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Alternatives Research and Development Foundation
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Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism

Journal Article published Jan 2016 in Toxicology Letters volume 243 on pages 98 to 110

Research funded by National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/K500471/1) | Alternatives Research and Development Foundation | European Commission | Libyan Ministry of Higher Education and Scientific Research

Authors: Philip M. Probert, Jeremy M. Palmer, Wasma Alhusainy, Aimen O. Amer, Ivonne M.C.M. Rietjens, Steven A. White, David E. Jones, Matthew C. Wright

Magnetic particles assisted capture and release of rare circulating tumor cells using wavy-herringbone structured microfluidic devices

Journal Article published 2017 in Lab on a Chip volume 17 issue 19 on pages 3291 to 3299

Research funded by National Science Foundation (CBET-1067502, CBET-1113040, DMS-1516236, IIP-1701136) | National Institutes of Health (R01HL131750, EB015105) | Alternatives Research and Development Foundation

Authors: Wentao Shi, Shunqiang Wang, Ahmad Maarouf, Christopher G. Uhl, Ran He, Doruk Yunus, Yaling Liu

An expandable donor-free supply of functional hepatocytes for toxicology

Journal Article published 2015 in Toxicology Research volume 4 issue 2 on pages 203 to 222

Research funded by CHIST-ERA (EC Contract No. 287596) | Alternatives Research and Development Foundation | Engineering and Physical Sciences Research Council | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/K500471/1)

Authors: Philip M. E. Probert, Stephanie K. Meyer, Fouzeyyah Alsaeedi, Andrew A. Axon, Emma A. Fairhall, Karen Wallace, Michelle Charles, Fiona Oakley, Paul A. Jowsey, Peter G. Blain, Matthew C. Wright

Understanding chemical allergen potency: role of NLRP12 and Blimp-1 in the induction of IL-18 in human keratinocytes

Journal Article published 1 Sep 2016 in Archives of Toxicology volume 91 issue 4 on pages 1783 to 1794

Research funded by Alternatives Research and Development Foundation (2014 Grants)

Authors: Angela Papale, Elena Kummer, Valentina Galbiati, Marina Marinovich, Corrado L. Galli, Emanuela Corsini

Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling

Journal Article published Dec 2016 in Reproductive Toxicology volume 66 on pages 68 to 83

Research funded by Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) | Alternatives Research and Development Foundation

Authors: Aileen S.W. Li, Yusuke Marikawa

Geometry design of herringbone structures for cancer cell capture in a microfluidic device

Journal Article published 18 Oct 2016 in Microfluidics and Nanofluidics volume 20 issue 11

Research funded by Alternatives Research and Development Foundation | National Science Foundation (CBET-1264808, DMS-1516236) | National Institutes of Health (EB015105) | Pennsylvania Infrastructure Technology Alliance

Authors: Shunqiang Wang, Salman Sohrabi, Jiang Xu, Jie Yang, Yaling Liu

Pancreatic progenitor-derived hepatocytes are viable and functional in a 3D high density bioreactor culture system

Journal Article published 2016 in Toxicology Research volume 5 issue 1 on pages 278 to 290

Research funded by Alternatives Research and Development Foundation

Authors: M. Richter, E. A. Fairhall, S. A. Hoffmann, S. Tröbs, F. Knöspel, P. M. E. Probert, F. Oakley, A. Stroux, M. C. Wright, K. Zeilinger

New experimental models of the blood-brain barrier for CNS drug discovery

Journal Article published 7 Nov 2016 in Expert Opinion on Drug Discovery volume 12 issue 1 on pages 89 to 103

Research funded by Alternatives Research and Development Foundation (N.A., R01DA029121)

Authors: Mohammad A. Kaisar, Ravi K. Sajja, Shikha Prasad, Vinay V. Abhyankar, Taylor Liles, Luca Cucullo

Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans -resveratrol

Journal Article published Sep 2018 in Toxicology and Applied Pharmacology volume 355 on pages 211 to 225

Research funded by Johns Hopkins University | Alternatives Research and Development Foundation | National Institutes of Health (P20GM103457, R03HD088970)

Authors: Iris Q. Kim, Yusuke Marikawa

Nanoparticle transport and delivery in a heterogeneous pulmonary vasculature

Journal Article published Jan 2017 in Journal of Biomechanics volume 50 on pages 240 to 247

Research funded by Alternatives Research and Development Foundation | Pennsylvania Infrastructure Technology Alliance | National Science Foundation (CBET-1113040, CBET-1067502) | National Institutes of Health (EB015105)

Authors: Salman Sohrabi, Shunqiang Wang, Jifu Tan, Jiang Xu, Jie Yang, Yaling Liu