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Alex's Lemonade Stand Foundation for Childhood Cancer
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Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model

Journal Article published 7 Mar 2018 in Clinical Cancer Research volume 24 issue 11 on pages 2585 to 2593

Research funded by Alex's Lemonade Stand Foundation for Childhood Cancer (NA) | St. Baldrick's Foundation (NA) | CURE Childhood Cancer (NA) | Solving Kids' Cancer (NA)

Authors: Ferro Nguyen, Ivan Alferiev, Peng Guan, David T. Guerrero, Venkatadri Kolla, Ganesh S. Moorthy, Michael Chorny, Garrett M. Brodeur

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Journal Article published Mar 2017 in Cell Reports volume 18 issue 12 on pages 2932 to 2942

Research funded by National Cancer Institute (K99/R00CA178189) | Mayo Center for Biomedical Discovery | Princess Margaret Cancer Foundation | Friends for Life and the Friends of DFCI | Mayo Clinic Cancer Center | Children's Neuroblastoma Cancer Foundation (CA196631-01A1) | National Institutes of Health (R37 CA49152) | Center for Individualized Medicine (R01 CA180692) | Fraternal Order of Eagles | Alex's Lemonade Stand Foundation for Childhood Cancer | V Foundation for Cancer Research | Center for Biomedical Discovery | CureSearch for Children’s Cancer Foundation

Authors: Xiaoling Zhang, Zhiwei Dong, Cheng Zhang, Choong Yong Ung, Shuning He, Ting Tao, Andre M. Oliveira, Alexander Meves, Baoan Ji, A. Thomas Look, Hu Li, Benjamin G. Neel, Shizhen Zhu

Methylome analysis and whole-exome sequencing reveal that brain tumors associated with encephalocraniocutaneous lipomatosis are midline pilocytic astrocytomas

Journal Article published 24 Aug 2018 in Acta Neuropathologica volume 136 issue 4 on pages 657 to 660

Research funded by Fundação de Amparo à Pesquisa do Estado de São Paulo (2015/20142-0) | Alex's Lemonade Stand Foundation for Childhood Cancer | Banting Research Foundation | National Institutes of Health (P01CA196539) | Canadian Institutes of Health Research (MOP286756) | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Authors: Elvis Terci Valera, Melissa K. McConechy, Tenzin Gayden, Barbara Rivera, David T. W. Jones, Andrea Wittmann, HyeRim Han, Eric Bareke, Hamid Nikbakht, Leonie Mikael, Rosane Gomes Queiroz, Veridiana Kiill Suazo, Ji Hoon Phi, Seung-Ki Kim, Sung-Hye Park, Raita Fukaya, Mi-Sun Yum, Tae-Sung Ko, Ricardo Santos de Oliveira, Helio Rubens Machado, María Sol Brassesco, Antonio Carlos do Santos, Gustavo Novelino Simão, Leandra Náira Zambelli Ramalho, Luciano Neder, Carlos Alberto Scrideli, Luiz Gonzaga Tone, Jacek Majewski, Nada Jabado

Nutritional risk factors predict severe acute graft-versus-host disease and early mortality in pediatric allogeneic hematopoietic stem cell transplantation

Journal Article published 28 Oct 2017 in Pediatric Blood & Cancer volume 65 issue 2 on page e26853

Research funded by American Cancer Society (MRSG-12-215-01-LIB) | Alex's Lemonade Stand Foundation Epidemiology Award | Children's Hospital of Philadelphia (Richard and Sheila Sanford Endowed Chair in Pediatric) | Alex's Lemonade Stand Foundation for Childhood Cancer (Epidemiology Award, Grant number: 37553)

Authors: Eva H. Kerby, Yimei Li, Kelly D. Getz, Elizabeth C. Smith, Laura T. Smith, Nancy J. Bunin, Alix E. Seif

N-methyladenine DNA Modification in Glioblastoma

Journal Article published Nov 2018 in Cell volume 175 issue 5 on pages 1228 to 1243.e20

Research funded by Ludwig Family Foundation (CA197718, CA154130, CA169117, CA171652, NS087913, NS089272, NS103434) | Peter D. Cristal Chair | Baylor College of Medicine (A217956-01, CA187780, NS089272) | Ferry Foundation | Children's Cancer Research Fund | BEAR Necessities Pediatric Cancer Foundation | Alex's Lemonade Stand Foundation for Childhood Cancer | Kimble Foundation | Gerald Kaufman Jr. Foundation | Rally | Cancer Prevention and Research Institute of Texas | Coulter Foundation

Authors: Qi Xie, Tao P. Wu, Ryan C. Gimple, Zheng Li, Briana C. Prager, Qiulian Wu, Yang Yu, Pengcheng Wang, Yinsheng Wang, David U. Gorkin, Cheng Zhang, Alexis V. Dowiak, Kaixuan Lin, Chun Zeng, Yinghui Sui, Leo J.Y. Kim, Tyler E. Miller, Li Jiang, Christine H. Lee, Zhi Huang, Xiaoguang Fang, Kui Zhai, Stephen C. Mack, Maike Sander, Shideng Bao, Amber E. Kerstetter-Fogle, Andrew E. Sloan, Andrew Z. Xiao, Jeremy N. Rich

Angiopoietin 2 signaling plays a critical role in neural crest cell migration

Journal Article published Dec 2016 in BMC Biology volume 14 issue 1

Research funded by Alex's Lemonade Stand Foundation for Childhood Cancer | Stowers Institute for Medical Research

Authors: Mary Cathleen McKinney, Rebecca McLennan, Paul M. Kulesa

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

Journal Article published Apr 2016 in Cancer Cell volume 29 issue 4 on pages 536 to 547

Research funded by National Cancer Institute | Prostate Cancer Foundation | U.S. Department of Defense (W81XWH-12-1-0206) | National Institutes of Health (U54 HG006097, U54 HL127365, K99CA184397, K08NS079485, 5R01CA172603-02, 2P30CA016042-39, 1R01CA181242-01A1, 1R01CA195505, U01 CA164188-01A) | Stand Up To Cancer | Alex's Lemonade Stand Foundation for Childhood Cancer | University of California, Los Angeles (T32CA09056, T32CA009120) | Movember Foundation | Prostate Dream Team Translational Cancer Research (SU2C-AACR-DT0812) | Tower Cancer Research Foundation

Authors: John K. Lee, John W. Phillips, Bryan A. Smith, Jung Wook Park, Tanya Stoyanova, Erin F. McCaffrey, Robert Baertsch, Artem Sokolov, Justin G. Meyerowitz, Colleen Mathis, Donghui Cheng, Joshua M. Stuart, Kevan M. Shokat, W. Clay Gustafson, Jiaoti Huang, Owen N. Witte

The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma

Journal Article published Jun 2017 in Cell Reports volume 19 issue 11 on pages 2304 to 2318

Research funded by National Institutes of Health (R01CA154923, R24OD016761, U54CA168512, K99CA175184) | Harvard Stem Cell Institute | Alex's Lemonade Stand Foundation for Childhood Cancer | St. Baldrick’s | Cancer Prevention and Research Institute of Texas (RR160062) | Specialized Histopathology Services at Massachusetts General Hospital (MGH) | MGH Cancer Center/Molecular Pathology Confocal Core | MGH CNY Flow Cytometry Core and Flow Image Analysis (1S10RR023440-01A1)

Authors: Myron S. Ignatius, Madeline N. Hayes, Riadh Lobbardi, Eleanor Y. Chen, Karin M. McCarthy, Prethish Sreenivas, Zainab Motala, Adam D. Durbin, Aleksey Molodtsov, Sophia Reeder, Alexander Jin, Sivasish Sindiri, Brian C. Beleyea, Deepak Bhere, Matthew S. Alexander, Khalid Shah, Charles Keller, Corinne M. Linardic, Petur G. Nielsen, David Malkin, Javed Khan, David M. Langenau

IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells

Journal Article published 28 May 2018 in Frontiers in Immunology volume 9

Research funded by National Institutes of Health (AI102893, A1064826) | National Cancer Institute (CA179363) | | American Cancer Society | Alex's Lemonade Stand Foundation for Childhood Cancer

Authors: Alex M. Abel, Aradhana A. Tiwari, Zachary J. Gerbec, Jason R. Siebert, Chao Yang, Nathan J. Schloemer, Kate J. Dixon, Monica S. Thakar, Subramaniam Malarkannan

Birth weight, fetal growth, and risk of pediatric rhabdomyosarcoma: an updated record linkage study in California

Journal Article published Feb 2016 in Annals of Epidemiology volume 26 issue 2 on pages 141 to 145

Research funded by Alex's Lemonade Stand Foundation for Childhood Cancer (034816)

Authors: Libby M. Morimoto, Kathryn McCauley, Xiaomei Ma, Joseph L. Wiemels, Anand P. Chokkalingam, Catherine Metayer