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Adrienne Helis Malvin Medical Research Foundation
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Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Journal Article published 1 Nov 2018 in STEM CELLS Translational Medicine volume 8 issue 2 on pages 112 to 123

Research funded by Maryland Stem Cell Research Fund | CAMS Initiative for Innovative Medicine (2016-I2M-1-008) | National Key Research and Development Program of China (2016YFA0101001, 2016YFC0903900) | CAMS Central Public Welfare Scientific Research Institute Basal Research Expenses (2017PT31004) | Adrienne Helis Malvin Medical Research Foundation | Johns Hopkins University

Authors: Yingchao Xue, Xiping Zhan, Shisheng Sun, Senthilkumar S. Karuppagounder, Shuli Xia, Valina L. Dawson, Ted M. Dawson, John Laterra, Jianmin Zhang, Mingyao Ying

Engineered T cells for cancer treatment

Journal Article published Jun 2014 in Cytotherapy volume 16 issue 6 on pages 713 to 733

Research funded by (U.S. National Institutes of Health National Cancer Institute and National Heart, Lung and Blood Institute) | V Foundation | Dana Foundation | James S. McDonnell Foundation | Adrienne Helis Malvin Medical Research Foundation

Authors: Usanarat Anurathapan, Ann M. Leen, Malcolm K. Brenner, Juan F. Vera

The camKK2/camKIV relay is an essential regulator of hepatic cancer

Journal Article published 9 May 2015 in Hepatology volume 62 issue 2 on pages 505 to 520

Research funded by National Institutes of Health (GM033976) | Adrienne Helis Malvin Medical Research Foundation (M2014)

Authors: Fumin Lin, Kathrina L. Marcelo, Kimal Rajapakshe, Cristian Coarfa, Adam Dean, Nathaniel Wilganowski, Holly Robinson, Eva Sevick, Karl-Dimiter Bissig, Lauren C. Goldie, Anthony R. Means, Brian York

Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia

Journal Article published 8 Jun 2018 in Leukemia volume 33 issue 1 on pages 52 to 63

Research funded by National Cancer Institute (RO1 CA160747, P30 125123) | Adrienne Helis Malvin Medical Research Foundation

Authors: Seth P. Boudreaux, Ryan P. Duren, Steven G. Call, Loc Nguyen, Pablo R. Freire, Padmini Narayanan, Michele S. Redell, Orla M. Conneely

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Journal Article published 31 Jan 2018 in Proceedings of the National Academy of Sciences volume 115 issue 7 on pages 1635 to 1640

Research funded by National Institute on Aging (AG046366, AG056841, P50AG005146) | St. Louis American Parkinson Disease Association (NA) | National Institute of General Medical Sciences (GM103418) | National Science Foundation (NA) | National Institute of Neurological Disorders and Stroke (NS082205, NS098006, NS075839, NS38377) | JPB Foundation (NA) | Adrienne Helis Malvin Medical Research Foundation (NA) | Diana Helis Henry Medical Research Foundation (NA)

Authors: Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, Valina L. Dawson

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

Journal Article published 31 Aug 2015 in Proceedings of the National Academy of Sciences volume 112 issue 37 on pages 11696 to 11701

Research funded by National Institute of Neurological Disorders and Stroke (NS38377) | JPB Foundation (No #) | Adrienne Helis Malvin Medical Research Foundation (M-1, M-2) | Diana Henry Helis Medical Research Foundation (H-2014) | Ministry of Science, ICT and Future Planning (NRF-2012R1A1A1012435) | Samsung (SBRI, SMX1132521)

Authors: Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin, Ted M. Dawson

MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling

Journal Article published 28 Jan 2019 in Journal of Clinical Investigation

Research funded by Congressionally Directed Medical Research Programs (W81XWH-07-1-0200, W81XWH-09-1-0651, W81XWH-13-1-0162, W81XWH-13-1-0163, W81XWH-17-1-0043) | Cancer Prevention and Research Institute of Texas (RP130651) | Adrienne Helis Malvin Medical Research Foundation (the MAPK4 as a Novel Therapeutic Target for Human Cancers Cancer Program) | National Institute of Health (P30 CA125123)

Authors: Wei Wang, Tao Shen, Bingning Dong, Chad J. Creighton, Yanling Meng, Wolong Zhou, Qing Shi, Hao Zhou, Yinjie Zhang, David D. Moore, Feng Yang

SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis

Journal Article published 20 Oct 2015 in Proceedings of the National Academy of Sciences volume 112 issue 44 on pages E6068 to E6077

Research funded by Cancer Prevention and Research Institute of Texas (RP120092) | National Cancer Institute (F31CA171350) | National Institute of Diabetes and Digestive and Kidney Diseases (P01 DK59820, 3U19DK062434, P30 DK079638, DK56338) | National Institute of General Medical Sciences (GM033976, T32 GM7330) | Susan G. Komen for the Cure (PDF14300468) | Welch Foundation (Q1521) | Adrienne Helis Malvin Medical Research Foundation (M2014) | Center for the Advancement of Science in Space (CASIS)

Authors: Tiffany Fleet, Bin Zhang, Fumin Lin, Bokai Zhu, Subhamoy Dasgupta, Erin Stashi, Bryan Tackett, Sundararajah Thevananther, Kimal I. Rajapakshe, Naomi Gonzales, Adam Dean, Jianqiang Mao, Nikolai Timchenko, Anna Malovannaya, Jun Qin, Cristian Coarfa, Francesco DeMayo, Clifford C. Dacso, Charles E. Foulds, Bert W. O’Malley, Brian York

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation – Clinical and functional study

Journal Article published Nov 2014 in Parkinsonism & Related Disorders volume 20 issue 11 on pages 1274 to 1278

Research funded by National Institutes of Health (NINDS NS38377, MDSCRF 2007-MSCRFI-0420-00, 2009-MSCRFII-0125-00, MDSCRF 2012-MSCRFII-0268-00, MDSCRF 2013-MSCRFII-0105-00, NINDS P50 NS072187, NINDS R01 NS078086, NINDS P50 NS072187) | Mayo Clinic Center | GHR Foundation | Marriott Family Foundation | Gerstner Family Career Development Award | JPB Foundation | Adrienne Helis Malvin Medical Research Foundation

Authors: Joanna Siuda, Barbara Jasinska-Myga, Magdalena Boczarska-Jedynak, Grzegorz Opala, Fabienne C. Fiesel, Elisabeth L. Moussaud-Lamodière, Leslie A. Scarffe, Valina L. Dawson, Owen A. Ross, Wolfdieter Springer, Ted M. Dawson, Zbigniew K. Wszolek

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

Journal Article published 31 Aug 2016 in Proceedings of the National Academy of Sciences volume 113 issue 37 on pages 10436 to 10441

Research funded by National Heart, Lung, and Blood Institute (R01-HL-61483, K99/R00-HL-112952) | Adrienne Helis Malvin Medical Research Foundation (m2014) | Friede Springer Herz Stiftung (FSHS-2013) | Roderick MacDonald Research Fund (15RDM005)

Authors: Anja Karlstaedt, Xiaotian Zhang, Heidi Vitrac, Romain Harmancey, Hernan Vasquez, Jing Han Wang, Margaret A. Goodell, Heinrich Taegtmeyer