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Aeras Global Tuberculosis Vaccine Foundation
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Adenovirus type 35-vectored tuberculosis vaccine has an acceptable safety and tolerability profile in healthy, BCG-vaccinated, QuantiFERON ® -TB Gold (+) Kenyan adults without evidence of tuberculosis

Journal Article published May 2016 in Vaccine volume 34 issue 21 on pages 2430 to 2436

Research funded by Aeras Global Tuberculosis Vaccine Foundation

Authors: Douglas S. Walsh, Victorine Owira, Mark Polhemus, Lucas Otieno, Ben Andagalu, Bernhards Ogutu, John Waitumbi, Anthony Hawkridge, Barbara Shepherd, Maria Grazia Pau, Jerald Sadoff, Macaya Douoguih, J. Bruce McClain

Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette–Guérin-Vaccinated Adults

Journal Article published 26 Mar 2018 in Frontiers in Immunology volume 9

Research funded by Aeras Global Tuberculosis Vaccine Foundation

Authors: Robert A. van den Berg, Laurane De Mot, Geert Leroux-Roels, Viviane Bechtold, Frédéric Clement, Margherita Coccia, Erik Jongert, Thomas G. Evans, Paul Gillard, Robbert G. van der Most

Immunogenicity and Protective Efficacy of the DAR-901 Booster Vaccine in a Murine Model of Tuberculosis

Journal Article published 20 Dec 2016 in PLOS ONE volume 11 issue 12 on page e0168521

Research funded by Aeras Global Tuberculosis Vaccine Foundation | Dartmouth College

Authors: Timothy Lahey, Dominick Laddy, Krystal Hill, Jacqueline Schaeffer, Alison Hogg, James Keeble, Belinda Dagg, Mei Mei Ho, Robert D. Arbeit, C. Fordham von Reyn

Editors: Thomas Jens Scriba

First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

Journal Article published Aug 2015 in Vaccine volume 33 issue 33 on pages 4130 to 4140

Research funded by Aeras Global Tuberculosis Vaccine Foundation

Authors: Angelique Kany Kany Luabeya, Benjamin M.N. Kagina, Michele D. Tameris, Hennie Geldenhuys, Soren T. Hoff, Zhongkai Shi, Ingrid Kromann, Mark Hatherill, Hassan Mahomed, Willem A. Hanekom, Peter Andersen, Thomas J. Scriba, Elisma Schoeman, Colleen Krohn, Cheryl L. Day, Hadn Africa, Lebohang Makhethe, Erica Smit, Yolande Brown, Sara Suliman, E. Jane Hughes, Peter Bang, Margaret A. Snowden, Bruce McClain, Gregory D. Hussey

Tuberculosis and Healthcare Workers in Underresourced Settings

Journal Article published 26 Apr 2016 in Clinical Infectious Diseases volume 62 issue suppl 3 on pages S229 to S230

Research funded by Aeras Global Tuberculosis Vaccine Foundation | National Institutes of Health | Bill and Melinda Gates Foundation

Authors: Thomas G. Evans, Linda-Gail Bekker

Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods

Journal Article published 11 Jan 2017 in Clinical and Vaccine Immunology volume 24 issue 3

Research funded by National Institute for Health Research | Aeras Global Tuberculosis Vaccine Foundation | Bill and Melinda Gates Foundation (OPP1084276/OPP1135288, OPP1110334, OPP1137034, OPP1160830) | Medical Research Council (MR/P002404/1)

Authors: Sophie J. Rhodes, Charlotte Sarfas, Gwenan M. Knight, Andrew White, Ansar A. Pathan, Helen McShane, Thomas G. Evans, Helen Fletcher, Sally Sharpe, Richard G. White

Editors: Helene F. Rosenberg

In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy

Journal Article published Sep 2016 in Vaccine volume 34 issue 39 on pages 4656 to 4665

Research funded by Universities Federation for Animal Welfare | EURIPRED | Aeras Global Tuberculosis Vaccine Foundation

Authors: Rachel Tanner, Matthew K. O’Shea, Helen A. Fletcher, Helen McShane

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

Journal Article published Jun 2016 in The Lancet volume 387 issue 10035 on pages 2312 to 2322

Research funded by South African Medical Research Council | Seventh Framework Programme (280873, 115308, 643381) | Grand Challenges in Global Health (37772) | Fogarty International Center (5 D43 TW000231) | Columbia University | National Institutes of Health (RO1-AI087915) | European Union | Bill and Melinda Gates Foundation (OPP1021972, OPP1023483, 37772, 37885) | Department of Science and Technology, Republic of South Africa | Carnegie Corporation of New York | Aeras Global Tuberculosis Vaccine Foundation | Claude Leon Foundation

Authors: Daniel E Zak, Adam Penn-Nicholson, Thomas J Scriba, Ethan Thompson, Sara Suliman, Lynn M Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, Gregory D Hussey, Deborah Abrahams, Fazlin Kafaar, Tony Hawkridge, Suzanne Verver, E Jane Hughes, Martin Ota, Jayne Sutherland, Rawleigh Howe, Hazel M Dockrell, W Henry Boom, Bonnie Thiel, Tom H M Ottenhoff, Harriet Mayanja-Kizza, Amelia C Crampin, Katrina Downing, Mark Hatherill, Joe Valvo, Smitha Shankar, Shreemanta K Parida, Stefan H E Kaufmann, Gerhard Walzl, Alan Aderem, Willem A Hanekom

Safety and immunogenicity of an inactivated whole cell tuberculosis vaccine booster in adults primed with BCG: A randomized, controlled trial of DAR-901

Journal Article published 12 May 2017 in PLOS ONE volume 12 issue 5 on page e0175215

Research funded by Dartmouth College | Aeras Global Tuberculosis Vaccine Foundation | Jack and Dorothy Byrne Foundation

Authors: C. Fordham von Reyn, Timothy Lahey, Robert D. Arbeit, Bernard Landry, Leway Kailani, Lisa V. Adams, Brenda C. Haynes, Todd Mackenzie, Wendy Wieland-Alter, Ruth I. Connor, Sue Tvaroha, David A. Hokey, Ann M. Ginsberg, Richard Waddell

Editors: Ray Borrow

Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

Journal Article published 12 Jul 2018 in New England Journal of Medicine volume 379 issue 2 on pages 138 to 149

Research funded by Sanofi | United Kingdom Department for International Development | Aeras Global Tuberculosis Vaccine Foundation

Authors: Elisa Nemes, Hennie Geldenhuys, Virginie Rozot, Kathryn T. Rutkowski, Frances Ratangee, Nicole Bilek, Simbarashe Mabwe, Lebohang Makhethe, Mzwandile Erasmus, Asma Toefy, Humphrey Mulenga, Willem A. Hanekom, Steven G. Self, Linda-Gail Bekker, Robert Ryall, Sanjay Gurunathan, Carlos A. DiazGranados, Peter Andersen, Ingrid Kromann, Thomas Evans, Ruth D. Ellis, Bernard Landry, David A. Hokey, Robert Hopkins, Ann M. Ginsberg, Thomas J. Scriba, Mark Hatherill