The leukocyte non-coding RNA landscape in critically ill patients with sepsis

JOURNAL ARTICLE published 11 December 2020 in eLife

Research funded by Innovative Medicines Initiative Joint Undertaking (115523) | Innovative Medicines Initiative Joint Undertaking (115620) | Innovative Medicines Initiative Joint Undertaking (115737) | Center for Translational Molecular Medicine (04I-201)

Authors: Brendon P Scicluna | Fabrice Uhel | Lonneke A van Vught | Maryse A Wiewel | Arie J Hoogendijk | Ingelore Baessman | Marek Franitza | Peter Nürnberg | Janneke Horn | Olaf L Cremer | Marc J Bonten | Marcus J Schultz | Tom van der Poll | Molecular Diagnosis and Risk Stratification in Sepsis (MARS) consortium

The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

JOURNAL ARTICLE published 13 December 2021 in eLife

Research funded by Shanghai basic research field Project (18JC1410100) | Shanghai Municipal Science and Technology Major Project (2018SHZDZX05) | The National Key Research and Development Program of China (2020YFA0112700) | Strategic Priority Research Program of Chinese Academy of Science (XDB32000000) | National Natural Science Foundation of China (31871035)

Authors: Hui Zhang | Haifang Wang | Xiaoyu Shen | Xinling Jia | Shuguang Yu | Xiaoying Qiu | Yufan Wang | Jiulin Du | Jun Yan | Jie He

CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions

JOURNAL ARTICLE published 30 July 2021 in eLife

Research funded by National Cancer Institute (CA229560) | National Cancer Institute (CA200572) | National Cancer Institute (P50CA102701)

Authors: Veethika Pandey | Alicia Fleming-Martinez | Ligia Bastea | Heike R Doeppler | Jillian Eisenhauer | Tam Le | Brandy Edenfield | Peter Storz

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

JOURNAL ARTICLE published 17 January 2017 in eLife

Research funded by National Institutes of Health (K08CA193982) | U.S. Department of Defense (W81XWH-14-0414) | St. Baldrick's Foundation (elope, Inc. St. Baldrick's Foundation Scholar Award) | Alex's Lemonade Stand Foundation for Childhood Cancer (Young Investigator Award) | Morgan Adams Foundation (Morgan Adams Research Science Award) | National Institutes of Health (P30CA046934) | Olivia Caldwell Foundation (Low Grade Glioma Grant) | National Institutes of Health (R01CA150925) | National Institutes of Health (RO1CA190170)

Authors: Jean M Mulcahy Levy | Shadi Zahedi | Andrea M Griesinger | Andrew Morin | Kurtis D Davies | Dara L Aisner | BK Kleinschmidt-DeMasters | Brent E Fitzwalter | Megan L Goodall | Jacqueline Thorburn | Vladimir Amani | Andrew M Donson | Diane K Birks | David M Mirsky | Todd C Hankinson | Michael H Handler | Adam L Green | Rajeev Vibhakar | Nicholas K Foreman | Andrew Thorburn

Lead-OR: A multimodal platform for deep brain stimulation surgery

JOURNAL ARTICLE published 20 May 2022 in eLife

Research funded by Deutsche Forschungsgemeinschaft (Emmy Noether Stipend 410169619) | Deutsche Forschungsgemeinschaft (Project ID 424778371) | Bundesministerium für Bildung und Forschung (Project iDBS FKZ01GQ1802) | Deutsches Zentrum für Luft- und Raumfahrt (DynaSti grant within the EU Joint Programme Neurodegenerative Disease Research JPND) | National Institutes of Health (2R01 MH113929)

Authors: Simón Oxenford | Jan Roediger | Clemens Neudorfer | Luka Milosevic | Christopher Güttler | Philipp Spindler | Peter Vajkoczy | Wolf-Julian Neumann | Andrea Kühn | Andreas Horn

The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

JOURNAL ARTICLE published 28 November 2018 in eLife

Research funded by Japan Society for the Promotion of Science (JP15K18516) | Japan Society for the Promotion of Science (16H02617) | Japan Society for the Promotion of Science (25253016) | Core Research for Evolutional Science and Technology (JPMJCR14M3) | Ministry of Education, Culture, Sports, Science and Technology (15H05901)

Authors: Akira Kawanabe | Masaki Hashimoto | Manami Nishizawa | Kazuhisa Nishizawa | Hirotaka Narita | Tomoko Yonezawa | Yuka Jinno | Souhei Sakata | Atsushi Nakagawa | Yasushi Okamura

Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans

JOURNAL ARTICLE published 25 January 2021 in eLife

Research funded by Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research (S) JP17H06113) | Japan Science and Technology Agency (CREST JP17H06113) | Japan Society for the Promotion of Science (Grants-in-Aid for Innovative Area "Artificial Intelligence and Brain Science" 19H04980) | University of Tokyo (Center for Integrative Science of Human Behavior (CiSHuB)) | Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research) | Japan Society for the Promotion of Science (Grants-in-Aid for Innovative Area 18H04881) | Japan Society for the Promotion of Science (Grant-in-Aid for challenging Exploratory Research 18K19323) | Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research 19K06952) | Salt Science Research Foundation (No. 1728 and No. 2043) | Japan Society for the Promotion of Science (Grant-in-Aid for Young Scientists 19K1628)

Authors: Chanhyun Park | Yuki Sakurai | Hirofumi Sato | Shinji Kanda | Yuichi Iino | Hirofumi Kunitomo

The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

JOURNAL ARTICLE published 15 January 2021 in eLife

Research funded by NIH Office of the Director (K08-DK113223) | NIH Office of the Director (R01-DK080063) | NIH Office of the Director (K08-DK107864) | U.S. Department of Veterans Affairs (1I01BX002901) | Indiana Clinical and Translational Sciences Institute (UL1TR002529) | NIH Office of the Director (T32DK120524) | NIH Office of the Director (R01-AI148282) | Indiana Clinical and Translational Sciences Institute (T32HL091816)

Authors: Danielle Janosevic | Jered Myslinski | Thomas W McCarthy | Amy Zollman | Farooq Syed | Xiaoling Xuei | Hongyu Gao | Yun-Long Liu | Kimberly S Collins | Ying-Hua Cheng | Seth Winfree | Tarek M El-Achkar | Bernhard Maier | Ricardo Melo Ferreira | Michael T Eadon | Takashi Hato | Pierre C Dagher

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

JOURNAL ARTICLE published 22 August 2019 in eLife

Research funded by British Heart Foundation (RG/15/13/31673) | British Heart Foundation (FS/13/1/29894) | Deutsche Forschungsgemeinschaft (VO 2134-1/1) | Medical Research Council (Confidence in Concept 2018) | Wellcome (206194) | British Heart Foundation (FS/15/58/31784) | Agence Nationale de la Recherche (ANR-17-CE14-0001-01)

Authors: Timo Vögtle | Sumana Sharma | Jun Mori | Zoltan Nagy | Daniela Semeniak | Cyril Scandola | Mitchell J Geer | Christopher W Smith | Jordan Lane | Scott Pollack | Riitta Lassila | Annukka Jouppila | Alastair J Barr | Derek J Ogg | Tina D Howard | Helen J McMiken | Juli Warwicker | Catherine Geh | Rachel Rowlinson | W Mark Abbott | Anita Eckly | Harald Schulze | Gavin J Wright | Alexandra Mazharian | Klaus Fütterer | Sundaresan Rajesh | Michael R Douglas | Yotis A Senis

Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis

JOURNAL ARTICLE published 25 November 2019 in eLife

Research funded by Lundbeck Foundation (RIBBDD Initiative R302-2018-2266) | Det Frie Forskningsråd (0602-01965B) | Nordea Foundation (Grant to the Center for Healthy Aging 114995)

Authors: Mette Mathiesen Janiurek | Rana Soylu-Kucharz | Christina Christoffersen | Krzysztof Kucharz | Martin Lauritzen

Against cortical reorganisation

JOURNAL ARTICLE published 21 November 2023 in eLife

Research funded by Wellcome Trust (215575/Z/19/Z) | Medical Research Council (MC_UU_00030/10)

Authors: Tamar R Makin | John W Krakauer

Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

JOURNAL ARTICLE published 27 August 2015 in eLife

Research funded by U.S. Department of Defense (DOD) (PR093405) | U.S. Department of Defense (DOD) (W81XWH-14-1-0117) | National Institute on Deafness and Other Communication Disorders (NIDCD) (DC–DC007905)

Authors: Shuang Li | Bopanna I Kalappa | Thanos Tzounopoulos

Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

JOURNAL ARTICLE published 4 March 2022 in eLife

Research funded by Horizon 2020 (ERACoBioTech 722361 (project IRONPLUGNPLAY)) | Agence Nationale de la Recherche (ANR-10-LABX-62-IBEID) | Agence Nationale de la Recherche (ANR-11-LABX-0003–01) | Agence Nationale de la Recherche (ANR-17-EURE-0003)

Authors: Francesca D'Angelo | Elena Fernández-Fueyo | Pierre Simon Garcia | Helena Shomar | Martin Pelosse | Rita Rebelo Manuel | Ferhat Büke | Siyi Liu | Niels van den Broek | Nicolas Duraffourg | Carol de Ram | Martin Pabst | Emmanuelle Bouveret | Simonetta Gribaldo | Béatrice Py | Sandrine Ollagnier de Choudens | Frédéric Barras | Gregory Bokinsky

Temporal profiling of redox-dependent heterogeneity in single cells

JOURNAL ARTICLE published 5 June 2018 in eLife

Research funded by Hebrew University of Jerusalem (Joint Berlin-Jerusalem postdoc fellowship) | Freie Universität Berlin (Joint Berlin-Jerusalem postdoc fellowship) | Israel Science Foundation (1765/13) | Human Frontier Science Program (CDA00064/2014) | United States-Israel Binational Science Foundation (2015056) | Marie Curie Career Integration (618806) | Israel Science Foundation (Legacy Heritage Biomedical Science Partnership, 1649/16)

Authors: Meytal Radzinski | Rosi Fassler | Ohad Yogev | William Breuer | Nadav Shai | Jenia Gutin | Sidra Ilyas | Yifat Geffen | Sabina Tsytkin-Kirschenzweig | Yaakov Nahmias | Tommer Ravid | Nir Friedman | Maya Schuldiner | Dana Reichmann

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

JOURNAL ARTICLE published 11 March 2019 in eLife

Research funded by National Institute of General Medical Sciences (U01GM98256-01) | National Institute of General Medical Sciences (R01GM083960) | National Institute of General Medical Sciences (P41GM109824) | National Institute of General Medical Sciences (R01GM112108) | University of Texas at Dallas (Start-up funds) | National Institute of General Medical Sciences (R01GM069909) | Welch Foundation (I-1532) | Leukemia and Lymphoma Society (Scholar Award) | University of Texas Southwestern Medical Center (Endowed Scholars Program)

Authors: Abhilash Padavannil | Prithwijit Sarkar | Seung Joong Kim | Tolga Cagatay | Jenny Jiou | Chad A Brautigam | Diana R Tomchick | Andrej Sali | Sheena D'Arcy | Yuh Min Chook

Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

JOURNAL ARTICLE published 5 September 2019 in eLife

Research funded by Asia Foundation for Cancer Research (AFCR17SC01) | National Institutes of Health (CA196878) | Research Grants Council, University Grants Committee (AOE-M09-12) | Research Grants Council, University Grants Committee (C6004-17G) | National Institutes of Health (CA217642) | National Institutes of Health (GM51586) | National Institutes of Health (DEO15964)

Authors: Zhijie Lin | Zhou Yang | Ruiling Xie | Zeyang Ji | Kunliang Guan | Mingjie Zhang

Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats

JOURNAL ARTICLE published 26 April 2021 in eLife

Research funded by Agence Nationale de la Recherche (ANR- 2010-BLAN-1404-01) | Fondation pour la Recherche Médicale (FRM DPA20140629788)

Authors: Youna Vandaele | Magalie Lenoir | Caroline Vouillac-Mendoza | Karine Guillem | Serge H Ahmed

Position representations of moving objects align with real-time position in the early visual response

JOURNAL ARTICLE published 19 January 2023 in eLife

Research funded by Australian Research Council (DP180102268) | Australian Research Council (FT200100246)

Authors: Philippa Anne Johnson | Tessel Blom | Simon van Gaal | Daniel Feuerriegel | Stefan Bode | Hinze Hogendoorn

Successor-like representation guides the prediction of future events in human visual cortex and hippocampus

JOURNAL ARTICLE published 2 February 2023 in eLife

Research funded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Veni Grant No. 016.Veni.195.435) | HORIZON EUROPE European Research Council (ERC Consolidator Grant 101000942 "Surprise")

Authors: Matthias Ekman | Sarah Kusch | Floris P de Lange

A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx

JOURNAL ARTICLE published 23 February 2022 in eLife

Research funded by National Natural Science Foundation of China (31870868) | National Natural Science Foundation of China (31970418) | National Natural Science Foundation of China (81373380) | National Natural Science Foundation of China (81802023) | Key Research & Development Plan in Social Development of Jiangsu Province (BE2020652)

Authors: Yang Yang | Jing Wu | Qiao Li | Jing Wang | Lixian Mu | Li Hui | Min Li | Wei Xu | Hailong Yang | Lin Wei