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3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model

Journal Article published Jun 2016 in Computer Methods and Programs in Biomedicine volume 129 on pages 51 to 62

Research funded by Royal Society of Edinburgh | National Research Foundation of Korea (NRF-2012K2A1A2033133, NRF-2013R1A1A2063656) | Age UK | Row Fogo Charitable Trust (R35865) | SINAPSE | Biotechnology and Biological Sciences Research Council | Medical Research Council (G0701120) | Economic and Social Research Council | Engineering and Physical Sciences Research Council | Centre of Cognitive Ageing and Cognitive Epidemiology (G0700704/84698)

Authors: Jaeil Kim, Maria del C. Valdés Hernández, Natalie A. Royle, Susana Muñoz Maniega, Benjamin S. Aribisala, Alan J. Gow, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw, Jinah Park

Risk and protective factors for structural brain ageing in the eighth decade of life

Journal Article published 19 Apr 2017 in Brain Structure and Function volume 222 issue 8 on pages 3477 to 3490

Research funded by Age UK (The Disconnected Mind) | Research Councils UK (MR/K026992/1)

Authors: Stuart J. Ritchie, Elliot M. Tucker-Drob, Simon R. Cox, David Alexander Dickie, Maria del C. Valdés Hernández, Janie Corley, Natalie A. Royle, Paul Redmond, Susana Muñoz Maniega, Alison Pattie, Benjamin S. Aribisala, Adele M. Taylor, Toni-Kim Clarke, Alan J. Gow, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary

Symptoms During Carotid Sinus Massage, Not Hemodynamic Change, Are Associated with White Matter Hyperintensity Volume on Magnetic Resonance Imaging

Journal Article published Oct 2014 in Journal of the American Geriatrics Society volume 62 issue 10 on pages 1988 to 1989

Research funded by Research into Ageing Fund | Age UK | British Geriatrics Society | the National Institute for Health Research Newcastle Biomedical Research Centre in Ageing & Chronic Disease

Authors: Claire McDonald, Michael Firbank, Mark Pearce, Andrew M. Blamire, Julia L. Newton, Simon Kerr

Relationships between socioeconomic position and objectively measured sedentary behaviour in older adults in three prospective cohorts

Journal Article published Jun 2017 in BMJ Open volume 7 issue 6 on page e016436

Research funded by Medical Research Council | Age UK

Authors: Richard John Shaw, Iva Čukić, Ian J Deary, Catharine R Gale, Sebastien FM Chastin, Philippa M Dall, Dawn A Skelton, Geoff Der

Topical Beta-Blockers and Cardiovascular Mortality: Systematic Review and Meta-Analysis with Data from the EPIC-Norfolk Cohort Study

Journal Article published 23 Aug 2016 in Ophthalmic Epidemiology volume 23 issue 5 on pages 277 to 284

Research funded by Age UK (262) | Cancer Research UK (C864/A14136) | Fight for Sight UK (Richard Desmond Charitable trust award to PJF) | Medical Research Council (G1000143) | National Institute for Health Research (Biomedical Research centre for Ophthalmology,Clinical Lectureship for JLY) | Wellcome Trust (Clinical Research training fellowship for APK)

Authors: Claude Pinnock, Jennifer L. Y. Yip, Anthony P. Khawaja, Robert Luben, Shabina Hayat, David C. Broadway, Paul J. Foster, Kay-Tee Khaw, Nick Wareham

Cognitive function in early and later life is associated with blood glucose in older individuals: analysis of the Lothian Birth Cohort of 1936

Journal Article published 2 Jun 2018 in Diabetologia volume 61 issue 9 on pages 1946 to 1955

Research funded by Medical Research Council (MR/K026992/1) | Age UK (Research Into Ageing programme grant)

Authors: Drew M. Altschul, John M. Starr, Ian J. Deary

The impact of volunteer befriending services for older people at the end of life: Mechanisms supporting wellbeing

Journal Article published 23 Feb 2016 in Progress in Palliative Care volume 24 issue 3 on pages 159 to 164

Research funded by Age UK (N/a)

Authors: Clare Gardiner, Sarah Barnes

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Journal Article published 12 Jan 2018 in Wellcome Open Research volume 3 on page 4

Research funded by Netherlands Genomics Initiative/Netherlands Consortium for Healthy Aging (050-060-810) | Knut och Alice Wallenberg Foundation (2013.0126) | Royal Society of Edinburgh | The Åke Wiberg foundation | National Institute of Nursing Research (R01-NR012459) | Netherlands Organization for Scientific Research (175.010.2005.011, 911-03-305 012) | National Institute on Aging (R01AG023629, 1R01AG032098- 01A1, N01AG62101, N01AG62103, N01AG62106) | Hjärt-Lungfonden (20140422) | Age UK | Research Institute for Diseases in the Elderly (014-93-015) | Federal State of Mecklenburg-West Pomerania | National Center for Advancing Translation Studies (UL1-TR-000040, UL1-TR-001079, UL1-TR-001881, DK063491) | Bundesministerium für Bildung und Forschung (03Z1CN22) | European Commission FP6 (LSHG-CT-2006-01947) | Scottish Funding Council (HR03006) | Leids Universitair Medisch Centrum | National Heart, Lung, and Blood Institute (N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, N02-HL-64278, R01-HL077612, R01-HL120393, HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086;grants:U01HL080295, R01HL068986, R01HL087652, R01HL105756, R01HL103612, R01HL120393, R01HL130114, HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C, HHSN268201500001I) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (33CS30-148470/1, 33CSCO-134276/1, 33CSCO-108796, 324730_135673, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, PMPDP3_129021/1, PMPDP3_141671/1) | U.S. Department of Health and Human Services (HHSN268201500003I) | National Institutes of Health (N01-AG012100, R01-AG028050) | U.S. Environmental Protection Agency (RD831697) | The Marcus Borgström Foundation | Wellcome Trust (202849, 068545, 064890, 098051, 084703) | National Center for Advancing Translational Sciences (UL1TR000124) | The Vleugels Foundation | Medical Research Council (G0501942, G0902313, MR/N011317/1, G1000861, G0000934, MR/K026992/1, K2007-66X-20270-01-3, 2011-2354, HHSN268200782096C) | Centre National de Génotypage | Vetenskapsrådet (2012-1397) | National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DK063491) | National Institute of Environmental Health Sciences (ZIA ES 043012) | Academy of Finland (213506, 129680, 265240, 263278) | Scottish Government Health Directorates (CZD/16/6) | Economic and Social Research Council (ES/H029745/1) | Swedish Society for Medical Research | Dutch Science Organisation (916.14.023) | Ministry of Science, Education and Sports of the Republic of Croatia (108-1080315-0302) | The Kjell och Märta Beijers Foundation

Authors: Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma'en Obeidat, Michael A. Province, Wei Gao, Beenish Qaiser, David J. Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, Elisabeth Altmaier, Jonathan Marten, Sarah E. Harris, Ani Manichaikul, Tess D. Pottinger, Ruifang Li-Gao, Allan Lind-Thomsen, Anubha Mahajan, Lies Lahousse, Medea Imboden, Alexander Teumer, Bram Prins, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Nora Franceschini, Colleen M. Sitlani, Jennifer A. Brody, Yohan Bossé, Wim Timens, Aldi Kraja, Anu Loukola, Wenbo Tang, Yongmei Liu, Jette Bork-Jensen, Johanne M. Justesen, Allan Linneberg, Leslie A. Lange, Rajesh Rawal, Stefan Karrasch, Jennifer E. Huffman, Blair H. Smith, Gail Davies, Kristin M. Burkart, Josyf C. Mychaleckyj, Tobias N. Bonten, Stefan Enroth, Lars Lind, Guy G. Brusselle, Ashish Kumar, Beate Stubbe, Mika Kähönen, Annah B. Wyss, Bruce M. Psaty, Susan R. Heckbert, Ke Hao, Taina Rantanen, Stephen B. Kritchevsky, Kurt Lohman, Tea Skaaby, Charlotta Pisinger, Torben Hansen, Holger Schulz, Ozren Polasek, Archie Campbell, John M. Starr, Stephen S. Rich, Dennis O. Mook-Kanamori, Åsa Johansson, Erik Ingelsson, André G. Uitterlinden, Stefan Weiss, Olli T. Raitakari, Vilmundur Gudnason, Kari E. North, Sina A. Gharib, Don D. Sin, Kent D. Taylor, George T. O'Connor, Jaakko Kaprio, Tamara B. Harris, Oluf Pederson, Henrik Vestergaard, James G. Wilson, Konstantin Strauch, Caroline Hayward, Shona Kerr, Ian J. Deary, R. Graham Barr, Renée de Mutsert, Ulf Gyllensten, Andrew P. Morris, M. Arfan Ikram, Nicole Probst-Hensch, Sven Gläser, Eleftheria Zeggini, Terho Lehtimäki, David P. Strachan, Josée Dupuis, Alanna C. Morrison, Ian P. Hall, Martin D. Tobin, Stephanie J. London, Understanding Society Scientific Group

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Journal Article published 21 Jun 2018 in Wellcome Open Research volume 3 on page 4

Research funded by Netherlands Genomics Initiative/Netherlands Consortium for Healthy Aging (050-060-810) | Knut och Alice Wallenberg Foundation (2013.0126) | Royal Society of Edinburgh | The Åke Wiberg foundation | National Institute of Nursing Research (R01- NR012459) | Netherlands Organization for Scientific Research (175.010.2005.011, 911-03-305 012) | National Institute on Aging (R01AG023629, 1R01AG032098- 01A1, N01AG62101, N01AG62103, N01AG62106) | Hjärt-Lungfonden (20140422) | Age UK | Research Institute for Diseases in the Elderly (014-93-015) | Federal State of Mecklenburg-West Pomerania | National Center for Advancing Translation Studies (UL1-TR-000040, UL1-TR-001079, UL1-TR-001881, DK063491) | Bundesministerium für Bildung und Forschung (03Z1CN22) | European Commission FP6 (LSHG-CT-2006-01947) | Scottish Funding Council (HR03006) | Leids Universitair Medisch Centrum | National Heart, Lung, and Blood Institute (HHSN268201300046C, HHSN268201300047C, HHSN268201300048C, HHSN268201300049C, HHSN268201300050C, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, N02-HL-64278, R01-HL077612, R01-HL120393, HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086; grants: U01HL080295, R01HL068986, R01HL087652, R01HL105756, R01HL103612, R01HL120393, R01HL130114, HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C, HHSN268201500001I) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (33CS30-148470/1, 33CSCO-134276/1, 33CSCO-108796, 324730_135673, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, PMPDP3_129021/1, PMPDP3_141671/1) | U.S. Department of Health and Human Services (HHSN268201500003I) | National Institutes of Health (N01-AG012100, R01-AG028050) | U.S. Environmental Protection Agency (RD831697) | The Marcus Borgström Foundation | Wellcome Trust (202849, 068545, 064890, 098051, 084703) | National Center for Advancing Translational Sciences (UL1TR001881) | National Institute of General Medical Sciences (U54GM115428) | The Vleugels Foundation | Centre National de Génotypage | Vetenskapsrådet (2012-1397) | National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DK063491) | National Institute of Environmental Health Sciences (ZIA ES 043012) | Academy of Finland (213506, 129680, 265240, 263278) | Scottish Government Health Directorates (CZD/16/6) | Economic and Social Research Council (ES/H029745/1) | Medical Research Council Canada (G0501942, G0902313, MR/N011317/1, G1000861, G0000934, MR/K026992/1, K2007-66X-20270-01-3, 2011-2354, HHSN268200782096C) | Swedish Society for Medical Research | Dutch Science Organisation (916.14.023) | Ministry of Science, Education and Sports of the Republic of Croatia (108-1080315-0302) | The Kjell och Märta Beijers Foundation

Authors: Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma'en Obeidat, Michael A. Province, Wei Gao, Beenish Qaiser, David J. Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, Elisabeth Altmaier, Jonathan Marten, Sarah E. Harris, Ani Manichaikul, Tess D. Pottinger, Ruifang Li-Gao, Allan Lind-Thomsen, Anubha Mahajan, Lies Lahousse, Medea Imboden, Alexander Teumer, Bram Prins, Leo-Pekka Lyytikäinen, Gudny Eiriksdottir, Nora Franceschini, Colleen M. Sitlani, Jennifer A. Brody, Yohan Bossé, Wim Timens, Aldi Kraja, Anu Loukola, Wenbo Tang, Yongmei Liu, Jette Bork-Jensen, Johanne M. Justesen, Allan Linneberg, Leslie A. Lange, Rajesh Rawal, Stefan Karrasch, Jennifer E. Huffman, Blair H. Smith, Gail Davies, Kristin M. Burkart, Josyf C. Mychaleckyj, Tobias N. Bonten, Stefan Enroth, Lars Lind, Guy G. Brusselle, Ashish Kumar, Beate Stubbe, Mika Kähönen, Annah B. Wyss, Bruce M. Psaty, Susan R. Heckbert, Ke Hao, Taina Rantanen, Stephen B. Kritchevsky, Kurt Lohman, Tea Skaaby, Charlotta Pisinger, Torben Hansen, Holger Schulz, Ozren Polasek, Archie Campbell, John M. Starr, Stephen S. Rich, Dennis O. Mook-Kanamori, Åsa Johansson, Erik Ingelsson, André G. Uitterlinden, Stefan Weiss, Olli T. Raitakari, Vilmundur Gudnason, Kari E. North, Sina A. Gharib, Don D. Sin, Kent D. Taylor, George T. O'Connor, Jaakko Kaprio, Tamara B. Harris, Oluf Pederson, Henrik Vestergaard, James G. Wilson, Konstantin Strauch, Caroline Hayward, Shona Kerr, Ian J. Deary, R. Graham Barr, Renée de Mutsert, Ulf Gyllensten, Andrew P. Morris, M. Arfan Ikram, Nicole Probst-Hensch, Sven Gläser, Eleftheria Zeggini, Terho Lehtimäki, David P. Strachan, Josée Dupuis, Alanna C. Morrison, Ian P. Hall, Martin D. Tobin, Stephanie J. London, Understanding Society Scientific Group

A statistical analysis of murine incisional and excisional acute wound models

Journal Article published Mar 2014 in Wound Repair and Regeneration volume 22 issue 2 on pages 281 to 287

Research funded by Research Councils UK | Medical Research Council | Age UK

Authors: David M. Ansell, Laura Campbell, Helen A. Thomason, Andrew Brass, Matthew J. Hardman

Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936

Journal Article published Jun 2014 in Neurobiology of Aging volume 35 issue 6 on pages 1513.e25 to 1513.e33

Research funded by Disconnected Mind project | Age UK | Scottish Funding Council | Lifelong Health and Wellbeing Initiative (G0700704/84698) | Biotechnology and Biological Sciences Research Council | Engineering and Physical Sciences Research Council | Economic and Social Research Council | Medical Research Council

Authors: Donald M. Lyall, Sarah E. Harris, Mark E. Bastin, Susana Muñoz Maniega, Catherine Murray, Michael W. Lutz, Ann M. Saunders, Allen D. Roses, Maria del C. Valdés Hernández, Natalie A. Royle, John M. Starr, David. J. Porteous, Joanna M. Wardlaw, Ian J. Deary

Reduced sensitivity for visual textures affects judgments of shape-from-shading and step-climbing behaviour in older adults

Journal Article published 5 Nov 2016 in Experimental Brain Research volume 235 issue 2 on pages 573 to 583

Research funded by Age UK

Authors: Andrew J. Schofield, Benjamin Curzon-Jones, Mark A. Hollands

A large margin algorithm for automated segmentation of white matter hyperintensity

Journal Article published May 2018 in Pattern Recognition volume 77 on pages 150 to 159

Research funded by China Scholarship Council | Age UK | Scottish Funding Council | Chief Scientist Office

Authors: Chen Qin, Ricardo Guerrero, Christopher Bowles, Liang Chen, David Alexander Dickie, Maria del C. Valdes-Hernandez, Joanna Wardlaw, Daniel Rueckert

Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936

Journal Article published 16 Feb 2018 in PLOS ONE volume 13 issue 2 on page e0192604

Research funded by Age UK (Disconnected Mind project grant) | Medical Research Council (G0701120, G1001245, MR/M013111/1, G0700704, MR/K026992/1) | Biotechnology and Biological Sciences Research Council | Economic and Social Research Council (C106891X)

Authors: Zander Crook, Tom Booth, Simon R. Cox, Janie Corley, Dominika Dykiert, Paul Redmond, Alison Pattie, Adele M. Taylor, Sarah E. Harris, John M. Starr, Ian J. Deary

Editors: Ornit Chiba-Falek

Undiagnosed long-term cognitive impairment in acutely hospitalised older medical patients with delirium: a prospective cohort study

Journal Article published 13 Apr 2016 in Age and Ageing volume 45 issue 4 on pages 493 to 499

Research funded by Research into Ageing Fund | Age UK | British Geriatrics Society (367)

Authors: Thomas A. Jackson, Alasdair M. J. MacLullich, John R. F. Gladman, Janet M. Lord, Bart Sheehan

The epigenetic clock and objectively measured sedentary and walking behavior in older adults: the Lothian Birth Cohort 1936

Journal Article published 8 Jan 2018 in Clinical Epigenetics volume 10 issue 1

Research funded by Medical Research Council (MR/K025023/1, MR/K026992/1, Mr/M01311/1) | Age UK (G1001245/96077)

Authors: Catharine R. Gale, on behalf of the Seniors USP Team, Riccardo E. Marioni, Iva Čukić, Sebastien F. Chastin, Philippa M. Dall, Manon L. Dontje, Dawn A. Skelton, Ian J. Deary

Detection, risk factors, and functional consequences of cerebral microinfarcts

Journal Article published Sep 2017 in The Lancet Neurology volume 16 issue 9 on pages 730 to 740

Research funded by Alberta Innovates - Health Solutions | Canadian Institutes of Health Research | Chief Scientist Office of the Scottish Executive | Dana Foundation | Navidea Biopharmaceuticals | Age UK | Michael J. Fox Foundation for Parkinson's Research | Alzheimer Society (AS-PG-14-033) | National Institute of Neurological Disorders and Stroke (NS085402, NS096997) | University of Calgary | British Heart Foundation | National Institutes of Health (UH2 NS100599-01, R01 AG26484, R01 NS096730) | Horizon 2020 Framework Programme (666881, 666881) | Fondation Brain Canada | Hjerteforeningen (2010T073) | Wellcome Trust (088134/Z/09) | Genentech | National Institute of General Medical Sciences (P20GM12345) | Alzheimer's Disease New Vision Award | National Medical Research Council (NMRC/CIRG/1446/2016, NMRC/CG/013/2013) | ZonMw (91711384, 91816616) | Medical Research Council (MR/K026992/1) | Southern California Clinical and Translational Science Institute (UL1TR000062) | Fondation Leducq (CVD-05) | Eli Lilly and Company | Canadian Partnership Against Cancer | Heart and Stroke Foundation of Canada | Innovate UK | Alzheimer's Association | European Union Joint Programme-Neurodegenerative Disease Research | National Science Foundation (1539034) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (019.153LW.014)

Authors: Susanne J van Veluw, Andy Y Shih, Eric E Smith, Christopher Chen, Julie A Schneider, Joanna M Wardlaw, Steven M Greenberg, Geert Jan Biessels

Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study

Journal Article published Dec 2018 in NeuroImage volume 183 on pages 884 to 896

Research funded by Age UK | Medical Research Council (MR/M01311/1, G1001245/96077) | National Institutes of Health (1R01AG054628-01A1)

Authors: C. Alloza, S.R. Cox, M. Blesa Cábez, P. Redmond, H.C. Whalley, S.J. Ritchie, S. Muñoz Maniega, M. del C. Valdés Hernández, E.M. Tucker-Drob, S.M. Lawrie, J.M. Wardlaw, I.J. Deary, M.E. Bastin

F-dynamics: Automated quantification of dendrite filopodia dynamics in living neurons

Journal Article published Oct 2014 in Journal of Neuroscience Methods volume 236 on pages 148 to 156

Research funded by Age UK (320)

Authors: Rita Hendricusdottir, Jeroen H.M. Bergmann

Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study

Journal Article published Jun 2017 in Alzheimer's & Dementia volume 13 issue 6 on pages 634 to 643

Research funded by Wellcome Trust | Row Fogo Charitable Trust | Age UK | Scottish Funding Council

Authors: Joanna M. Wardlaw, Stephen J. Makin, Maria C. Valdés Hernández, Paul A. Armitage, Anna K. Heye, Francesca M. Chappell, Susana Muñoz-Maniega, Eleni Sakka, Kirsten Shuler, Martin S. Dennis, Michael J. Thrippleton