Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus

JOURNAL ARTICLE published 7 May 2024 in eLife

Research funded by National Institutes of Health (P41GM109824) | National Institutes of Health (R01GM083960) | American Lung Association (923055)

Authors: Natalia E Ketaren | Fred D Mast | Peter C Fridy | Jean Paul Olivier | Tanmoy Sanyal | Andrej Sali | Brian T Chait | Michael P Rout | John D Aitchison

Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

JOURNAL ARTICLE published 2 September 2020 in eLife

Research funded by National Institute of General Medical Sciences (1R01GM117104)

Authors: Connor J Thompson | Zhaoqian Su | Vinh H Vu | Yinghao Wu | Deborah E Leckband | Daniel K Schwartz

Hippocampal place cell remapping occurs with memory storage of aversive experiences

JOURNAL ARTICLE published 19 July 2023 in eLife

Research funded by National Science Foundation (NeuroNex 1704708) | National Institute of Mental Health (RO1-MH062122)

Authors: Garrett J Blair | Changliang Guo | Shiyun Wang | Michael S Fanselow | Peyman Golshani | Daniel Aharoni | Hugh T Blair

Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

JOURNAL ARTICLE published 18 February 2022 in eLife

Research funded by Interreg (BlueFish) | Biotechnology and Biological Sciences Research Council (BB/P017215/1)

Authors: Charlotte E Davies | Jessica E Thomas | Sophie H Malkin | Frederico M Batista | Andrew F Rowley | Christopher J Coates

Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations

JOURNAL ARTICLE published 6 December 2022 in eLife

Research funded by National Science Foundation (1715591) | Gordon and Betty Moore Foundation (1901709) | National Institutes of Health (1R21CA207832-01)

Authors: I Can Kazan | Prerna Sharma | Mohammad Imtiazur Rahman | Andrey Bobkov | Raimund Fromme | Giovanna Ghirlanda | S Banu Ozkan

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

JOURNAL ARTICLE published 12 May 2017 in eLife

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (2012_149278) | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (20020_163042/1) | Agence Nationale de la Recherche (ANR-14-ACHN-0016)

Authors: Duccio Malinverni | Alfredo Jost Lopez | Paolo De Los Rios | Gerhard Hummer | Alessandro Barducci

Functional links between sensory representations, choice activity, and sensorimotor associations in parietal cortex

JOURNAL ARTICLE published 20 October 2020 in eLife

Research funded by Alfred P. Sloan Foundation (FG-2016-6468) | Whitehall Foundation (2016-08-18) | Greater Milwaukee Foundation (Shaw Scientist Award) | National Institutes of Health (EY029438)

Authors: Ting-Yu Chang | Raymond Doudlah | Byounghoon Kim | Adhira Sunkara | Lowell W Thompson | Meghan E Lowe | Ari Rosenberg

Real-time experimental control using network-based parallel processing

JOURNAL ARTICLE published 7 February 2019 in eLife

Research funded by Alfred P. Sloan Foundation (FG-2016-6468) | Whitehall Foundation (2016-08-18) | National Institutes of Health (DC014305) | National Institutes of Health (EY029438) | Greater Milwaukee Foundation (Shaw Scientist Award)

Authors: Byounghoon Kim | Shobha Channabasappa Kenchappa | Adhira Sunkara | Ting-Yu Chang | Lowell Thompson | Raymond Doudlah | Ari Rosenberg

Early analysis of the Australian COVID-19 epidemic

JOURNAL ARTICLE published 13 August 2020 in eLife

Authors: David J Price | Freya M Shearer | Michael T Meehan | Emma McBryde | Robert Moss | Nick Golding | Eamon J Conway | Peter Dawson | Deborah Cromer | James Wood | Sam Abbott | Jodie McVernon | James M McCaw

Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

JOURNAL ARTICLE published 29 March 2018 in eLife

Research funded by National Institutes of Health (RO1 CA077373) | National Science Foundation (DGE 1106400)

Authors: Timothy J Wendorff | James M Berger

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

JOURNAL ARTICLE published 24 December 2021 in eLife

Research funded by National Institute of General Medical Sciences (R01GM141045-01) | National Cancer Institute (R01CA030490) | National Institute of General Medical Sciences (F32GM116393) | Cancer Prevention and Research Institute of Texas (RR200070) | Welch Foundation (I-2074-20210327)

Authors: Matthew W Parker | Jonchee A Kao | Alvin Huang | James M Berger | Michael R Botchan

Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

JOURNAL ARTICLE published 4 May 2021 in eLife

Research funded by National Institutes of Health (R35GM118037) | National Institutes of Health (R37MH63105)

Authors: Hongki Song | Thomas L Torng | Amy S Orr | Axel T Brunger | William T Wickner

Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

JOURNAL ARTICLE published 15 November 2016 in eLife

Research funded by Telethon (GGP14095) | Associazione Italiana Ricerca sul Cancro (IG14581) | Telethon (GGP 12189)

Authors: Piergiorgio La Rosa | Pamela Bielli | Claudia Compagnucci | Eleonora Cesari | Elisabetta Volpe | Stefano Farioli Vecchioli | Claudio Sette

Periprotein lipidomes of Saccharomyces cerevisiae provide a flexible environment for conformational changes of membrane proteins

JOURNAL ARTICLE published 17 April 2020 in eLife

Research funded by Ministry of Economic Affairs and Climate Policy, The Netherlands (BE-BASIC) | European Research Council (ERC Advanced #670578) | NIH (AR048632)

Authors: Joury S van 't Klooster | Tan-Yun Cheng | Hendrik R Sikkema | Aike Jeucken | Branch Moody | Bert Poolman

The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development

JOURNAL ARTICLE published 19 July 2021 in eLife

Research funded by Engineering and Physical Sciences Research Council (EP/F500351/1) | Engineering and Physical Sciences Research Council (EP/I017909/1) | Natural Environment Research Council (NE/R010579/1) | Biotechnology and Biological Sciences Research Council (BB/S003681/1) | Biotechnology and Biological Sciences Research Council (BB/V003542/1)

Authors: Marco Colnaghi | Andrew Pomiankowski | Nick Lane

Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

JOURNAL ARTICLE published 2 June 2020 in eLife

Research funded by National Institutes of Health (HL122918) | National Institutes of Health (HD092316)

Authors: Racquel Domingo-Gonzalez | Fabio Zanini | Xibing Che | Min Liu | Robert C Jones | Michael A Swift | Stephen R Quake | David N Cornfield | Cristina M Alvira

Bronchus-associated macrophages efficiently capture and present soluble inhaled antigens and are capable of local Th2 cell activation

JOURNAL ARTICLE published 29 September 2022 in eLife

Research funded by National Heart, Lung, and Blood Institute (DP2HL117752) | National Institute of Allergy and Infectious Diseases (R21AI130495) | National Institute of Allergy and Infectious Diseases (T32AI007334-31) | National Heart, Lung, and Blood Institute (T32HL007731-28)

Authors: Xin-Zi Tang | Lieselotte S M Kreuk | Cynthia Cho | Ross J Metzger | Christopher D C Allen

Molecular architecture underlying fluid absorption by the developing inner ear

JOURNAL ARTICLE published 10 October 2017 in eLife

Research funded by National Institute on Deafness and Other Communication Disorders (Z01-DC000060) | National Institute on Deafness and Other Communication Disorders (Z01-DC000059) | National Institute on Deafness and Other Communication Disorders (Z01-DC000086) | National Institute on Deafness and Other Communication Disorders (Z01-DC000088) | National Institute on Deafness and Other Communication Disorders (R01-DC012151) | National Center for Research Resources (P20-RR017686)

Authors: Keiji Honda | Sung Huhn Kim | Michael C Kelly | Joseph C Burns | Laura Constance | Xiangming Li | Fei Zhou | Michael Hoa | Matthew W Kelley | Philine Wangemann | Robert J Morell | Andrew J Griffith

Filopodia powered by class x myosin promote fusion of mammalian myoblasts

JOURNAL ARTICLE published 14 September 2021 in eLife

Research funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR075637) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54-AR-052646) | Fondation Leducq (13CVD04) | Muscular Dystrophy Association (MDA549004) | National Institute of General Medical Sciences (R01-GM134531) | National Cancer Institute (T32CA009156)

Authors: David W Hammers | Cora C Hart | Michael K Matheny | Ernest G Heimsath | Young il Lee | John A Hammer | Richard E Cheney | H Lee Sweeney

Molecular and spatial profiling of the paraventricular nucleus of the thalamus

JOURNAL ARTICLE published 3 March 2023 in eLife

Research funded by National Institute of Mental Health (1ZIAMH002950) | National Institute of Neurological Disorders and Stroke (ZIANS003153)

Authors: Claire Gao | Chiraag A Gohel | Yan Leng | Jun Ma | David Goldman | Ariel J Levine | Mario A Penzo