The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

JOURNAL ARTICLE published 8 February 2021 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (R01 NS102586) | National Institute of General Medical Sciences (R01 GM124038) | NIH Office of the Director (DP1 EB016986) | National Institute of Neurological Disorders and Stroke (F32 NS100331) | National Institute of Neurological Disorders and Stroke (F32116105) | Department of Neurobiology, Harvard Medical School (Fix Fund Postdoctoral Fellowship) | Department of Neurobiology, Harvard Medical School (Mahoney Postdoctoral Fellowship)

Authors: Carlos Manlio Díaz-García | Dylan J Meyer | Nidhi Nathwani | Mahia Rahman | Juan Ramón Martínez-François | Gary Yellen

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

JOURNAL ARTICLE published 19 July 2021 in eLife

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK123097) | National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK114857) | American Heart Association (20POST35210465)

Authors: Shintaro Ide | Yoshihiko Kobayashi | Kana Ide | Sarah A Strausser | Koki Abe | Savannah Herbek | Lori L O'Brien | Steven D Crowley | Laura Barisoni | Aleksandra Tata | Purushothama Rao Tata | Tomokazu Souma

Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration

JOURNAL ARTICLE published 23 September 2020 in eLife

Research funded by National Institutes of Health (R01DE027568) | National Institutes of Health (R01HL14058) | National Institutes of Health (R01DE027538) | American Heart Association (18PRE34050063) | National Institutes of Health (K99DE028592)

Authors: Shashank Gandhi | Erica J Hutchins | Krystyna Maruszko | Jong H Park | Matthew Thomson | Marianne E Bronner

Cnidarians are CLOCKing in

JOURNAL ARTICLE published 8 May 2024 in eLife

Authors: Erica R Kwiatkowski | Patrick Emery

A versatile system to record cell-cell interactions

JOURNAL ARTICLE published 7 October 2020 in eLife

Research funded by National Cancer Institute (R01-CA175336) | National Cancer Institute (R01-CA207133) | National Cancer Institute (R01-CA230919) | Tobacco-Related Disease Research Program (27FT-0044) | National Science Foundation (Graduate Research Fellowship Program) | Stanford University (Anne T. and Robert M. Bass Fellowship) | National Institutes of Health (CA196029) | National Cancer Institute (K25-CA201545) | Stanford University School of Medicine (Dean’s Postdoctoral Fellowship)

Authors: Rui Tang | Christopher W Murray | Ian L Linde | Nicholas J Kramer | Zhonglin Lyu | Min K Tsai | Leo C Chen | Hongchen Cai | Aaron D Gitler | Edgar Engleman | Wonjae Lee | Monte M Winslow

A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

JOURNAL ARTICLE published 1 June 2017 in eLife

Authors: Bin Qi | Marina Kniazeva | Min Han

MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

JOURNAL ARTICLE published 14 January 2020 in eLife

Research funded by National Cancer Institute (CA208735) | National Cancer Institute (CA222676) | National Cancer Institute (R01CA166348) | National Cancer Institute (U01CA212007) | National Cancer Institute (U01CA231776) | National Cancer Institute (1R21CA223403) | Fondation pour la Recherche Médicale (FRM grant) | American College of Gastroenterology (ACG Career Development Grant)

Authors: Renumathy Dhanasekaran | Virginie Baylot | Minsoon Kim | Sibu Kuruvilla | David I Bellovin | Nia Adeniji | Anand Rajan KD | Ian Lai | Meital Gabay | Ling Tong | Maya Krishnan | Jangho Park | Theodore Hu | Mustafa A Barbhuiya | Andrew J Gentles | Kasthuri Kannan | Phuoc T Tran | Dean W Felsher

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

JOURNAL ARTICLE published 13 March 2019 in eLife

Research funded by Deutsche Forschungsgemeinschaft (EXC257) | Deutsche Forschungsgemeinschaft (SFB958) | Deutsche Forschungsgemeinschaft (SH650/2-1)

Authors: Nils Rademacher | Benno Kuropka | Stella-Amrei Kunde | Markus C Wahl | Christian Freund | Sarah A Shoichet

Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency

JOURNAL ARTICLE published 25 July 2018 in eLife

Research funded by Agence Nationale de la Recherche (NanoDom) | H2020 European Research Council (nano-dyn-syn)

Authors: Kalina T Haas | Benjamin Compans | Mathieu Letellier | Thomas M Bartol | Dolors Grillo-Bosch | Terrence J Sejnowski | Matthieu Sainlos | Daniel Choquet | Olivier Thoumine | Eric Hosy

Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

JOURNAL ARTICLE published 5 July 2022 in eLife

Research funded by National Institutes of Health (R01AI127219) | National Institutes of Health (R01AI147777) | National Institutes of Health (P01AI131374) | National Institutes of Health (R01DK123733) | National Institutes of Health (R01AG062383) | National Institutes of Health (R01NS117458) | National Institutes of Health (R21AI143385) | National Institutes of Health (UM1AI164559) | National Institutes of Health (UM1AI164567)

Authors: Tongcui Ma | Matthew McGregor | Leila Giron | Guorui Xie | Ashley F George | Mohamed Abdel-Mohsen | Nadia R Roan

The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

JOURNAL ARTICLE published 20 January 2020 in eLife

Research funded by National Science Foundation (1615991) | National Institutes of Health (GM110283) | National Institutes of Health (GM121491) | National Institutes of Health (GM130556) | Israel Science Foundation (ISF 386/18) | United States-Israel Binational Science Foundation (BSF-2015851) | National Institutes of Health (GM052468) | National Institutes of Health (GM124889)

Authors: Tatyana Bodrug | Elizabeth M Wilson-Kubalek | Stanley Nithianantham | Alex F Thompson | April Alfieri | Ignas Gaska | Jennifer Major | Garrett Debs | Sayaka Inagaki | Pedro Gutierrez | Larisa Gheber | Richard J McKenney | Charles Vaughn Sindelar | Ronald Milligan | Jason Stumpff | Steven S Rosenfeld | Scott T Forth | Jawdat Al-Bassam

Consensus designs and thermal stability determinants of a human glutamate transporter

JOURNAL ARTICLE published 18 October 2018 in eLife

Research funded by H2020 Excellent Science (ERC Starting grant 309657) | Centre National de la Recherche Scientifique (UMR 3528) | Agence Nationale de la Recherche (CACSICE grant ANR-11-EQPX-008)

Authors: Erica Cirri | Sébastien Brier | Reda Assal | Juan Carlos Canul-Tec | Julia Chamot-Rooke | Nicolas Reyes

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

JOURNAL ARTICLE published 30 June 2020 in eLife

Research funded by American Heart Association (20POST35210202) | National Institutes of Health (T32 GM088118) | National Institutes of Health (R35GM128777) | Damon Runyon Cancer Research Foundation (DFS‐20‐16) | National Institutes of Health (R00GM112982)

Authors: Ljuvica R Kolich | Ya-Ting Chang | Nicolas Coudray | Sabrina I Giacometti | Mark R MacRae | Georgia L Isom | Evelyn M Teran | Gira Bhabha | Damian C Ekiert

The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1

JOURNAL ARTICLE published 26 November 2018 in eLife

Research funded by Région Grand Est (jeunes chercheurs fellowship) | ATIP-Avenir (CDP 0B1INSB-HS-9ADO1051) | Labex (ANR-10-LABEX-30-HS)

Authors: Piotr Sosnowski | Linas Urnavicius | Andreas Boland | Robert Fagiewicz | Johan Busselez | Gabor Papai | Helgo Schmidt

Modelling dynamics in protein crystal structures by ensemble refinement

JOURNAL ARTICLE published 18 December 2012 in eLife

Research funded by European Research Council (233229) | National Institutes of Health (P01GM063210) | The Netherlands Organization for Scientific Research (NWO) (01.80.104.00) | European Research Council (233229) | National Institutes of Health (P01GM063210) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (01.80.104.00)

Authors: B Tom Burnley | Pavel V Afonine | Paul D Adams | Piet Gros

Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity

JOURNAL ARTICLE published 12 November 2021 in eLife

Research funded by Human Frontier Science Program (RGY0070/2007) | Agence Nationale de la Recherche (ANR 2011 MALZ 003 01) | Fondation pour la Recherche Médicale (FDT20100920106)

Authors: Anastassios Karagiannis | Thierry Gallopin | Alexandre Lacroix | Fabrice Plaisier | Juliette Piquet | Hélène Geoffroy | Régine Hepp | Jérémie Naudé | Benjamin Le Gac | Richard Egger | Bertrand Lambolez | Dongdong Li | Jean Rossier | Jochen F Staiger | Hiromi Imamura | Susumu Seino | Jochen Roeper | Bruno Cauli

Direction-dependent arm kinematics reveal optimal integration of gravity cues

JOURNAL ARTICLE published 2 November 2016 in eLife

Research funded by Agence Nationale de la Recherche (projet MOTION, 14-CE30-007-01) | National Institute of Neurological Disorders and Stroke (R21-NS-075944-02)

Authors: Jeremie Gaveau | Bastien Berret | Dora E Angelaki | Charalambos Papaxanthis

The Na+/K+ pump dominates control of glycolysis in hippocampal dentate granule cells

JOURNAL ARTICLE published 12 October 2022 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (R01 NS102586) | National Institute of General Medical Sciences (R01 GM124038) | National Institute of Neurological Disorders and Stroke (F32 NS116105) | National Institute of Neurological Disorders and Stroke (F32 NS100331) | Harvard Mahoney Neuroscience Institute (Postdoctoral Fellowship)

Authors: Dylan J Meyer | Carlos Manlio Díaz-García | Nidhi Nathwani | Mahia Rahman | Gary Yellen

Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors

JOURNAL ARTICLE published 18 March 2015 in eLife

Research funded by National Medical Research Council (NMRC) (1054/2011) | Duke-NUS Graduate Medical School (Start-up Funding)

Authors: Ayesa Syenina | Cyril J Jagaraj | Siti AB Aman | Aishwarya Sridharan | Ashley L St John

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

JOURNAL ARTICLE published 22 November 2016 in eLife

Research funded by National Institutes of Health (DK097153) | National Institutes of Health (AG047200) | National Institutes of Health (AG047745) | National Institutes of Health (AG023122) | National Institutes of Health (DK089503)

Authors: Siming Ma | Akhil Upneja | Andrzej Galecki | Yi-Miau Tsai | Charles F Burant | Sasha Raskind | Quanwei Zhang | Zhengdong D Zhang | Andrei Seluanov | Vera Gorbunova | Clary B Clish | Richard A Miller | Vadim N Gladyshev