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Alzheimer Forschung Initiative
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Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells

Journal Article published 12 Mar 2018 in BMC Genomics volume 19 issue 1

Research funded by Heinrich-Heine-Universität Düsseldorf (Research Commission of the Medical Faculty 30/2016) | Deutsche Forschungsgemeinschaft (SCHE692/3-1, SCHE692/4-1, EXC 1003, Grant FF-2014-01 Cells in Motion–Cluster of Excellence, IZKF, Grant Alf3/018/16, FOR 2107, AL 1145/5-2) | Alzheimer Forschung Initiative (14835)

Authors: Shafaqat Ali, Alexander Hoven, Regine J. Dress, Heiner Schaal, Judith Alferink, Stefanie Scheu

Resting-state global functional connectivity as a biomarker of cognitive reserve in mild cognitive impairment

Journal Article published 5 Oct 2016 in Brain Imaging and Behavior volume 11 issue 2 on pages 368 to 382

Research funded by National Institutes of Health (U01 AG024904) | U.S. Department of Defense (US) (W81XWH-12-2-0012) | LMUexcellent | European Research Council (PCIG12-GA-2012-334259) | Alzheimer Forschung Initiative (DE-15035)

Authors: N. Franzmeier, for the Alzheimer’s Disease Neuroimaging Initiative, M. Á. Araque Caballero, A. N. W. Taylor, L. Simon-Vermot, K. Buerger, B. Ertl-Wagner, C. Mueller, C. Catak, D. Janowitz, E. Baykara, B. Gesierich, M. Duering, M. Ewers

Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment

Journal Article published 7 Aug 2017 in Frontiers in Aging Neuroscience volume 9

Research funded by European Commission (PCIG12-GA-2012-334259) | Alzheimer Forschung Initiative (DE-15035, SO1336, DE-12819)

Authors: Nicolai Franzmeier, Jens Göttler, Timo Grimmer, Alexander Drzezga, Miguel A. Áraque-Caballero, Lee Simon-Vermot, Alexander N. W. Taylor, Katharina Bürger, Cihan Catak, Daniel Janowitz, Claudia Müller, Marco Duering, Christian Sorg, Michael Ewers

Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating d-Peptides in the Interaction with Amyloid-Beta Monomers

Journal Article published 12 Jun 2018 in ACS Chemical Neuroscience volume 9 issue 11 on pages 2679 to 2688

Research funded by Helmholtz-Gemeinschaft | Forschungszentrum Jülich | Alzheimer Forschung Initiative

Authors: Tamar Ziehm, Alexander K. Buell, Dieter Willbold

SUMO1-conjugation is altered during normal aging but not by increased amyloid burden

Journal Article published 6 Apr 2018 in Aging Cell volume 17 issue 4 on page e12760

Research funded by Alzheimer Forschung Initiative (AFI DE-15009)

Authors: Trayana Stankova, Lars Piepkorn, Thomas A. Bayer, Olaf Jahn, Marilyn Tirard

N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

Journal Article published 4 Oct 2017 in Alzheimer's Research & Therapy volume 9 issue 1

Research funded by Alzheimer Forschung Initiative (16103) | Stiftung VERUM

Authors: Oliver Wirths, Susanne Walter, Inga Kraus, Hans W. Klafki, Martina Stazi, Timo J. Oberstein, Jorge Ghiso, Jens Wiltfang, Thomas A. Bayer, Sascha Weggen

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Journal Article published Jan 2017 in Cell Reports volume 18 issue 2 on pages 391 to 405

Research funded by Medical Research Council (MR/K022687/1) | Spanish Ministry of Economy and Competitiveness with FEDER (BFU2015-66689, RYC-2013-12817) | Alzheimer Forschung Initiative

Authors: Katharine Askew, Kaizhen Li, Adrian Olmos-Alonso, Fernando Garcia-Moreno, Yajie Liang, Philippa Richardson, Tom Tipton, Mark A. Chapman, Kristoffer Riecken, Sol Beccari, Amanda Sierra, Zoltán Molnár, Mark S. Cragg, Olga Garaschuk, V. Hugh Perry, Diego Gomez-Nicola

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

Journal Article published Feb 2018 in Biomedical Journal volume 41 issue 1 on pages 21 to 33

Research funded by FHU VasCog research network | Alzheimer Forschung Initiative | Association France Alzheimer | Centre National de la Recherche Scientifique | DN2M | Lille Métropole Communauté Urbaine | Fondation pour la Recherche Médicale | FUI MEDIALZ | Région Nord/Pas-de-Calais | Institut National de la Santé et de la Recherche Médicale | Fondation de France | Agence Nationale de la Recherche | Fondation Plan Alzheimer | Federación Española de Enfermedades Raras | Université Lille 1 - Sciences et Technologies | programs d'investissements d'avenir LabEx (excellence laboratory) DISTALZ

Authors: Cyril Laurent, Luc Buée, David Blum

Prolyl endopeptidase is involved in the degradation of neural cell adhesion moleculesin vitro

Journal Article published 26 Aug 2016 in Journal of Cell Science volume 129 issue 20 on pages 3792 to 3802

Research funded by Seventh Framework Programme (EP-7-HEALTH-2007-223077) | Eesti Teadusfondi (8740) | Eesti Teadusagentuur (IUT2-3) | Deutsche Forschungsgemeinschaft (MO 2249/2-1 MO 2249/2-2) | Alzheimer Forschung Initiative (1186) | Universiteit Antwerpen (FFB3551) | Sächsische Aufbaubank | European Social Fund (SAB100154907) | European Commission

Authors: Külli Jaako, Alexander Waniek, Keiti Parik, Linda Klimaviciusa, Anu Aonurm-Helm, Aveli Noortoots, Kaili Anier, Roos Van Elzen, Melanie Gérard, Anne-Marie Lambeir, Steffen Roßner, Markus Morawski, Alexander Zharkovsky

Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology

Journal Article published 16 Jul 2018 in Brain

Research funded by Alzheimer Forschung Initiative (#16037) | National Institutes of Health (1K23EB019023, R01AG052653-01A1, U01 AG024904) | Knut och Alice Wallenbergs Stiftelse | the Wallenberg Centre for Molecular and Translational Medicine | Vetenskapsrådet | U.S. Department of Defense (W81XWH-12-2-0012) | National Institute on Aging | National Institute of Biomedical Imaging and Bioengineering

Authors: Michel J Grothe, Jorge Sepulcre, Gabriel Gonzalez-Escamilla, Irina Jelistratova, Michael Schöll, Oskar Hansson, Stefan J Teipel, Alzheimer’s Disease Neuroimaging Initiative

Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts

Journal Article published 2018 in Neural Plasticity volume 2018 on pages 1 to 11

Research funded by Alzheimer Forschung Initiative (15038, JE 528/6-1)

Authors: Peter Jedlicka, Julia Muellerleile, Stephan W. Schwarzacher

Cognitive Improvement and Brain Changes after Real-Time Functional MRI Neurofeedback Training in Healthy Elderly and Prodromal Alzheimer’s Disease

Journal Article published 9 Aug 2017 in Frontiers in Neurology volume 8

Research funded by Alzheimer Forschung Initiative (AFI 13812) | Bundesministerium für Bildung und Forschung (BMBF 01GQ1402)

Authors: Christian Hohenfeld, Nils Nellessen, Imis Dogan, Hanna Kuhn, Christine Müller, Federica Papa, Simon Ketteler, Rainer Goebel, Armin Heinecke, N. Jon Shah, Jörg B. Schulz, Martina Reske, Kathrin Reetz

Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

Journal Article published 11 May 2017 in Frontiers in Molecular Neuroscience volume 10

Research funded by Deutsche Forschungsgemeinschaft (FOR1332) | Alzheimer Forschung Initiative (16011) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A_146532)

Authors: Lukas P. Feilen, Kevin Haubrich, Paul Strecker, Sabine Probst, Simone Eggert, Gunter Stier, Irmgard Sinning, Uwe Konietzko, Stefan Kins, Bernd Simon, Klemens Wild

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Journal Article published 19 Oct 2018 in Acta Neuropathologica Communications volume 6 issue 1

Research funded by Alzheimer Forschung Initiative (16013)

Authors: Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirths

Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines

Journal Article published May 2018 in Brain Pathology volume 28 issue 3 on pages 427 to 430

Research funded by Deutsche Forschungsgemeinschaft (WA1477/4) | Alzheimer Forschung Initiative (12854)

Authors: Sathish Kumar, Jeffrey L. Frost, Carl W. Cotman, Elizabeth Head, Roberta Palmour, Cynthia A. Lemere, Jochen Walter

Hippocampal formation alterations differently contribute to autobiographic memory deficits in mild cognitive impairment and Alzheimer's disease

Journal Article published 4 Apr 2017 in Hippocampus volume 27 issue 6 on pages 702 to 715

Research funded by Alzheimer Forschung Initiative

Authors: Dusan Hirjak, Robert C. Wolf, Barbara Remmele, Ulrich Seidl, Anne K. Thomann, Katharina M. Kubera, Johannes Schröder, Klaus H. Maier-Hein, Philipp A. Thomann

γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation

Journal Article published 23 Oct 2017 in Journal of Neurochemistry volume 143 issue 4 on pages 445 to 454

Research funded by Deutsche Forschungsgemeinschaft | Bundesministerium für Bildung und Forschung | Alzheimer Forschung Initiative | IMI2 Program of the European Union (EU)

Authors: Jochen Walter, Nadja Kemmerling, Patrick Wunderlich, Konstantin Glebov

Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways

Journal Article published 2017 in Chemical Science volume 8 issue 7 on pages 4996 to 5004

Research funded by Alzheimer Forschung Initiative (Erwin Niehaus-Preis) | Helmholtz-Gemeinschaft

Authors: C. Dammers, M. Schwarten, A. K. Buell, D. Willbold

Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin

Journal Article published 27 Oct 2017 in Molecular Neurobiology volume 55 issue 7 on pages 5809 to 5829

Research funded by Alzheimer Forschung Initiative | Technische Universität Kaiserslautern

Authors: Simone Eggert, Carolin Thomas, Stefan Kins, Guido Hermey

Explorative results from multistep screening for potential genetic risk loci of Alzheimer’s disease in the longitudinal VITA study cohort

Journal Article published 12 Oct 2017 in Journal of Neural Transmission volume 125 issue 1 on pages 77 to 87

Research funded by Ludwig Boltzmann Institute of Aging Research (N.A.) | Alzheimer Forschung Initiative (09802) | Interdisziplinäres Zentrum für Klinische Forschung (IZKF (Z-6)

Authors: Claus-Jürgen Scholz, Heike Weber, Susanne Jungwirth, Walter Danielczyk, Andreas Reif, Karl-Heinz Tragl, Peter Fischer, Peter Riederer, Jürgen Deckert, Edna Grünblatt