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A. Alfred Taubman Medical Research Institute
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Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS

Journal Article published 2 May 2018 in Annals of Clinical and Translational Neurology volume 5 issue 6 on pages 730 to 740

Research funded by National Institute of Neurological Disorders and Stroke (1R01NS077982) | Amyotrophic Lateral Sclerosis Association | A. Alfred Taubman Medical Research Institute | philanthropic sources

Authors: Stephen A. Goutman, Morton B. Brown, Jonathan D. Glass, Nicholas M. Boulis, Karl Johe, Tom Hazel, Merit Cudkowicz, Nazem Atassi, Lawrence Borges, Parag G. Patil, Stacey A. Sakowski, Eva L. Feldman

Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice

Journal Article published 18 Aug 2017 in Annals of Clinical and Translational Neurology volume 4 issue 10 on pages 749 to 755

Research funded by A. Alfred Taubman Medical Research Institute | Program for Neurology Research & Discovery | Robert E. Nederlander Sr. Program for Alzheimer's Research | University of Michigan Clinician Scientist Training Programs (NINDS R25NS089450, NIH T32NS07222)

Authors: Lisa M. McGinley, Osama N. Kashlan, Kevin S. Chen, Elizabeth S. Bruno, John M. Hayes, Carey Backus, Seth Feldman, Bader N. Kashlan, Karl Johe, Eva L. Feldman

Severe streptomycin ototoxicity in the mouse utricle leads to a flat epithelium but the peripheral neural degeneration is delayed

Journal Article published Nov 2017 in Hearing Research volume 355 on pages 33 to 41

Research funded by R. Jamison and Betty Williams Professorship | A. Alfred Taubman Medical Research Institute | National Natural Science Foundation of China (81100717, 81570912) | China Scholarship Council (2008616087) | NIH-NIDCD (R01-DC01634, R01-DC014832, P30-DC05188)

Authors: Guo-Peng Wang, Ishani Basu, Lisa A. Beyer, Hiu Tung Wong, Donald L. Swiderski, Shu-Sheng Gong, Yehoash Raphael

Early initiation of chemoradiation following index craniotomy is associated with decreased survival in high-grade glioma

Journal Article published 25 Jul 2017 in Journal of Neuro-Oncology volume 135 issue 2 on pages 325 to 333

Research funded by A. Alfred Taubman Medical Research Institute | Mark Trauner Brain Research Fund

Authors: Jay K. Nathan, Amanda L. Brezzell, Michelle M. Kim, Denise Leung, D. Andrew Wilkinson, Shawn L. Hervey-Jumper

Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation

Journal Article published 2 Feb 2016 in Acta Neuropathologica volume 131 issue 4 on pages 639 to 640

Research funded by National Institute on Deafness and Other Communication Disorders (DC011990, DC009606) | National Institute of Neurological Disorders and Stroke (R25NS089450) | A. Alfred Taubman Medical Research Institute

Authors: Kevin S. Chen, Jeremy C. McIntyre, Andrew P. Lieberman, Jeffrey R. Martens, Parag G. Patil

A distinctive, low-grade oncocytic fumarate hydratase-deficient renal cell carcinoma, morphologically reminiscent of succinate dehydrogenase-deficient renal cell carcinoma

Journal Article published 12 Apr 2017 in Histopathology volume 71 issue 1 on pages 42 to 52

Research funded by A. Alfred Taubman Medical Research Institute | Uehara Memorial Foundation

Authors: Steven C Smith, Deepika Sirohi, Chisato Ohe, Jonathan B McHugh, Jason L Hornick, Jigna Kalariya, Sushil Karia, Katie Snape, Shirley V Hodgson, Andi K Cani, Daniel Hovelson, Daniel J Luthringer, Guido Martignoni, Ying-Bei Chen, Scott A Tomlins, Rohit Mehra, Mahul B Amin

The neurovascular unit and the pathophysiologic basis of diabetic retinopathy

Journal Article published 10 Nov 2016 in Graefe's Archive for Clinical and Experimental Ophthalmology volume 255 issue 1 on pages 1 to 6

Research funded by National Eye Institute (EY20582, P30EY007003) | National Institute of Diabetes and Digestive and Kidney Diseases (DP3DK094292) | Research to Prevent Blindness (n/a) | Juvenile Diabetes Research Foundation International (US) (17-2012-378) | A. Alfred Taubman Medical Research Institute (N/A)

Authors: Thomas W. Gardner, Jose R. Davila

Persistent macular puckering following excision of causative orbital tumor

Journal Article published Jun 2018 in American Journal of Ophthalmology Case Reports volume 10 on pages 196 to 197

Research funded by Research to Prevent Blindness | A. Alfred Taubman Medical Research Institute

Authors: Curtis J. Heisel, David N. Zacks, Alon Kahana

A novel approach to study motor neurons from zebrafish embryos and larvae in culture

Journal Article published Apr 2012 in Journal of Neuroscience Methods volume 205 issue 2 on pages 277 to 282

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (NIH5P60 DK20572) | A. Alfred Taubman Medical Research Institute | Program for Neurology Research and Discovery

Authors: Stacey A. Sakowski, J. Simon Lunn, Angela S. Busta, Madeline Palmer, James J. Dowling, Eva L. Feldman

Transcriptional networks of murine diabetic peripheral neuropathy and nephropathy: common and distinct gene expression patterns

Journal Article published 21 Mar 2016 in Diabetologia volume 59 issue 6 on pages 1297 to 1306

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (R24 DK082841) | American Diabetes Association | Juvenile Diabetes Research Foundation International (Postdoctoral Research Fellowship) | A. Alfred Taubman Medical Research Institute

Authors: Junguk Hur, Phillipe D. O’Brien, Viji Nair, Lucy M. Hinder, Brett A. McGregor, Hosagrahar V. Jagadish, Matthias Kretzler, Frank C. Brosius, Eva L. Feldman

Concurrent nuclear ERG and MYC protein overexpression defines a subset of locally advanced prostate cancer: Potential opportunities for synergistic targeted therapeutics

Journal Article published 8 Mar 2016 in The Prostate volume 76 issue 9 on pages 845 to 853

Research funded by Prostate Cancer Foundation | National Cancer Institute Prostate SPORE (P50 CA186786) | Early Detection Research Network (UO1 CA113913) | American Cancer Society | A. Alfred Taubman Medical Research Institute | Howard Hughes Medical Institute

Authors: Aaron M. Udager, Angelo M. DeMarzo, Yang Shi, Jessica L. Hicks, Xuhong Cao, Javed Siddiqui, Hui Jiang, Arul M. Chinnaiyan, Rohit Mehra

Diabetes and obesity are the main metabolic drivers of peripheral neuropathy

Journal Article published 14 Feb 2018 in Annals of Clinical and Translational Neurology volume 5 issue 4 on pages 397 to 405

Research funded by A. Alfred Taubman Medical Research Institute | National Institutes of Health (NS079417) | National Institute of Diabetes and Digestive and Kidney Diseases (1-R01-DK-107956-01, 1UC4DK101108, R24 082841)

Authors: Brian C. Callaghan, LeiLi Gao, Yufeng Li, Xianghai Zhou, Evan Reynolds, Mousumi Banerjee, Rodica Pop-Busui, Eva L. Feldman, Linong Ji

Dual CCR2/CCR5 antagonist treatment attenuates adipose inflammation, but not microvascular complications in ob/ob mice

Journal Article published 2 Jun 2017 in Diabetes, Obesity and Metabolism volume 19 issue 10 on pages 1468 to 1472

Research funded by Juvenile Diabetes Research Foundation | A. Alfred Taubman Medical Research Institute | Walbridge Aldinger Graduate Fellowship Fund | Robert C Graham Fund | National Institutes of Health (1DP3DK094292, 1R24082841) | Program for Neurology Research and Discovery | University of Michigan Center for Organogenesis Non-Traditional Post-Doctoral Fellowship | Milstein, Nathan and Rose Research Fund | American Diabetes Association | Sinai Medical Staff Foundation Neuroscience Scholar Fund 2 | Novo Nordisk Foundation (NNF14SA0006)

Authors: Phillipe D. O'Brien, Lucy M. Hinder, Sebastian D. Parlee, John M. Hayes, Carey Backus, Hongyu Zhang, Lijun Ma, Stacey A. Sakowski, Frank C. Brosius, Eva L. Feldman

Independent surgical validation of the new prostate cancer grade-grouping system

Journal Article published 19 Apr 2016 in BJU International volume 118 issue 5 on pages 763 to 769

Research funded by Prostate Cancer Foundation | A. Alfred Taubman Medical Research Institute

Authors: Daniel E. Spratt, Adam I. Cole, Ganesh S. Palapattu, Alon Z. Weizer, William C. Jackson, Jeffrey S. Montgomery, Robert T. Dess, Shuang G. Zhao, Jae Y. Lee, Angela Wu, Lakshmi P. Kunju, Emily Talmich, David C. Miller, Brent K. Hollenbeck, Scott A. Tomlins, Felix Y. Feng, Rohit Mehra, Todd M. Morgan

The Management of Diabetic Neuropathy in CKD

Journal Article published Feb 2010 in American Journal of Kidney Diseases volume 55 issue 2 on pages 365 to 385

Research funded by American Diabetes Association (1-08-CR-48) | Juvenile Diabetes Research Foundation (1-2008-1025, 4-200-421) | Michigan Diabetes Research and Training Center (5P60-DK020572, 5P60-DK020572) | Animal Models of Diabetic Complications Consortium (U01-DK076160) | A. Alfred Taubman Medical Research Institute | Program for Neurology Research and Discovery | Doris Duke Foundation (HL092237) | NIH (HL092237-02S109)

Authors: Rodica Pop-Busui, Laurel Roberts, Subramaniam Pennathur, Mathias Kretzler, Frank C. Brosius, Eva L. Feldman

Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story

Journal Article published Jul 2018 in Experimental Neurology volume 305 on pages 33 to 43

Research funded by National Institutes of Health (R24 DK082841, R01 DK107956, T32 1T32DK101357-01) | Novo Nordisk (NNF14SA0006) | American Diabetes Association | Program for Neurology Research & Discovery | Milstein, Nathan and Rose Research Fund | Sinai Medical Staff Foundation | A. Alfred Taubman Medical Research Institute

Authors: Lucy M. Hinder, Benjamin J. Murdock, Meeyoung Park, Diane E. Bender, Phillipe D. O'Brien, Amy E. Rumora, Junguk Hur, Eva L. Feldman

HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C

Journal Article published 7 Jun 2018 in JCI Insight volume 3 issue 11

Research funded by American Heart Association (15PRE25090023, Undergraduate Student Research Fellowship, Grant-in-Aid) | A. Alfred Taubman Medical Research Institute (Taubman Scholar Grant) | National Heart, Lung, and Blood Institute (HL131327-01, R01 HL093338-01) | National Institute of General Medical Sciences (5R01 GM094231) | National Institute of Neurological Disorders and Stroke (R01 NS059690) | The Children’s Cardiomyopathy Foundation | The Lefkofsky Foundation (Lefkofsky Scholar Award) | University of Michigan (Protein Folding Diseases Initiative)

Authors: Amelia A. Glazier, Neha Hafeez, Dattatreya Mellacheruvu, Venkatesha Basrur, Alexey I. Nesvizhskii, Lap Man Lee, Hao Shao, Vi Tang, Jaime M. Yob, Jason E. Gestwicki, Adam S. Helms, Sharlene M. Day

TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+adipose tissue macrophage production in obese mice

Journal Article published 10 Apr 2018 in Journal of Biological Chemistry volume 293 issue 23 on pages 8775 to 8786

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK K08DK10175, F32KD105676, DK090262) | A. Alfred Taubman Medical Research Institute (Edith Briskin/SKS Foundation) | University of Michigan (Pediatrics Janette Ferrantino Investigator Award)

Authors: Cameron Griffin, Leila Eter, Nico Lanzetta, Simin Abrishami, Mita Varghese, Kaitlin McKernan, Lindsey Muir, Jamie Lane, Carey N. Lumeng, Kanakadurga Singer

Autocrine Production of IGF-I Increases Stem Cell-Mediated Neuroprotection

Journal Article published 23 Apr 2015 in STEM CELLS volume 33 issue 5 on pages 1480 to 1489

Research funded by Cox Foundation | Virginia Gentlemen Foundation | Program for Neurology Research & Discovery | A. Alfred Taubman Medical Research Institute

Authors: J. Simon Lunn, Stacey A. Sakowski, Lisa M. McGinley, Crystal Pacut, Thomas G. Hazel, Karl Johe, Eva L. Feldman

Enabling Low-Power, Multi-Modal Neural Interfaces Through a Common, Low-Bandwidth Feature Space

Journal Article published May 2016 in IEEE Transactions on Neural Systems and Rehabilitation Engineering volume 24 issue 5 on pages 521 to 531

Research funded by Plastic Surgery Foundation | Wallace H. Coulter Foundation | A. Alfred Taubman Medical Research Institute | Frederick A. Coller Surgical Society

Authors: Zachary T. Irwin, David E. Thompson, Karen E. Schroeder, Derek M. Tat, Ali Hassani, Autumn J. Bullard, Shoshana L. Woo, Melanie G. Urbanchek, Adam J. Sachs, Paul S. Cederna, William C. Stacey, Parag G. Patil, Cynthia A. Chestek