Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

Journal Article published Feb 2019 in Brain, Behavior, and Immunity volume 76 on pages 126 to 138

Research funded by British Heart Foundation (PG/13/8/29989)

Authors: Raymond Wong, Nikolett Lénárt, Laura Hill, Lauren Toms, Graham Coutts, Bernadett Martinecz, Eszter Császár, Gábor Nyiri, Athina Papaemmanouil, Ari Waisman, Werner Müller, Markus Schwaninger, Nancy Rothwell, Sheila Francis, Emmanuel Pinteaux, Adam Denés, Stuart M. Allan

How calcium signals in myocytes and pericytes are integrated across in situ microvascular networks and control microvascular tone

Journal Article published Sep 2013 in Cell Calcium volume 54 issue 3 on pages 163 to 174

Research funded by British Heart Foundation (PG/12/62/29823)

Authors: Lyudmyla Borysova, Susan Wray, David A. Eisner, Theodor Burdyga

Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures

Journal Article published Nov 2019 in Stem Cell Reports volume 13 issue 5 on pages 817 to 831

Research funded by British Heart Foundation (PG/12/31/2952RE/13/5/30177CH/12/4/29762) | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/K001744/1) | Medical Research Council (MR/K026666/1) | Stroke Association | Manchester Centre for Genomic Medicine

Authors: Joseph Kelleher, Adam Dickinson, Stuart Cain, Yanhua Hu, Nicola Bates, Adam Harvey, Jianzhen Ren, Wenjun Zhang, Fiona C. Moreton, Keith W. Muir, Christopher Ward, Rhian M. Touyz, Pankaj Sharma, Qingbo Xu, Susan J. Kimber, Tao Wang

The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries

Journal Article published Jan 2011 in Cell Calcium volume 49 issue 1 on pages 66 to 77

Research funded by British Heart Foundation | Higher Education Commision, Pakistan

Authors: S. Mumtaz, G. Burdyga, L. Borisova, Susan Wray, T. Burdyga

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Journal Article published Sep 2015 in Journal of Molecular and Cellular Cardiology volume 86 on pages 42 to 53

Research funded by British Heart Foundation (FS/11/59/28938PG/12/69/29784PG/10/96/28661PG/14/61/31015)

Authors: Dario Melgari, Yihong Zhang, Aziza El Harchi, Christopher E. Dempsey, Jules C. Hancox

Multiple targets for flecainide action: implications for cardiac arrhythmogenesis

Journal Article published Apr 2018 in British Journal of Pharmacology volume 175 issue 8 on pages 1260 to 1278

Research funded by Wellcome (105727/Z/14/Z) | British Heart Foundation (PG/13/39/3029) | Medical Research Council (MR/M001288/1) | Sudden Arrhythmic Death Syndrome | Research Support Fund, Faculty of Health and Medical Science, University of Surrey | Fundamental Research Grant Scheme, Ministry of Education, Malaysia | McVeigh Benefaction | National Health and Medical Research Council (NH&MRC) of Australia (APP1126201)

Authors: Samantha C Salvage, Karthik H Chandrasekharan, Kamalan Jeevaratnam, Angela F Dulhunty, Andrew J Thompson, Antony P Jackson, Christopher L-H Huang

Pleiotropic mechanisms of action of perhexiline in heart failure

Journal Article published Sep 2016 in Expert Opinion on Therapeutic Patents volume 26 issue 9 on pages 1049 to 1059

Research funded by British Heart Foundation (FS/09/028/27602) | Cardiff University (Cardiff Partnership Fund) | Wellcome (094219/Z/10/Z)

Authors: Christopher H. George, Alice N. Mitchell, Ryan Preece, Mark L. Bannister, Zaheer Yousef

Carbenoxolone and 18β‐glycyrrhetinic acid inhibit inositol 1,4,5‐trisphosphate‐mediated endothelial cell calcium signalling and depolarise mitochondria

Journal Article published Feb 2021 in British Journal of Pharmacology volume 178 issue 4 on pages 896 to 912

Research funded by Wellcome Trust (202924/Z/16/Z204682/Z/16/Z) | British Heart Foundation (PG/16/54/32230RG/F/20/110007PG/20/9/34859)

Authors: Charlotte Buckley, Xun Zhang, Calum Wilson, John G. McCarron

TAM receptors in cardiovascular disease

Journal Article published 1 Jul 2019 in Cardiovascular Research volume 115 issue 8 on pages 1286 to 1295

Research funded by British Heart Foundation (FS/16/55/32731PG/12/81/29897RE/13/5/30177) | Engineering and Physical Sciences Research Council (EPSRC) (EP/L014165/1) | Arthritis Research UK (RACE20298) | National Institutes of Health (HL132412HL127464HL075662) | European Commission Marie Skłodowska-Curie Individual Fellowships (661369)

Authors: Lucy McShane, Ira Tabas, Greg Lemke, Mariola Kurowska-Stolarska, Pasquale Maffia

Clusters of specialized detector cells provide sensitive and high fidelity receptor signaling in the intact endothelium

Journal Article published May 2016 in The FASEB Journal volume 30 issue 5 on pages 2000 to 2013

Research funded by Wellcome (092292/Z/10/Z) | British Heart Foundation (PG/11/70/29086)

Authors: Calum Wilson, Christopher D. Saunter, John M. Girkin, John G. McCarron