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Aeras Global Tuberculosis Vaccine Foundation
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Adenovirus type 35-vectored tuberculosis vaccine has an acceptable safety and tolerability profile in healthy, BCG-vaccinated, QuantiFERON ® -TB Gold (+) Kenyan adults without evidence of tuberculosis

Journal Article published May 2016 in Vaccine volume 34 issue 21 on pages 2430 to 2436

Research funded by Aeras Global Tuberculosis Vaccine Foundation

Authors: Douglas S. Walsh, Victorine Owira, Mark Polhemus, Lucas Otieno, Ben Andagalu, Bernhards Ogutu, John Waitumbi, Anthony Hawkridge, Barbara Shepherd, Maria Grazia Pau, Jerald Sadoff, Macaya Douoguih, J. Bruce McClain

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

Journal Article published 9 May 2017 in mBio volume 8 issue 3

Research funded by Harvard Center for AIDS Research (A1060354) | National Institutes of Health (AI114674, AI089443) | Burroughs Wellcome Fund | Aeras Global Tuberculosis Vaccine Foundation

Authors: Constance J. Martin, Anthony M. Cadena, Vivian W. Leung, Philana Ling Lin, Pauline Maiello, Nathan Hicks, Michael R. Chase, JoAnne L. Flynn, Sarah M. Fortune

Editors: Christina L. Stallings

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine

Journal Article published 9 Mar 2017 in PLOS Pathogens volume 13 issue 3 on page e1006250

Research funded by National Institute of Allergy and Infectious Diseases (AI105684, AI096213-01, 1R21AI115091) | Aeras Global Tuberculosis Vaccine Foundation (1U18 FD004012) | Juergen Manchot Foundation | Alberta Glycomics Centre | Secretaría de Estado de Investigación, Desarrollo e Innovación (Ramon y Cajal Award) | Ikerbasque, Basque Foundation for Science

Authors: Rafael Prados-Rosales, Leandro Carreño, Tingting Cheng, Caroline Blanc, Brian Weinrick, Adel Malek, Todd L. Lowary, Andres Baena, Maju Joe, Yu Bai, Rainer Kalscheuer, Ana Batista-Gonzalez, Noemi A. Saavedra, Leticia Sampedro, Julen Tomás, Juan Anguita, Shang-Cheng Hung, Ashish Tripathi, Jiayong Xu, Aharona Glatman-Freedman, Williams R. Jacobs, John Chan, Steven A. Porcelli, Jacqueline M. Achkar, Arturo Casadevall

Editors: Padmini Salgame

Identification of Mycobacterium tuberculosis using volatile biomarkers in culture and exhaled breath

Journal Article published 30 Oct 2018 in Journal of Breath Research volume 13 issue 1 on page 016004

Research funded by National Institutes of Health (AI111871, AI114674) | Aeras Global Tuberculosis Vaccine Foundation | Burroughs Wellcome Fund (1014106)

Authors: Theodore R Mellors, Mavra Nasir, Flavio A Franchina, Agnieszka Smolinska, Lionel Blanchet, JoAnne L Flynn, Jaime Tomko, Melanie O’Malley, Charles A Scanga, Philana Ling Lin, Jeff Wagner, Jane E Hill

A blood RNA signature for tuberculosis disease risk: a prospective cohort study

Journal Article published Jun 2016 in The Lancet volume 387 issue 10035 on pages 2312 to 2322

Research funded by South African Medical Research Council | Seventh Framework Programme (280873, 115308, 643381) | Grand Challenges in Global Health (37772) | Fogarty International Center (5 D43 TW000231) | Columbia University | National Institutes of Health (RO1-AI087915) | European Union | Bill and Melinda Gates Foundation (OPP1021972, OPP1023483, 37772, 37885) | Department of Science and Technology, Republic of South Africa | Carnegie Corporation of New York | Aeras Global Tuberculosis Vaccine Foundation | Claude Leon Foundation

Authors: Daniel E Zak, Adam Penn-Nicholson, Thomas J Scriba, Ethan Thompson, Sara Suliman, Lynn M Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, Gregory D Hussey, Deborah Abrahams, Fazlin Kafaar, Tony Hawkridge, Suzanne Verver, E Jane Hughes, Martin Ota, Jayne Sutherland, Rawleigh Howe, Hazel M Dockrell, W Henry Boom, Bonnie Thiel, Tom H M Ottenhoff, Harriet Mayanja-Kizza, Amelia C Crampin, Katrina Downing, Mark Hatherill, Joe Valvo, Smitha Shankar, Shreemanta K Parida, Stefan H E Kaufmann, Gerhard Walzl, Alan Aderem, Willem A Hanekom

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Journal Article published 21 Jan 2016 in Science volume 351 issue 6274 on pages 714 to 720

Research funded by National Institutes of Health (P01-AI094417, R37-AI054292, R01-DE021291, R01-AI095113, R01-AI117802, R01-AI059457, U24-OD010850, P51-OD011092, P50-GM065794, HHSN272201100013C) | Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (UM1-AI100645-01) | Bill and Melinda Gates Foundation (OPP1108533, OPP1133649) | Aeras Global Tuberculosis Vaccine Foundation | Los Alamos National Laboratory

Authors: S. G. Hansen, H. L. Wu, B. J. Burwitz, C. M. Hughes, K. B. Hammond, A. B. Ventura, J. S. Reed, R. M. Gilbride, E. Ainslie, D. W. Morrow, J. C. Ford, A. N. Selseth, R. Pathak, D. Malouli, A. W. Legasse, M. K. Axthelm, J. A. Nelson, G. M. Gillespie, L. C. Walters, S. Brackenridge, H. R. Sharpe, C. A. Lopez, K. Fruh, B. T. Korber, A. J. McMichael, S. Gnanakaran, J. B. Sacha, L. J. Picker

Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette–Guérin-Vaccinated Adults

Journal Article published 26 Mar 2018 in Frontiers in Immunology volume 9

Research funded by Aeras Global Tuberculosis Vaccine Foundation

Authors: Robert A. van den Berg, Laurane De Mot, Geert Leroux-Roels, Viviane Bechtold, Frédéric Clement, Margherita Coccia, Erik Jongert, Thomas G. Evans, Paul Gillard, Robbert G. van der Most

In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy

Journal Article published Sep 2016 in Vaccine volume 34 issue 39 on pages 4656 to 4665

Research funded by Universities Federation for Animal Welfare | EURIPRED | Aeras Global Tuberculosis Vaccine Foundation

Authors: Rachel Tanner, Matthew K. O’Shea, Helen A. Fletcher, Helen McShane

Tuberculosis and Healthcare Workers in Underresourced Settings

Journal Article published 26 Apr 2016 in Clinical Infectious Diseases volume 62 issue suppl 3 on pages S229 to S230

Research funded by Aeras Global Tuberculosis Vaccine Foundation | National Institutes of Health | Bill and Melinda Gates Foundation

Authors: Thomas G. Evans, Linda-Gail Bekker

Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods

Journal Article published 11 Jan 2017 in Clinical and Vaccine Immunology volume 24 issue 3

Research funded by National Institute for Health Research | Aeras Global Tuberculosis Vaccine Foundation | Bill and Melinda Gates Foundation (OPP1084276/OPP1135288, OPP1110334, OPP1137034, OPP1160830) | Medical Research Council (MR/P002404/1)

Authors: Sophie J. Rhodes, Charlotte Sarfas, Gwenan M. Knight, Andrew White, Ansar A. Pathan, Helen McShane, Thomas G. Evans, Helen Fletcher, Sally Sharpe, Richard G. White

Editors: Helene F. Rosenberg