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Showing results for ISSN matching 0022-2623

Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

JOURNAL ARTICLE published 1 December 2000 in Journal of Medicinal Chemistry

Authors: Kazuyuki Ohmoto | Tetsuya Yamamoto | Toshihide Horiuchi | Hirotoshi Imanishi | Yoshihiko Odagaki | Kazuhito Kawabata | Tomohiko Sekioka | Yasushi Hirota | Shozo Matsuoka | Hisao Nakai | Masaaki Toda | John C. Cheronis | Lyle W. Spruce | Albert Gyorkos | Maciej Wieczorek

https://doi.org/10.1021/jm0004087 Actions

Preparation of Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for SPECT Imaging

JOURNAL ARTICLE published 24 October 2013 in Journal of Medicinal Chemistry

Authors: Naoya Harada | Hiroyuki Kimura | Masahiro Ono | Hideo Saji

https://doi.org/10.1021/jm400895s Actions

Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores

JOURNAL ARTICLE published 23 December 2021 in Journal of Medicinal Chemistry

Research funded by National Natural Science Foundation of China (81874291,82073698,82122065) | Higher Education Discipline Innovation Project (B18035) | West China Hospital of Sichuan University (ZYJC18024) | Sichuan Science and Technology Program (22GJHZ0253)

Authors: You-Cai Xiao | Jun-Lin Yu | Qing-Qing Dai | Gen Li | Guo-Bo Li

https://doi.org/10.1021/acs.jmedchem.1c01691 Actions

Characterization and Solubilization of Pyrrole–Imidazole Polyamide Aggregates

JOURNAL ARTICLE published 14 June 2012 in Journal of Medicinal Chemistry

Authors: Amanda E. Hargrove | Jevgenij A. Raskatov | Jordan L. Meier | David C. Montgomery | Peter B. Dervan

https://doi.org/10.1021/jm300380a Actions

Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors

JOURNAL ARTICLE published 12 June 2014 in Journal of Medicinal Chemistry

Authors: Giovanni Marzaro | Antonio Coluccia | Alessandro Ferrarese | Paola Brun | Ignazio Castagliuolo | Maria Teresa Conconi | Giuseppe La Regina | Ruoli Bai | Romano Silvestri | Ernest Hamel | Adriana Chilin

https://doi.org/10.1021/jm500034j Actions

Synthesis and Pharmacological Evaluation of Fluorescent and Photoactivatable Analogues of Antiplasmodial Naphthylisoquinolines

JOURNAL ARTICLE published 1 November 2007 in Journal of Medicinal Chemistry

Authors: Gerhard Bringmann | Christian M. Gampe | Yanina Reichert | Torsten Bruhn | Johan H. Faber | Martin Mikyna | Matthias Reichert | Matthias Leippe | Reto Brun | Christoph Gelhaus

https://doi.org/10.1021/jm061464w Actions

Molecular Dynamics Simulations of the Bis-Intercalated Complexes of Ditercalinium and Flexi-Di with the Hexanucleotide d(GCGCGC)2:  Theoretical Analysis of the Interaction and Rationale for the Sequence Binding Specificity

JOURNAL ARTICLE published 1 January 1996 in Journal of Medicinal Chemistry

Authors: Beatriz de Pascual-Teresa | José Gallego | Angel R. Ortiz | Federico Gago

https://doi.org/10.1021/jm9604179 Actions

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogs

JOURNAL ARTICLE published April 1991 in Journal of Medicinal Chemistry

Authors: Gregory S. Bisacchi | Abbe Braitman | Christopher W. Cianci | Junius M. Clark | A. Kirk Field | Moira E. Hagen | Deborah R. Hockstein | Mary F. Malley | Toomas Mitt

https://doi.org/10.1021/jm00108a026 Actions

Discovery of Novel PPAR Ligands by a Virtual Screening Approach Based on Pharmacophore Modeling, 3D Shape, and Electrostatic Similarity Screening

JOURNAL ARTICLE published 23 October 2008 in Journal of Medicinal Chemistry

Authors: Patrick Markt | Rasmus K. Petersen | Esben N. Flindt | Karsten Kristiansen | Johannes Kirchmair | Gudrun Spitzer | Simona Distinto | Daniela Schuster | Gerhard Wolber | Christian Laggner | Thierry Langer

https://doi.org/10.1021/jm800128k Actions

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

JOURNAL ARTICLE published 1 June 2008 in Journal of Medicinal Chemistry

Authors: Helena Nordström | Thomas Gossas | Markku Hämäläinen | Per Källblad | Susanne Nyström | Hans Wallberg | U. Helena Danielson

https://doi.org/10.1021/jm8000289 Actions

Emerging Therapies for the Prevention or Treatment of Postmenopausal Osteoporosis

JOURNAL ARTICLE published 1 January 1999 in Journal of Medicinal Chemistry

Authors: Masahiko Sato | Timothy A. Grese | Jeffrey A. Dodge | Henry U. Bryant | Charles H. Turner

https://doi.org/10.1021/jm980344o Actions

Aminoimidazoles as Potent and Selective Human β-Secretase (BACE1) Inhibitors

JOURNAL ARTICLE published 22 October 2009 in Journal of Medicinal Chemistry

Authors: Michael S. Malamas | Jim Erdei | Iwan Gunawan | Keith Barnes | Matthew Johnson | Yu Hui | Jim Turner | Yun Hu | Erik Wagner | Kristi Fan | Andrea Olland | Jonathan Bard | Albert J. Robichaud

https://doi.org/10.1021/jm9006752 Actions

Synthesis, Molecular Modeling Studies, and Pharmacological Activity of Selective A1Receptor Antagonists

JOURNAL ARTICLE published 1 October 2002 in Journal of Medicinal Chemistry

Authors: Francesco Bondavalli | Maurizio Botta | Olga Bruno | Andrea Ciacci | Federico Corelli | Paola Fossa | Antonio Lucacchini | Fabrizio Manetti | Claudia Martini | Giulia Menozzi | Luisa Mosti | Angelo Ranise | Silvia Schenone | Andrea Tafi | Maria Letizia Trincavelli

https://doi.org/10.1021/jm0209580 Actions

Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

JOURNAL ARTICLE published 25 April 2013 in Journal of Medicinal Chemistry

Authors: Kevin W. Hunt | Adam W. Cook | Ryan J. Watts | Christopher T. Clark | Guy Vigers | Darin Smith | Andrew T. Metcalf | Indrani W. Gunawardana | Michael Burkard | April A. Cox | Mary K. Geck Do | Darrin Dutcher | Allen A. Thomas | Sumeet Rana | Nicholas C. Kallan | Robert K. DeLisle | James P. Rizzi | Kelly Regal | Douglas Sammond | Robert Groneberg | Michael Siu | Hans Purkey | Joseph P. Lyssikatos | Allison Marlow | Xingrong Liu | Tony P. Tang

https://doi.org/10.1021/jm4002154 Actions

Synthesis of Cytotoxic 6E-Hydroximino-4-ene Steroids:  Structure/Activity Studies

JOURNAL ARTICLE published 1 August 2001 in Journal of Medicinal Chemistry

Authors: Noé Deive | Jaime Rodríguez | Carlos Jiménez

https://doi.org/10.1021/jm010867n Actions

Design, Synthesis, and Inhibitory Activity of Potent, Photoswitchable Mast Cell Activation Inhibitors

JOURNAL ARTICLE published 13 June 2013 in Journal of Medicinal Chemistry

Authors: Willem A. Velema | Marco van der Toorn | Wiktor Szymanski | Ben L. Feringa

https://doi.org/10.1021/jm400115k Actions

Piperidino Groups in Antitussive Activity

JOURNAL ARTICLE published March 1963 in Journal of Medicinal Chemistry

Authors: Yoshitoshi Kasé | Tomokazu Yuizono | Mieko Muto

https://doi.org/10.1021/jm00338a007 Actions

Design and SAR of Novel Potassium Channel Openers Targeted for Urge Urinary Incontinence. 2. Selective and Potent Benzylamino Cyclobutenediones

JOURNAL ARTICLE published 1 March 2000 in Journal of Medicinal Chemistry

Authors: Adam M. Gilbert | Madelene M. Antane | Thomas M. Argentieri | John A. Butera | Gerardo D. Francisco | Chris Freeden | Eric G. Gundersen | Russell F. Graceffa | David Herbst | Bradford H. Hirth | Joseph R. Lennox | Geraldine McFarlane | N. Wesley Norton | Dominick Quagliato | Jeffrey H. Sheldon | Dawn Warga | Alexandra Wojdan | Morgan Woods

https://doi.org/10.1021/jm9905108 Actions

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues

JOURNAL ARTICLE published 24 September 2015 in Journal of Medicinal Chemistry

Authors: Andrew T. Bockus | Joshua A. Schwochert | Cameron R. Pye | Chad E. Townsend | Vong Sok | Maria A. Bednarek | R. Scott Lokey

https://doi.org/10.1021/acs.jmedchem.5b00919 Actions

First X-ray Cocrystal Structure of a Bacterial FabH Condensing Enzyme and a Small Molecule Inhibitor Achieved Using Rational Design and Homology Modeling

JOURNAL ARTICLE published 1 January 2003 in Journal of Medicinal Chemistry

Authors: Robert A. Daines | Israil Pendrak | Kelvin Sham | Glenn S. Van Aller | Alex K. Konstantinidis | John T. Lonsdale | Cheryl A. Janson | Xiayang Qiu | Martin Brandt | Sanjay S. Khandekar | Carol Silverman | Martha S. Head

https://doi.org/10.1021/jm025571b Actions
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