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Showing results for ISSN matching 0022-2623

Dihydroxynitrobenzaldehydes and hydroxymethoxynitrobenzaldehydes: synthesis and biological activity as catechol-O-methyltransferase inhibitors

JOURNAL ARTICLE published November 1992 in Journal of Medicinal Chemistry

Authors: Rosa A. Perez | Eldiberto Fernandez-Alvarez | Ofelia Nieto | F. Javier Piedrafita

https://doi.org/10.1021/jm00102a011 Actions

Synthesis of Novel N-1 (Allyloxymethyl) Analogues of 6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, Emivirine) with Improved Activity Against HIV-1 and Its Mutants

JOURNAL ARTICLE published 1 December 2002 in Journal of Medicinal Chemistry

Authors: Nasser R. El-Brollosy | Per T. Jørgensen | Berit Dahan | Anne Marie Boel | Erik B. Pedersen | Claus Nielsen

https://doi.org/10.1021/jm020949r Actions

Acyclic purine phosphonate analogs as antiviral agents. Synthesis and structure-activity relationships

JOURNAL ARTICLE published April 1990 in Journal of Medicinal Chemistry

Authors: Choung Un Kim | Bing Yu Luh | Peter F. Misco | Joanne J. Bronson | Michael J. M. Hitchcock | Ismail Ghazzouli | John C. Martin

https://doi.org/10.1021/jm00166a019 Actions

2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine Bis(2,2,2-trifluoroethyl) Esters as Novel HBV-Specific Antiviral Reagents

JOURNAL ARTICLE published 1 July 2002 in Journal of Medicinal Chemistry

Authors: Kouichi Sekiya | Hideaki Takashima | Naoko Ueda | Naohiro Kamiya | Satoshi Yuasa | Yoshiyuki Fujimura | Masaru Ubasawa

https://doi.org/10.1021/jm020036x Actions

Development of Nonsymmetrical 1,4-Disubstituted Anthraquinones That Are Potently Active against Cisplatin-Resistant Ovarian Cancer Cells

JOURNAL ARTICLE published 1 October 2005 in Journal of Medicinal Chemistry

Authors: Klaus Pors | Jane A. Plumb | Robert Brown | Paul Teesdale-Spittle | Mark Searcey | Paul J. Smith | Laurence H. Patterson

https://doi.org/10.1021/jm050438f Actions

Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 Carbonyl Functionality Reveals the Essential Role of the sn-1 Carbonyl at the Lipid Interface in the Binding of DAG-Lactones to Protein Kinase C

JOURNAL ARTICLE published 1 September 2005 in Journal of Medicinal Chemistry

Authors: Ji-Hye Kang | Megan L. Peach | Yongmei Pu | Nancy E. Lewin | Marc C. Nicklaus | Peter M. Blumberg | Victor E. Marquez

https://doi.org/10.1021/jm050352m Actions

Indenopyrazoles as Novel Cyclin Dependent Kinase (CDK) Inhibitors

JOURNAL ARTICLE published 1 April 2001 in Journal of Medicinal Chemistry

Authors: David A. Nugiel | Ana-Marie Etzkorn | Anup Vidwans | Pamela A. Benfield | Michael Boisclair | Catherine R. Burton | Sarah Cox | Phillip M. Czerniak | Deborah Doleniak | Steven P. Seitz

https://doi.org/10.1021/jm0100032 Actions

Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity

JOURNAL ARTICLE published 10 September 2015 in Journal of Medicinal Chemistry

Authors: Edward J. Hennessy | Vibha Oza | Ammar Adam | Kate Byth | Lillian Castriotta | Gurmit Grewal | Geraldine A. Hamilton | Victor M. Kamhi | Paula Lewis | Danyang Li | Paul Lyne | Linda Öster | Michael T. Rooney | Jamal C. Saeh | Li Sha | Qibin Su | Shengua Wen | Yafeng Xue | Bin Yang

https://doi.org/10.1021/acs.jmedchem.5b01078 Actions

Structural Properties of Dibenzosuberanylpiperazine Derivatives for Efficient Reversal of Chloroquine Resistance in Plasmodium chabaudi

JOURNAL ARTICLE published 1 May 2003 in Journal of Medicinal Chemistry

Authors: Yumiko Osa | Seiki Kobayashi | Yoko Sato | Yumiko Suzuki | Kouichi Takino | Tsutomu Takeuchi | Yoshiyuki Miyata | Masakazu Sakaguchi | Hiroaki Takayanagi

https://doi.org/10.1021/jm020379v Actions

4-(ω-(Alkyloxy)alkyl)-1H-imidazole Derivatives as Histamine H3 Receptor Antagonists/Agonists

JOURNAL ARTICLE published 1 May 2004 in Journal of Medicinal Chemistry

Authors: Galina Meier | Michael Krause | Annette Hüls | Xavier Ligneau | Heinz H. Pertz | Jean-Michel Arrang | C. Robin Ganellin | Jean-Charles Schwartz | Walter Schunack | Holger Stark

https://doi.org/10.1021/jm031065q Actions

Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity

JOURNAL ARTICLE published 9 January 2020 in Journal of Medicinal Chemistry

Research funded by Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (VEGA 1/0127/18,VEGA 1/0670/18,VEGA 2/0005/2018) | European Cooperation in Science and Technology (CA15135) | Türkiye Bilimsel ve Teknolojik Arastirma Kurumu (215S19,JRP 2015/7) | Slovenská Akadémia Vied (JRP 2015/7) | Agentúra na Podporu Výskumu a Vývoja (APVV SK-FR-2015-0014,APVV-15-0455)

Authors: Matúš Hlaváč | Lucia Kováčiková | Marta Šoltésová Prnová | Peter Šramel | Gabriela Addová | Magdaléna Májeková | Gilles Hanquet | Andrej Boháč | Milan Štefek

https://doi.org/10.1021/acs.jmedchem.9b01747 Actions

Discovery of Highly Potent Microsomal Prostaglandin E2 Synthase 1 Inhibitors Using the Active Conformation Structural Model and Virtual Screen

JOURNAL ARTICLE published 25 April 2013 in Journal of Medicinal Chemistry

Authors: Shan He | Cong Li | Ying Liu | Luhua Lai

https://doi.org/10.1021/jm301900x Actions

Cobalt derivatives of Schiff bases of aliphatic amines as antitumor agents

JOURNAL ARTICLE published March 1972 in Journal of Medicinal Chemistry

Authors: Ernest M. Hodnett | William J. Dunn

https://doi.org/10.1021/jm00273a037 Actions

1-Deaza-6-methylthiopurine Ribonucleoside1

JOURNAL ARTICLE published May 1966 in Journal of Medicinal Chemistry

Authors: John A. Montgomery | Kathleen Hewson

https://doi.org/10.1021/jm00321a021 Actions

Further Studies on 2,4-Diamino-5-(2‘,5‘-disubstituted benzyl)pyrimidines as Potent and Selective Inhibitors of Dihydrofolate Reductases from Three Major Opportunistic Pathogens of AIDS

JOURNAL ARTICLE published 1 April 2003 in Journal of Medicinal Chemistry

Authors: Andre Rosowsky | Ronald A. Forsch | Sherry F. Queener

https://doi.org/10.1021/jm020466n Actions

Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure–Activity Relationship Analysis

JOURNAL ARTICLE published 8 July 2021 in Journal of Medicinal Chemistry

Research funded by Ministry of Health and Welfare (MOHW104-TDL-B-212-124-003) | National Health Research Institutes (NHRI-104A1-PDCO-0315162) | Universit??t zu K??ln (KMU-SH000151) | Kaohsiung Veterans General Hospital (VGHKS109-181) | Academia Sinica (AS-KPQ-105-TPP) | Kaohsiung Medical University (105KMUOR02,105KMUOR05,KMU-DT105004,KMU-SH000151,KMU-TP104H05,KMU-TP105E08,KMU-TP105E14,NSYSUKMU107-P015,S107006) | Ministry of Science and Technology, Taiwan (MOST105-2632-B-037-001) | KMU Global Networking Talent Plan (105KMUOR02 and 105KMUOR05)

Authors: Rajni Kant | Ming-Hui Yang | Chih-Hua Tseng | Chia-Hung Yen | Wei-You Li | Yu-Chang Tyan | Marcelo Chen | Cherng-Chyi Tzeng | Wei-Cheng Chen | Kaiting You | Wen-Chieh Wang | Yeh-Long Chen | Yi-Ming Arthur Chen

https://doi.org/10.1021/acs.jmedchem.1c00093 Actions

Synthesis of Nitroindole Derivatives with High Affinity and Selectivity for Melatoninergic Binding Sites MT3

JOURNAL ARTICLE published 1 April 2002 in Journal of Medicinal Chemistry

Authors: Véronique Leclerc | Saïd Yous | Philippe Delagrange | Jean A. Boutin | Pierre Renard | Daniel Lesieur

https://doi.org/10.1021/jm011053+ Actions

Additions and Corrections-Synthesis, Binding Studies, and Structure-Activity Relationships of 1-Aryl- and 2-Aryl[1]benzopyranopyrazol-4-ones, Central Benzodiazepine Receptor Ligands

JOURNAL ARTICLE published March 1988 in Journal of Medicinal Chemistry

Authors: Vittoria Colotta | Lucia Cecchi | Guido Filacchioni | Fabrizio Melani | Giovanna Palazzino | Antonio Lucacchini

https://doi.org/10.1021/jm00398a600 Actions

Inhibition studies on antibody to poly(L-tyrosyl-L-glutamyl-L-alanylglycyl)glycine-1-14C ethyl ester. Synthesis and immunochemical properties of poly(L-alanyl-L-glutamy1-L-alanylglycyl)glycine-1-14C ethyl ester

JOURNAL ARTICLE published January 1972 in Journal of Medicinal Chemistry

Authors: Brian J. Johnson | Charles Cheng | Nora Tsang

https://doi.org/10.1021/jm00271a027 Actions

Antimalarial phenathrene amino alcohols. 1. Fluorine-containing 3- and 6-substituted 9-phenanthrenemethanols

JOURNAL ARTICLE published October 1971 in Journal of Medicinal Chemistry

Authors: Edward A. Nodiff | Keiichi Tanabe | Christoph Seyfried | Shin Matsuura | Yasuaki Kondo | Eugene H. Chen | Mahesh P. Tyagi

https://doi.org/10.1021/jm00292a007 Actions
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