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Showing results for ISSN matching 0022-2623

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a Series of Anti-HIV-1 Agents of the Dihydro-alkoxy-benzyl-oxopyrimidine Family with Peculiar Structure−Activity Relationship Profile

JOURNAL ARTICLE published 1 August 2008 in Journal of Medicinal Chemistry

Authors: Maxim B. Nawrozkij | Dante Rotili | Domenico Tarantino | Giorgia Botta | Alexandre S. Eremiychuk | Ira Musmuca | Rino Ragno | Alberta Samuele | Samantha Zanoli | Mercedes Armand-Ugón | Imma Clotet-Codina | Ivan A. Novakov | Boris S. Orlinson | Giovanni Maga | José A. Esté | Marino Artico | Antonello Mai

https://doi.org/10.1021/jm800340w Actions

Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold

JOURNAL ARTICLE published 10 December 2015 in Journal of Medicinal Chemistry

Authors: Rafaela Gladysz | Yves Adriaenssens | Hans De Winter | Jurgen Joossens | Anne-Marie Lambeir | Koen Augustyns | Pieter Van der Veken

https://doi.org/10.1021/acs.jmedchem.5b01171 Actions

Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-κB Activation

JOURNAL ARTICLE published 13 June 2013 in Journal of Medicinal Chemistry

Authors: Yu Zhao | Jia Su | Masuo Goto | Susan L. Morris-Natschke | Yan Li | Qin-Shi Zhao | Zhu-Jun Yao | Kuo-Hsiung Lee

https://doi.org/10.1021/jm400479p Actions

Synthesis and Glutathione S-Transferase Structure−Affinity Relationships of Nonpeptide and Peptidase-Stable Glutathione Analogues

JOURNAL ARTICLE published 1 June 1998 in Journal of Medicinal Chemistry

Authors: Philippe Klotz | Amal Slaoui-Hasnaoui | Jean-Louis Banères | Jean-Frédéric Duckert | Jean-Claude Rossi | Abdelali Kerbal

https://doi.org/10.1021/jm970518m Actions

Synthesis and Identification of [1,2,4]Thiadiazole Derivatives as a New Series of Potent and Orally Active Dual Agonists of Peroxisome Proliferator-Activated Receptors α and δ

JOURNAL ARTICLE published 1 August 2007 in Journal of Medicinal Chemistry

Authors: Lan Shen | Yan Zhang | Aihua Wang | Ellen Sieber-McMaster | Xiaoli Chen | Patricia Pelton | Jun Z. Xu | Maria Yang | Peifang Zhu | Lubing Zhou | Michael Reuman | Zhiyong Hu | Ronald Russell | Alan C. Gibbs | Hamish Ross | Keith Demarest | William V. Murray | Gee-Hong Kuo

https://doi.org/10.1021/jm070511x Actions

Synthesis and Protein Kinase C Inhibitory Activities of Balanol Analogs with Replacement of the Perhydroazepine Moiety

JOURNAL ARTICLE published 1 January 1997 in Journal of Medicinal Chemistry

Authors: Yen-Shi Lai | José S. Mendoza | G. Erik Jagdmann | David S. Menaldino | Christopher K. Biggers | Julia M. Heerding | Joseph W. Wilson | Steven E. Hall | Jack B. Jiang | William P. Janzen | Lawrence M. Ballas

https://doi.org/10.1021/jm960497g Actions

Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

JOURNAL ARTICLE published 1 April 2008 in Journal of Medicinal Chemistry

Authors: Leo Alig | Jochem Alsenz | Mirjana Andjelkovic | Stefanie Bendels | Agnès Bénardeau | Konrad Bleicher | Anne Bourson | Pascale David-Pierson | Wolfgang Guba | Stefan Hildbrand | Dagmar Kube | Thomas Lübbers | Alexander V. Mayweg | Robert Narquizian | Werner Neidhart | Matthias Nettekoven | Jean-Marc Plancher | Cynthia Rocha | Mark Rogers-Evans | Stephan Röver | Gisbert Schneider | Sven Taylor | Pius Waldmeier

https://doi.org/10.1021/jm701487t Actions

Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis

JOURNAL ARTICLE published 23 October 2008 in Journal of Medicinal Chemistry

Authors: Jöel Robichaud | W. Cameron Black | Michel Thérien | Julie Paquet | Renata M. Oballa | Christopher I. Bayly | Daniel J. McKay | Qingping Wang | Elise Isabel | Serge Léger | Christophe Mellon | Donald B. Kimmel | Gregg Wesolowski | M. David Percival | Fréderic Massé | Sylvie Desmarais | Jean-Pierre Falgueyret | Sheldon N. Crane

https://doi.org/10.1021/jm800610j Actions

Chemical Behavior and in Vitro Activity of Mixed Phosphine Gold(I) Compounds on Melanoma Cell Lines

JOURNAL ARTICLE published 1 March 2008 in Journal of Medicinal Chemistry

Authors: Francesco Caruso | Claudio Pettinari | Francesco Paduano | Raffaella Villa | Fabio Marchetti | Elena Monti | Miriam Rossi

https://doi.org/10.1021/jm700978a Actions

2013 Philip S. Portoghese Medicinal Chemistry Lectureship: Drug Discovery Targeting Allosteric Sites

JOURNAL ARTICLE published 25 September 2014 in Journal of Medicinal Chemistry

Research funded by National Institutes of Health (U54MH084659) | National Institute of Mental Health (MH082867) | National Institute on Drug Abuse (DA023947)

Authors: Craig W. Lindsley

https://doi.org/10.1021/jm5011786 Actions

Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl- and 8-ethynyladenosine

JOURNAL ARTICLE published January 1995 in Journal of Medicinal Chemistry

Authors: Stefano Manfredini | Pier G. Baraldi | Rita Bazzanini | Mirella Marangoni | Daniele Simoni | Jan Balzarini | Erik De Clercq

https://doi.org/10.1021/jm00001a025 Actions

Synthesis and Antimalarial Activities of Several Fluorinated Artemisinin Derivatives

JOURNAL ARTICLE published September 1995 in Journal of Medicinal Chemistry

Authors: Yu Ming Pu | Daniel S. Torok | Herman Ziffer | Xing-Qing Pan | Steven R. Meshnick

https://doi.org/10.1021/jm00020a028 Actions

General Model for Estimation of the Inhibition of Protein Kinases Using Monte Carlo Simulations

JOURNAL ARTICLE published 1 May 2004 in Journal of Medicinal Chemistry

Authors: Yukio Tominaga | William L. Jorgensen

https://doi.org/10.1021/jm0304358 Actions

Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3.beta.-Hydroxy-.DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase by 6-Azaandrost-4-en-3-ones: Optimization of the C17 Substituent

JOURNAL ARTICLE published July 1995 in Journal of Medicinal Chemistry

Authors: Stephen V. Frye | Curt D. Haffner | Patrick R. Maloney | Roger N. Hiner | George F. Dorsey | Robert A. Noe | Rayomand J. Unwalla | Kenneth W. Batchelor | H. Neal Bramson | J. Darren Stuart | Stephanie L. Schweiker | John Van Arnold | D. Mark Bickett | Marcia L. Moss | Gaochoa Tian | Frank W. Lee | Timothy K. Tippin | Michael K. James | Mary K. Grizzle | James E. Long | Dallas K. Croom

https://doi.org/10.1021/jm00014a015 Actions

Deriving Knowledge through Data Mining High-Throughput Screening Data

JOURNAL ARTICLE published 1 December 2004 in Journal of Medicinal Chemistry

Authors: David J. Diller | Doug W. Hobbs

https://doi.org/10.1021/jm049902r Actions

New Sedative and Hypotensive Phenylpiperazine Esters and Carbamates

JOURNAL ARTICLE published March 1963 in Journal of Medicinal Chemistry

Authors: Shin Hayao | R. N. Schut | W. G. Strycker

https://doi.org/10.1021/jm00338a011 Actions

DNA Sequence-Specific Reading by Echinomycin: Role of Hydrogen Bonding and Stacking Interactions

JOURNAL ARTICLE published May 1994 in Journal of Medicinal Chemistry

Authors: Jose Gallego | F. J. Luque | Modesto Orozco | Carolina Burgos | Julio Alvarez-Builla | M. Melia Rodrigo | Federico Gago

https://doi.org/10.1021/jm00037a010 Actions

Molecular Determinants of Ligand Binding Modes in the Histamine H4 Receptor: Linking Ligand-Based Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) Models to in Silico Guided Receptor Mutagenesis Studies

JOURNAL ARTICLE published 8 December 2011 in Journal of Medicinal Chemistry

Authors: Enade P. Istyastono | Saskia Nijmeijer | Herman D. Lim | Andrea van de Stolpe | Luc Roumen | Albert J. Kooistra | Henry F. Vischer | Iwan J. P. de Esch | Rob Leurs | Chris de Graaf

https://doi.org/10.1021/jm201042n Actions

Crystallographic Investigation of the Inhibition Mode of a VIM-2 Metallo-β-lactamase from Pseudomonas aeruginosa by a Mercaptocarboxylate Inhibitor

JOURNAL ARTICLE published 27 December 2007 in Journal of Medicinal Chemistry

Authors: Yoshihiro Yamaguchi | Wanchun Jin | Kazuyo Matsunaga | Shinnji Ikemizu | Yuriko Yamagata | Jun-ichi Wachino | Naohiro Shibata | Yoshichika Arakawa | Hiromasa Kurosaki

https://doi.org/10.1021/jm701031n Actions

Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs

JOURNAL ARTICLE published June 1993 in Journal of Medicinal Chemistry

Authors: Phenil J. Patel | William S. Messer | Richard A. Hudson

https://doi.org/10.1021/jm00065a012 Actions
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