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Alfred Benzon Foundation
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Emerging Poly-Agonists for Obesity and Type 2 Diabetes

Journal Article published 26 Sep 2017 in Obesity volume 25 issue 10 on pages 1647 to 1649

Research funded by Danish Council of Independent Research/Medicine (5053-00155B) | Alfred Benzon Foundation | Lundbeckfonden | Helmholtz Alliance ICEMED | Helmholtz Initiative on Personalized Medicine iMed | Helmholtz crossprogram topic “Metabolic Dysfunction,” | Alexander von Humboldt-Stiftung | Deutsche Forschungsgemeinschaft (SFB1123) | H2020 European Research Council (695054)

Authors: Maximilian Kleinert, Christoffer Clemmensen, Kerstin Stemmer, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp

B cell tolerance to epidermal ribonuclear-associated neo-autoantigen in vivo

Journal Article published 20 Nov 2017 in Clinical & Experimental Immunology volume 191 issue 2 on pages 151 to 165

Research funded by Marie Curie International Outgoing Fellowship | National Institutes of Health (R37 5AI054636) | Alfred Benzon Foundation | FP7 People: Marie-Curie Actions (330134)

Authors: S. E. Degn, E. Alicot, M. C. Carroll

Comparative morphology of the snake spectacle using light and transmission electron microscopy

Journal Article published 18 May 2015 in Veterinary Ophthalmology volume 19 issue 4 on pages 285 to 290

Research funded by Uddannelses- og Forskningsministeriet (10-091595) | Alfred Benzon Foundation

Authors: Mari-Ann O. Da Silva, Mads F. Bertelsen, Tobias Wang, Jan U. Prause, Thøger Svahn, Steffen Heegaard

POVME 3.0: Software for Mapping Binding Pocket Flexibility

Journal Article published 30 Aug 2017 in Journal of Chemical Theory and Computation volume 13 issue 9 on pages 4584 to 4592

Research funded by NIH Office of the Director (DP2 OD007237) | National Institute of General Medical Sciences (P41 GM103426) | Alfred Benzon Foundation

Authors: Jeffrey R. Wagner, Jesper Sørensen, Nathan Hensley, Celia Wong, Clare Zhu, Taylor Perison, Rommie E. Amaro

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Journal Article published Oct 2016 in Cell volume 167 issue 3 on pages 843 to 857.e14

Research funded by Helmholtz Association | German Federal Ministry of Education and Research (01KX1012) | H2020 European Research Council (ERC AdG°249929) | Schwerpunktprogram 1629 ThyroidTransAct (BI893/5-2) | Alfred Benzon Foundation | ANR | European Union | Deutsche Forschungsgemeinschaft (DFG-TS226/1-1 and DFG: SFB1123-A4, SFB1123-A1 and DFG: SFB1123-A4, DFG-BI893/2-2, DFG-BI893/8-1, SFB1123-A4) | German Center for Diabetes Research | Alexander von Humboldt-Stiftung | DFG/MCT8 Defizienz (GZ TS226/3-1 AOBJ:623001 [SPP1629])

Authors: Brian Finan, Christoffer Clemmensen, Zhimeng Zhu, Kerstin Stemmer, Karine Gauthier, Luisa Müller, Meri De Angelis, Kristin Moreth, Frauke Neff, Diego Perez-Tilve, Katrin Fischer, Dominik Lutter, Miguel A. Sánchez-Garrido, Peng Liu, Jan Tuckermann, Mohsen Malehmir, Marc E. Healy, Achim Weber, Mathias Heikenwalder, Martin Jastroch, Maximilian Kleinert, Sigrid Jall, Sara Brandt, Frédéric Flamant, Karl-Werner Schramm, Heike Biebermann, Yvonne Döring, Christian Weber, Kirk M. Habegger, Michaela Keuper, Vasily Gelfanov, Fa Liu, Josef Köhrle, Jan Rozman, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis, Susanna M. Hofmann, Bin Yang, Matthias H. Tschöp, Richard DiMarchi, Timo D. Müller

Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide

Journal Article published Nov 2015 in Biochemical and Biophysical Research Communications volume 467 issue 1 on pages 53 to 57

Research funded by Alfred Benzon Foundation | Brdr. Hartmann Foundation | Danish Natural Science Council

Authors: Ole Kristensen

Localization of serglycin in human neutrophil granulocytes and their precursors

Journal Article published 10 May 2004 in Journal of Leukocyte Biology volume 76 issue 2 on pages 406 to 415

Research funded by Sundhed og Sygdom, Det Frie Forskningsråd | Alfred Benzon Foundation

Authors: Carsten Utoft Niemann, Jack Bernard Cowland, Pia Klausen, Jon Askaa, Jero Calafat, Niels Borregaard

Molecular Regulation of Fatty Acid Oxidation in Skeletal Muscle during Aerobic Exercise

Journal Article published Jan 2018 in Trends in Endocrinology & Metabolism volume 29 issue 1 on pages 18 to 30

Research funded by Sundhed og Sygdom, Det Frie Forskningsråd | Lundbeck Research Foundation | Novo Nordisk UK Research Foundation | University of Copenhagen Excellence Program for Interdisciplinary Research | Danish Diabetes Academy | Alfred Benzon Foundation

Authors: Anne-Marie Lundsgaard, Andreas Mæchel Fritzen, Bente Kiens

Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying

Journal Article published Nov 2017 in European Journal of Pharmaceutics and Biopharmaceutics volume 120 on pages 9 to 21

Research funded by Independent Research Fund Denmark | FP7 Marie Curie Actions (DFF-4093-00292, DFF-12-131927, DFF-4093-00062) | Lundbeckfonden (R181-2014-3793) | Hørslev-Fonden | Alfred Benzon Foundation | Drug Research Academy | Technology and Production Sciences (26-02-0019)

Authors: Monica Agnoletti, Adam Bohr, Kaushik Thanki, Feng Wan, Xianghui Zeng, Johan Peter Boetker, Mingshi Yang, Camilla Foged

Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells

Journal Article published 6 Jun 2016 in The FEBS Journal volume 283 issue 13 on pages 2476 to 2493

Research funded by Alfred Benzon Foundation | Lundbeckfonden (R108-A10265, R93-A8846) | The Lundbeck Foundation Research Initiative on Blood Brain and Drug Delivery | The Danish Diabetes Academy | Novo Nordisk Foundation | The Intramural Program of NICHD, NIH

Authors: Stine C. Klinger, Anne Højland, Shweta Jain, Mads Kjolby, Peder Madsen, Anna Dorst Svendsen, Gunilla Olivecrona, Juan S. Bonifacino, Morten S. Nielsen

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

Journal Article published Oct 2017 in Cell Metabolism volume 26 issue 4 on pages 620 to 632.e6

Research funded by Helmholtz Alliance ICEMED | German Federal Ministry of Education and Research (01KX1012) | Lundbeckfonden | H2020 European Research Council (AdG°249929, AdG° 695054) | Alfred Benzon Foundation | Deutsche Forschungsgemeinschaft (TS226/3-1, Tu220/13-1, INST 40/492-1, SFB 1149, SFB 1123, SFB 1052, ANR- 15-CE14-0030) | Helmholtz Initiative on Personalized Medicine iMed | German Center for Diabetes Research | Alexander von Humboldt-Stiftung | Initiative and Networking Fund of the Helmholtz Association | Helmholtz cross-program “Metabolic Dysfunction,”

Authors: Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, Bin Yang, Sini S. Joseph, Dominik Lutter, Chun-Xia Yi, Elisabeth Graf, Cristina García-Cáceres, Beata Legutko, Katrin Fischer, Robert Brommage, Philippe Zizzari, Bernardo S. Franklin, Martin Krueger, Marco Koch, Sabine Vettorazzi, Pengyun Li, Susanna M. Hofmann, Mostafa Bakhti, Aimée Bastidas-Ponce, Heiko Lickert, Tim M. Strom, Valerie Gailus-Durner, Ingo Bechmann, Diego Perez-Tilve, Jan Tuckermann, Martin Hrabě de Angelis, Darleen Sandoval, Daniela Cota, Eicke Latz, Randy J. Seeley, Timo D. Müller, Richard D. DiMarchi, Brian Finan, Matthias H. Tschöp

Lipid-Loving ANTs: Molecular Simulations of Cardiolipin Interactions and the Organization of the Adenine Nucleotide Translocase in Model Mitochondrial Membranes

Journal Article published 4 Nov 2016 in Biochemistry volume 55 issue 45 on pages 6238 to 6249

Research funded by Engineering and Physical Sciences Research Council | Medical Research Council | Wellcome Trust | Biotechnology and Biological Sciences Research Council | Seventh Framework Programme | Alfred Benzon Foundation

Authors: George Hedger, Sarah L. Rouse, Jan Domański, Matthieu Chavent, Heidi Koldsø, Mark S. P. Sansom

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity

Journal Article published 15 Dec 2017 in eLife volume 6

Research funded by National Institutes of Health (DK52539) | Pew Charitable Trusts | Alfred Benzon Foundation | Lundbeckfonden

Authors: Ana Paula Arruda, Benedicte Mengel Pers, Günes Parlakgul, Ekin Güney, Ted Goh, Erika Cagampan, Grace Yankun Lee, Renata L Goncalves, Gökhan S Hotamisligil

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

Journal Article published 11 Sep 2017 in eLife volume 6

Research funded by National Institute on Aging (R01 AG028127, R01 AG050104) | American Federation for Aging Research (Breakthroughs in Gerontology Award) | Alfred Benzon Foundation (Postdoctoral Fellowship)

Authors: Martin Borch Jensen, Yanyan Qi, Rebeccah Riley, Liya Rabkina, Heinrich Jasper

Publisher’s note

Journal Article published Oct 2017 in Journal of Molecular Graphics and Modelling volume 77 on page 250

Research funded by NC3Rs studentship and was also a Cephalosporin Scholar at Lady Margaret Hall, Oxford | Advanced Research Computing (ARC) facility | EPSRC UK National Service for Computational Chemistry Software (NSCCS) at Imperial College London (EP/J003921/1) | ARCHER UK National Supercomputing Services | UK High-End Computing Consortium for Biomolecular Simulation, HECBioSim | Engineering and Physical Sciences Research Council (EP/L000253/1) | Alfred Benzon Foundation | MRC (MR/M000435/1) | Biotechnology and Biological Sciences Research Council (BB/M006395/1)

Insights into channel dysfunction from modelling and molecular dynamics simulations

Journal Article published Apr 2018 in Neuropharmacology volume 132 on pages 20 to 30

Research funded by Medical Research Council (MR/M000435/1) | Biotechnology and Biological Sciences Research Council (BB/M006395/1) | Alfred Benzon Foundation | Carlsbergfondet (CF15-0867)

Authors: Maria Musgaard, Teresa Paramo, Laura Domicevica, Ole Juul Andersen, Philip C. Biggin

Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter

Journal Article published Jun 2016 in Bioorganic & Medicinal Chemistry volume 24 issue 12 on pages 2725 to 2738

Research funded by The Danish Council for Independent Research Natural Sciences and the Lundbeck | Carlsberg Foundations | Alfred Benzon Foundation | Lundbeckfonden

Authors: Anne Brinkø, Maja T. Larsen, Heidi Koldsø, Louise Besenbacher, Anders Kolind, Birgit Schiøtt, Steffen Sinning, Henrik H. Jensen

Functional Validation of Heteromeric Kainate Receptor Models

Journal Article published Nov 2017 in Biophysical Journal volume 113 issue 10 on pages 2173 to 2177

Research funded by Medical Research Council (MR/M000435/1) | Alfred Benzon Foundation | Fonds de Recherche en Santé du Québec | Canadian Institutes of Health Research | Engineering and Physical Sciences Research Council (EPSRC) National Service for Computational Chemistry Software (NSCCS) (EP/J003921/1) | Engineering and Physical Sciences Research Council (EP/L000253/1) | Biotechnology and Biological Sciences Research Council | MRC

Authors: Teresa Paramo, Patricia M.G.E. Brown, Maria Musgaard, Derek Bowie, Philip C. Biggin

The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation

Journal Article published 31 May 2016 in Molecular and Cellular Biology volume 36 issue 17 on pages 2226 to 2235

Research funded by Ellison Medical Foundation | HHS | NIH | National Institute of General Medical Sciences (NIGMS) (DP2 GM119132) | National Institute of General Medical Sciences (R01 GM077243, F31 GM106655, F31 GM083624) | Alfred Benzon Foundation | The Lundbeck Foundation (R140-2013-13425)

Authors: Marcos Arribas-Layton, Jaclyn Dennis, Eric J. Bennett, Christian K. Damgaard, Jens Lykke-Andersen

Capturing change in clonal composition amongst single mouse germinal centers

Journal Article published 1 Aug 2018 in eLife volume 7

Research funded by Howard Hughes Medical Institute | Marie Curie International Fellowships | Alfred Benzon Foundation | National Institutes of Health (R21AI117737, R01AI039246) | Alliance for Lupus Research

Authors: Daniel J Firl, Soren E Degn, Timothy Padera, Michael C Carroll