Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis

JOURNAL ARTICLE published 30 November 2016 in Science Translational Medicine

Research funded by Deutsche Forschungsgemeinschaft (SFB 1123,SFB 914)

Authors: Tobias Petzold | Manuela Thienel | Ildiko Konrad | Irene Schubert | Ron Regenauer | Boj Hoppe | Michael Lorenz | Annekathrin Eckart | Sue Chandraratne | Carsten Lennerz | Christof Kolb | Daniel Braun | Janina Jamasbi | Richard Brandl | Siegmund Braun | Wolfgang Siess | Christian Schulz | Steffen Massberg

Digital Genomic Quantification of Tumor-Infiltrating Lymphocytes

JOURNAL ARTICLE published 4 December 2013 in Science Translational Medicine

Authors: Harlan S. Robins | Nolan G. Ericson | Jamie Guenthoer | Kathy C. O’Briant | Muneesh Tewari | Charles W. Drescher | Jason H. Bielas

Structure-based drug design identifies polythiophenes as antiprion compounds

JOURNAL ARTICLE published 5 August 2015 in Science Translational Medicine

Research funded by European Union Seventh Framework Program (Bio-NMR 261863) | Agence Nationale de la Recherche (ANR-11-BSV-8021-01,ANR-12-BS08-0013-01) | Swiss National Science Foundation (200020_146757,315230_149897)

Authors: Uli S. Herrmann | Anne K. Schütz | Hamid Shirani | Danzhi Huang | Dino Saban | Mario Nuvolone | Bei Li | Boris Ballmer | Andreas K. O. Åslund | Jeffrey J. Mason | Elisabeth Rushing | Herbert Budka | Sofie Nyström | Per Hammarström | Anja Böckmann | Amedeo Caflisch | Beat H. Meier | K. Peter R. Nilsson | Simone Hornemann | Adriano Aguzzi

RNAi Therapies: Drugging the Undruggable

JOURNAL ARTICLE published 11 June 2014 in Science Translational Medicine

Authors: Sherry Y. Wu | Gabriel Lopez-Berestein | George A. Calin | Anil K. Sood

Anti–CTLA-4 therapy broadens the melanoma-reactive CD8 ⁺ T cell response

JOURNAL ARTICLE published 17 September 2014 in Science Translational Medicine

Authors: Pia Kvistborg | Daisy Philips | Sander Kelderman | Lois Hageman | Christian Ottensmeier | Deborah Joseph-Pietras | Marij J. P. Welters | Sjoerd van der Burg | Ellen Kapiteijn | Olivier Michielin | Emanuela Romano | Carsten Linnemann | Daniel Speiser | Christian Blank | John B. Haanen | Ton N. Schumacher

Applying What We Know to Accelerate Cancer Prevention

JOURNAL ARTICLE published 28 March 2012 in Science Translational Medicine

Authors: Graham A. Colditz | Kathleen Y. Wolin | Sarah Gehlert

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

JOURNAL ARTICLE published 23 November 2016 in Science Translational Medicine

Research funded by National Cancer Institute (K08 CA181475) | Damon Runyon Cancer Research Foundation (DRG-2195-14) | NIH (P30 CA008748)

Authors: Jill Bayliss | Piali Mukherjee | Chao Lu | Siddhant U. Jain | Chan Chung | Daniel Martinez | Benjamin Sabari | Ashley S. Margol | Pooja Panwalkar | Abhijit Parolia | Melike Pekmezci | Richard C. McEachin | Marcin Cieslik | Benita Tamrazi | Benjamin A. Garcia | Gaspare La Rocca | Mariarita Santi | Peter W. Lewis | Cynthia Hawkins | Ari Melnick | C. David Allis | Craig B. Thompson | Arul M. Chinnaiyan | Alexander R. Judkins | Sriram Venneti

Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests

JOURNAL ARTICLE published 14 April 2021 in Science Translational Medicine

Research funded by National Science Foundation (U54GM088558) | National Science Foundation (NIH DP5) | National Science Foundation (IIS 1837992)

Authors: Netta Barak | Roni Ben-Ami | Tal Sido | Amir Perri | Aviad Shtoyer | Mila Rivkin | Tamar Licht | Ayelet Peretz | Judith Magenheim | Irit Fogel | Ayalah Livneh | Yutti Daitch | Esther Oiknine-Djian | Gil Benedek | Yuval Dor | Dana G. Wolf | Moran Yassour | A. Klochendler | A. Eden | A. Klar | A. Geldman | A. Arbel | B. Shalom | B. L. Ochana | D. Avrahami-Tzfati | D. Neiman | D. Steinberg | D. Ben Zvi | E. Shpigel | G. Atlan | H. Klein | H. Chekroun | H. Shani | I. Hazan | I. Ansari | I. Magenheim | J. Moss | L. Peretz | L. Feigin | M. Saraby | M. Sherman | M. Bentata | M. Avital | M. Kott | M. Peyser | M. Weitz | M. Shacham | M. Grunewald | N. Sasson | N. Wallis | N. Azazmeh | N. Tzarum | O. Fridlich | R. Sher | R Condiotti | R. Refaeli | R. Zaken-Gallili | R. Helman | S. Ofek | S. Tzaban | S. Piyanzin | S. Anzi | S. Dagan | S. Lilenthal | T. Friehmann | Y. Kaufman | A. Saada | A. Dekel | A. Yeffet | A. Shaag | A. Michael-Gayego | E. Shay | E. Arbib | H. Onallah | K. Ben-Meir | L. Levinzon | L. Cohen-Daniel | L. Natan | M. Hamdan | M. Shwieki | O. Vorontsov | R. Barsuk | R. Abramovitch | R. Gutorov | S. Sirhan | S. Abdeen | Y. Yachnin | H. Golan-Berman | E. Amir | T. Fridman | E. Chabube Kripper | T. Miriam Rohrlich | G. Batshon | L. Mendelovitz | The Hebrew University-Hadassah COVID-19 Diagnosis Team

A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft

JOURNAL ARTICLE published 13 August 2014 in Science Translational Medicine

Authors: Thusitha Gajanayake | Radu Olariu | Franck M. Leclère | Ashish Dhayani | Zijiang Yang | Anjan K. Bongoni | Yara Banz | Mihai A. Constantinescu | Jeffrey M. Karp | Praveen Kumar Vemula | Robert Rieben | Esther Vögelin

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

JOURNAL ARTICLE published 17 February 2021 in Science Translational Medicine

Research funded by National Institutes of Health (RO1 HL136918) | National Institutes of Health (R01 HL063030) | National Institutes of Health (R01 HL137259) | National Institutes of Health (T32 AG058527) | National Institutes of Health (R01 HD086026) | American Heart Association (19CDA34760185) | Magic That Matters Fund (MTMF) | American Heart Association (17GRNT33670405) | Fondation Leducq (16CVD02) | Maryland Stem Cell Research Fund (2015-MSCRFI-1622) | Gilead Foundation (Gilead Research Scholars in Cardiovascular Disease Fund) | Fondation Leducq (16CVD04) | University of Padova Strategico Grant (DYCENDI) | Heart Rhythm Society (Cardiac Pacing and Electrophysiology Fellowship Award)

Authors: Stephen P. Chelko | Gizem Keceli | Andrea Carpi | Nunzianna Doti | Jacopo Agrimi | Angeliki Asimaki | Carlos Bueno Beti | Matthew Miyamoto | Nuria Amat-Codina | Djahida Bedja | An-Chi Wei | Brittney Murray | Crystal Tichnell | Chulan Kwon | Hugh Calkins | Cynthia A. James | Brian O’Rourke | Marc K. Halushka | Edon Melloni | Jeffrey E. Saffitz | Daniel P. Judge | Menotti Ruvo | Richard N. Kitsis | Peter Andersen | Fabio Di Lisa | Nazareno Paolocci

How to know when physicians are ready for genomic medicine

JOURNAL ARTICLE published 13 May 2015 in Science Translational Medicine

Research funded by U. S. National Institutes of Health (KL2-TR001100,L30-DK089597,R01-HG005092,U01-HG006500,U19-HD077671)

Authors: Jason L. Vassy | Bruce R. Korf | Robert C. Green

Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression

JOURNAL ARTICLE published 23 October 2013 in Science Translational Medicine

Authors: Raffit Hassan | Andrew C. Miller | Elad Sharon | Anish Thomas | James C. Reynolds | Alexander Ling | Robert J. Kreitman | Markku M. Miettinen | Seth M. Steinberg | Daniel H. Fowler | Ira Pastan

Efficacy and costs of spinal muscular atrophy drugs

JOURNAL ARTICLE published 11 November 2020 in Science Translational Medicine

Authors: Jonathan J. Darrow | Monica Sharma | Mansa Shroff | Anita K. Wagner

Tumor-derived circulating endothelial cell clusters in colorectal cancer

JOURNAL ARTICLE published 29 June 2016 in Science Translational Medicine

Authors: Igor Cima | Say Li Kong | Debarka Sengupta | Iain B. Tan | Wai Min Phyo | Daniel Lee | Min Hu | Ciprian Iliescu | Irina Alexander | Wei Lin Goh | Mehran Rahmani | Nur-Afidah Mohamed Suhaimi | Jess H. Vo | Joyce A. Tai | Joanna H. Tan | Clarinda Chua | Rachel Ten | Wan Jun Lim | Min Hoe Chew | Charlotte A. E. Hauser | Rob M. van Dam | Wei-Yen Lim | Shyam Prabhakar | Bing Lim | Poh Koon Koh | Paul Robson | Jackie Y. Ying | Axel M. Hillmer | Min-Han Tan

Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity

JOURNAL ARTICLE published 12 March 2014 in Science Translational Medicine

Authors: Christian Jörg Braun | Kaan Boztug | Anna Paruzynski | Maximilian Witzel | Adrian Schwarzer | Michael Rothe | Ute Modlich | Rita Beier | Gudrun Göhring | Doris Steinemann | Raffaele Fronza | Claudia Regina Ball | Reinhard Haemmerle | Sonja Naundorf | Klaus Kühlcke | Martina Rose | Chris Fraser | Liesl Mathias | Rudolf Ferrari | Miguel R. Abboud | Waleed Al-Herz | Irina Kondratenko | László Maródi | Hanno Glimm | Brigitte Schlegelberger | Axel Schambach | Michael Heinrich Albert | Manfred Schmidt | Christof von Kalle | Christoph Klein

Cortical GABAergic excitation contributes to epileptic activities around human glioma

JOURNAL ARTICLE published 9 July 2014 in Science Translational Medicine

Authors: Johan Pallud | Michel Le Van Quyen | Franck Bielle | Christophe Pellegrino | Pascale Varlet | Marianne Labussiere | Noémie Cresto | Marie-Joseph Dieme | Michel Baulac | Charles Duyckaerts | Nazim Kourdougli | Geneviève Chazal | Bertrand Devaux | Claudio Rivera | Richard Miles | Laurent Capelle | Gilles Huberfeld

Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid α-glucosidase

JOURNAL ARTICLE published 29 November 2017 in Science Translational Medicine

Research funded by National Heart, Lung, and Blood Institute (award305222,F32-HL119059) | National Heart, Lung, and Blood Institute (award305223,R01-HL092096) | National Center for Research Resources (award305224,S10-OD01058001-A1)

Authors: Francesco Puzzo | Pasqualina Colella | Maria G. Biferi | Deeksha Bali | Nicole K. Paulk | Patrice Vidal | Fanny Collaud | Marcelo Simon-Sola | Severine Charles | Romain Hardet | Christian Leborgne | Amine Meliani | Mathilde Cohen-Tannoudji | Stephanie Astord | Bernard Gjata | Pauline Sellier | Laetitia van Wittenberghe | Alban Vignaud | Florence Boisgerault | Martine Barkats | Pascal Laforet | Mark A. Kay | Dwight D. Koeberl | Giuseppe Ronzitti | Federico Mingozzi

Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study

JOURNAL ARTICLE published 7 October 2020 in Science Translational Medicine

Authors: Brendan Conlon | Berthold Langguth | Caroline Hamilton | Stephen Hughes | Emma Meade | Ciara O Connor | Martin Schecklmann | Deborah A. Hall | Sven Vanneste | Sook Ling Leong | Thavakumar Subramaniam | Shona D’Arcy | Hubert H. Lim

Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms

JOURNAL ARTICLE published 14 June 2023 in Science Translational Medicine

Authors: Yasuyuki Shima | Shota Sasagawa | Nakao Ota | Rieko Oyama | Minoru Tanaka | Mie Kubota-Sakashita | Hirochika Kawakami | Mika Kobayashi | Naoko Takubo | Atsuko Nakanishi Ozeki | Xiaoning Sun | Yeon-Jeong Kim | Yoichiro Kamatani | Koichi Matsuda | Kazuhiro Maejima | Masashi Fujita | Kosumo Noda | Hiroyasu Kamiyama | Rokuya Tanikawa | Motoo Nagane | Junji Shibahara | Toru Tanaka | Yoshiyuki Rikitake | Nobuko Mataga | Satoru Takahashi | Kenjiro Kosaki | Hideyuki Okano | Tomomi Furihata | Ryo Nakaki | Nobuyoshi Akimitsu | Youichiro Wada | Toshihisa Ohtsuka | Hiroki Kurihara | Hiroyuki Kamiguchi | Shigeo Okabe | Masato Nakafuku | Tadafumi Kato | Hidewaki Nakagawa | Nobuhito Saito | Hirofumi Nakatomi

Erratum for the Review “Insights into dengue immunity from vaccine trials”

JOURNAL ARTICLE published 16 August 2023 in Science Translational Medicine

Authors: E. E. Ooi | S. Kalimuddin