Tumor-derived circulating endothelial cell clusters in colorectal cancer

JOURNAL ARTICLE published 29 June 2016 in Science Translational Medicine

Authors: Igor Cima | Say Li Kong | Debarka Sengupta | Iain B. Tan | Wai Min Phyo | Daniel Lee | Min Hu | Ciprian Iliescu | Irina Alexander | Wei Lin Goh | Mehran Rahmani | Nur-Afidah Mohamed Suhaimi | Jess H. Vo | Joyce A. Tai | Joanna H. Tan | Clarinda Chua | Rachel Ten | Wan Jun Lim | Min Hoe Chew | Charlotte A. E. Hauser | Rob M. van Dam | Wei-Yen Lim | Shyam Prabhakar | Bing Lim | Poh Koon Koh | Paul Robson | Jackie Y. Ying | Axel M. Hillmer | Min-Han Tan

Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer

JOURNAL ARTICLE published 16 March 2022 in Science Translational Medicine

Authors: Erik Wennerberg | Sumit Mukherjee | Sheila Spada | Clarey Hung | Christopher J. Agrusa | Chuang Chen | Amanda Valeta-Magara | Nils-Petter Rudqvist | Samantha J. Van Nest | Mohamed K. Kamel | Abu Nasar | Navneet Narula | Vivek Mittal | Geoffrey J. Markowitz | Xi Kathy Zhou | Prasad S. Adusumilli | Alain C. Borczuk | Thomas E. White | Abdul G. Khan | Paul J. Balderes | Ivo C. Lorenz | Nasser Altorki | Sandra Demaria | Timothy E. McGraw | Brendon M. Stiles

The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI

JOURNAL ARTICLE published November 2023 in Science Translational Medicine

Authors: Francesco Trepiccione | Anna Iervolino | Mariavittoria D’Acierno | Sabrina Siccardi | Vincenzo Costanzo | Donato Sardella | Luigi R. De La Motte | Luciano D’Apolito | Antonio Miele | Alessandra F. Perna | Giovanna Capolongo | Miriam Zacchia | Sebastian Frische | Rikke Nielsen | Leopoldo Staiano | Irene Sambri | Rossella De Cegli | Robert Unwin | Dominique Eladari | Giovambattista Capasso

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR -mutant lung cancer

JOURNAL ARTICLE published September 2021 in Science Translational Medicine

Authors: Pınar Özden Eser | Raymond M. Paranal | Jieun Son | Elena Ivanova | Yanan Kuang | Heidi M. Haikala | Ciric To | Jeffrey J. Okoro | Kshiti H. Dholakia | Jihyun Choi | Yoonji Eum | Atsuko Ogino | Pavlos Missios | Dalia Ercan | Man Xu | Michael J. Poitras | Stephen Wang | Kenneth Ngo | Michael Dills | Masahiko Yanagita | Timothy Lopez | Mika Lin | Jeanelle Tsai | Nicolas Floch | Emily S. Chambers | Jennifer Heng | Rana Anjum | Alison D. Santucci | Kesi Michael | Alwin G. Schuller | Darren Cross | Paul D. Smith | Geoffrey R. Oxnard | David A. Barbie | Lynette M. Sholl | Magda Bahcall | Sangeetha Palakurthi | Prafulla C. Gokhale | Cloud P. Paweletz | George Q. Daley | Pasi A. Jänne

Transcriptome-based identification of tumor-reactive and bystander CD8 ⁺ T cell receptor clonotypes in human pancreatic cancer

JOURNAL ARTICLE published 15 November 2023 in Science Translational Medicine

Authors: Zibo Meng | Aaron Rodriguez Ehrenfried | Chin Leng Tan | Laura K. Steffens | Hannes Kehm | Stefan Zens | Claudia Lauenstein | Alina Paul | Marius Schwab | Jonas D. Förster | Mogjiborahman Salek | Angelika B. Riemer | Heshui Wu | Christoph Eckert | Carl-Stephan Leonhardt | Oliver Strobel | Michael Volkmar | Isabel Poschke | Rienk Offringa

Keratinocytes: From passive targets to active mediators of systemic autoimmunity

JOURNAL ARTICLE published 27 April 2022 in Science Translational Medicine

Authors: Antonios Psarras | Edward M. Vital

Next-generation RSV vaccines avoid flipping out

JOURNAL ARTICLE published 21 December 2022 in Science Translational Medicine

Authors: Mark E. Peeples

Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”

JOURNAL ARTICLE published 17 May 2023 in Science Translational Medicine

Authors: Eduardo A. Albornoz | Richard Gordon | Vinod Kumar | Avril A. B. Robertson | Kate Schroder | Trent M. Woodruff

Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease

JOURNAL ARTICLE published 18 June 2014 in Science Translational Medicine

Authors: Shunsuke Minagawa | Jianlong Lou | Robert I. Seed | Anthony Cormier | Shenping Wu | Yifan Cheng | Lynne Murray | Ping Tsui | Jane Connor | Ronald Herbst | Cedric Govaerts | Tyren Barker | Stephanie Cambier | Haruhiko Yanagisawa | Amanda Goodsell | Mitsuo Hashimoto | Oliver J. Brand | Ran Cheng | Royce Ma | Kate J. McKnelly | Weihua Wen | Arthur Hill | David Jablons | Paul Wolters | Hideya Kitamura | Jun Araya | Andrea J. Barczak | David J. Erle | Louis F. Reichardt | James D. Marks | Jody L. Baron | Stephen L. Nishimura

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

JOURNAL ARTICLE published 26 June 2019 in Science Translational Medicine

Research funded by Swiss National Science Foundation (310030_173010) | Swiss National Science Foundation (310030_163085)

Authors: Karin Steinbach | Ilena Vincenti | Kristof Egervari | Mario Kreutzfeldt | Franziska van der Meer | Nicolas Page | Bogna Klimek | Irène Rossitto-Borlat | Giovanni Di Liberto | Andreas Muschaweckh | Ingrid Wagner | Karim Hammad | Christine Stadelmann | Thomas Korn | Oliver Hartley | Daniel D. Pinschewer | Doron Merkler

Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats

JOURNAL ARTICLE published 6 December 2023 in Science Translational Medicine

Authors: Wensen Jiang | Juliane D. Glaeser | Giselle Kaneda | Julia Sheyn | Jacob T. Wechsler | Stephen Stephan | Khosrowdad Salehi | Julie L. Chan | Wafa Tawackoli | Pablo Avalos | Christopher Johnson | Chloe Castaneda | Linda E.A. Kanim | Teerachat Tanasansomboon | Joshua E. Burda | Oksana Shelest | Haneen Yameen | Tiffany G. Perry | Michael Kropf | Jason M. Cuellar | Dror Seliktar | Hyun W. Bae | Laura S. Stone | Dmitriy Sheyn

Elastin-like recombinamers-based hydrogel modulates post-ischemic remodeling in a non-transmural myocardial infarction in sheep

JOURNAL ARTICLE published 17 February 2021 in Science Translational Medicine

Research funded by Science Foundation Ireland (13/RC/2073) | EU (NMP-2014-646075) | EU FP7 (317304) | Ministry of Science of the Spanish Government (PCIN-2015-010, MAT2016-78903-R)

Authors: Paolo Contessotto | Doriana Orbanić | Mark Da Costa | Chunsheng Jin | Peter Owens | Sandrine Chantepie | Clizia Chinello | John Newell | Fulvio Magni | Dulce Papy-Garcia | Niclas G. Karlsson | Michelle Kilcoyne | Peter Dockery | José C. Rodríguez-Cabello | Abhay Pandit

Nociceptive brain activity as a measure of analgesic efficacy in infants

JOURNAL ARTICLE published 3 May 2017 in Science Translational Medicine

Research funded by Wellcome Trust (award283655)

Authors: Caroline Hartley | Eugene P. Duff | Gabrielle Green | Gabriela Schmidt Mellado | Alan Worley | Richard Rogers | Rebeccah Slater

Translating diagnostics and drug delivery technologies to low-resource settings

JOURNAL ARTICLE published 12 October 2022 in Science Translational Medicine

Authors: Erin M. Euliano | Alexandros A. Sklavounos | Aaron R. Wheeler | Kevin J. McHugh

Burned to the Bone

JOURNAL ARTICLE published 24 September 2014 in Science Translational Medicine

Authors: Jonathan A. Forsberg | Thomas A. Davis | Eric A. Elster | Jeffrey M. Gimble

Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates

JOURNAL ARTICLE published 2 May 2018 in Science Translational Medicine

Research funded by National Institutes of Health (R21HD079095) | National Institutes of Health (P51OD011107) | National Institutes of Health (R24OD010962) | Simons Foundation (274472) | Simons Foundation (342873)

Authors: Karen J. Parker | Joseph P. Garner | Ozge Oztan | Erna R. Tarara | Jiang Li | Valentina Sclafani | Laura A. Del Rosso | Katie Chun | Sean W. Berquist | Michael G. Chez | Sonia Partap | Antonio Y. Hardan | Elliott H. Sherr | John P. Capitanio

Preterm Cerebellar Growth Impairment After Postnatal Exposure to Glucocorticoids

JOURNAL ARTICLE published 19 October 2011 in Science Translational Medicine

Authors: Emily W. Y. Tam | Vann Chau | Donna M. Ferriero | A. James Barkovich | Kenneth J. Poskitt | Colin Studholme | Eric D.-Y. Fok | Ruth E. Grunau | David V. Glidden | Steven P. Miller

Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection

JOURNAL ARTICLE published 16 September 2015 in Science Translational Medicine

Research funded by NIH (TW009237,R01 AI077376,R01 AI084787) | National Institute of General Medical Sciences (T32GM081061) | Office of Research Infrastructure Programs (P51 RR000167) | Research Facilities Improvement Program (RR15459-01,RR020141-01) | University of Wisconsin's Medical Scientist Training Program (T32 GM008692) | National Research Service Award (T32 AI55397)

Authors: Adam L. Bailey | Michael Lauck | Mariel Mohns | Eric J. Peterson | Kerry Beheler | Kevin G. Brunner | Kristin Crosno | Andres Mejia | James Mutschler | Matthew Gehrke | Justin Greene | Adam J. Ericsen | Andrea Weiler | Gabrielle Lehrer-Brey | Thomas C. Friedrich | Samuel D. Sibley | Esper G. Kallas | Saverio Capuano | Jeffrey Rogers | Tony L. Goldberg | Heather A. Simmons | David H. O’Connor

Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models

JOURNAL ARTICLE published 8 July 2020 in Science Translational Medicine

Authors: Paolo La Montanara | Arnau Hervera | Lucas L. Baltussen | Thomas H. Hutson | Ilaria Palmisano | Francesco De Virgiliis | Guiping Kong | Jessica Chadwick | Yunan Gao | Katalin Bartus | Qasim A. Majid | Nikos Gorgoraptis | Kingsley Wong | Jenny Downs | Tommaso Pizzorusso | Sila K. Ultanir | Helen Leonard | Hongwei Yu | David S. Millar | Nagy Istvan | Nicholas D. Mazarakis | Simone Di Giovanni

A prefusion-stabilized RSV F subunit vaccine elicits B cell responses with greater breadth and potency than a postfusion F vaccine

JOURNAL ARTICLE published 21 December 2022 in Science Translational Medicine

Authors: Lauren A. Chang | Emily Phung | Michelle C. Crank | Kaitlyn M. Morabito | Tonya Villafana | Filip Dubovsky | Judith Falloon | Mark T. Esser | Bob C. Lin | Grace L. Chen | Barney S. Graham | Tracy J. Ruckwardt