Development of a Quantitative Model of Pregnane X Receptor (PXR) Mediated Xenobiotic Metabolizing Enzyme Induction

JOURNAL ARTICLE published October 2010 in Bulletin of Mathematical Biology

Authors: Nicholas S. Luke | Michael J. DeVito | Imran Shah | Hisham A. El-Masri

Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction

COMPONENT published

Development of a Quantitative Model Incorporating Key Events in a Hepatotoxic Mode of Action to Predict Tumor Incidence

JOURNAL ARTICLE published May 2010 in Toxicological Sciences

Authors: Nicholas S. Luke | Reeder Sams | Michael J. DeVito | Rory B. Conolly | Hisham A. El-Masri

A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes

JOURNAL ARTICLE published November 2015 in Toxicology

Authors: Aneta Doricakova | Radim Vrzal

The effect of pregnane X receptor (PXR)‐mediated CYP3A induction on acetaminophen hepatotoxicity

JOURNAL ARTICLE published January 2007 in The FASEB Journal

Authors: XIAOCHAO MA | CHI CHEN | Yatrik Shah | Keiichirou Morimura | Kristopher W. Krausz | Jeffrey R. Idle | FRANK J GONZALEZ

Faculty Opinions recommendation of Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.

DATASET published 17 August 2021 in Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

Authors: John Lowe

Effect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice

JOURNAL ARTICLE published June 2011 in European Journal of Pharmacology

Authors: Wael M. El-Sayed

The Induction of Cytochrome P450 3A5 (CYP3A5) in the Human Liver and Intestine Is Mediated by the Xenobiotic Sensors Pregnane X Receptor (PXR) and Constitutively Activated Receptor (CAR)

JOURNAL ARTICLE published September 2004 in Journal of Biological Chemistry

Authors: Oliver Burk | Ina Koch | Judy Raucy | Elisabeth Hustert | Michel Eichelbaum | Jürgen Brockmöller | Ulrich M. Zanger | Leszek Wojnowski

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

JOURNAL ARTICLE published 25 November 2016 in Frontiers in Pharmacology

Research funded by Czech Scientific Agency (GACR 303/12/G163 to P.P.)

Authors: Petr Pavek

Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction

JOURNAL ARTICLE published 15 June 2018 in International Journal of Molecular Sciences

Authors: Jurjen Duintjer Tebbens | Malek Azar | Elfriede Friedmann | Martin Lanzendörfer | Petr Pávek

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development

JOURNAL ARTICLE published February 2013 in Drug Metabolism Reviews

Authors: Michael W. Sinz

Development of Antioxidant and Xenobiotic Metabolizing Enzyme Systems

BOOK CHAPTER published 2004 in The Lung

Authors: Michelle V. Fanucchi

Development of Antioxidant and Xenobiotic Metabolizing Enzyme Systems

BOOK CHAPTER published 2014 in The Lung

Authors: Michelle V. Fanucchi

A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis

JOURNAL ARTICLE published April 2022 in Toxicology Letters

Authors: Clara Bay | Hisham A. El-Masri

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

JOURNAL ARTICLE published October 2010 in Advanced Drug Delivery Reviews

Authors: Antonia H. Tolson | Hongbing Wang

Employing a Mechanistic Model for the Mapk Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response

JOURNAL ARTICLE published 1 July 2010 in Dose-Response

Authors: Nicholas S. Luke | Michael J. DeVito | Christopher J. Portier | Hisham A. El-Masri

Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR)

JOURNAL ARTICLE published October 2004 in Mechanisms of Ageing and Development

Authors: Ibtissam Echchgadda | Chung S. Song | Tae-Sung Oh | Sung-Hwan Cho | Omar J. Rivera | Bandana Chatterjee

Xenobiotic metabolizing enzyme polymorphisms and survival in lung cancer patients

JOURNAL ARTICLE published 2010 in Frontiers in Pharmacology

Authors: Iscan Mumtaz

Analyses of xenobiotic metabolizing enzyme activities in human reconstructed skin equivalents

JOURNAL ARTICLE published July 2010 in Toxicology Letters

Authors: C. Jäckh

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

JOURNAL ARTICLE published 26 September 2000 in Proceedings of the National Academy of Sciences

Authors: Christoph Handschin | Michael Podvinec | Urs A. Meyer