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Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

JOURNAL ARTICLE published 2 September 2020 in eLife

Research funded by National Institute of General Medical Sciences (1R01GM117104)

Authors: Connor J Thompson | Zhaoqian Su | Vinh H Vu | Yinghao Wu | Deborah E Leckband | Daniel K Schwartz

Tackling variants with antibodies

JOURNAL ARTICLE published 28 March 2022 in eLife

Authors: Elizabeth H Aitken | Stephen J Rogerson

The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons

JOURNAL ARTICLE published 10 January 2024 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (R35NS116798) | National Institute on Deafness and Other Communication Disorders (DC004450) | Japan Society for the Promotion of Science (KAKENHI 22K06838)

Authors: Tenzin Ngodup | Tomohiko Irie | Seán P Elkins | Laurence O Trussell

Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

JOURNAL ARTICLE published 11 February 2014 in eLife

Authors: Margaret Stratton | Il-Hyung Lee | Moitrayee Bhattacharyya | Sune M Christensen | Luke H Chao | Howard Schulman | Jay T Groves | John Kuriyan

Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila

JOURNAL ARTICLE published 19 January 2024 in eLife

Research funded by National Institutes of Health (R35 GM150517) | National Institutes of Health (R00 GM127605) | National Institutes of Health (R35 GM119557) | Canadian Institutes of Health Research (PJT-153072)

Authors: Sophie A Fleck | Puja Biswas | Emily D DeWitt | Rebecca L Knuteson | Robert C Eisman | Travis Nemkov | Angelo D'Alessandro | Jason M Tennessen | Elizabeth Rideout | Lesley N Weaver

The aging epigenome

JOURNAL ARTICLE published 28 April 2022 in eLife

Authors: Brandon L Pierce

Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'

JOURNAL ARTICLE published 30 January 2019 in eLife

Authors: David J Goldhamer | John B Lees-Shepard

A matter of timing

JOURNAL ARTICLE published 1 January 2019 in eLife

Authors: Michael W Perry | Claude Desplan

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

JOURNAL ARTICLE published 19 January 2024 in eLife

Research funded by National Institute of Diabetes and Digestive and Kidney Diseases (DK084171) | National Institute of Diabetes and Digestive and Kidney Diseases (DK099134) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR077533)

Authors: Dylan C Sarver | Jean Garcia-Diaz | Muzna Saqib | Ryan C Riddle | G William Wong

Into the fourth dimension

JOURNAL ARTICLE published 4 October 2017 in eLife

Authors: David L Des Marais

Planting molecular functions in an ecological context with Arabidopsis thaliana

JOURNAL ARTICLE published 25 March 2015 in eLife

Research funded by Deutsche Forschungsgemeinschaft (DFG) (SPP1529 ADAPTOMICS, Kr1967/10-2) | Deutsche Forschungsgemeinschaft (DFG) (SPP1529 ADAPTOMICS, Kr1967/12-1)

Authors: Ute Krämer

A gut feeling about arthritis

JOURNAL ARTICLE published 5 November 2013 in eLife

Authors: Diane Mathis

Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

JOURNAL ARTICLE published 18 March 2024 in eLife

Research funded by KU Leuven (C24/17/061) | Marie-Marguerite Delacroix Foundation (Doctoral Fellowship)

Authors: Sergi Llambrich | Birger Tielemans | Ellen Saliën | Marta Atzori | Kaat Wouters | Vicky Van Bulck | Mark Platt | Laure Vanherp | Nuria Gallego Fernandez | Laura Grau de la Fuente | Harish Poptani | Lieve Verlinden | Uwe Himmelreich | Anca Croitor | Catia Attanasio | Zsuzsanna Callaerts-Vegh | Willy Gsell | Neus Martínez-Abadías | Greetje Vande Velde

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

JOURNAL ARTICLE published 18 March 2024 in eLife

Research funded by National Institutes of Health (R35GM139636) | National Cancer Institute (U54AI170792) | Deutsche Forschungsgemeinschaft (GZ: TR 1668/1-1) | National Institutes of Health (1F30CA247147)

Authors: Raphael Trenker | Devan Diwanji | Tanner Bingham | Kliment A Verba | Natalia Jura

Sensitive remote homology search by local alignment of small positional embeddings from protein language models

JOURNAL ARTICLE published 15 March 2024 in eLife

Authors: Sean R Johnson | Meghana Peshwa | Zhiyi Sun

WRNIP1 prevents transcription-associated genomic instability

JOURNAL ARTICLE published 15 March 2024 in eLife

Research funded by Fondazione AIRC per la ricerca sul cancro ETS (Investigator grant 19971) | Fondazione AIRC per la ricerca sul cancro ETS (Investigator grant 17383)

Authors: Pasquale Valenzisi | Veronica Marabitti | Pietro Pichierri | Annapaola Franchitto

Immunomodulatory drug discovery from herbal medicines: Insights from organ-specific activity and xenobiotic defenses

JOURNAL ARTICLE published 15 November 2021 in eLife

Research funded by National Institutes of Health (GM131753)

Authors: Jue Shi | Jui-Hsia Weng | Timothy J Mitchison

Putting perception into action with inverse optimal control for continuous psychophysics

JOURNAL ARTICLE published 10 October 2022 in eLife

Research funded by Hessian Ministry of Higher Education, Science, Research and Art (The Adaptive Mind)

Authors: Dominik Straub | Constantin A Rothkopf

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

JOURNAL ARTICLE published 23 April 2021 in eLife

Research funded by Office of the Dean for Research, Princeton University (Princeton COVID-19 research funds) | Howard Hughes Medical Institute (Investigator lab) | Boston University (Start-up fund) | Boston University (Peter Paul Career Development Professorship) | National Institute of General Medical Sciences (GM095467) | National Heart, Lung, and Blood Institute (HL122531) | National Institute of General Medical Sciences (GM134949) | National Institute of General Medical Sciences (GM124072) | National Institute of General Medical Sciences (GM120351) | Burroughs Wellcome Fund (Award for Investigators in Pathogenesis) | Longer Life Foundation (Longer Life Foundation—RGA/Washington University Collaboration) | Uehara Memorial Foundation (Postdoctoral fellowship award) | Japan Society for the Promotion of Science (Research Fellowships for Young Scientists)

Authors: David W Sanders | Chanelle C Jumper | Paul J Ackerman | Dan Bracha | Anita Donlic | Hahn Kim | Devin Kenney | Ivan Castello-Serrano | Saori Suzuki | Tomokazu Tamura | Alexander H Tavares | Mohsan Saeed | Alex S Holehouse | Alexander Ploss | Ilya Levental | Florian Douam | Robert F Padera | Bruce D Levy | Clifford P Brangwynne

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

JOURNAL ARTICLE published 10 June 2015 in eLife

Research funded by Fonds De La Recherche Scientifique - FNRS (FNRS- F 5/4/5.MCF/KP. Project de secherche (PDR) T.0036.13.) | European Commission (EC) (Projects Naimit and BetaBat, in the Framework Programme 7 of the European Community.) | Fédération Wallonie-Bruxelles (the Communaute Française de Belgique-Actions de Recherche Concertees (ARC).) | Fonds De La Recherche Scientifique - FNRS (FNRS post-doctoral fellowship.) | Governo Brasil (PDE/CSF Pós-Doutorado no Exterior) | Juvenile Diabetes Research Foundation International (JDRF) (JDRF Career Development Award.) | European Commission (EC) (European Union's Seventh Framework Programme [FP7/2007-2013] under grant agreement 261441 PEVNET.)

Authors: Laura Marroqui | Miguel Lopes | Reinaldo S dos Santos | Fabio A Grieco | Merja Roivainen | Sarah J Richardson | Noel G Morgan | Anne Op de beeck | Decio L Eizirik