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Adrienne Helis Malvin Medical Research Foundation
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LRRK2 pathobiology in Parkinson's disease

Journal Article published 10 Oct 2014 in Journal of Neurochemistry volume 131 issue 5 on pages 554 to 565

Research funded by National Institute of Neurological Disorders and Stroke (NS38377) | Adrienne Helis Malvin Medical Research Foundation | Diana Helis Henry Medical Research Foundation | JPB Foundation

Authors: Ian Martin, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson

Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer

Journal Article published Jan 2017 in Molecular Therapy volume 25 issue 1 on pages 249 to 258

Research funded by Dan L. Duncan Comprehensive Cancer Center (P30 CA125123) | Ruth L. Kirschstein National Research Service Award (F32 CA189423) | Dan L. Duncan Chair | National Institutes of Health | Fayez Sarofim Chair | NIH-NCI (P01 CA094237, P50 CA126752, P50 CA186784) | Elsa U. Pardee Foundation | Adrienne Helis Malvin Medical Research Foundation | American Cancer Society | Mentored Research Scholars Grant in Applied and Clinical Research (MRSG-14-197-01, -, LI, B)

Authors: Somala Mohammed, Sujita Sukumaran, Pradip Bajgain, Norihiro Watanabe, Helen E. Heslop, Cliona M. Rooney, Malcolm K. Brenner, William E. Fisher, Ann M. Leen, Juan F. Vera

Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor

Journal Article published Jun 2014 in Molecular Therapy volume 22 issue 6 on pages 1211 to 1220

Research funded by National Cancer Institute (P01 CA094237, P50 CA126752) | Adrienne Helis Malvin Medical Research Foundation | U.S. Department of Defense (W81XWH-11-1-0625) | Dan L. Duncan Cancer Center, Baylor College of Medicine (P30CA125123) | Dan L. Duncan Chair | Fayez Sarofim Chair

Authors: Ann M Leen, Sujita Sukumaran, Norihiro Watanabe, Somala Mohammed, Jacqueline Keirnan, Ryu Yanagisawa, Usanarat Anurathapan, David Rendon, Helen E Heslop, Cliona M Rooney, Malcolm K Brenner, Juan F Vera

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation – Clinical and functional study

Journal Article published Nov 2014 in Parkinsonism & Related Disorders volume 20 issue 11 on pages 1274 to 1278

Research funded by National Institutes of Health (NINDS NS38377, MDSCRF 2007-MSCRFI-0420-00, 2009-MSCRFII-0125-00, MDSCRF 2012-MSCRFII-0268-00, MDSCRF 2013-MSCRFII-0105-00, NINDS P50 NS072187, NINDS R01 NS078086, NINDS P50 NS072187) | Mayo Clinic Center | GHR Foundation | Marriott Family Foundation | Gerstner Family Career Development Award | JPB Foundation | Adrienne Helis Malvin Medical Research Foundation

Authors: Joanna Siuda, Barbara Jasinska-Myga, Magdalena Boczarska-Jedynak, Grzegorz Opala, Fabienne C. Fiesel, Elisabeth L. Moussaud-Lamodière, Leslie A. Scarffe, Valina L. Dawson, Owen A. Ross, Wolfdieter Springer, Ted M. Dawson, Zbigniew K. Wszolek

The camKK2/camKIV relay is an essential regulator of hepatic cancer

Journal Article published 9 May 2015 in Hepatology volume 62 issue 2 on pages 505 to 520

Research funded by National Institutes of Health (GM033976) | Adrienne Helis Malvin Medical Research Foundation (M2014)

Authors: Fumin Lin, Kathrina L. Marcelo, Kimal Rajapakshe, Cristian Coarfa, Adam Dean, Nathaniel Wilganowski, Holly Robinson, Eva Sevick, Karl-Dimiter Bissig, Lauren C. Goldie, Anthony R. Means, Brian York

Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia

Journal Article published 8 Jun 2018 in Leukemia

Research funded by National Cancer Institute (RO1 CA160747, P30 125123) | Adrienne Helis Malvin Medical Research Foundation

Authors: Seth P. Boudreaux, Ryan P. Duren, Steven G. Call, Loc Nguyen, Pablo R. Freire, Padmini Narayanan, Michele S. Redell, Orla M. Conneely

Disrupting a negative feedback loop drives endocrine therapy-resistant breast cancer

Journal Article published 6 Aug 2018 in Proceedings of the National Academy of Sciences volume 115 issue 33 on pages 8236 to 8238

Research funded by Adrienne Helis Malvin Medical Research Foundation (Cancer Program M-2017)

Authors: Charles E. Foulds

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

Journal Article published 31 Aug 2015 in Proceedings of the National Academy of Sciences volume 112 issue 37 on pages 11696 to 11701

Research funded by National Institute of Neurological Disorders and Stroke (NS38377) | JPB Foundation (No #) | Adrienne Helis Malvin Medical Research Foundation (M-1, M-2) | Diana Henry Helis Medical Research Foundation (H-2014) | Ministry of Science, ICT and Future Planning (NRF-2012R1A1A1012435) | Samsung (SBRI, SMX1132521)

Authors: Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin, Ted M. Dawson

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Journal Article published 31 Jan 2018 in Proceedings of the National Academy of Sciences volume 115 issue 7 on pages 1635 to 1640

Research funded by National Institute on Aging (AG046366, AG056841, P50AG005146) | St. Louis American Parkinson Disease Association (NA) | National Institute of General Medical Sciences (GM103418) | National Science Foundation (NA) | National Institute of Neurological Disorders and Stroke (NS082205, NS098006, NS075839, NS38377) | JPB Foundation (NA) | Adrienne Helis Malvin Medical Research Foundation (NA) | Diana Helis Henry Medical Research Foundation (NA)

Authors: Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, Valina L. Dawson

SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis

Journal Article published 20 Oct 2015 in Proceedings of the National Academy of Sciences volume 112 issue 44 on pages E6068 to E6077

Research funded by Cancer Prevention and Research Institute of Texas (RP120092) | National Cancer Institute (F31CA171350) | National Institute of Diabetes and Digestive and Kidney Diseases (P01 DK59820, 3U19DK062434, P30 DK079638, DK56338) | National Institute of General Medical Sciences (GM033976, T32 GM7330) | Susan G. Komen for the Cure (PDF14300468) | Welch Foundation (Q1521) | Adrienne Helis Malvin Medical Research Foundation (M2014) | Center for the Advancement of Science in Space (CASIS)

Authors: Tiffany Fleet, Bin Zhang, Fumin Lin, Bokai Zhu, Subhamoy Dasgupta, Erin Stashi, Bryan Tackett, Sundararajah Thevananther, Kimal I. Rajapakshe, Naomi Gonzales, Adam Dean, Jianqiang Mao, Nikolai Timchenko, Anna Malovannaya, Jun Qin, Cristian Coarfa, Francesco DeMayo, Clifford C. Dacso, Charles E. Foulds, Bert W. O’Malley, Brian York