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Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Research funded by National Science Foundation (DBI2030790,IIS1901191) | National Institute of General Medical Sciences (GM136422,S10OD026825) | National Institute of Allergy and Infectious Diseases (AI081062,AI134678)

Authors: Edison Ong | Xiaoqiang Huang | Robin Pearce | Yang Zhang | Yongqun He

D155Y substitution of SARS-CoV-2 ORF3a weakens binding with Caveolin-1

JOURNAL ARTICLE published 2022 in Computational and Structural Biotechnology Journal

Authors: Suchetana Gupta | Ditipriya Mallick | Kumarjeet Banerjee | Shrimon Mukherjee | Soumyadev Sarkar | Sonny TM Lee | Partha Basuchowdhuri | Siddhartha S Jana

Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Research funded by US Department of Defense Prostate Cancer Research Program (W81XWH-18-1-0189) | Department of Science and Technology, Ministry of Science and Technology, India (SB/S2/RJN-049/2018) | National Cancer Institute (1R01CA233585-02)

Authors: Priyanka Chakraborty | Emily L. Chen | Isabelle McMullen | Andrew J. Armstrong | Mohit Kumar Jolly | Jason A. Somarelli

Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: Insights from an agent-based model

JOURNAL ARTICLE published 2020 in Computational and Structural Biotechnology Journal

Research funded by Medical Research Council (MR/N021444/1) | Engineering and Physical Sciences Research Council (EP/R041695/1,EP/S01876X/1) | European Commission (766840)

Authors: Daniel Ward | Sandra Montes Olivas | Alexander Fletcher | Martin Homer | Lucia Marucci

Unraveling membrane properties at the organelle-level with LipidDyn

JOURNAL ARTICLE published 2022 in Computational and Structural Biotechnology Journal

Authors: Simone Scrima | Matteo Tiberti | Alessia Campo | Elisabeth Corcelle-Termeau | Delphine Judith | Mads Møller Foged | Knut Kristoffer Bundgaard Clemmensen | Sharon A. Tooze | Marja Jäättelä | Kenji Maeda | Matteo Lambrughi | Elena Papaleo

MOSGA 2: Comparative genomics and validation tools

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Authors: Roman Martin | Hagen Dreßler | Georges Hattab | Thomas Hackl | Matthias G. Fischer | Dominik Heider

A drug repurposing method based on inhibition effect on gene regulatory network

JOURNAL ARTICLE published 2023 in Computational and Structural Biotechnology Journal

Authors: Xianbin Li | Minzhen Liao | Bing Wang | Xiangzhen Zan | Yanhao Huo | Yue Liu | Zhenshen Bao | Peng Xu | Wenbin Liu

Method development for cross-study microbiome data mining: Challenges and opportunities

JOURNAL ARTICLE published 2020 in Computational and Structural Biotechnology Journal

Authors: Xiaoquan Su | Gongchao Jing | Yufeng Zhang | Shunyao Wu

Mitotic chromosome organization: General rules meet species-specific variability

JOURNAL ARTICLE published 2020 in Computational and Structural Biotechnology Journal

Authors: Tomáš Beseda | Petr Cápal | Ivona Kubalová | Veit Schubert | Jaroslav Doležel | Hana Šimková

Epigenetic modifications: Allusive clues of lncRNA functions in plants

JOURNAL ARTICLE published 2023 in Computational and Structural Biotechnology Journal

Authors: Wenjing Yang | Quanzi Bai | Yan Li | Jianghua Chen | Changning Liu

Recursive Motif Analyses Identify Brain Epigenetic Transcription Regulatory Modules

JOURNAL ARTICLE published 2019 in Computational and Structural Biotechnology Journal

Research funded by NIH (NS094574)

Authors: Sharmi Banerjee | Xiaoran Wei | Hehuang Xie

A computational analysis of transcriptional profiles from CD8(+) T lymphocytes reveals potential mechanisms of HIV/AIDS control and progression

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Authors: Sergey Ivanov | Dmitry Filimonov | Olga Tarasova

COSMO: A dynamic programming algorithm for multicriteria codon optimization

JOURNAL ARTICLE published 2020 in Computational and Structural Biotechnology Journal

Authors: Akito Taneda | Kiyoshi Asai

Advances in the development of therapeutic strategies against COVID-19 and perspectives in the drug design for emerging SARS-CoV-2 variants

JOURNAL ARTICLE published 2022 in Computational and Structural Biotechnology Journal

Authors: Jialing Yin | Chengcheng Li | Chunhong Ye | Zhihui Ruan | Yicong Liang | Yongkui Li | Jianguo Wu | Zhen Luo

Dissecting nucleotide selectivity in viral RNA polymerases

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Authors: Chunhong Long | Moises Ernesto Romero | Daniel La Rocco | Jin Yu

A murine model to study the gut bacteria parameters during complex antibiotics like cefotaxime and ceftriaxone treatment

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Authors: Matthieu Grégoire | Florian Berteau | Ronan Bellouard | Quentin Lebastard | Philippe Aubert | Jacques Gonzales | François Javaudin | Anne Bessard | Pascale Bemer | Éric Batard | Didier Lepelletier | Michel Neunlist | Emmanuel Montassier | Éric Dailly

Maize specialized metabolome networks reveal organ-preferential mixed glycosides

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Authors: Sandrien Desmet | Yvan Saeys | Kevin Verstaen | Rebecca Dauwe | Hoon Kim | Claudiu Niculaes | Atsushi Fukushima | Geert Goeminne | Ruben Vanholme | John Ralph | Wout Boerjan | Kris Morreel

De novo genome assembly of the potent medicinal plant Rehmannia glutinosa using nanopore technology

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Authors: Ligang Ma | Chengming Dong | Chi Song | Xiaolan Wang | Xiaoke Zheng | Yan Niu | Shilin Chen | Weisheng Feng

Assessing comparative importance of DNA sequence and epigenetic modifications on gene expression using a deep convolutional neural network

JOURNAL ARTICLE published 2022 in Computational and Structural Biotechnology Journal

Research funded by National Science Foundation (2134986) | National Institutes of Health (R01-HL149300)

Authors: Shang Gao | Jalees Rehman | Yang Dai

Structure based prediction of a novel GPR120 antagonist based on pharmacophore screening and molecular dynamics simulations

JOURNAL ARTICLE published 2021 in Computational and Structural Biotechnology Journal

Research funded by Delhi Technological University (PB04185)

Authors: Ajay Pal | James F. Curtin | Gemma K. Kinsella