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Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics:  C2‘ ‘ Ether Analogues of Paromomycin

JOURNAL ARTICLE published 1 May 2007 in Journal of Medicinal Chemistry

Authors: Stephen Hanessian | Janek Szychowski | Susanta Sekhar Adhikari | Guillermo Vasquez | Pachamuthu Kandasamy | Eric E. Swayze | Michael T. Migawa | Ray Ranken | Boris François | Julia Wirmer-Bartoschek | Jiro Kondo | Eric Westhof

https://doi.org/10.1021/jm061200+ Actions

Synthesis and Cytotoxic Evaluation of Combretafurans, Potential Scaffolds for Dual-Action Antitumoral Agents

JOURNAL ARTICLE published 1 August 2006 in Journal of Medicinal Chemistry

Authors: Tracey Pirali | Sara Busacca | Lorena Beltrami | Daniela Imovilli | Francesca Pagliai | Gianluca Miglio | Alberto Massarotti | Luisella Verotta | Gian Cesare Tron | Giovanni Sorba | Armando A. Genazzani

https://doi.org/10.1021/jm060621o Actions

Synthesis and Characterization of a Novel Gadolinium-Based Contrast Agent for Magnetic Resonance Imaging of Myelination

JOURNAL ARTICLE published 28 February 2013 in Journal of Medicinal Chemistry

Authors: Luca Frullano | Junqing Zhu | Robert H. Miller | Yanming Wang

https://doi.org/10.1021/jm301435z Actions

Nitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity

JOURNAL ARTICLE published 22 May 2014 in Journal of Medicinal Chemistry

Research funded by National Institutes of Health (GM049725)

Authors: Soosung Kang | Wei Tang | Huiying Li | Georges Chreifi | Pavel Martásek | Linda J. Roman | Thomas L. Poulos | Richard B. Silverman

https://doi.org/10.1021/jm5004182 Actions

7-Deazaadenines Bearing Polar Substituents:  Structure−Activity Relationships of New A1 and A3 Adenosine Receptor Antagonists

JOURNAL ARTICLE published 1 November 2000 in Journal of Medicinal Chemistry

Authors: Sonja Hess | Christa E. Müller | Wolfram Frobenius | Ulrike Reith | Karl-Norbert Klotz | Kurt Eger

https://doi.org/10.1021/jm000967d Actions

Application of the λ-Dynamics Method To Evaluate the Relative Binding Free Energies of Inhibitors to HCV Protease

JOURNAL ARTICLE published 1 December 2003 in Journal of Medicinal Chemistry

Authors: Zhuyan Guo | James Durkin | Thierry Fischmann | Richard Ingram | Andrew Prongay | Rumin Zhang | Vincent Madison

https://doi.org/10.1021/jm030040o Actions

1-[(ω-Aminoalkyl)amino]-4-[N-(ω-aminoalkyl)carbamoyl]-9-oxo-9,10-dihydro- acridines as Intercalating Cytotoxic Agents:  Synthesis, DNA Binding, and Biological Evaluation

JOURNAL ARTICLE published 1 November 1997 in Journal of Medicinal Chemistry

Authors: Ippolito Antonini | Paolo Polucci | Terence C. Jenkins | Lloyd R. Kelland | Ernesto Menta | Nicoletta Pescalli | Barbara Stefanska | Jan Mazerski | Sante Martelli

https://doi.org/10.1021/jm970114u Actions

Fluorine-Substituted Cyclofenil Derivatives as Estrogen Receptor Ligands:  Synthesis and Structure−Affinity Relationship Study of Potential Positron Emission Tomography Agents for Imaging Estrogen Receptors in Breast Cancer

JOURNAL ARTICLE published 1 April 2006 in Journal of Medicinal Chemistry

Authors: Jai Woong Seo | John S. Comninos | Dae Yoon Chi | Dong Wook Kim | Kathryn E. Carlson | John A. Katzenellenbogen

https://doi.org/10.1021/jm0512037 Actions

Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α

JOURNAL ARTICLE published 1 March 2007 in Journal of Medicinal Chemistry

Authors: Katherine L. Lee | Megan A. Foley | Lihren Chen | Mark L. Behnke | Frank E. Lovering | Steven J. Kirincich | Weiheng Wang | Jaechul Shim | Steve Tam | Marina W. H. Shen | SooPeang Khor | Xin Xu | Debra G. Goodwin | Manjunath K. Ramarao | Cheryl Nickerson-Nutter | Frances Donahue | M. Sherry Ku | James D. Clark | John C. McKew

https://doi.org/10.1021/jm061131z Actions

Synthesis and Antiviral Activity of Novel 5-(1-Cyanamido-2-haloethyl) and 5-(1-Hydroxy(or methoxy)-2-azidoethyl) Analogues of Uracil Nucleosides

JOURNAL ARTICLE published 1 October 2001 in Journal of Medicinal Chemistry

Authors: Rakesh Kumar | Dinesh Rai | Sanjay K. Sharma | Holly A. Saffran | Ryan Blush | D. Lorne J. Tyrrell

https://doi.org/10.1021/jm010226s Actions

Synthesis and Biological Evaluation of Selective Aromatase Expression Regulators in Breast Cancer Cells

JOURNAL ARTICLE published 1 April 2007 in Journal of Medicinal Chemistry

Authors: Bin Su | Serena Landini | Danyetta D. Davis | Robert W. Brueggemeier

https://doi.org/10.1021/jm061133j Actions

Design and Synthesis of New Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase

JOURNAL ARTICLE published 1 December 2000 in Journal of Medicinal Chemistry

Authors: Kazuyuki Ohmoto | Tetsuya Yamamoto | Toshihide Horiuchi | Hirotoshi Imanishi | Yoshihiko Odagaki | Kazuhito Kawabata | Tomohiko Sekioka | Yasushi Hirota | Shozo Matsuoka | Hisao Nakai | Masaaki Toda | John C. Cheronis | Lyle W. Spruce | Albert Gyorkos | Maciej Wieczorek

https://doi.org/10.1021/jm0004087 Actions

Preparation of Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for SPECT Imaging

JOURNAL ARTICLE published 24 October 2013 in Journal of Medicinal Chemistry

Authors: Naoya Harada | Hiroyuki Kimura | Masahiro Ono | Hideo Saji

https://doi.org/10.1021/jm400895s Actions

Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores

JOURNAL ARTICLE published 23 December 2021 in Journal of Medicinal Chemistry

Research funded by National Natural Science Foundation of China (81874291,82073698,82122065) | Higher Education Discipline Innovation Project (B18035) | West China Hospital of Sichuan University (ZYJC18024) | Sichuan Science and Technology Program (22GJHZ0253)

Authors: You-Cai Xiao | Jun-Lin Yu | Qing-Qing Dai | Gen Li | Guo-Bo Li

https://doi.org/10.1021/acs.jmedchem.1c01691 Actions

Characterization and Solubilization of Pyrrole–Imidazole Polyamide Aggregates

JOURNAL ARTICLE published 14 June 2012 in Journal of Medicinal Chemistry

Authors: Amanda E. Hargrove | Jevgenij A. Raskatov | Jordan L. Meier | David C. Montgomery | Peter B. Dervan

https://doi.org/10.1021/jm300380a Actions

Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors

JOURNAL ARTICLE published 12 June 2014 in Journal of Medicinal Chemistry

Authors: Giovanni Marzaro | Antonio Coluccia | Alessandro Ferrarese | Paola Brun | Ignazio Castagliuolo | Maria Teresa Conconi | Giuseppe La Regina | Ruoli Bai | Romano Silvestri | Ernest Hamel | Adriana Chilin

https://doi.org/10.1021/jm500034j Actions

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogs

JOURNAL ARTICLE published April 1991 in Journal of Medicinal Chemistry

Authors: Gregory S. Bisacchi | Abbe Braitman | Christopher W. Cianci | Junius M. Clark | A. Kirk Field | Moira E. Hagen | Deborah R. Hockstein | Mary F. Malley | Toomas Mitt

https://doi.org/10.1021/jm00108a026 Actions

Discovery of Novel PPAR Ligands by a Virtual Screening Approach Based on Pharmacophore Modeling, 3D Shape, and Electrostatic Similarity Screening

JOURNAL ARTICLE published 23 October 2008 in Journal of Medicinal Chemistry

Authors: Patrick Markt | Rasmus K. Petersen | Esben N. Flindt | Karsten Kristiansen | Johannes Kirchmair | Gudrun Spitzer | Simona Distinto | Daniela Schuster | Gerhard Wolber | Christian Laggner | Thierry Langer

https://doi.org/10.1021/jm800128k Actions

Emerging Therapies for the Prevention or Treatment of Postmenopausal Osteoporosis

JOURNAL ARTICLE published 1 January 1999 in Journal of Medicinal Chemistry

Authors: Masahiko Sato | Timothy A. Grese | Jeffrey A. Dodge | Henry U. Bryant | Charles H. Turner

https://doi.org/10.1021/jm980344o Actions

Synthesis, Molecular Modeling Studies, and Pharmacological Activity of Selective A1Receptor Antagonists

JOURNAL ARTICLE published 1 October 2002 in Journal of Medicinal Chemistry

Authors: Francesco Bondavalli | Maurizio Botta | Olga Bruno | Andrea Ciacci | Federico Corelli | Paola Fossa | Antonio Lucacchini | Fabrizio Manetti | Claudia Martini | Giulia Menozzi | Luisa Mosti | Angelo Ranise | Silvia Schenone | Andrea Tafi | Maria Letizia Trincavelli

https://doi.org/10.1021/jm0209580 Actions
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