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Adrienne Helis Malvin Medical Research Foundation
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Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Journal Article published 31 Jan 2018 in Proceedings of the National Academy of Sciences volume 115 issue 7 on pages 1635 to 1640

Research funded by National Institute on Aging (AG046366, AG056841, P50AG005146) | St. Louis American Parkinson Disease Association (NA) | National Institute of General Medical Sciences (GM103418) | National Science Foundation (NA) | National Institute of Neurological Disorders and Stroke (NS082205, NS098006, NS075839, NS38377) | JPB Foundation (NA) | Adrienne Helis Malvin Medical Research Foundation (NA) | Diana Helis Henry Medical Research Foundation (NA)

Authors: Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, Valina L. Dawson

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

Journal Article published 31 Aug 2015 in Proceedings of the National Academy of Sciences volume 112 issue 37 on pages 11696 to 11701

Research funded by National Institute of Neurological Disorders and Stroke (NS38377) | JPB Foundation (No #) | Adrienne Helis Malvin Medical Research Foundation (M-1, M-2) | Diana Henry Helis Medical Research Foundation (H-2014) | Ministry of Science, ICT and Future Planning (NRF-2012R1A1A1012435) | Samsung (SBRI, SMX1132521)

Authors: Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin, Ted M. Dawson

Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer

Journal Article published Jan 2017 in Molecular Therapy volume 25 issue 1 on pages 249 to 258

Research funded by Dan L. Duncan Comprehensive Cancer Center (P30 CA125123) | Ruth L. Kirschstein National Research Service Award (F32 CA189423) | Dan L. Duncan Chair | National Institutes of Health | Fayez Sarofim Chair | NIH-NCI (P01 CA094237, P50 CA126752, P50 CA186784) | Elsa U. Pardee Foundation | Adrienne Helis Malvin Medical Research Foundation | American Cancer Society | Mentored Research Scholars Grant in Applied and Clinical Research (MRSG-14-197-01, -, LI, B)

Authors: Somala Mohammed, Sujita Sukumaran, Pradip Bajgain, Norihiro Watanabe, Helen E. Heslop, Cliona M. Rooney, Malcolm K. Brenner, William E. Fisher, Ann M. Leen, Juan F. Vera

SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis

Journal Article published 20 Oct 2015 in Proceedings of the National Academy of Sciences volume 112 issue 44 on pages E6068 to E6077

Research funded by Cancer Prevention and Research Institute of Texas (RP120092) | National Cancer Institute (F31CA171350) | National Institute of Diabetes and Digestive and Kidney Diseases (P01 DK59820, 3U19DK062434, P30 DK079638, DK56338) | National Institute of General Medical Sciences (GM033976, T32 GM7330) | Susan G. Komen for the Cure (PDF14300468) | Welch Foundation (Q1521) | Adrienne Helis Malvin Medical Research Foundation (M2014) | Center for the Advancement of Science in Space (CASIS)

Authors: Tiffany Fleet, Bin Zhang, Fumin Lin, Bokai Zhu, Subhamoy Dasgupta, Erin Stashi, Bryan Tackett, Sundararajah Thevananther, Kimal I. Rajapakshe, Naomi Gonzales, Adam Dean, Jianqiang Mao, Nikolai Timchenko, Anna Malovannaya, Jun Qin, Cristian Coarfa, Francesco DeMayo, Clifford C. Dacso, Charles E. Foulds, Bert W. O’Malley, Brian York

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation – Clinical and functional study

Journal Article published Nov 2014 in Parkinsonism & Related Disorders volume 20 issue 11 on pages 1274 to 1278

Research funded by National Institutes of Health (NINDS NS38377, MDSCRF 2007-MSCRFI-0420-00, 2009-MSCRFII-0125-00, MDSCRF 2012-MSCRFII-0268-00, MDSCRF 2013-MSCRFII-0105-00, NINDS P50 NS072187, NINDS R01 NS078086, NINDS P50 NS072187) | Mayo Clinic Center | GHR Foundation | Marriott Family Foundation | Gerstner Family Career Development Award | JPB Foundation | Adrienne Helis Malvin Medical Research Foundation

Authors: Joanna Siuda, Barbara Jasinska-Myga, Magdalena Boczarska-Jedynak, Grzegorz Opala, Fabienne C. Fiesel, Elisabeth L. Moussaud-Lamodière, Leslie A. Scarffe, Valina L. Dawson, Owen A. Ross, Wolfdieter Springer, Ted M. Dawson, Zbigniew K. Wszolek

Engineered T cells for cancer treatment

Journal Article published Jun 2014 in Cytotherapy volume 16 issue 6 on pages 713 to 733

Research funded by (U.S. National Institutes of Health National Cancer Institute and National Heart, Lung and Blood Institute) | V Foundation | Dana Foundation | James S. McDonnell Foundation | Adrienne Helis Malvin Medical Research Foundation

Authors: Usanarat Anurathapan, Ann M. Leen, Malcolm K. Brenner, Juan F. Vera

LRRK2 pathobiology in Parkinson's disease

Journal Article published 10 Oct 2014 in Journal of Neurochemistry volume 131 issue 5 on pages 554 to 565

Research funded by National Institute of Neurological Disorders and Stroke (NS38377) | Adrienne Helis Malvin Medical Research Foundation | Diana Helis Henry Medical Research Foundation | JPB Foundation

Authors: Ian Martin, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson

CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

Journal Article published 10 May 2018 in Journal for ImmunoTherapy of Cancer volume 6 issue 1

Research funded by National Cancer Institute (P01 CA094237, P50 CA126752, P50 CA186784, P30 CA125123) | Pancreatic Cancer Action Network (16-65-LEEN) | American Cancer Society (MRSG-14-197-01–LIB) | Cancer Prevention and Research Institute of Texas (RR170024) | V Foundation for Cancer Research (T2016-006) | Elsa U. Pardee Foundation | Adrienne Helis Malvin Medical Research Foundation

Authors: Pradip Bajgain, Supannikar Tawinwung, Lindsey D’Elia, Sujita Sukumaran, Norihiro Watanabe, Valentina Hoyos, Premal Lulla, Malcolm K. Brenner, Ann M. Leen, Juan F. Vera

The camKK2/camKIV relay is an essential regulator of hepatic cancer

Journal Article published 9 May 2015 in Hepatology volume 62 issue 2 on pages 505 to 520

Research funded by National Institutes of Health (GM033976) | Adrienne Helis Malvin Medical Research Foundation (M2014)

Authors: Fumin Lin, Kathrina L. Marcelo, Kimal Rajapakshe, Cristian Coarfa, Adam Dean, Nathaniel Wilganowski, Holly Robinson, Eva Sevick, Karl-Dimiter Bissig, Lauren C. Goldie, Anthony R. Means, Brian York

Kinetics of Tumor Destruction by Chimeric Antigen Receptor-modified T Cells

Journal Article published Mar 2014 in Molecular Therapy volume 22 issue 3 on pages 623 to 633

Research funded by Mahidol University | U.S. Department of Defense (W81XWH-11-1-0625) | National Institutes of Health (CA094237, P50 CA058183) | Adrienne Helis Malvin Medical Research Foundation | Dan L. Duncan Cancer Center, Baylor College of Medicine (P30CA125123) | Dan L. Duncan Chair | Fayez Sarofim Chair

Authors: Usanarat Anurathapan, Robert C Chan, Hakeem F Hindi, Roopa Mucharla, Pradip Bajgain, Brendan C Hayes, William E Fisher, Helen E Heslop, Cliona M Rooney, Malcolm K Brenner, Ann M Leen, Juan F Vera

Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia

Journal Article published 8 Jun 2018 in Leukemia

Research funded by National Cancer Institute (RO1 CA160747, P30 125123) | Adrienne Helis Malvin Medical Research Foundation

Authors: Seth P. Boudreaux, Ryan P. Duren, Steven G. Call, Loc Nguyen, Pablo R. Freire, Padmini Narayanan, Michele S. Redell, Orla M. Conneely

Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor

Journal Article published Jun 2014 in Molecular Therapy volume 22 issue 6 on pages 1211 to 1220

Research funded by National Cancer Institute (P01 CA094237, P50 CA126752) | Adrienne Helis Malvin Medical Research Foundation | U.S. Department of Defense (W81XWH-11-1-0625) | Dan L. Duncan Cancer Center, Baylor College of Medicine (P30CA125123) | Dan L. Duncan Chair | Fayez Sarofim Chair

Authors: Ann M Leen, Sujita Sukumaran, Norihiro Watanabe, Somala Mohammed, Jacqueline Keirnan, Ryu Yanagisawa, Usanarat Anurathapan, David Rendon, Helen E Heslop, Cliona M Rooney, Malcolm K Brenner, Juan F Vera

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis

Journal Article published Dec 2015 in Developmental Cell volume 35 issue 5 on pages 553 to 567

Research funded by WELBIO | New York Stem Cell Foundation | Maryland Stem Cell Research Fund | ARC (ARC11/16-01) | European Research Council (ERC-2012-StG 310489-tRNAmodi) | Max-Planck-Gesellschaft | Marie Curie | Fonds Léon Fredericq | Fondation Simone et Pierre Clerdent | Fondation Médicale Reine Elisabeth | Federaal Wetenschapsbeleid | European Molecular Biology Organization | North Rhine-Westphalian Ministry for Innovation, Science and Research (314-400 010 09) | EMBO (ALTF1291-2010) | Adrienne Helis Malvin Medical Research Foundation | Fonds De La Recherche Scientifique - FNRS

Authors: Sophie Laguesse, Catherine Creppe, Danny D. Nedialkova, Pierre-Paul Prévot, Laurence Borgs, Sandra Huysseune, Bénédicte Franco, Guérin Duysens, Nathalie Krusy, Gabsang Lee, Nicolas Thelen, Marc Thiry, Pierre Close, Alain Chariot, Brigitte Malgrange, Sebastian A. Leidel, Juliette D. Godin, Laurent Nguyen

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

Journal Article published 31 Aug 2016 in Proceedings of the National Academy of Sciences volume 113 issue 37 on pages 10436 to 10441

Research funded by National Heart, Lung, and Blood Institute (R01-HL-61483, K99/R00-HL-112952) | Adrienne Helis Malvin Medical Research Foundation (m2014) | Friede Springer Herz Stiftung (FSHS-2013) | Roderick MacDonald Research Fund (15RDM005)

Authors: Anja Karlstaedt, Xiaotian Zhang, Heidi Vitrac, Romain Harmancey, Hernan Vasquez, Jing Han Wang, Margaret A. Goodell, Heinrich Taegtmeyer

Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment

Journal Article published 7 Jun 2018 in Cancer Discovery

Research funded by National Cancer Institute (P01 CA094237, NCI-CA125123, P50 CA126752, P50 CA186784) | National Institutes of Health (UM1HG006348, 1R01DK114356) | Cancer Prevention and Research Institute of Texas (RP120092) | Pancreatic Cancer Action Network (16-65-LEEN) | V Foundation for Cancer Research (T2016-006) | Elsa U. Pardee Foundation | National Pancreas Foundation | Adrienne Helis Malvin Medical Research Foundation | American Cancer Society (MRSG-14-197-01-LIB)

Authors: Sujita Sukumaran, Norihiro Watanabe, Pradip Bajgain, Kanchana Raja, Somala Mohammed, William E. Fisher, Malcolm K. Brenner, Ann M. Leen, Juan F. Vera