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Alexander and Margaret Stewart Trust
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Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition

Journal Article published 22 Sep 2015 in Journal of Medicinal Chemistry volume 58 issue 19 on pages 7659 to 7671

Research funded by Alexander and Margaret Stewart Trust | National Cancer Institute (P30 CA014236) | National Research Foundation of Korea (NRF-2012R1A4A1028835) | American Cancer Society (122057-RSG-12-045-01-CDD) | National Science Foundation

Authors: Do-Yeon Kwon, Hye Eun Lee, Douglas H. Weitzel, Kyunghye Park, Sun Hee Lee, Chen-Ting Lee, Tesia N. Stephenson, Hyeri Park, Michael C. Fitzgerald, Jen-Tsan Chi, Robert A. Mook, Mark W. Dewhirst, You Mie Lee, Jiyong Hong

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

Journal Article published Jun 2018 in The American Journal of Human Genetics volume 102 issue 6 on pages 1204 to 1211

Research funded by Knut och Alice Wallenbergs Stiftelse (2015.0327) | Vetenskapsrådet (2016-00250) | National Human Genome Research Institute (U54, HG003067, R01 HG006855) | National Institute of Mental Health (1U01MH105666-01, 1R01MH101244-02, R01 MH077139, RC2 MH089905) | National Institute of Diabetes and Digestive and Kidney Diseases (1U54DK105566-02) | Stanley Center for Psychiatric Research | Alexander and Margaret Stewart Trust | Sylvan C. Herman Foundation | Sydäntutkimussäätiö

Authors: Andrea Ganna, F. Kyle Satterstrom, Seyedeh M. Zekavat, Indraniel Das, Mitja I. Kurki, Claire Churchhouse, Jessica Alfoldi, Alicia R. Martin, Aki S. Havulinna, Andrea Byrnes, Wesley K. Thompson, Philip R. Nielsen, Konrad J. Karczewski, Elmo Saarentaus, Manuel A. Rivas, Namrata Gupta, Olli Pietiläinen, Connor A. Emdin, Francesco Lescai, Jonas Bybjerg-Grauholm, Jason Flannick, Josep M. Mercader, Miriam Udler, Markku Laakso, Veikko Salomaa, Christina Hultman, Samuli Ripatti, Eija Hämäläinen, Jukka S. Moilanen, Jarmo Körkkö, Outi Kuismin, Merete Nordentoft, David M. Hougaard, Ole Mors, Thomas Werge, Preben Bo Mortensen, Daniel MacArthur, Mark J. Daly, Patrick F. Sullivan, Adam E. Locke, Aarno Palotie, Anders D. Børglum, Sekar Kathiresan, Benjamin M. Neale

High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation

Journal Article published 20 Sep 2016 in mBio volume 7 issue 5

Research funded by National Cancer Institute (R35CA197262) | Alexander and Margaret Stewart Trust

Authors: Elizabeth A. White, Karl Münger, Peter M. Howley

Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA

Journal Article published Jan 2014 in Developmental Biology volume 385 issue 1 on pages 2 to 12

Research funded by NIH (RO1 DK060127) | Juvenile Diabetes Research Foundation, American Diabetes Association (1-12-BS-187) | the Herbert Graetz Fund, Shirley and William Fleisher Family Foundation | Alexander and Margaret Stewart Trust | Swiss National Foundation (PBGEP3-121298, #R7-A714-B576) | the Media, Advanced Microscopy, Advanced Genomics/Genetics, and Bioinformatics Cores of Joslin Diabetes Endocrinology Research Center (NIH DK-36836)

Authors: KaiHui Hu He, Kirstine Juhl, Michael Karadimos, Ilham El Khattabi, Connor Fitzpatrick, Susan Bonner-Weir, Arun Sharma

Structural Characterization and in Vivo Evaluation of β-Hairpin Peptidomimetics as Specific CXCR4 Imaging Agents

Journal Article published 3 Feb 2015 in Molecular Pharmaceutics volume 12 issue 3 on pages 941 to 953

Research funded by Alexander and Margaret Stewart Trust | National Cancer Institute (P30 CA006973, P50 CA103175, R01CA166131) | Congressionally Directed Medical Research Programs (W81XWH-12-BCRP-IDEA)

Authors: Wojciech G. Lesniak, Emilia Sikorska, Hassan Shallal, Babak Behnam Azad, Ala Lisok, Mrudula Pullambhatla, Martin G. Pomper, Sridhar Nimmagadda

ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast

Journal Article published 1 Oct 2013 in eLife volume 2

Research funded by Charles A King Trust, Bank of America | Alexander and Margaret Stewart Trust Cancer Pilot Grant | National Institutes of Health (R01 GM088248, R01 GM088248) | Alexander and Margaret Stewart Trust

Authors: Hannah G Blitzblau, Andreas Hochwagen

Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia

Journal Article published 11 Dec 2014 in eLife volume 3

Research funded by National Center for Advancing Translational Sciences (UL1 TR000040) | National Institutes of Health (1 U54 CA121852-05, 1R01CA185486-01, 1R01CA179044-01A1) | Associazione Italiana per la Ricerca sul Cancro (Special Program Molecular Clinical Oncology, 5x1000, No. 10007, My First AIRC Grant 2012) | Ministero dell’Istruzione, dell’Università e della Ricerca (Futuro in Ricerca 2002 and 2012) | Instituto Nazionale di Fisica Nucleare (PRIN 2008, PRIN 2009) | Ministero della Salute (2008 and 2010) | Alexander and Margaret Stewart Trust

Authors: Jiguang Wang, Hossein Khiabanian, Davide Rossi, Giulia Fabbri, Valter Gattei, Francesco Forconi, Luca Laurenti, Roberto Marasca, Giovanni Del Poeta, Robin Foà, Laura Pasqualucci, Gianluca Gaidano, Raul Rabadan

Widespread Translational Remodeling during Human Neuronal Differentiation

Journal Article published Nov 2017 in Cell Reports volume 21 issue 7 on pages 2005 to 2016

Research funded by Canadian Institutes of Health Research (356733) | Pew Charitable Trusts | Alexander and Margaret Stewart Trust | Siebel Stem Cell Center | National Institutes of Health (R01CA196884, R01NS097823, S10 OD018174) | Howard Hughes Medical Institute | Alfred P. Sloan Foundation (FR-2015-65790) | Hellman Family Faculty Fund | Helen Hay Whitney Foundation (F-1077)

Authors: John D. Blair, Dirk Hockemeyer, Jennifer A. Doudna, Helen S. Bateup, Stephen N. Floor

Proper activation of MafA is required for optimal differentiation and maturation of pancreatic β-cells

Journal Article published Dec 2015 in Best Practice & Research Clinical Endocrinology & Metabolism volume 29 issue 6 on pages 821 to 831

Research funded by NIH/NIDDK (RO1DK06127) | Juvenile Diabetes Research Foundation (1-2008-53) | American Diabetes Association (7-08-RA-146; 1-12-BS-187) | Herbert Graetz Fund | Shirley and William Fleisher Family Foundation | Alexander and Margaret Stewart Trust | Sharma laboratory

Authors: Ilham El Khattabi, Arun Sharma

Analyzing Circulating Tumor Cells One at a Time

Journal Article published Oct 2018 in Trends in Cell Biology volume 28 issue 10 on pages 764 to 775

Research funded by NIH K22 (K22 CA175228-01A1) | NIH DP2 (DP2 CA206653) | Donald E. and Delia B. Baxter Foundation | Stop Cancer Foundation | Wright Foundation | Pew Charitable Trusts | Alexander and Margaret Stewart Trust

Authors: Veronica Ortiz, Min Yu