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A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes

JOURNAL ARTICLE published November 2015 in Toxicology

Authors: Aneta Doricakova | Radim Vrzal

https://doi.org/10.1016/j.tox.2015.08.012 Actions

A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis

JOURNAL ARTICLE published April 2022 in Toxicology Letters

Authors: Clara Bay | Hisham A. El-Masri

https://doi.org/10.1016/j.toxlet.2022.02.002 Actions

Analyses of xenobiotic metabolizing enzyme activities in human reconstructed skin equivalents

JOURNAL ARTICLE published July 2010 in Toxicology Letters

Authors: C. Jäckh

https://doi.org/10.1016/j.toxlet.2010.03.391 Actions

Species differences in the induction and activation of the pregnane X receptor (PXR)

JOURNAL ARTICLE published September 2006 in Toxicology

Authors: Anthony J. Zucker | Gordon G. Gibson | Barry Jones | Maurice Dickins | Nick Plant

https://doi.org/10.1016/j.tox.2006.05.060 Actions

Xenobiotic Receptor-Mediated Toxicity

BOOK CHAPTER published 2010 in Comprehensive Toxicology

Authors: G.H. Perdew | I.A. Murray | J.M. Peters

https://doi.org/10.1016/b978-0-08-046884-6.00117-2 Actions

Differential dose–response relationships for hepatic Cyp2b10 induction and cell proliferation in wild type mice and mice humanized (huPXR/huCAR) for the constitutive androstane receptor (CAR) and pregnane X receptor (PXR) administered phenobarbitone (PB)

JOURNAL ARTICLE published September 2014 in Toxicology Letters

Authors: Clifford Elcombe | Audrey Vardy

https://doi.org/10.1016/j.toxlet.2014.06.245 Actions

Concentration addition model to assess activation of the Pregnane X Receptor (PXR) by pesticide mixtures found in the French diet

JOURNAL ARTICLE published August 2013 in Toxicology Letters

Authors: G. de Sousa | A. Nawaz | R. Rahmani

https://doi.org/10.1016/j.toxlet.2013.05.461 Actions

Dioxins: model chemicals for assessing receptor-mediated toxicity

JOURNAL ARTICLE published September 1995 in Toxicology

Authors: Michael J. DeVito | Linda S. Birnbaum

https://doi.org/10.1016/0300-483x(95)03040-m Actions

3,4-Methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition

JOURNAL ARTICLE published May 2011 in Toxicology Letters

Authors: Irene Antolino-Lobo | Jan Meulenbelt | Sandra M. Nijmeijer | Roel F. Maas-Bakker | Irma Meijerman | Martin van den Berg | Majorie B.M. van Duursen

https://doi.org/10.1016/j.toxlet.2011.03.007 Actions

Drug/xenobiotic-metabolizing enzyme (XME) expression in the EpiAirway in vitro human airway model: Utility for assessing tracheal/bronchial biotransformation of inhaled pharmaceuticals and environmental chemicals

JOURNAL ARTICLE published September 2006 in Toxicology Letters

Authors: Jennifer Bolmarcich | Gina Stolper | George R. Jackson | Mitcehll Klausner | Patrick J. Hayden

https://doi.org/10.1016/j.toxlet.2006.07.123 Actions

QSAR model for human pregnane X receptor (PXR) binding: Screening of environmental chemicals and correlations with genotoxicity, endocrine disruption and teratogenicity

JOURNAL ARTICLE published August 2012 in Toxicology and Applied Pharmacology

Authors: Marianne Dybdahl | Nikolai G. Nikolov | Eva Bay Wedebye | Svava Ósk Jónsdóttir | Jay R. Niemelä

https://doi.org/10.1016/j.taap.2012.05.008 Actions

Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures

OTHER published 26 March 2010 in Quantitative Modeling in Toxicology

Authors: Hisham A. El‐Masri | Michael A. Lyons | Raymond S. H. Yang

https://doi.org/10.1002/9780470686263.ch14 Actions

Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism

JOURNAL ARTICLE published November 2010 in Toxicology

Authors: Yvonne Fery | Stefan O. Mueller | Dieter Schrenk

https://doi.org/10.1016/j.tox.2010.08.008 Actions

Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity

JOURNAL ARTICLE published January 2015 in Archives of Toxicology

Authors: Yun-Ping Lim | Ching-Hao Cheng | Wei-Cheng Chen | Shih-Yu Chang | Dong-Zong Hung | Jih-Jung Chen | Lei Wan | Wei-Chih Ma | Yu-Hsien Lin | Cing-Yu Chen | Tsuyoshi Yokoi | Miki Nakajima | Chao-Jung Chen

https://doi.org/10.1007/s00204-014-1230-x Actions

Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes

JOURNAL ARTICLE published 1 September 2010 in Toxicology Letters

Authors: Jian Yang | Chunshu Hao | Dongfang Yang | Deshi Shi | Xiulong Song | Xiaofei Luan | Gang Hu | Bingfang Yan

https://doi.org/10.1016/j.toxlet.2010.06.003 Actions

Harman induces CYP1A1 enzyme through an aryl hydrocarbon receptor mechanism

JOURNAL ARTICLE published 15 November 2010 in Toxicology and Applied Pharmacology

Authors: Mohamed A.M. El Gendy | Ayman O.S. El-Kadi

https://doi.org/10.1016/j.taap.2010.08.014 Actions

Enzyme induction and histopathology elucidate aryl hydrocarbon receptor–mediated versus non–aryl hydrocarbon receptor–mediated effects of Aroclor 1268 in American mink (Neovison vison)

JOURNAL ARTICLE published March 2016 in Environmental Toxicology and Chemistry

Authors: William R. Folland | John L. Newsted | Scott D. Fitzgerald | Phyllis C. Fuchsman | Patrick W. Bradley | John Kern | Kurunthachalam Kannan | Matthew J. Zwiernik

https://doi.org/10.1002/etc.3203 Actions

Prediction of Aryl Hydrocarbon Receptor-Mediated Enzyme Induction of Drugs and Chemicals by mRNA Quantification

JOURNAL ARTICLE published 1 December 1998 in Chemical Research in Toxicology

Authors: Roland Frötschl | Lubomir Chichmanov | Ullrich Kleeberg | Alfred G. Hildebrandt | Ivar Roots | Jürgen Brockmöller

https://doi.org/10.1021/tx980164h Actions

Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments

JOURNAL ARTICLE published 17 September 2009 in Inhalation Toxicology

Authors: Hisham A. El-Masri | Sean Dowd | Rex A. Pegram | Randy Harrison | Sisouphanh J. Yavanhxay | Jane Ellen Simmons | Marina Evans

https://doi.org/10.1080/08958370903005751 Actions

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

JOURNAL ARTICLE published 17 June 2010 in Journal of Toxicology and Environmental Health, Part B

Authors: Daniel M. Rotroff | Andrew L. Beam | David J. Dix | Adam Farmer | Kimberly M. Freeman | Keith A. Houck | Richard S. Judson | Edward L. LeCluyse | Matthew T. Martin | David M. Reif | Stephen S. Ferguson

https://doi.org/10.1080/10937404.2010.483949 Actions
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