Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer

JOURNAL ARTICLE published 15 November 2023 in Science Translational Medicine

Authors: Zibo Meng | Aaron Rodriguez Ehrenfried | Chin Leng Tan | Laura K. Steffens | Hannes Kehm | Stefan Zens | Claudia Lauenstein | Alina Paul | Marius Schwab | Jonas D. Förster | Mogjiborahman Salek | Angelika B. Riemer | Heshui Wu | Christoph Eckert | Carl-Stephan Leonhardt | Oliver Strobel | Michael Volkmar | Isabel Poschke | Rienk Offringa

Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy

JOURNAL ARTICLE published 24 February 2021 in Science Translational Medicine

Research funded by National Natural Science Foundation of China (81773098) | National Natural Science Foundation of China (8201101247) | Pearl River S and T Nova Program of Guangzhou (201806010036) | Fundamental Research Funds for the Central Universities (19ykpy151) | National Key Research and Development Program of China Stem Cell and Translational Research (2017YFC1308800) | Natural Science Foundation of Guangdong Province (2019A1515010229) | Key Program of Guangzhou Scientific Research Plan (201804020010) | Guangdong Provincial Science and technology plan (2017A020215199) | Guangdong Special Young Talent Plan of Scientific and Technological Innovation (2019TQ05Y510) | Guangdong International Joint Research Program (2020A0505100027)

Authors: Weisi Lu | Yunling Xie | Binjie Huang | Tenghui Ma | Huaiming Wang | Boxiong Deng | Shaomin Zou | Wencong Wang | Qin Tang | Ziqing Yang | Xuri Li | Lei Wang | Lekun Fang

Keratinocytes: From passive targets to active mediators of systemic autoimmunity

JOURNAL ARTICLE published 27 April 2022 in Science Translational Medicine

Authors: Antonios Psarras | Edward M. Vital

Immunotherapy Against HPV16/18 Generates Potent T _H 1 and Cytotoxic Cellular Immune Responses

JOURNAL ARTICLE published 10 October 2012 in Science Translational Medicine

Authors: Mark L. Bagarazzi | Jian Yan | Matthew P. Morrow | Xuefei Shen | R. Lamar Parker | Jessica C. Lee | Mary Giffear | Panyupa Pankhong | Amir S. Khan | Kate E. Broderick | Christine Knott | Feng Lin | Jean D. Boyer | Ruxandra Draghia-Akli | C. Jo White | J. Joseph Kim | David B. Weiner | Niranjan Y. Sardesai

Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity

JOURNAL ARTICLE published 17 July 2019 in Science Translational Medicine

Research funded by NIH Office of the Director (P51 OD011092) | National Institute of Allergy and Infectious Diseases (R01 AI095113) | National Institute of Allergy and Infectious Diseases (P01 AI094417) | National Institute of Allergy and Infectious Diseases (R37 AI054292) | National Institute of Allergy and Infectious Diseases (R01 AI059457) | National Institute of Allergy and Infectious Diseases (U42 OD023038) | Bill and Melinda Gates Foundation (OPP1033121)

Authors: Emily E. Marshall | Daniel Malouli | Scott G. Hansen | Roxanne M. Gilbride | Colette M. Hughes | Abigail B. Ventura | Emily Ainslie | Andrea N. Selseth | Julia C. Ford | David Burke | Craig N. Kreklywich | Jennie Womack | Alfred W. Legasse | Michael K. Axthelm | Christoph Kahl | Daniel Streblow | Paul T. Edlefsen | Louis J. Picker | Klaus Früh

An open-label phase 1 clinical trial of the anti-α ₄ β ₇ monoclonal antibody vedolizumab in HIV-infected individuals

JOURNAL ARTICLE published 11 September 2019 in Science Translational Medicine

Authors: Michael C. Sneller | Katherine E. Clarridge | Catherine Seamon | Victoria Shi | Marek D. Zorawski | Jesse Shawn Justement | Jana Blazkova | Erin D. Huiting | Michael A. Proschan | Jorge Rodrigo Mora | Michael Shetzline | Susan Moir | Henry Clifford Lane | Tae-Wook Chun | Anthony S. Fauci

A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children

JOURNAL ARTICLE published 4 November 2015 in Science Translational Medicine

Research funded by NIAID (HHS 272200900010C)

Authors: Ruth A. Karron | Cindy Luongo | Bhagvanji Thumar | Karen M. Loehr | Janet A. Englund | Peter L. Collins | Ursula J. Buchholz

FcγRIIB expressed on CD8 ⁺ T cells limits responsiveness to PD-1 checkpoint inhibition in cancer

JOURNAL ARTICLE published 23 August 2023 in Science Translational Medicine

Authors: Kelsey B. Bennion | Marvi Tariq | Megan M. Wyatt | Charlotte Duneton | Kirsten M. Baecher | Chrystal M. Paulos | Ragini R. Kudchadkar | Michael C. Lowe | Mandy L. Ford

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease

JOURNAL ARTICLE published 24 December 2014 in Science Translational Medicine

Authors: Xiao-Hong Lu | Virginia B. Mattis | Nan Wang | Ismael Al-Ramahi | Nick van den Berg | Silvina A. Fratantoni | Henry Waldvogel | Erin Greiner | Alex Osmand | Karla Elzein | Jingbo Xiao | Sipke Dijkstra | Remko de Pril | Harry V. Vinters | Richard Faull | Ethan Signer | Seung Kwak | Juan J. Marugan | Juan Botas | David F. Fischer | Clive N. Svendsen | Ignacio Munoz-Sanjuan | X. William Yang

Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

JOURNAL ARTICLE published 3 February 2010 in Science Translational Medicine

Authors: Yoriko Saito | Hiroshi Kitamura | Atsushi Hijikata | Mariko Tomizawa-Murasawa | Satoshi Tanaka | Shinsuke Takagi | Naoyuki Uchida | Nahoko Suzuki | Akiko Sone | Yuho Najima | Hidetoshi Ozawa | Atsushi Wake | Shuichi Taniguchi | Leonard D. Shultz | Osamu Ohara | Fumihiko Ishikawa

Wide-field computational imaging of pathology slides using lens-free on-chip microscopy

JOURNAL ARTICLE published 17 December 2014 in Science Translational Medicine

Authors: Alon Greenbaum | Yibo Zhang | Alborz Feizi | Ping-Luen Chung | Wei Luo | Shivani R. Kandukuri | Aydogan Ozcan

Next-generation RSV vaccines avoid flipping out

JOURNAL ARTICLE published 21 December 2022 in Science Translational Medicine

Authors: Mark E. Peeples

The enhancer landscape predetermines the skeletal regeneration capacity of stromal cells

JOURNAL ARTICLE published 22 March 2023 in Science Translational Medicine

Authors: Sarah Hochmann | Kristy Ou | Rodolphe Poupardin | Michaela Mittermeir | Martin Textor | Salaheddine Ali | Martin Wolf | Agnes Ellinghaus | Dorit Jacobi | Juri A. J. Elmiger | Samantha Donsante | Mara Riminucci | Richard Schäfer | Uwe Kornak | Oliver Klein | Katharina Schallmoser | Katharina Schmidt-Bleek | Georg N. Duda | Julia K. Polansky | Sven Geissler | Dirk Strunk

Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”

JOURNAL ARTICLE published 17 May 2023 in Science Translational Medicine

Authors: Eduardo A. Albornoz | Richard Gordon | Vinod Kumar | Avril A. B. Robertson | Kate Schroder | Trent M. Woodruff

Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease

JOURNAL ARTICLE published 18 June 2014 in Science Translational Medicine

Authors: Shunsuke Minagawa | Jianlong Lou | Robert I. Seed | Anthony Cormier | Shenping Wu | Yifan Cheng | Lynne Murray | Ping Tsui | Jane Connor | Ronald Herbst | Cedric Govaerts | Tyren Barker | Stephanie Cambier | Haruhiko Yanagisawa | Amanda Goodsell | Mitsuo Hashimoto | Oliver J. Brand | Ran Cheng | Royce Ma | Kate J. McKnelly | Weihua Wen | Arthur Hill | David Jablons | Paul Wolters | Hideya Kitamura | Jun Araya | Andrea J. Barczak | David J. Erle | Louis F. Reichardt | James D. Marks | Jody L. Baron | Stephen L. Nishimura

Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections

JOURNAL ARTICLE published 12 August 2015 in Science Translational Medicine

Research funded by Medical Research Council (MR/J014648/1)

Authors: Geraldine Taylor | Michelle Thom | Stefania Capone | Angiolo Pierantoni | Efrain Guzman | Rebecca Herbert | Elisa Scarselli | Federico Napolitano | Alessandro Giuliani | Antonella Folgori | Stefano Colloca | Riccardo Cortese | Alfredo Nicosia | Alessandra Vitelli

MHC Heterozygote Advantage in Simian Immunodeficiency Virus–Infected Mauritian Cynomolgus Macaques

JOURNAL ARTICLE published 10 March 2010 in Science Translational Medicine

Authors: Shelby L. O’Connor | Jennifer J. Lhost | Ericka A. Becker | Ann M. Detmer | Randall C. Johnson | Caitlin E. MacNair | Roger W. Wiseman | Julie A. Karl | Justin M. Greene | Benjamin J. Burwitz | Benjamin N. Bimber | Simon M. Lank | Jennifer J. Tuscher | Edward T. Mee | Nicola J. Rose | Ronald C. Desrosiers | Austin L. Hughes | Thomas C. Friedrich | Mary Carrington | David H. O’Connor

Translating diagnostics and drug delivery technologies to low-resource settings

JOURNAL ARTICLE published 12 October 2022 in Science Translational Medicine

Authors: Erin M. Euliano | Alexandros A. Sklavounos | Aaron R. Wheeler | Kevin J. McHugh

Burned to the Bone

JOURNAL ARTICLE published 24 September 2014 in Science Translational Medicine

Authors: Jonathan A. Forsberg | Thomas A. Davis | Eric A. Elster | Jeffrey M. Gimble

Precision medicine: Beyond the inflection point

JOURNAL ARTICLE published 12 August 2015 in Science Translational Medicine

Authors: Sam Hawgood | India G. Hook-Barnard | Theresa C. O’Brien | Keith R. Yamamoto