Challenges and solutions for the downstream purification of therapeutic proteins

JOURNAL ARTICLE published 16 January 2024 in Antibody Therapeutics

Authors: Shuo Tang | Jiaoli Tao | Ying Li

The influence of variable-heavy chain families on IgG2, 3, 4, FcγRs and B-cell superantigens protein G and L binding using biolayer interferometry

JOURNAL ARTICLE published 22 July 2023 in Antibody Therapeutics

Authors: Anthony M Deacy | Samuel Ken-En Gan

DEVELOPMENT OF A SELECTIVE CD16A-BASED NK CELL ENGAGER UTILIZING ANTIBODIES TARGETING A SINGLE AMINO ACID VARIATION

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Authors: Wuxiang Liao | Christine Tumanut | Lin Li | Adam Corper | Dilip Challa | Alex Chang | Hydari Begum | Elinaz Farokhi | Catherine Woods | Xiaomin Fan

Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody

JOURNAL ARTICLE published 13 April 2022 in Antibody Therapeutics

Research funded by National Science Foundation (CBET-0967821)

Authors: Hussain Dahodwala | Sophia D Amenyah | Sarah Nicoletti | Matthew N Henry | Diane J Lees-Murdock | Susan T Sharfstein

Efficient production of bispecific antibodies—optimization of transfection strategy leads to high-level stable cell line generation of a Fabs-in-tandem immunoglobin

JOURNAL ARTICLE published 22 July 2023 in Antibody Therapeutics

Authors: Shiyong Gong | Chengbin Wu

Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method

JOURNAL ARTICLE published 17 April 2023 in Antibody Therapeutics

Authors: Yang Dou | Ke Xu | Yong-Qiang Deng | Zijing Jia | Jun Lan | Xiaoyu Xu | Guorui Zhang | Tianshu Cao | Pan Liu | Xiangxi Wang | Xinquan Wang | Lingjie Xu | Pan Du | Cheng-Feng Qin | Hong Liu | Yafeng Li | Guizhen Wu | Kang Wang | Bai Lu

Preclinical evaluation of ISH0339, a tetravalent broadly neutralizing bispecific antibody against SARS-CoV-2 with long-term protection

JOURNAL ARTICLE published 17 April 2023 in Antibody Therapeutics

Authors: Huabing Yang | Yuxin Chen | Dongcheng Jiang | Xiaoli Feng | Ying Xu | Jiayu Wei | Qingcui Zou | Qiaojiang Yang | Jihong Chen | Xiaoling Jiang | Chunling Qin | Zhenzhen Huang | Chongbing Wu | Ying Zhou | Minghua Li | Liusong Yin

High-specificity antibodies and detection methods for quantifying phosphorylated tau from clinical samples

JOURNAL ARTICLE published 1 January 2021 in Antibody Therapeutics

Research funded by National Science Foundation (1706743)

Authors: Monika Arbaciauskaite | Yu Lei | Yong Ku Cho

The approval of sintilimab for classical Hodgkin's lymphoma: views and perspectives of anti-PD-1/PD-L1 antibodies in China

JOURNAL ARTICLE published 5 April 2019 in Antibody Therapeutics

Authors: Mi Deng

Safety and immunogenicity evaluation of inactivated whole-virus-SARS-COV-2 as emerging vaccine development in Egypt

JOURNAL ARTICLE published 19 July 2021 in Antibody Therapeutics

Authors: Amani A Saleh | Mohamed A Saad | Islam Ryan | Magdy Amin | Mohamed I Shindy | Wael A Hassan | Mahmoud Samir | Ayman A Khattab | Sherein S Abdelgayed | Mohamed G Seadawy | Hossam M Fahmy | Khaled Amer

Novel monkey mAbs induced by a therapeutic vaccine targeting the hepatitis B surface antigen effectively suppress hepatitis B virus in mice

JOURNAL ARTICLE published 8 October 2021 in Antibody Therapeutics

Research funded by Fujian Provincial Medical Innovation Foundation (2017-CXB-20) | National Science and Technology (2017ZX10202203-009-003) | National Natural Science Foundation of China (31870925)

Authors: Yuanzhi Chen | Xinchu Xiang | Ruoyao Qi | Yiwen Wang | Yang Huang | Min You | Yangfei Xian | Yangtao Wu | Rao Fu | Ciming Kang | Jixian Tang | Hai Yu | Tianying Zhang | Quan Yuan | Wenxin Luo | Ningshao Xia

Massively multiplexed affinity characterization of therapeutic antibodies against SARS-CoV-2 variants

JOURNAL ARTICLE published 13 April 2022 in Antibody Therapeutics

Research funded by National Science Foundation (2033772)

Authors: Emily Engelhart | Randolph Lopez | Ryan Emerson | Charles Lin | Colleen Shikany | Daniel Guion | Mary Kelley | David Younger

In vitro generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2

JOURNAL ARTICLE published 3 October 2023 in Antibody Therapeutics

Research funded by Horizon 2020 (899670) | European Research Council (834631) | EPSRC Future Vaccine Manufacturing and Research Hub (EP/R013764/1) | EPSRC (EP/M022609/1) | MRC (MR/V027506/1,MR/R020566/1,MR/V027506/1) | United States Food and Drug Administration (HHSF223201510104C) | European Research Council (294852) | University of Bristol (BB/L01386X/1) | BBSRC (BB/R000484/1) | Wellcome Trust (221708/Z/20/Z,206181/Z/17/Z,202904/Z/16/Z)

Authors: Dora Buzas | Adrian H Bunzel | Oskar Staufer | Emily J Milodowski | Grace L Edmunds | Joshua C Bufton | Beatriz V Vidana Mateo | Sathish K N Yadav | Kapil Gupta | Charlotte Fletcher | Maia K Williamson | Alexandra Harrison | Ufuk Borucu | Julien Capin | Ore Francis | Georgia Balchin | Sophie Hall | Mirella V Vega | Fabien Durbesson | Srikanth Lingappa | Renaud Vincentelli | Joe Roe | Linda Wooldridge | Rachel Burt | Ross J L Anderson | Adrian J Mulholland | Jonathan Hare | Mick Bailey | Andrew D Davidson | Adam Finn | David Morgan | Jamie Mann | Joachim Spatz | Frederic Garzoni | Christiane Schaffitzel | Imre Berger

Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

JOURNAL ARTICLE published 8 December 2020 in Antibody Therapeutics

Research funded by Innovation Fund for Medical Sciences (2019RU022)

Authors: Yang Huang | Hui Sun | Hai Yu | Shaowei Li | Qingbing Zheng | Ningshao Xia

Author Index

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation

JOURNAL ARTICLE published 1 October 2022 in Antibody Therapeutics

Research funded by Science Foundation Ireland (14/BIAP/B2959)

Authors: Ruth Bone | Brian J Fennell | Amy Tam | Richard Sheldon | Karl Nocka | Sreeja Varghese | Chew Shun Chang | Heike C Hawerkamp | Aoife Yeow | Sean P Saunders | Emily Hams | Patrick T Walsh | Orla Cunningham | Padraic G Fallon

A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy

JOURNAL ARTICLE published 8 December 2020 in Antibody Therapeutics

Authors: Zhihui Kuang | Li Li | Pan Zhang | Bingliang Chen | Min Wu | Haiqing Ni | Shuai Yi | Jia Zou | Junjian Liu

Comparability strategy and demonstration for post-approval production cell line change of a bevacizumab biosimilar IBI305

JOURNAL ARTICLE published 22 July 2023 in Antibody Therapeutics

Authors: Zhouyi Wu | Gangling Xu | Wu He | Chuanfei Yu | Wanqiu Huang | Shirui Zheng | Dian Kang | Michael H Xie | Xingjun Cao | Lan Wang | Kaikun Wei

A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice

JOURNAL ARTICLE published 18 January 2023 in Antibody Therapeutics

Research funded by Welch Foundation (AU-0042-20030616) | Cancer Prevention and Research Institute of Texas (RP190561,RP150551) | National Institutes of Health (DK122708)

Authors: Leike Li | Yankai Wen | Daniel Wrapp | Jongmin Jeong | Peng Zhao | Wei Xiong | Constance Lynn Atkins | Zhao Shan | Deng Hui | Jason S McLellan | Ningyan Zhang | Cynthia Ju | Zhiqiang An

OVERCOMING TECHNICAL CHALLENGES OF BISPECIFIC AND MULTI-SPECIFIC ANTIBODIES USING NOVEL TECHNOLOGY PLATFORMS

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Authors: Jianqing Xu | Shuang Wang | Xinzhao Fan | George Wang | Jijie Gu | Siwei Nie