Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

JOURNAL ARTICLE published 3 October 2018 in eLife

Research funded by National Institute of Allergy and Infectious Diseases (AI030492) | National Institute of General Medical Sciences (GM107629)

Authors: Donghyun Park | Maria Lara-Tejero | M Neal Waxham | Wenwei Li | Bo Hu | Jorge E Galán | Jun Liu

Fully automated, sequential focused ion beam milling for cryo-electron tomography

JOURNAL ARTICLE published 9 March 2020 in eLife

Research funded by Swiss National Science Foundation (#31003A_179255) | European Research Council (#679209)

Authors: Tobias Zachs | Andreas Schertel | João Medeiros | Gregor L Weiss | Jannik Hugener | Joao Matos | Martin Pilhofer

Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

JOURNAL ARTICLE published 13 October 2020 in eLife

Research funded by National Institute for Health Research (AI 132378) | Human Frontier Science Program (RGY0066/2016) | Wellcome Trust (100993/Z/13/Z) | Wellcome Trust (109007/Z/15/A)

Authors: Dihia Moussaoui | James P Robblee | Daniel Auguin | Elena B Krementsova | Silvia Haase | Thomas CA Blake | Jake Baum | Julien Robert-Paganin | Kathleen M Trybus | Anne Houdusse

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

JOURNAL ARTICLE published 1 July 2019 in eLife

Research funded by ARC Centre of Excellence in Advanced Molecular Imaging (CE140100011) | Australian Research Council (FL180100019)

Authors: Sergey Gorelick | Genevieve Buckley | Gediminas Gervinskas | Travis K Johnson | Ava Handley | Monica Pia Caggiano | James C Whisstock | Roger Pocock | Alex de Marco

Structure of the human ATM kinase and mechanism of Nbs1 binding

JOURNAL ARTICLE published 25 January 2022 in eLife

Research funded by National Cancer Institute (5F32CA247320) | National Cancer Institute (CA008748)

Authors: Christopher Warren | Nikola P Pavletich

Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

JOURNAL ARTICLE published 4 November 2021 in eLife

Research funded by National Cancer Institute (T32CA009657) | National Institute of General Medical Sciences (F32GM120962) | National Institute of General Medical Sciences (K99GM134150) | Academia Sinica (AS-CFII-108-119) | National Institute of General Medical Sciences (R01GM055264) | National Institute of General Medical Sciences (R35GM122562) | National Science Foundation (2030277) | National Institute of Diabetes and Digestive and Kidney Diseases (U54DK107979) | National Institute of General Medical Sciences (R01GM111428) | National Institute of General Medical Sciences (R35GM139429)

Authors: Sarah G Swygert | Dejun Lin | Stephanie Portillo-Ledesma | Po-Yen Lin | Dakota R Hunt | Cheng-Fu Kao | Tamar Schlick | William S Noble | Toshio Tsukiyama

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

JOURNAL ARTICLE published 25 November 2020 in eLife

Research funded by National Institutes of Health (R35GM128777) | National Institutes of Health (R00GM112982) | Damon Runyon Cancer Research Foundation (DFS-20-16) | Pew Charitable Trusts (PEW-00033055) | American Heart Association (20POST35210202) | National Institutes of Health (T32 GM088118)

Authors: Nicolas Coudray | Georgia L Isom | Mark R MacRae | Mariyah N Saiduddin | Gira Bhabha | Damian C Ekiert

Prediction of enzymatic pathways by integrative pathway mapping

JOURNAL ARTICLE published 29 January 2018 in eLife

Research funded by National Institutes of Health (U54 GM093342) | National Institute of General Medical Sciences (P41-GM103311)

Authors: Sara Calhoun | Magdalena Korczynska | Daniel J Wichelecki | Brian San Francisco | Suwen Zhao | Dmitry A Rodionov | Matthew W Vetting | Nawar F Al-Obaidi | Henry Lin | Matthew J O'Meara | David A Scott | John H Morris | Daniel Russel | Steven C Almo | Andrei L Osterman | John A Gerlt | Matthew P Jacobson | Brian K Shoichet | Andrej Sali

The structure of plant photosystem I super-complex at 2.8 Å resolution

JOURNAL ARTICLE published 15 June 2015 in eLife

Authors: Yuval Mazor | Anna Borovikova | Nathan Nelson

ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

JOURNAL ARTICLE published 12 March 2018 in eLife

Research funded by National Heart, Lung, and Blood Institute (Intramural Research Program) | National Center for Advancing Translational Sciences (Intramural Research Program)

Authors: Thomas D Baird | Ken Chih-Chien Cheng | Yu-Chi Chen | Eugen Buehler | Scott E Martin | James Inglese | J Robert Hogg

Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation

JOURNAL ARTICLE published 15 October 2020 in eLife

Research funded by National Institutes of Health (DP5-OD023072) | National Science Foundation (IOS-1612268)

Authors: M Regina Scarpin | Samuel Leiboff | Jacob O Brunkard

Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81

JOURNAL ARTICLE published 20 September 2023 in eLife

Research funded by Swiss National Science Foundation (CRSII5_170925) | ERC (788442) | HFSP (LT000588/2019) | DFG (390939984)

Authors: Valentin Chabert | Geun-Don Kim | Danye Qiu | Guizhen Liu | Lydie Michaillat Mayer | Muhammed Jamsheer K | Henning J Jessen | Andreas Mayer

Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure

JOURNAL ARTICLE published 16 September 2019 in eLife

Research funded by Gatsby Charitable Foundation (Group Leader Fellowship) | H2020 European Research Council (Project Award) | Biotechnology and Biological Sciences Research Council (Project Award) | Deutsche Forschungsgemeinschaft (Project Award) | Deutsche Forschungsgemeinschaft (Heisenberg Fellowship)

Authors: Yi Liu | Tobias Maierhofer | Katarzyna Rybak | Jan Sklenar | Andy Breakspear | Matthew G Johnston | Judith Fliegmann | Shouguang Huang | M Rob G Roelfsema | Georg Felix | Christine Faulkner | Frank LH Menke | Dietmar Geiger | Rainer Hedrich | Silke Robatzek

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

JOURNAL ARTICLE published 16 November 2020 in eLife

Research funded by Cancer Research Institute (Clinic and Laboratory Integration Program) | Pew Charitable Trusts (Biomedical Scholars Program) | The Mark Foundation for Cancer Research (Emerging Leader Award) | National Institutes of Health (T32 Training Grant AI007245)

Authors: James B Eaglesham | Kacie L McCarty | Philip J Kranzusch

Spatio-temporal associations between deforestation and malaria incidence in Lao PDR

JOURNAL ARTICLE published 9 March 2021 in eLife

Research funded by Bill and Melinda Gates Foundation (OPP1116450)

Authors: Francois Rerolle | Emily Dantzer | Andrew A Lover | John M Marshall | Bouasy Hongvanthong | Hugh JW Sturrock | Adam Bennett

Biogenesis of phased siRNAs on membrane-bound polysomes in Arabidopsis

JOURNAL ARTICLE published 12 December 2016 in eLife

Research funded by Shenzhen municipality (JCYJ20151116155209176) | Shenzhen municipality (KQCX2015033110464302) | National Natural Science Foundation of China (31210103901) | Gordon and Betty Moore Foundation (GBMF3046) | National Institutes of Health (GM061146) | Guangdong Innovation Research Team Funds (2014ZT05S078) | National Natural Science Foundation of China (91440105)

Authors: Shengben Li | Brandon Le | Xuan Ma | Shaofang Li | Chenjiang You | Yu Yu | Bailong Zhang | Lin Liu | Lei Gao | Ting Shi | Yonghui Zhao | Beixin Mo | Xiaofeng Cao | Xuemei Chen

Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis

JOURNAL ARTICLE published 6 December 2019 in eLife

Research funded by National Science Foundation (MCB1727362) | National Institute of Food and Agriculture (MICL02598) | National Science Foundation (NPGI-1811055) | U.S. Department of Energy (DE-FG02-91ER20021) | U.S. Department of Energy (DE‐SC0018409)

Authors: Pengfei Cao | Sang-Jin Kim | Anqi Xing | Craig A Schenck | Lu Liu | Nan Jiang | Jie Wang | Robert L Last | Federica Brandizzi

Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer

JOURNAL ARTICLE published 13 February 2017 in eLife

Research funded by U.S. Department of Defense (W81XWH-16-1-0270) | National Cancer Institute (R01CA168899) | American Cancer Society (12–038-01-CCE) | National Cancer Institute (R01CA172382) | National Cancer Institute (R01CA190289)

Authors: Jianneng Li | Mohammad Alyamani | Ao Zhang | Kai-Hsiung Chang | Michael Berk | Zhenfei Li | Ziqi Zhu | Marianne Petro | Cristina Magi-Galluzzi | Mary-Ellen Taplin | Jorge A Garcia | Kevin Courtney | Eric A Klein | Nima Sharifi

Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1

JOURNAL ARTICLE published 7 October 2019 in eLife

Research funded by Royal Society (UF090321) | Biotechnology and Biological Sciences Research Council (BB/L006219/1) | H2020 European Research Council (678511)

Authors: Michael J Skelly | James J Furniss | Heather Grey | Ka-Wing Wong | Steven H Spoel

Rapid recycling of glutamate transporters on the astroglial surface

JOURNAL ARTICLE published 16 April 2021 in eLife

Research funded by Wellcome Trust (212251_Z_18_Z) | European Research Council (323113) | European Commission (857562) | National Science Centre Poland (2017/26/D/NZ3/01017)

Authors: Piotr Michaluk | Janosch Peter Heller | Dmitri A Rusakov