anders, Antonio Pea, Alessia Nottegar, Nicola Veronese, Jin He, Matthew J Weiss, Paola Capelli, Aldo Scarpa, Pedram Argani, Payal Kapur, Laura D Wood