Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice

JOURNAL ARTICLE published 24 November 2021 in Science Translational Medicine

Authors: Michaele B. Manigrasso | Piul Rabbani | Lander Egaña-Gorroño | Nosirudeen Quadri | Laura Frye | Boyan Zhou | Sergey Reverdatto | Lisa S. Ramirez | Stephen Dansereau | Jinhong Pan | Huilin Li | Vivette D. D’Agati | Ravichandran Ramasamy | Robert J. DeVita | Alexander Shekhtman | Ann Marie Schmidt

Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair

JOURNAL ARTICLE published 4 November 2015 in Science Translational Medicine

Authors: Firas L. Tarish | Niklas Schultz | Anna Tanoglidi | Hans Hamberg | Henry Letocha | Katalin Karaszi | Freddie C. Hamdy | Torvald Granfors | Thomas Helleday

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

JOURNAL ARTICLE published 20 November 2013 in Science Translational Medicine

Authors: Eloise Hudry | Jonathan Dashkoff | Alysson D. Roe | Shuko Takeda | Robert M. Koffie | Tadafumi Hashimoto | Maria Scheel | Tara Spires-Jones | Michal Arbel-Ornath | Rebecca Betensky | Beverly L. Davidson | Bradley T. Hyman

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

JOURNAL ARTICLE published 29 September 2010 in Science Translational Medicine

Authors: Silvia Buonamici | Juliet Williams | Michael Morrissey | Anlai Wang | Ribo Guo | Anthony Vattay | Kathy Hsiao | Jing Yuan | John Green | Beatriz Ospina | Qunyan Yu | Lance Ostrom | Paul Fordjour | Dustin L. Anderson | John E. Monahan | Joseph F. Kelleher | Stefan Peukert | Shifeng Pan | Xu Wu | Sauveur-Michel Maira | Carlos García-Echeverría | Kimberly J. Briggs | D. Neil Watkins | Yung-mae Yao | Christoph Lengauer | Markus Warmuth | William R. Sellers | Marion Dorsch

Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma

JOURNAL ARTICLE published 18 January 2017 in Science Translational Medicine

Research funded by National Cancer Institute (P50CA114747) | NCI (RO1 CA082214,RO1 CA135486,R01 CA155769,R21 NS081594,R21 CA189223) | Royal Society (107610/Z/15/Z)

Authors: Khun Visith Keu | Timothy H. Witney | Shahriar Yaghoubi | Jarrett Rosenberg | Anita Kurien | Rachel Magnusson | John Williams | Frezghi Habte | Jamie R. Wagner | Stephen Forman | Christine Brown | Martin Allen-Auerbach | Johannes Czernin | Winson Tang | Michael C. Jensen | Behnam Badie | Sanjiv S. Gambhir

A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis

JOURNAL ARTICLE published 5 December 2018 in Science Translational Medicine

Authors: Marcel Maier | Tobias Welt | Fabian Wirth | Fabio Montrasio | Daniel Preisig | Jordan McAfoose | Fernando G. Vieira | Luka Kulic | Claudia Späni | Thilo Stehle | Steve Perrin | Markus Weber | Christoph Hock | Roger M. Nitsch | Jan Grimm

Acute inflammatory response via neutrophil activation protects against the development of chronic pain

JOURNAL ARTICLE published 11 May 2022 in Science Translational Medicine

Authors: Marc Parisien | Lucas V. Lima | Concetta Dagostino | Nehme El-Hachem | Gillian L. Drury | Audrey V. Grant | Jonathan Huising | Vivek Verma | Carolina B. Meloto | Jaqueline R. Silva | Gabrielle G. S. Dutra | Teodora Markova | Hong Dang | Philippe A. Tessier | Gary D. Slade | Andrea G. Nackley | Nader Ghasemlou | Jeffrey S. Mogil | Massimo Allegri | Luda Diatchenko

Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism

JOURNAL ARTICLE published 21 January 2015 in Science Translational Medicine

Research funded by NIH (NIH/NS50220) | National Institute of Mental Health (NIMH) (R01 MH081754-02R) | NIH/National Institute of Neurological Disorders and Stroke (NINDS) (R01 NS049501,R01 NS074312) | NIH Autism Centers of Excellence (ACE) (1P50-HD055784-01) | Network (5R01-MH081754-04)

Authors: Olga Peñagarikano | María T. Lázaro | Xiao-Hong Lu | Aaron Gordon | Hongmei Dong | Hoa A. Lam | Elior Peles | Nigel T. Maidment | Niall P. Murphy | X. William Yang | Peyman Golshani | Daniel H. Geschwind

Temporal Dynamics of the Human Vaginal Microbiota

JOURNAL ARTICLE published 2 May 2012 in Science Translational Medicine

Authors: Pawel Gajer | Rebecca M. Brotman | Guoyun Bai | Joyce Sakamoto | Ursel M. E. Schütte | Xue Zhong | Sara S. K. Koenig | Li Fu | Zhanshan (Sam) Ma | Xia Zhou | Zaid Abdo | Larry J. Forney | Jacques Ravel

The microbiota in pneumonia: From protection to predisposition

JOURNAL ARTICLE published 13 January 2021 in Science Translational Medicine

Research funded by DFG (KE 2379/1-1) | DFG (SFB-TR84 C9) | DFG (SFB-TR84 A1/A5) | German Federal Ministry of Education and Research (FKZ 16GW0247)

Authors: Charlotte Thibeault | Norbert Suttorp | Bastian Opitz

Notch4 Normalization Reduces Blood Vessel Size in Arteriovenous Malformations

JOURNAL ARTICLE published 18 January 2012 in Science Translational Medicine

Authors: Patrick A. Murphy | Tyson N. Kim | Gloria Lu | Andrew W. Bollen | Chris B. Schaffer | Rong A. Wang

A targeted real-time early warning score (TREWScore) for septic shock

JOURNAL ARTICLE published 5 August 2015 in Science Translational Medicine

Research funded by National Science Foundation (ID 1232825) | Google Research (ID 1202463721)

Authors: Katharine E. Henry | David N. Hager | Peter J. Pronovost | Suchi Saria

The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model

JOURNAL ARTICLE published 16 March 2016 in Science Translational Medicine

Research funded by NIH (HHSN272200900010C)

Authors: Beth D. Kirkpatrick | Stephen S. Whitehead | Kristen K. Pierce | Cecilia M. Tibery | Palmtama L. Grier | Noreen A. Hynes | Catherine J. Larsson | Beulah P. Sabundayo | Kawsar R. Talaat | Anna Janiak | Marya P. Carmolli | Catherine J. Luke | Sean A. Diehl | Anna P. Durbin

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice

JOURNAL ARTICLE published 2 August 2017 in Science Translational Medicine

Research funded by Howard Hughes Medical Institute (award299942,None)

Authors: Aslihan Selimbeyoglu | Christina K. Kim | Masatoshi Inoue | Soo Yeun Lee | Alice S. O. Hong | Isaac Kauvar | Charu Ramakrishnan | Lief E. Fenno | Thomas J. Davidson | Matthew Wright | Karl Deisseroth

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

JOURNAL ARTICLE published 7 November 2012 in Science Translational Medicine

Authors: Kevin S. Thorneloe | Mui Cheung | Weike Bao | Hasan Alsaid | Stephen Lenhard | Ming-Yuan Jian | Melissa Costell | Kristeen Maniscalco-Hauk | John A. Krawiec | Alan Olzinski | Earl Gordon | Irina Lozinskaya | Lou Elefante | Pu Qin | Daniel S. Matasic | Chris James | James Tunstead | Brian Donovan | Lorena Kallal | Anna Waszkiewicz | Kalindi Vaidya | Elizabeth A. Davenport | Jonathan Larkin | Mark Burgert | Linda N. Casillas | Robert W. Marquis | Guosen Ye | Hilary S. Eidam | Krista B. Goodman | John R. Toomey | Theresa J. Roethke | Beat M. Jucker | Christine G. Schnackenberg | Mary I. Townsley | John J. Lepore | Robert N. Willette

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53 -deficient cancers to mTOR inhibition

JOURNAL ARTICLE published 18 December 2019 in Science Translational Medicine

Research funded by National Institutes of Health (CA200900)

Authors: Na Kong | Wei Tao | Xiang Ling | Junqing Wang | Yuling Xiao | Sanjun Shi | Xiaoyuan Ji | Aram Shajii | Silvia Tian Gan | Na Yoon Kim | Dan G. Duda | Tian Xie | Omid C. Farokhzad | Jinjun Shi

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

JOURNAL ARTICLE published 21 May 2014 in Science Translational Medicine

Authors: Steven L. Highfill | Yongzhi Cui | Amber J. Giles | Jillian P. Smith | Hua Zhang | Elizabeth Morse | Rosandra N. Kaplan | Crystal L. Mackall

AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T _H 1 response with a diverse TCR repertoire

JOURNAL ARTICLE published 17 November 2021 in Science Translational Medicine

Authors: Phillip A. Swanson | Marcelino Padilla | Wesley Hoyland | Kelly McGlinchey | Paul A. Fields | Sagida Bibi | Saul N. Faust | Adrian B. McDermott | Teresa Lambe | Andrew J. Pollard | Nicholas M. Durham | Elizabeth J. Kelly | AstraZeneca/Oxford/VRC Study Group

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

JOURNAL ARTICLE published 8 February 2012 in Science Translational Medicine

Authors: Ryohei Katayama | Alice T. Shaw | Tahsin M. Khan | Mari Mino-Kenudson | Benjamin J. Solomon | Balazs Halmos | Nicholas A. Jessop | John C. Wain | Alan Tien Yeo | Cyril Benes | Lisa Drew | Jamal Carlos Saeh | Katherine Crosby | Lecia V. Sequist | A. John Iafrate | Jeffrey A. Engelman

Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health

JOURNAL ARTICLE published 24 January 2024 in Science Translational Medicine

Authors: Seyedeh Maryam Zekavat | Saman Doroodgar Jorshery | Franziska G. Rauscher | Katrin Horn | Sayuri Sekimitsu | Satoshi Koyama | Trang T. Nguyen | Maria C. Costanzo | Dongkeun Jang | Noël P. Burtt | Andreas Kühnapfel | Yusrah Shweikh | Yixuan Ye | Vineet Raghu | Hongyu Zhao | Marzyeh Ghassemi | Tobias Elze | Ayellet V. Segrè | Janey L. Wiggs | Lucian Del Priore | Markus Scholz | Jay C. Wang | Pradeep Natarajan | Nazlee Zebardast