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Daiichi Sankyo Foundation of Life Science
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Simple Derivation of Spinal Motor Neurons from ESCs/iPSCs Using Sendai Virus Vectors

Journal Article published Mar 2017 in Molecular Therapy - Methods & Clinical Development volume 4 on pages 115 to 125

Research funded by Program for Intractable Diseases Research | Research Project for Practical Applications of Regenerative Medicine | Core Center for iPS Cell Research of Research Center Network | Daiichi Sankyo Foundation of Life Science

Authors: Kazuya Goto, Keiko Imamura, Kenichi Komatsu, Kohnosuke Mitani, Kazuhiro Aiba, Norio Nakatsuji, Makoto Inoue, Akihiro Kawata, Hirofumi Yamashita, Ryosuke Takahashi, Haruhisa Inoue

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

Journal Article published Feb 2014 in Immunity volume 40 issue 2 on pages 199 to 212

Research funded by Japan Science and Technology Agency | Ministry of Education, Culture, Sports, Science and Technology | Daiichi Sankyo Foundation of Life Science (24115004, 23249023) | Takeda Science Foundation

Authors: Masahide Funabiki, Hiroki Kato, Yoshiki Miyachi, Hideaki Toki, Hiromi Motegi, Maki Inoue, Osamu Minowa, Aiko Yoshida, Katashi Deguchi, Hiroshi Sato, Sadayoshi Ito, Toshihiko Shiroishi, Kunio Takeyasu, Tetsuo Noda, Takashi Fujita

Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats

Journal Article published 16 Oct 2015 in Angewandte Chemie volume 127 issue 49 on pages 14981 to 14984

Research funded by JSPS | Ministry of Education, Culture, Sports, Science and Technology (20117003, 23249004, 26111012, 25113707, 15H05951) | Daiichi Sankyo Foundation of Life Science | Mochida Memorial Foundation for Medical and Pharmaceutical Research

Authors: Ryosuke Kojima, Hideo Takakura, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, Yasuteru Urano

CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis

Journal Article published 16 Nov 2017 in JCI Insight volume 2 issue 22

Research funded by Takeda Science Foundation (none) | Takeda Medical Research Foundation (none) | The Uehara Memorial Foundation (none) | Suzuken Memorial Foundation (none) | Daiichi Sankyo Foundation of Life Science (none) | Japan Diabetes Society (none) | Joint Usage/Research Program of Medical Research Institute, Tokyo Medical and Dental University (none) | Ministry of Education, Culture, Sports, Science and Technology (16H05171, 16KT0110, 16K08732, 17K19686, 17H05500)

Authors: Michiko Itoh, Takayoshi Suganami, Hideaki Kato, Sayaka Kanai, Ibuki Shirakawa, Takeru Sakai, Toshihiro Goto, Masahiro Asakawa, Isao Hidaka, Hiroshi Sakugawa, Koji Ohnishi, Yoshihiro Komohara, Kenichi Asano, Isao Sakaida, Masato Tanaka, Yoshihiro Ogawa

Purification, molecular cloning and functional characterization of swine phosphatidylethanolamine-binding protein 4 from seminal plasma

Journal Article published Jul 2012 in Biochemical and Biophysical Research Communications volume 423 issue 4 on pages 690 to 696

Research funded by Japan Society for the Promotion of Science (JSPS) | Ministry of Education, Culture, Sports, Science and Technology | Mochida Foundation for Medical and Pharmaceutical Research, Suzuken Memorial Foundation | Daiichi Sankyo Foundation of Life Science

Authors: Li-Ping An, Toshinaga Maeda, Tomohisa Sakaue, Keisuke Takeuchi, Takuya Yamane, Pei-Ge Du, Iwao Ohkubo, Hisakazu Ogita

A high-affinity monoclonal antibody against the FLAG tag useful for G-protein-coupled receptor study

Journal Article published Jun 2012 in Analytical Biochemistry volume 425 issue 2 on pages 157 to 165

Research funded by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (21390083, 22116001, 22116002, 20790232, 22790296) | Mochida Memorial Foundation and Takeda Science Foundation | Uehara Memorial Foundation | Mitsubishi Foundation | Daiichi Sankyo Foundation of Life Science | Japan Society for the Promotion of Science

Authors: Fumiyuki Sasaki, Toshiaki Okuno, Kazuko Saeki, Liu Min, Naoya Onohara, Haruyasu Kato, Takao Shimizu, Takehiko Yokomizo

Adipose tissue inflammation in diabetes and heart failure

Journal Article published Jan 2013 in Microbes and Infection volume 15 issue 1 on pages 11 to 17

Research funded by Mitsui Life Social Welfare Foundation | Japan Diabetes Foundation | Mitsubishi Pharma Research Foundation | Takeda Science Foundation | Ministry of Education, Culture, Sports, Science and Technology | Life Science Foundation of Japan | Naito Foundation | NOVARTIS Foundation for the Promotion Science | Daiichi Sankyo Foundation of Life Science | Uehara Memorial Foundation | Japanese Society of Anti-aging Medicine

Authors: Ippei Shimizu, Yohko Yoshida, Taro Katsuno, Tohru Minamino

Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells

Journal Article published 9 Feb 2016 in Immunology volume 147 issue 4 on pages 476 to 487

Research funded by Japan Society for the Promotion of Science (23390075, 25118718, 25860376, 15K19133, 26462852) | Naito Foundation | Uehara Memorial Foundation | Daiichi Sankyo Foundation of Life Science | National Institutes of Health | National Institute of Allergy and Infectious Diseases

Authors: Junpei Suzuki, Saho Maruyama, Hidekazu Tamauchi, Makoto Kuwahara, Mika Horiuchi, Masumi Mizuki, Mizuki Ochi, Tatsuya Sawasaki, Jinfang Zhu, Masaki Yasukawa, Masakatsu Yamashita

Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes

Journal Article published Jun 2014 in Virology volume 458-459 on pages 22 to 32

Research funded by National Institutes of Health (RO1 AI047140, RO1 AI077719, RO1 AI079665) | Daiichi Sankyo Foundation of Life Science | KANAE Foundation for the Promotion of Medical Science | American Heart Association (12POST8610009, 14SDG17790005)

Authors: Masaharu Iwasaki, Shuzo Urata, Yoshitake Cho, Nhi Ngo, Juan C. de la Torre

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Journal Article published Aug 2018 in Cell Stem Cell

Research funded by Takeda Science Foundation | Japan Agency for Medical Research and Development (AMED) | SENSHIN Medical Research Foundation | Daiichi Sankyo Foundation of Life Science | Japan Society for the Promotion of Science (JSPS) (17H04179) | JSPS (16K19426, 18K08114) | Miyata Cardiac Research Promotion Foundation | Nakatomi Foundation | Keio University Grant-in-Aid for Encouragement of Young Medical Scientists (02-002-0022, 02-002-0017) | Keio University Medical Science Fund | Japan Heart Foundation Research Grant | Research Center Network for Realization of Regenerative Medicine

Authors: Taketaro Sadahiro, Mari Isomi, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Fumiya Tamura, Hidenori Tani, Shugo Tohyama, Jun Fujita, Hiroyuki Miyoshi, Yoshifumi Kawamura, Naoki Goshima, Yuka W. Iwasaki, Kensaku Murano, Kuniaki Saito, Mayumi Oda, Peter Andersen, Chulan Kwon, Hideki Uosaki, Hirofumi Nishizono, Keiichi Fukuda, Masaki Ieda

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

Journal Article published Oct 2016 in Immunity volume 45 issue 4 on pages 737 to 748

Research funded by Ministry of Education, Culture, Sports, Science and Technology | Core Research for Evolutional Science and Technology | Takeda Science Foundation | Mochida Memorial Foundation for Medical and Pharmaceutical Research | Daiichi Sankyo Foundation of Life Science

Authors: Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Elena Krayukhina, Masato Taoka, Yoshio Yamauchi, Hiromi Tanji, Toshiaki Isobe, Susumu Uchiyama, Kensuke Miyake, Toshiyuki Shimizu

The transcription factor Klf5 is essential for intrahepatic biliary epithelial tissue remodeling after cholestatic liver injury

Journal Article published 9 Mar 2018 in Journal of Biological Chemistry volume 293 issue 17 on pages 6214 to 6229

Research funded by Japan Society for the Promotion of Science (22118006, 24112507, 24590342, 26112704, 26253023, 15H01369, 15J08420, 17H05497) | Core Research for Evolutional Science and Technology (15652259) | Takeda Science Foundation (Life science research grant) | Daiichi Sankyo Foundation of Life Science (Research grant)

Authors: Hajime Okada, Minami Yamada, Kenji Kamimoto, Cindy Yuet-Yin Kok, Kota Kaneko, Masatsugu Ema, Atsushi Miyajima, Tohru Itoh

Diacylglycerol kinase δ1 transiently translocates to the plasma membrane in response to high glucose

Journal Article published Dec 2012 in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research volume 1823 issue 12 on pages 2210 to 2216

Research funded by Hamaguchi Foundation | Terumo Life Science Foundation | Ministry of Education, Culture, Sports, Science and Technology | Futaba Electronics Memorial Foundation | Naito Foundation | Japan Science and Technology Agency | Daiichi Sankyo Foundation of Life Science | Ono Medical Research Foundation | Food Science Institute Foundation | Japan Foundation for Applied Enzymology | Daiwa Securities Health Foundation

Authors: Masato Takeuchi, Shizuka Sakiyama, Takako Usuki, Hiromichi Sakai, Fumio Sakane

Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

Journal Article published Jan 2018 in Cell Stem Cell volume 22 issue 1 on pages 91 to 103.e5

Research funded by Research Center Network for Realization of Regenerative Medicine and the Practical Research Project for Rare/Intractable Diseases | Japan Agency for Medical Research and Development (AMED) | the Japan Society for the Promotion of Science (JSPS) (JP25670394) | Keio University Program for the Advancement of Next Generation Research Projects | SENSHIN Medical Research Foundation | Takeda Science Foundation | Daiichi Sankyo Foundation of Life Science | Novartis Research Grant | Japan Society for the Promotion of Science (JP16K19428)

Authors: Kazutaka Miyamoto, Mizuha Akiyama, Fumiya Tamura, Mari Isomi, Hiroyuki Yamakawa, Taketaro Sadahiro, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Shota Kurotsu, Hidenori Tani, Li Wang, Li Qian, Makoto Inoue, Yoshinori Ide, Junko Kurokawa, Tsunehisa Yamamoto, Tomohisa Seki, Ryo Aeba, Hiroyuki Yamagishi, Keiichi Fukuda, Masaki Ieda

Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction

Journal Article published Jan 2018 in Biochemical and Biophysical Research Communications volume 495 issue 1 on pages 884 to 891

Research funded by Japan Agency for Medical Research and Development | Keio University | SENSHIN Medical Research Foundation | Takeda Science Foundation | Daiichi Sankyo Foundation of Life Science | Novartis Research | Japan Society for the Promotion of Science (JP17J06637)

Authors: Shota Kurotsu, Rina Osakabe, Mari Isomi, Fumiya Tamura, Taketaro Sadahiro, Naoto Muraoka, Hidenori Kojima, Sho Haginiwa, Hidenori Tani, Kaori Nara, Yoshiaki Kubota, Masatsugu Ema, Keiichi Fukuda, Takeshi Suzuki, Masaki Ieda

Pioglitazone ameliorates systolic and diastolic cardiac dysfunction in rat model of angiotensin II-induced hypertension

Journal Article published Jul 2013 in International Journal of Cardiology volume 167 issue 2 on pages 409 to 415

Research funded by the Ministry of Education, Science, and Culture of Japan (19590937) | Takeda Science Foundation | Daiichi Sankyo Foundation of Life Science | Okinaka Memorial Institute for Medical Research | Daiwa Securities Health Foundation

Authors: Aiko Sakamoto, Makiko Hongo, Kyoko Furuta, Kan Saito, Ryozo Nagai, Nobukazu Ishizaka

New Class of Bioluminogenic Probe Based on Bioluminescent Enzyme-Induced Electron Transfer: BioLeT

Journal Article published 19 Mar 2015 in Journal of the American Chemical Society volume 137 issue 12 on pages 4010 to 4013

Research funded by Ministry of Education, Culture, Sports, Science and Technology (20117003, 23249004, 26111012) | Daiichi Sankyo Foundation of Life Science | Japan Society for the Promotion of Science | Mochida Memorial Foundation for Medical and Pharmaceutical Research | Tokyo Society of Medical Sciences, University of Tokyo

Authors: Hideo Takakura, Ryosuke Kojima, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, Yasuteru Urano

Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior

Journal Article published 30 May 2016 in Journal of Neurochemistry volume 138 issue 3 on pages 448 to 456

Research funded by Terumo Life Science Foundation | Ministry of Education, Culture, Sports, Science and Technology (22370047, 23116505, 25116704, 26291017, 15K14470) | Futaba Electronics Memorial Foundation | Naito Foundation | Japan Science and Technology Agency (AS221Z00794F, AS231Z00139G, AS251Z01788Q) | Hamaguchi Foundation for the Advancement of Biochemistry | Daiichi Sankyo Foundation of Life Science | Ono Medical Research Foundation | Food Science Institute Foundation | Japan Foundation for Applied Enzymology | Asahi Group Holdings | Daiwa Securities Health Foundation | Skylark Food Science Institute

Authors: Takeshi Isozaki, Suguru Komenoi, Qiang Lu, Takako Usuki, Shuntaro Tomokata, Daisuke Matsutomo, Hiromichi Sakai, Kana Bando, Hiroshi Kiyonari, Fumio Sakane

Diacylglycerol kinase ζ generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation

Journal Article published Dec 2016 in Biochemistry and Biophysics Reports volume 8 on pages 352 to 359

Research funded by Terumo Life Science Foundation | Futaba Electronics Memorial Foundation | Naito Foundation | MEXT/JSPS KAKENHI (22370047, 23116505, 25116704, 26291017, 15K14470, 15J05821) | Japan Science and Technology Agency (AS221Z00794F, AS231Z00139G, AS251Z01788Q, AS2621643Q) | Hamaguchi Foundation for the Advancement of Biochemistry | Daiichi Sankyo Foundation of Life Science | Ono Medical Research Foundation | Asahi Group Foundation | Food Science Institute Foundation | Japan Foundation for Applied Enzymology | Japan Milk Academic Alliance | Daiwa Securities Health Foundation | Skylark Food Science Institute

Authors: Satoru Mizuno, Sayaka Kado, Kaoru Goto, Daisuke Takahashi, Fumio Sakane

Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice

Journal Article published 31 Aug 2016 in Journal of Virology volume 90 issue 22 on pages 10102 to 10112

Research funded by KANAE Foundation for the Promotion of Medical Science | National Institute of Allergy and Infectious Diseases (AI047140, AI077719) | Japan Society for the Promotion of Science | Daiichi Sankyo Foundation of Life Science

Authors: Masaharu Iwasaki, Cherie T. Ng, Beatrice Cubitt, Juan C. de la Torre

Editors: D. S. Lyles