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ALS Society of Canada
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Corticospinal tract degeneration in ALS unmasked in T1-weighted images using texture analysis

Journal Article published 27 Oct 2018 in Human Brain Mapping

Research funded by Fondation Brain Canada | Canadian Institutes of Health Research | ALS Society of Canada | Amyotrophic Lateral Sclerosis Association

Authors: Abdullah Ishaque, Dennell Mah, Peter Seres, Collin Luk, Wendy Johnston, Sneha Chenji, Christian Beaulieu, Yee-Hong Yang, Sanjay Kalra

Protein Transfer Free Energy Obeys Entropy-Enthalpy Compensation

Journal Article published 26 Oct 2015 in The Journal of Physical Chemistry B volume 119 issue 44 on pages 14130 to 14144

Research funded by Natural Sciences and Engineering Research Council of Canada | PrioNet Canada | ALS Society of Canada | Alberta Prion Research Institute

Authors: Eric A. Mills, Steven S. Plotkin

A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization

Journal Article published Nov 2018 in European Journal of Cell Biology

Research funded by McFeat Family Fund | Michael Halls Foundation | ALS Society of Canada

Authors: Michael V. Tavolieri, Cristian A. Droppelmann, Danae Campos-Melo, Kathryn Volkening, Michael J. Strong

Automatic extraction of abnormal lip movement features from the alternating motion rate task in amyotrophic lateral sclerosis

Journal Article published 25 Sep 2018 in International Journal of Speech-Language Pathology on pages 1 to 14

Research funded by NIH-NIDCD (R01DC009890, R01DC0135470, K24DC016312) | ALS Society of Canada (FRN126682)

Authors: Panying Rong, Yana Yunusova, Brian Richburg, Jordan R. Green

Investigating Default Mode and Sensorimotor Network Connectivity in Amyotrophic Lateral Sclerosis

Journal Article published 20 Jun 2016 in PLOS ONE volume 11 issue 6 on page e0157443

Research funded by University of alberta Hospital Foundation | ALS Society of Canada | Amyotrophic Lateral Sclerosis Association

Authors: Sneha Chenji, Shankar Jha, Dawon Lee, Matthew Brown, Peter Seres, Dennell Mah, Sanjay Kalra

Editors: Cristina Cereda

Transcriptional regulation of mouse hypoglossal motor neuron somatotopic map formation

Journal Article published 19 Dec 2015 in Brain Structure and Function volume 221 issue 8 on pages 4187 to 4202

Research funded by Canadian Institutes of Health Research (MOP-123500) | ALS Society of Canada

Authors: Xin Chen, Jae Woong Wang, Adele Salin-Cantegrel, Rola Dali, Stefano Stifani

Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses

Journal Article published 4 Dec 2017 in CNS Neuroscience & Therapeutics volume 24 issue 2 on pages 126 to 134

Research funded by ALS Society of Canada | Fondation Brain Canada | Canadian Institutes of Health Research

Authors: Peng Zhou, Teng Guan, Zhao Jiang, Mike Namaka, Qing-Jun Huang, Ji-Ming Kong

Cerebral Degeneration in Amyotrophic Lateral Sclerosis Revealed by 3-Dimensional Texture Analysis

Journal Article published 30 Mar 2016 in Frontiers in Neuroscience volume 10

Research funded by ALS Society of Canada | Amyotrophic Lateral Sclerosis Association | Alberta Innovates - Technology Futures | Natural Sciences and Engineering Research Council of Canada | Queen Elizabeth II Graduate Scholarship

Authors: Rouzbeh Maani, Yee-Hong Yang, Derek Emery, Sanjay Kalra

Conserved DNA methylation combined with differential frontal cortex and cerebellar expression distinguishes C9orf72-associated and sporadic ALS, and implicates SERPINA1 in disease

Journal Article published 14 Aug 2017 in Acta Neuropathologica volume 134 issue 5 on pages 715 to 728

Research funded by Donors Cure Foundation | National Institute on Aging (AG16574-17J PILOT 2) | ALS Society of Canada | National Institute of Neurological Disorders and Stroke (R21NS074121, P01NS084974, P01NS084974, P01NS084974) | Fondation Brain Canada | Siragusa Foundation | Institute of Genetics | Mayo Clinic | Robert and Clarice Smith & Abigail Van Buren Alzheimer’s Disease Research Foundation | Amyotrophic Lateral Sclerosis Association

Authors: Mark T. W. Ebbert, Christian A. Ross, Luc J. Pregent, Rebecca J. Lank, Cheng Zhang, Rebecca B. Katzman, Karen Jansen-West, Yuping Song, Edroaldo Lummertz da Rocha, Carla Palmucci, Pamela Desaro, Amelia E. Robertson, Ana M. Caputo, Dennis W. Dickson, Kevin B. Boylan, Rosa Rademakers, Tamas Ordog, Hu Li, Veronique V. Belzil

Validation of Clinical Observations of Mastication in Persons with ALS

Journal Article published 23 Jan 2016 in Dysphagia volume 31 issue 3 on pages 367 to 375

Research funded by National Institute on Deafness and Other Communication Disorders (R01DC009890, R01DC0135470) | ALS Society of Canada (Denise Ramsay Discovery Grant) | Canadian Institutes of Health Research (FRN126682)

Authors: Meg Simione, Erin M. Wilson, Yana Yunusova, Jordan R. Green

Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics

Journal Article published 29 Sep 2015 in eLife volume 4

Research funded by ALS Society of Canada (Bernice Ramsay Discovery Grant) | Canadian Consortium on Neurodegeneration in Aging

Authors: Kevin C Hadley, Rishi Rakhit, Hongbo Guo, Yulong Sun, James EN Jonkman, Joanne McLaurin, Lili-Naz Hazrati, Andrew Emili, Avijit Chakrabartty

Tumor prevention facilitates delayed transplant of stem cell-derived motoneurons

Journal Article published 1 Jul 2016 in Annals of Clinical and Translational Neurology volume 3 issue 8 on pages 637 to 649

Research funded by Canadian Institutes of Health Research (FRN 74633) | Natural Sciences and Engineering Research Council of Canada | ALS Society of Canada | Canada Foundation for Innovation | Nova Scotia Research Innovation Trust | Canada Research Chairs

Authors: Philippe Magown, Robert M. Brownstone, Victor F. Rafuse

Phase to Phase with TDP-43

Journal Article published 30 Jan 2017 in Biochemistry volume 56 issue 6 on pages 809 to 823

Research funded by Canadian Institutes of Health Research | Alzheimer Society | Institute of Genetics | ALS Society of Canada

Authors: Yulong Sun, Avijit Chakrabartty

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

Journal Article published 18 Jul 2018 in Nature Communications volume 9 issue 1

Research funded by ALS Society of Canada (ALS Cycle of Hope Doctoral Award) | Canadian Institutes of Health Research (Vanier Canada Graduate Scholarship, 142174)

Authors: Maneka Chitiprolu, Chantal Jagow, Veronique Tremblay, Emma Bondy-Chorney, Geneviève Paris, Alexandre Savard, Gareth Palidwor, Francesca A. Barry, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Janice Robertson, Mathieu Lavallée-Adam, John Woulfe, Jean-François Couture, Jocelyn Côté, Derrick Gibbings

An Optimized Approach to Recover Secreted Proteins from Fibroblast Conditioned-Media for Secretomic Analysis

Journal Article published 31 Mar 2016 in Frontiers in Cellular Neuroscience volume 10

Research funded by Canadian Institutes of Health Research | Canada Research Chairs | ALS Society of Canada | W. Garfield Weston Foundation

Authors: Bastien Paré, Lydia T. Deschênes, Roxane Pouliot, Nicolas Dupré, Francois Gros-Louis

Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis

Journal Article published Nov 2018 in Experimental Neurology volume 309 on pages 193 to 204

Research funded by Valeant Pharmaceuticals International Inc. | Amyotrophic Lateral Sclerosis Association | Health Research | ALS Society of Canada | Fondation Brain Canada

Authors: Kallol Dutta, Priyanka Patel, Jean-Pierre Julien

Adducin at the Neuromuscular Junction in Amyotrophic Lateral Sclerosis: Hanging on for Dear Life

Journal Article published 29 Jan 2016 in Frontiers in Cellular Neuroscience volume 10

Research funded by Natural Sciences and Engineering Research Council of Canada | ALS Society of Canada

Authors: Charles Krieger, Simon Ji Hau Wang, Soo Hyun Yoo, Nicholas Harden

Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs

Journal Article published 20 Jul 2018 in Molecular Brain volume 11 issue 1

Research funded by ERA-Net for Research Programmes on Rare Diseases (E-Rare) | ALS Society of Canada

Authors: Danae Campos-Melo, Zachary C. E. Hawley, Michael J. Strong

Maple Syrup Decreases TDP-43 Proteotoxicity in a Caenorhabditis elegans Model of Amyotrophic Lateral Sclerosis (ALS)

Journal Article published 20 Apr 2016 in Journal of Agricultural and Food Chemistry volume 64 issue 17 on pages 3338 to 3344

Research funded by Canadian Institutes of Health Research | Fonds de Recherche du Québec - Santé | Fondation du CHUM | Muscular Dystrophy Association | ALS Society of Canada

Authors: Catherine Aaron, Gabrielle Beaudry, J. Alex Parker, Martine Therrien

Enteroviral Infection: The Forgotten Link to Amyotrophic Lateral Sclerosis?

Journal Article published 12 Mar 2018 in Frontiers in Molecular Neuroscience volume 11

Research funded by ALS Society of Canada

Authors: Yuan Chao Xue, Ralph Feuer, Neil Cashman, Honglin Luo