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Cambridge Institute for Medical Research, University of Cambridge
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Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse

Journal Article published 11 Apr 2018 in Immunity, Inflammation and Disease volume 6 issue 2 on pages 312 to 321

Research funded by Wellcome Trust (103930) | Cambridge Institute for Medical Research, University of Cambridge (100140) | National Institute of Arthritis and Musculoskeletal and Skin Diseases

Authors: Jeansun Lee, Nele M.G. Dieckmann, James R. Edgar, Gillian M. Griffiths, Richard M. Siegel

BTR: training asynchronous Boolean models using single-cell expression data

Journal Article published 6 Sep 2016 in BMC Bioinformatics volume 17 issue 1

Research funded by Bloodwise (12029) | Biotechnology and Biological Sciences Research Council (BB/I00050X/1) | Cambridge Institute for Medical Research, University of Cambridge (RP-PG-0310-1002) | Microsoft Research (2012-023) | Wellcome Trust (100140/Z/12/Z; 097922/Z/11/Z)

Authors: Chee Yee Lim, Huange Wang, Steven Woodhouse, Nir Piterman, Lorenz Wernisch, Jasmin Fisher, Berthold Göttgens

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress

Journal Article published May 2018 in Developmental Cell volume 45 issue 4 on pages 481 to 495.e8

Research funded by Wellcome Trust (108042, 100140, 107064) | Cambridge Institute for Medical Research, University of Cambridge (093026) | Medical Research Council | National Institute for Health Research

Authors: Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D. Barbosa, Che-Hsiung Liu, Ursula Weber, Marek Mlodzik, Kadri Oras, Simon Collier, M. Mahmood Hussain, Liang Dong, Satish Patel, Anna Alvarez-Guaita, Vladimir Saudek, Benjamin J. Jenkins, Albert Koulman, Marcus K. Dymond, Roger C. Hardie, Symeon Siniossoglou, David B. Savage

Shared genetic risk contributes to type 1 and type 2 diabetes etiology

Journal Article published 7 Nov 2018 in Human Molecular Genetics

Research funded by Cambridge Institute for Medical Research, University of Cambridge (079895) | National Institute of Diabetes and Digestive and Kidney Diseases | Diabetes Research | National Institute of Allergy and Infectious Diseases | National Institute for Health Research Cambridge Biomedical Centre | Diabetes 664 Control and Complications Trial | National Center for Research Resources | Wellcome Trust (076113) | Juvenile Diabetes Research Foundation International | National Institute of Child Health and Human Development (U01DK062418) | Epidemiology of Diabetes Interventions and Complications | National Human Genome Research Institute | General Clinical Research Center Program | National Institute of Health

Authors: Anthony Aylward, Joshua Chiou, Mei-Lin Okino, Nikita Kadakia, Kyle J Gaulton

Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases

Journal Article published Apr 2018 in Neurobiology of Disease

Research funded by Cambridge Institute for Medical Research, University of Cambridge (100140/Z/12/Z) | UK Dementia Research Institute | The Tau Consortium | Alzheimer's Research UK | Astra Zeneca | Det Frie Forskningsråd (6110-00461B) | Lundbeckfonden (R210-2015-3372) | Parkinsonforeningen

Authors: Patrick Ejlerskov, Avraham Ashkenazi, David C. Rubinsztein

Quantification and propagation of errors when converting vertebrate biomineral oxygen isotope data to temperature for palaeoclimate reconstruction

Journal Article published Oct 2014 in Palaeogeography, Palaeoclimatology, Palaeoecology volume 412 on pages 99 to 107

Research funded by Cambridge Institute for Medical Research, University of Cambridge | Royal Society of Canada

Authors: Alexander J.E. Pryor, Rhiannon E. Stevens, Tamsin C. O'Connell, John R. Lister

Transcriptional network control of normal and leukaemic haematopoiesis

Journal Article published Dec 2014 in Experimental Cell Research volume 329 issue 2 on pages 255 to 264

Research funded by Leukaemia and Lymphoma Research | Medical Research Council | Biotechnology and Biological Sciences Research Council | Cancer Research UK | Leukemia and Lymphoma Society | National Institute on Handicapped Research | Wellcome Trust to the Wellcome Trust | Cambridge Institute for Medical Research, University of Cambridge | Raymond and Beverly Sackler Foundation

Authors: Jonathan I. Sive, Berthold Göttgens

Mammalian autophagy and the plasma membrane

Journal Article published 6 Nov 2016 in The FEBS Journal volume 284 issue 5 on pages 672 to 679

Research funded by Wellcome Trust (095317/Z/11/Z) | Cambridge Institute for Medical Research, University of Cambridge (100140/Z/12/Z)

Authors: Mariana Pavel, David C. Rubinsztein

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

Journal Article published 29 Jul 2015 in Diabetes volume 64 issue 11 on pages 3891 to 3902

Research funded by Juvenile Diabetes Research Foundation International (4-2007-1003) | Wellcome Trust (WT061858/091157) | NIHR Cambridge Biomedical Research Centre | Cambridge Institute for Medical Research, University of Cambridge (100140)

Authors: Jennie H.M. Yang, Antony J. Cutler, Ricardo C. Ferreira, James L. Reading, Nicholas J. Cooper, Chris Wallace, Pamela Clarke, Deborah J. Smyth, Christopher S. Boyce, Guo-Jian Gao, John A. Todd, Linda S. Wicker, Timothy I.M. Tree

Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice

Journal Article published Aug 2013 in Neurobiology of Aging volume 34 issue 8 on pages 2077.e1 to 2077.e9

Research funded by Cambridge Institute for Medical Research, University of Cambridge (079895) | National Institute of Diabetes and Digestive and Kidney Diseases | National Institute of Allergy and Infectious Diseases | National Institute of Child Health and Human Development (NICHD) | National Institute for Health Research Cambridge Biomedical Research Centre | Wellcome Trust (076113/B/04/Z) | Research into Ageing (GGP09037) | Juvenile Diabetes Research Foundation International | Medical Research Council (G0000934) | National Human Genome Research Institute

Authors: Lisa S. Nolan, Hannes Maier, Irm Hermans-Borgmeyer, Giorgia Girotto, Russell Ecob, Nicola Pirastu, Barbara A. Cadge, Christian Hübner, Paolo Gasparini, David P. Strachan, Adrian Davis, Sally J. Dawson