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A. Alfred Taubman Medical Research Institute
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Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome

Journal Article published 5 Apr 2017 in Disease Models & Mechanisms volume 10 issue 6 on pages 717 to 725

Research funded by National Institutes of Health (1DP3DK094292, 1R24082841, 5K01NS079461, 5-R24-DK-082941, T32 AG000114) | Novo Nordisk (NNF14SA0006) | Juvenile Diabetes Research Foundation | American Diabetes Association | A. Alfred Taubman Medical Research Institute

Authors: Lucy M. Hinder, Phillipe D. O'Brien, John M. Hayes, Carey Backus, Andrew P. Solway, Catrina Sims-Robinson, Eva L. Feldman

GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states

Journal Article published 26 Apr 2017 in PLOS Genetics volume 13 issue 4 on page e1006745

Research funded by National Institutes of Health (AR44882, T32-HD60555, T32-AR07197, AR069071) | A. Alfred Taubman Medical Research Institute | Dermatology Foundation | National Psoriasis Foundation | Arthritis National Research Foundation

Authors: Rachel Herndon Klein, Ziguang Lin, Amelia Soto Hopkin, William Gordon, Lam C. Tsoi, Yun Liang, Johann E. Gudjonsson, Bogi Andersen

Editors: Vladimir Botchkarev

Myeloid cell plasticity in the evolution of central nervous system autoimmunity

Journal Article published Jan 2018 in Annals of Neurology volume 83 issue 1 on pages 131 to 141

Research funded by National Institutes of Health (R01 NS057670, 5T32GM7863-34) | Veterans Administration (1I01RX000416, 1I01BX001387) | National Institute of Neurological Disorders and Stroke | A. Alfred Taubman Medical Research Institute | U.S. Department of Veterans Affairs

Authors: David A. Giles, Jesse M. Washnock-Schmid, Patrick C. Duncker, Somiah Dahlawi, Gerald Ponath, David Pitt, Benjamin M. Segal

Concurrent nuclear ERG and MYC protein overexpression defines a subset of locally advanced prostate cancer: Potential opportunities for synergistic targeted therapeutics

Journal Article published 8 Mar 2016 in The Prostate volume 76 issue 9 on pages 845 to 853

Research funded by Prostate Cancer Foundation | National Cancer Institute Prostate SPORE (P50 CA186786) | Early Detection Research Network (UO1 CA113913) | American Cancer Society | A. Alfred Taubman Medical Research Institute | Howard Hughes Medical Institute

Authors: Aaron M. Udager, Angelo M. DeMarzo, Yang Shi, Jessica L. Hicks, Xuhong Cao, Javed Siddiqui, Hui Jiang, Arul M. Chinnaiyan, Rohit Mehra

Early initiation of chemoradiation following index craniotomy is associated with decreased survival in high-grade glioma

Journal Article published 25 Jul 2017 in Journal of Neuro-Oncology volume 135 issue 2 on pages 325 to 333

Research funded by A. Alfred Taubman Medical Research Institute | Mark Trauner Brain Research Fund

Authors: Jay K. Nathan, Amanda L. Brezzell, Michelle M. Kim, Denise Leung, D. Andrew Wilkinson, Shawn L. Hervey-Jumper

Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation

Journal Article published 2 Feb 2016 in Acta Neuropathologica volume 131 issue 4 on pages 639 to 640

Research funded by National Institute on Deafness and Other Communication Disorders (DC011990, DC009606) | National Institute of Neurological Disorders and Stroke (R25NS089450) | A. Alfred Taubman Medical Research Institute

Authors: Kevin S. Chen, Jeremy C. McIntyre, Andrew P. Lieberman, Jeffrey R. Martens, Parag G. Patil

Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis

Journal Article published 28 Oct 2015 in Arthritis & Rheumatology volume 67 issue 11 on pages 3016 to 3026

Research funded by NIH (KL2-RR-024149, K23-AR-061436, K08-AR-060802, UL1-TR-000371) | Scleroderma Foundation | A. Alfred Taubman Medical Research Institute | Doris Duke Foundation (2013106) | U.S. Department of Defense (W81XWH-13-1-0452)

Authors: Shervin Assassi, William R. Swindell, Minghua Wu, Filemon D. Tan, Dinesh Khanna, Daniel E. Furst, Donald P. Tashkin, Richard R. Jahan-Tigh, Maureen D. Mayes, Johann E. Gudjonsson, Jeffrey T. Chang

HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C

Journal Article published 7 Jun 2018 in JCI Insight volume 3 issue 11

Research funded by American Heart Association (15PRE25090023, Undergraduate Student Research Fellowship, Grant-in-Aid) | A. Alfred Taubman Medical Research Institute (Taubman Scholar Grant) | National Heart, Lung, and Blood Institute (HL131327-01, R01 HL093338-01) | National Institute of General Medical Sciences (5R01 GM094231) | National Institute of Neurological Disorders and Stroke (R01 NS059690) | The Children’s Cardiomyopathy Foundation | The Lefkofsky Foundation (Lefkofsky Scholar Award) | University of Michigan (Protein Folding Diseases Initiative)

Authors: Amelia A. Glazier, Neha Hafeez, Dattatreya Mellacheruvu, Venkatesha Basrur, Alexey I. Nesvizhskii, Lap Man Lee, Hao Shao, Vi Tang, Jaime M. Yob, Jason E. Gestwicki, Adam S. Helms, Sharlene M. Day

Transcriptional networks of murine diabetic peripheral neuropathy and nephropathy: common and distinct gene expression patterns

Journal Article published 21 Mar 2016 in Diabetologia volume 59 issue 6 on pages 1297 to 1306

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (R24 DK082841) | American Diabetes Association | Juvenile Diabetes Research Foundation International (Postdoctoral Research Fellowship) | A. Alfred Taubman Medical Research Institute

Authors: Junguk Hur, Phillipe D. O’Brien, Viji Nair, Lucy M. Hinder, Brett A. McGregor, Hosagrahar V. Jagadish, Matthias Kretzler, Frank C. Brosius, Eva L. Feldman

Dual CCR2/CCR5 antagonist treatment attenuates adipose inflammation, but not microvascular complications in ob/ob mice

Journal Article published 2 Jun 2017 in Diabetes, Obesity and Metabolism volume 19 issue 10 on pages 1468 to 1472

Research funded by Juvenile Diabetes Research Foundation | A. Alfred Taubman Medical Research Institute | Walbridge Aldinger Graduate Fellowship Fund | Robert C Graham Fund | National Institutes of Health (1DP3DK094292, 1R24082841) | Program for Neurology Research and Discovery | University of Michigan Center for Organogenesis Non-Traditional Post-Doctoral Fellowship | Milstein, Nathan and Rose Research Fund | American Diabetes Association | Sinai Medical Staff Foundation Neuroscience Scholar Fund 2 | Novo Nordisk Foundation (NNF14SA0006)

Authors: Phillipe D. O'Brien, Lucy M. Hinder, Sebastian D. Parlee, John M. Hayes, Carey Backus, Hongyu Zhang, Lijun Ma, Stacey A. Sakowski, Frank C. Brosius, Eva L. Feldman