Trade-off shapes diversity in eco-evolutionary dynamics

JOURNAL ARTICLE published 17 August 2018 in eLife

Authors: Farnoush Farahpour | Mohammadkarim Saeedghalati | Verena S Brauer | Daniel Hoffmann

Recurrent network model for learning goal-directed sequences through reverse replay

JOURNAL ARTICLE published 3 July 2018 in eLife

Research funded by Ministry of Education, Culture, Sports, Science, and Technology (15H04265) | Core Research for Evolutional Science and Technology (JPMJCR13W1) | Ministry of Education, Culture, Sports, Science, and Technology (16H01289) | Ministry of Education, Culture, Sports, Science, and Technology (17H06036)

Authors: Tatsuya Haga | Tomoki Fukai

Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo

JOURNAL ARTICLE published 19 September 2017 in eLife

Research funded by National Institute of General Medical Sciences (GM077349) | National Institute of General Medical Sciences (T32 GM07270) | National Institute of General Medical Sciences (GM023377)

Authors: Matthew L Schwartz | Daniel P Nickerson | Braden T Lobingier | Rachael L Plemel | Mengtong Duan | Cortney G Angers | Michael Zick | Alexey J Merz

Cis-regulatory evolution integrated the Bric-à-brac transcription factors into a novel fruit fly gene regulatory network

JOURNAL ARTICLE published 3 January 2018 in eLife

Research funded by National Science Foundation (IOS-1555906) | National Institutes of Health (5R01GM114093-02)

Authors: Maxwell J Roeske | Eric M Camino | Sumant Grover | Mark Rebeiz | Thomas Michael Williams

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

JOURNAL ARTICLE published 17 November 2017 in eLife

Research funded by National Institutes of Health (AI 18785) | National Institutes of Health (AI 092108) | National Institutes of Health (AI 103736) | National Institutes of Health (DK099317)

Authors: Philippa Marrack | Sai Harsha Krovi | Daniel Silberman | Janice White | Eleanor Kushnir | Maki Nakayama | James Crooks | Thomas Danhorn | Sonia Leach | Randy Anselment | James Scott-Browne | Laurent Gapin | John Kappler

A new genus of horse from Pleistocene North America

JOURNAL ARTICLE published 28 November 2017 in eLife

Research funded by National Science Foundation (PLR-1417036) | National Science Foundation (PLR-09090456) | Danish Council for Independent Research Natural Sciences (4002-00152B) | European Research Council (ERC-CoG-2015-681605) | Gordon and Betty Moore Foundation (GBMF3804) | Norges Forskningsråd (250963)

Authors: Peter D Heintzman | Grant D Zazula | Ross DE MacPhee | Eric Scott | James A Cahill | Brianna K McHorse | Joshua D Kapp | Mathias Stiller | Matthew J Wooller | Ludovic Orlando | John Southon | Duane G Froese | Beth Shapiro

Dyslexics’ faster decay of implicit memory for sounds and words is manifested in their shorter neural adaptation

JOURNAL ARTICLE published 24 January 2017 in eLife

Research funded by Israel Science Foundation (616/11) | German-Israeli Foundation for Scientific Research and Development (I-1303-105.4/2015) | Israel Science Foundation (2425/15)

Authors: Sagi Jaffe-Dax | Or Frenkel | Merav Ahissar

Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

JOURNAL ARTICLE published 2 February 2018 in eLife

Research funded by Fundação para a Ciência e a Tecnologia (PTDC/BIA-BCM/118684/2010) | Fundação para a Ciência e a Tecnologia (SFRH/BPD/79325/2011) | Human Frontier Science Program (RGP0022/2012) | Fundação Bial (283/14) | Fundação Bial (279/16) | European Commission (FLiACT ITN)

Authors: Kathrin Steck | Samuel J Walker | Pavel M Itskov | Célia Baltazar | José-Maria Moreira | Carlos Ribeiro

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

JOURNAL ARTICLE published 7 February 2018 in eLife

Research funded by Horizon 2020 Framework Programme (HEALTH-F4-2007-201413) | National Institutes of Health (U01-DK105535) | Wellcome Trust (099673/Z/12/Z) | National Institutes of Health (R01-DK098032) | Wellcome Trust (106130) | National Institutes of Health (R01-MH090941) | Wellcome Trust (095101/Z/10/Z) | Wellcome Trust (200837/Z/16/Z) | Wellcome Trust (090532) | Wellcome Trust (098381) | National Institutes of Health (U01-DK085545) | Wellcome Trust (090367)

Authors: Matthias Thurner | Martijn van de Bunt | Jason M Torres | Anubha Mahajan | Vibe Nylander | Amanda J Bennett | Kyle J Gaulton | Amy Barrett | Carla Burrows | Christopher G Bell | Robert Lowe | Stephan Beck | Vardhman K Rakyan | Anna L Gloyn | Mark I McCarthy

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

JOURNAL ARTICLE published 25 July 2018 in eLife

Research funded by National Institutes of Health (2U19AI089674) | Bill and Melinda Gates Foundation (OPP1110495)

Authors: Isabel Rodriguez-Barraquer | Emmanuel Arinaitwe | Prasanna Jagannathan | Moses R Kamya | Phillip J Rosenthal | John Rek | Grant Dorsey | Joaniter Nankabirwa | Sarah G Staedke | Maxwell Kilama | Chris Drakeley | Isaac Ssewanyana | David L Smith | Bryan Greenhouse

Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality

JOURNAL ARTICLE published 9 March 2020 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (5R37NS081242) | National Institute of Mental Health (5R01MH083686) | National Institutes of Health (F32NS070514-01A1)

Authors: Amina A Kinkhabwala | Yi Gu | Dmitriy Aronov | David W Tank

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

JOURNAL ARTICLE published 31 March 2016 in eLife

Research funded by National Institute of General Medical Sciences (F32GM112308) | Wellcome Trust (095951) | Gordon and Betty Moore Foundation (GBMF775) | National Institutes of Health (CA164803)

Authors: Ruzbeh Mosadeghi | Kurt M Reichermeier | Martin Winkler | Anne Schreiber | Justin M Reitsma | Yaru Zhang | Florian Stengel | Junyue Cao | Minsoo Kim | Michael J Sweredoski | Sonja Hess | Alexander Leitner | Ruedi Aebersold | Matthias Peter | Raymond J Deshaies | Radoslav I Enchev

GLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems

JOURNAL ARTICLE published 19 August 2015 in eLife

Research funded by National Science Foundation (MCB-115795) | U.S. Department of Energy (DE-SC0008769) | National Science Foundation (MCB-0519898) | National Science Foundation (IOS-0820854) | National Institutes of Health (GM48707) | Consejo Nacional de Ciencia y Tecnología (National Council of Science and Technology, Mexico) (CB-2014-01-238101) | U.S. Department of Energy (DE-AI02-07ER64452)

Authors: Rubén Rellán-Álvarez | Guillaume Lobet | Heike Lindner | Pierre-Luc Pradier | Jose Sebastian | Muh-Ching Yee | Yu Geng | Charlotte Trontin | Therese LaRue | Amanda Schrager-Lavelle | Cara H Haney | Rita Nieu | Julin Maloof | John P Vogel | José R Dinneny

Pupil diameter encodes the idiosyncratic, cognitive complexity of belief updating

JOURNAL ARTICLE published 18 May 2020 in eLife

Research funded by National Science Foundation (NSF-NCS 1533623) | National Institute of Biomedical Imaging and Bioengineering (R01 EB026945) | National Institute of Mental Health (F32 MH117924)

Authors: Alexandre LS Filipowicz | Christopher M Glaze | Joseph W Kable | Joshua I Gold

Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

JOURNAL ARTICLE published 10 February 2017 in eLife

Research funded by National Eye Institute (EY06837) | National Eye Institute (EY001157) | National Natural Science Foundation of China (31471053) | Antonio Champalimaud Foundation, Portugal (Antonio Champalimaud Vision Award) | Howard Hughes Medical Institute (International Student Research Fellowships)

Authors: Wendy Wing Sze Yue | Rikard Frederiksen | Xiaozhi Ren | Dong-Gen Luo | Takahiro Yamashita | Yoshinori Shichida | M Carter Cornwall | King-Wai Yau

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

JOURNAL ARTICLE published 13 November 2020 in eLife

Research funded by National Institute of Neurological Disorders and Stroke (NS094637)

Authors: Markus Terrey | Scott I Adamson | Alana L Gibson | Tianda Deng | Ryuta Ishimura | Jeffrey H Chuang | Susan L Ackerman

Functional visualization of NK cell-mediated killing of metastatic single tumor cells

JOURNAL ARTICLE published 3 February 2022 in eLife

Research funded by Japan Society for the Promotion of Science (18K15317) | Japan Society for the Promotion of Science (15H05949) | Japan Society for the Promotion of Science (19H00993) | Japan Agency for Medical Research and Development (19gm5010003h0003) | Core Research for Evolutional Science and Technology (JPMJCR1654)

Authors: Hiroshi Ichise | Shoko Tsukamoto | Tsuyoshi Hirashima | Yoshinobu Konishi | Choji Oki | Shinya Tsukiji | Satoshi Iwano | Atsushi Miyawaki | Kenta Sumiyama | Kenta Terai | Michiyuki Matsuda

Efficient sampling and noisy decisions

JOURNAL ARTICLE published 15 September 2020 in eLife

Research funded by European Commission (grant agreement No. 758604) | ERC (ENTRAINER)

Authors: Joseph A Heng | Michael Woodford | Rafael Polania

Alternative polyadenylation mediates genetic regulation of gene expression

JOURNAL ARTICLE published 25 June 2020 in eLife

Research funded by National Institutes of Health (T32 GM09197) | National Institutes of Health (F31HL149259) | National Institutes of Health (R01GM130738) | National Institutes of Health (K12 HL119995)

Authors: Briana E Mittleman | Sebastian Pott | Shane Warland | Tony Zeng | Zepeng Mu | Mayher Kaur | Yoav Gilad | Yang Li

Multimeric single-domain antibody complexes protect against bunyavirus infections

JOURNAL ARTICLE published 21 April 2020 in eLife

Research funded by Innovative Medicines Initiative (ZAPI (grant agreement no. 115760)) | Ministerio de Ciencia Tecnología y Telecomunicaciones (Student Fellowship (PEM-066-2015-II)) | Universidad de Costa Rica (Student Fellowship (OAICE-CAB-05-56-2016))

Authors: Paul J Wichgers Schreur | Sandra van de Water | Michiel Harmsen | Erick Bermúdez-Méndez | Dubravka Drabek | Frank Grosveld | Kerstin Wernike | Martin Beer | Andrea Aebischer | Olalekan Daramola | Sara Rodriguez Conde | Karen Brennan | Dorota Kozub | Maiken Søndergaard Kristiansen | Kieran K Mistry | Ziyan Deng | Jan Hellert | Pablo Guardado-Calvo | Félix A Rey | Lucien van Keulen | Jeroen Kortekaas