Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by National Institutes of Health (1DP1AI150593,P01-DK011794,R01-AI087879)

Authors: Ross W. Cheloha | Fabian A. Fischer | Thomas J. Gardella | Hidde L. Ploegh

Temporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture system

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Authors: William J. Tipping | Andrew S. Merchant | Rebecca Fearon | Nicholas C. O. Tomkinson | Karen Faulds | Duncan Graham

Ru(ii)/BODIPY core co-encapsulated ratiometric nanotools for intracellular O₂ sensing in live cancer cells

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by Irish Research Council (GOIPD/2018/495,GOIPG/2016/702) | Science Foundation Ireland (12/RC/2276_P2,19/FFP/6428) | European Regional Development Fund (13/RC/2073)

Authors: Karmel Sofia Gkika | Anna Kargaard | Christopher S. Burke | Ciaran Dolan | Andreas Heise | Tia E. Keyes

Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation

JOURNAL ARTICLE published 2023 in RSC Chemical Biology

Research funded by Division of Molecular and Cellular Biosciences (CAREER 2045562,CHE 1904146,GFRP) | Research Corporation for Science Advancement (Cottrell Scholar Award) | National Institutes of Health (NIGMS R35 GM128836)

Authors: Joshua D. Jones | Monika K. Franco | Tyler J. Smith | Laura R. Snyder | Anna G. Anders | Brandon T. Ruotolo | Robert T. Kennedy | Kristin S. Koutmou

Binding affinity-based intracellular drug detection enabled by a unimolecular cucurbit[7]uril-dye conjugate

JOURNAL ARTICLE published 2023 in RSC Chemical Biology

Research funded by Helmholtz-Gemeinschaft (Program Materials Systems Engineering) | Chongqing Postdoctoral Science Foundation (No. CSTB2023NSCQ-BHX0180) | Deutsche Forschungsgemeinschaft (Heisenbergprofessur Projektnummer: 406232485,LE 2936/9-1)

Authors: Yanxi Liu | Changming Hu | Julian A. Serna | Frank Biedermann | Pavel A. Levkin

Modified internucleoside linkages for nuclease-resistant oligonucleotides

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by Agence Nationale de la Recherche (ANR “TALAN”-ANR-19-CE07-0004-01)

Authors: Guillaume Clavé | Maeva Reverte | Jean-Jacques Vasseur | Michael Smietana

Arabidopsis thalianaNudiXes have RNA-decapping activity

JOURNAL ARTICLE published 2023 in RSC Chemical Biology

Research funded by Ministerstvo Školství, Mládeže a Tělovýchovy (ERC CZ (LL1603)) | HORIZON EUROPE Framework Programme (ERC StG 2022 No 101041374 - StressRNaction) | Narodowe Centrum Nauki (UMO-2018/29/B/NZ3/01980)

Authors: Maria-Bianca Mititelu | Oldřich Hudeček | Agnieszka Gozdek | Roberto Benoni | Ondřej Nešuta | Szymon Krasnodębski | Joanna Kufel | Hana Cahová

Bioorthogonal protein labelling enables the study of antigen processing of citrullinated and carbamylated auto-antigens

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by Reumafonds (15-2-202) | H2020 European Research Council (ERC-CoG-865175)

Authors: Tyrza van Leeuwen | Can Araman | Linda Pieper Pournara | Arieke S. B. Kampstra | Thomas Bakkum | Mikkel H. S. Marqvorsen | Clarissa R. Nascimento | G. J. Mirjam Groenewold | Willemijn van der Wulp | Marcel G. M. Camps | George M. C. Janssen | Peter A. van Veelen | Gerard J. P. van Westen | Antonius P. A. Janssen | Bogdan I. Florea | Herman S. Overkleeft | Ferry A. Ossendorp | René E. M. Toes | Sander I. van Kasteren

Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by European Commission (631871) | China Scholarship Council (20170663005)

Authors: Dominic W. P. Collis | Gokhan Yilmaz | Yichen Yuan | Alessandra Monaco | Guy Ochbaum | Yejiao Shi | Clare O’Malley | Veselina Uzunova | Richard Napier | Ronit Bitton | C. Remzi Becer | Helena S. Azevedo

Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by Innovation and Technology Commission (ITCPD/17-9) | Research Grants Council, University Grants Committee (17309616,AoE/M-09/12,AoE/P-705/16,T13-605/18-W)

Authors: Ilona Christy Unarta | Jianchao Xu | Yuan Shang | Carina Hey Pui Cheung | Ruichi Zhu | Xudong Chen | Siqin Cao | Peter Pak-Hang Cheung | Donald Bierer | Mingjie Zhang | Xuhui Huang | Xuechen Li

A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography

JOURNAL ARTICLE published 2021 in RSC Chemical Biology

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (200020_178998) | H2020 European Research Council (ERC Adv. Grant no. 885076)

Authors: Stéphane Baeriswyl | Hippolyte Personne | Ivan Di Bonaventura | Thilo Köhler | Christian van Delden | Achim Stocker | Sacha Javor | Jean-Louis Reymond

A prodrug strategy for the in vivo imaging of aldehyde dehydrogenase activity

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by Wellcome Trust (107610/Z/15/Z,220221/Z/20/Z)

Authors: Raul Pereira | Renée L. Flaherty | Richard S. Edwards | Hannah E. Greenwood | Adam J. Shuhendler | Timothy H. Witney

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JOURNAL ARTICLE published 2022 in RSC Chemical Biology

A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by National Natural Science Foundation of China (2207070006) | Natural Science Foundation of Jiangsu Province (BK20202299)

Authors: Feifei Wang | Hao Kong | Xiangfeng Meng | Xiao Tian | Changjiang Wang | Lei Xu | Xiang Zhang | Lei Wang | Ran Xie

A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by National Natural Science Foundation of China (22125702,22077107,92059109) | Natural Science Foundation of Fujian Province (2020J02001)

Authors: Zhaoxuan Yang | Jiaqi Huang | Yaying Lin | Xiangjie Luo | Haojin Lin | Hongyu Lin | Jinhao Gao

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JOURNAL ARTICLE published 2022 in RSC Chemical Biology

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JOURNAL ARTICLE published 2022 in RSC Chemical Biology

CLiB – a novel cardiolipin-binder isolated via data-driven and in vitro screening

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Authors: Isabel Kleinwächter | Bernadette Mohr | Aljoscha Joppe | Nadja Hellmann | Tristan Bereau | Heinz D. Osiewacz | Dirk Schneider

Hydrophobic cavity-directed azide-acetyllysine photochemistry for profiling non-histone interacting partners of bromodomain protein 1

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by National Institutes of Health (R01GM123234) | Cancer Institute, University of Pittsburgh (P30CA047904)

Authors: Jordan Kuwik | Shana Wagner | Babu Sudhamalla | Ronald Debiec | Kabirul Islam

Towards identification of protein–protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation

JOURNAL ARTICLE published 2022 in RSC Chemical Biology

Research funded by H2020 Marie Skłodowska-Curie Actions (675179) | Engineering and Physical Sciences Research Council (EP/K039202/1,EP/N013573/1)

Authors: Sonja Srdanović | Zsofia Hegedüs | Stuart L. Warriner | Andrew J. Wilson