Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

JOURNAL ARTICLE published 18 January 2018 in eLife

Research funded by National Institutes of Health (GM122510) | National Institutes of Health (AI048689) | National Institutes of Health (DK064540) | National Institutes of Health (1F31DK107057) | National Institutes of Health (DK101171-02) | Svenska Forskningsrådet Formas (621-2013-5379) | Agence Nationale de la Recherche (ANR-14-CE09-0004) | Paris Pasteur University (Graduate Research Fellowship) | Washington University School of Medicine in St. Louis (Lucille P. Markey Pathway for Pathobiology) | Washington University School of Medicine in St. Louis (Monsanto Excellence Fund Graduate Fellowship)

Authors: Caitlin N Spaulding | Henry Louis Schreiber | Weili Zheng | Karen W Dodson | Jennie E Hazen | Matt S Conover | Fengbin Wang | Pontus Svenmarker | Areli Luna-Rico | Olivera Francetic | Magnus Andersson | Scott Hultgren | Edward H Egelman

HIPK4 is essential for murine spermiogenesis

JOURNAL ARTICLE published 12 March 2020 in eLife

Research funded by American Cancer Society (125153-PF-13-377-01-DMC) | National Institutes of Health (R21 HD78385)

Authors: J Aaron Crapster | Paul G Rack | Zane J Hellmann | Austen D Le | Christopher M Adams | Ryan D Leib | Joshua E Elias | John Perrino | Barry Behr | Yanfeng Li | Jennifer Lin | Hong Zeng | James K Chen

Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

JOURNAL ARTICLE published 28 February 2024 in eLife

Research funded by French Infrastructure for Integrated Structural Biology (ANR-10-INBS-05) | GENCI (A0120713412)

Authors: Ekaterina Smirnova | Emmanuelle Bignon | Patrick Schultz | Gabor Papai | Adam Ben Shem

Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

JOURNAL ARTICLE published 22 March 2022 in eLife

Authors: Mai Ahmed | Yutaka Kojima | Ichiro Masai

Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

JOURNAL ARTICLE published 20 January 2022 in eLife

Research funded by Damon Runyon Cancer Research Foundation (postdoctoral fellowship) | Damon Runyon Cancer Research Foundation (Dale Frey Scientist Award) | Howard Hughes Medical Institute (Investigator) | Welch Foundation (I-1544) | Damon Runyon Cancer Research Foundation (DRG-2249-16) | Damon Runyon Cancer Research Foundation (DFS-38-20)

Authors: Lindsay B Case | Milagros De Pasquale | Lisa Henry | Michael K Rosen

ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate

JOURNAL ARTICLE published 8 June 2017 in eLife

Research funded by Memorial Sloan-Kettering Cancer Center (P30-CA008748)

Authors: Wenfu Ma | Elena Goldberg | Jonathan Goldberg

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

JOURNAL ARTICLE published 25 February 2020 in eLife

Research funded by National Institutes of Health (DA010711) | National Institutes of Health (DA012864) | National Institutes of Health (OD023048) | National Institutes of Health (GM130142) | Swiss National Science Foundation (P300PA_164712) | Swiss National Science Foundation (PCEFP3_181282) | National Institutes of Health (R21DA045884)

Authors: Miriam Stoeber | Damien Jullié | Joy Li | Soumen Chakraborty | Susruta Majumdar | Nevin A Lambert | Aashish Manglik | Mark von Zastrow

Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis

JOURNAL ARTICLE published 9 December 2019 in eLife

Research funded by National Research Foundation of Korea (2015M3C7A1030964) | National Research Foundation of Korea (2017M3C7A1047875) | National Research Foundation of Korea (2017R1A5A1015366) | National Research Foundation of Korea (2017R1A2B2009031) | Ministry of Science, ICT and Future Planning (19-BR-02-01)

Authors: Youngsik Woo | Soo Jeong Kim | Bo Kyoung Suh | Yongdo Kwak | Hyun-Jin Jung | Truong Thi My Nhung | Dong Jin Mun | Ji-Ho Hong | Su-Jin Noh | Seunghyun Kim | Ahryoung Lee | Seung Tae Baek | Minh Dang Nguyen | Youngshik Choe | Sang Ki Park

Decoding the activated stem cell phenotype of the neonatally maturing pituitary

JOURNAL ARTICLE published 14 June 2022 in eLife

Research funded by Fonds Wetenschappelijk Onderzoek (11A3320N) | Fonds Wetenschappelijk Onderzoek (1141717N) | Fonds Wetenschappelijk Onderzoek (1S14218N) | Fonds Wetenschappelijk Onderzoek (11W9215N)

Authors: Emma Laporte | Florian Hermans | Silke De Vriendt | Annelies Vennekens | Diether Lambrechts | Charlotte Nys | Benoit Cox | Hugo Vankelecom

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

JOURNAL ARTICLE published 27 June 2022 in eLife

Research funded by National Health and Medical Research Council (Project grant#1053792) | National Health and Medical Research Council (Project grant#1162052) | Cancer Council Victoria (project grant#1184873) | National Health and Medical Research Council (Fellowship#1058586) | Victorian Cancer Agency (Research Fellowship (MCRF19007)

Authors: Haoran Zhu | Keefe T Chan | Xinran Huang | Carmelo Cerra | Shaun Blake | Anna S Trigos | Dovile Anderson | Darren J Creek | David P De Souza | Xi Wang | Caiyun Fu | Metta Jana | Elaine Sanij | Richard B Pearson | Jian Kang

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

JOURNAL ARTICLE published 2 August 2021 in eLife

Research funded by National Institutes of Health (R01AI157975) | National Institutes of Health (R01AI089728) | National Institutes of Health (R35GM118047)

Authors: Gang Ye | Joseph Gallant | Jian Zheng | Christopher Massey | Ke Shi | Wanbo Tai | Abby Odle | Molly Vickers | Jian Shang | Yushun Wan | Lanying Du | Hideki Aihara | Stanley Perlman | Aaron LeBeau | Fang Li

Automated systematic evaluation of cryo-EM specimens with SmartScope

JOURNAL ARTICLE published 23 August 2022 in eLife

Research funded by National Institute of Environmental Health Sciences (ZIC ES103326) | National Institute of Environmental Health Sciences (ZIA ES103341) | National Institute of Environmental Health Sciences (Z01 ES065078) | Chan Zuckerberg Initiative (2021-234602)

Authors: Jonathan Bouvette | Qinwen Huang | Amanda A Riccio | William C Copeland | Alberto Bartesaghi | Mario J Borgnia

Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis

JOURNAL ARTICLE published 11 May 2023 in eLife

Research funded by National Heart, Lung, and Blood Institute (R35 HL161169) | National Heart, Lung, and Blood Institute (R01 HL146461) | National Heart, Lung, and Blood Institute (R01 HL132156) | National Heart, Lung, and Blood Institute (T32 HL105355)

Authors: Rachel Warren | Handeng Lyu | Kylie Klinkhammer | Stijn P De Langhe

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

JOURNAL ARTICLE published 6 December 2021 in eLife

Research funded by National Institutes of Health (AI154048) | National Institutes of Health (AI118426) | National Institutes of Health (AI083359) | Welch Foundation (I-1704) | National Institutes of Health (AI158124)

Authors: Nicholas Rinkenberger | Michael E Abrams | Sumit K Matta | John W Schoggins | Neal M Alto | L David Sibley

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

JOURNAL ARTICLE published 2 July 2019 in eLife

Research funded by Wellcome Trust (WT210711) | Medical Research Council (MC_UP_A025_1011)

Authors: Samuel E Lacey | Shaoda He | Sjors HW Scheres | Andrew P Carter

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

JOURNAL ARTICLE published 13 March 2019 in eLife

Research funded by Heidelberg Biosciences International Graduate School (Graduate Student Fellowship) | Deutsche Forschungsgemeinschaft (EXC 81) | Deutsche Forschungsgemeinschaft (MA 1764/2-1)

Authors: Rolf M Schmidt | Julia P Schessner | Georg HH Borner | Sebastian Schuck

A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency

JOURNAL ARTICLE published 14 December 2020 in eLife

Research funded by National Institute of General Medical Sciences (R35GM124780) | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK110358) | National Human Genome Research Institute (R01HG009299) | Glenn Foundation for Medical Research (Glenn Award) | National Human Genome Research Institute (T32HG008962) | Might family (Bertrand T Might Fellowship) | National Institute of General Medical Sciences (T32GM007464)

Authors: Dana M Talsness | Katie G Owings | Emily Coelho | Gaelle Mercenne | John M Pleinis | Raghavendran Partha | Kevin A Hope | Aamir R Zuberi | Nathan L Clark | Cathleen M Lutz | Aylin R Rodan | Clement Y Chow

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

JOURNAL ARTICLE published 15 March 2016 in eLife

Authors: Margarita C Dinamarca | Francesca Guzzetti | Anna Karpova | Dmitry Lim | Nico Mitro | Stefano Musardo | Manuela Mellone | Elena Marcello | Jennifer Stanic | Tanmoy Samaddar | Adeline Burguière | Antonio Caldarelli | Armando A Genazzani | Julie Perroy | Laurent Fagni | Pier Luigi Canonico | Michael R Kreutz | Fabrizio Gardoni | Monica Di Luca

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

JOURNAL ARTICLE published 28 March 2017 in eLife

Research funded by National Institutes of Health (R21 CA202540 01) | National Institutes of Health (T32GM007739) | National Institutes of Health (P50-CA172012)

Authors: Viviana Anelli | Jacques A Villefranc | Sagar Chhangawala | Raul Martinez-McFaline | Eleonora Riva | Anvy Nguyen | Akanksha Verma | Rohan Bareja | Zhengming Chen | Theresa Scognamiglio | Olivier Elemento | Yariv Houvras

Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

JOURNAL ARTICLE published 5 September 2019 in eLife

Research funded by Asia Foundation for Cancer Research (AFCR17SC01) | National Institutes of Health (CA196878) | Research Grants Council, University Grants Committee (AOE-M09-12) | Research Grants Council, University Grants Committee (C6004-17G) | National Institutes of Health (CA217642) | National Institutes of Health (GM51586) | National Institutes of Health (DEO15964)

Authors: Zhijie Lin | Zhou Yang | Ruiling Xie | Zeyang Ji | Kunliang Guan | Mingjie Zhang