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Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by National Institute of General Medical Sciences (GM057374,GM113251,GM131693)

Authors: Jeanette R. McConnell | H. Jane Dyson | Shelli R. McAlpine

https://doi.org/10.1039/d0md00387e Actions

The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by Research England (ref.131911)

Authors: Manuela Jörg | Katrina S. Madden

https://doi.org/10.1039/d1md00022e Actions

Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by Carnegie Trust for the Universities of Scotland (Ref-70260) | Biotechnology and Biological Sciences Research Council (BB/N007638/1)

Authors: Daniel P. Brooke | Leah M. C. McGee | Federica Giordani | Jasmine M. Cross | Abedawn I. Khalaf | Craig Irving | Kirsten Gillingwater | Craig D. Shaw | Katharine C. Carter | Michael P. Barrett | Colin J. Suckling | Fraser J. Scott

https://doi.org/10.1039/d1md00110h Actions

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by National Institute of Allergy and Infectious Diseases (R37 AI054193,R01 AI054193) | Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky (0395/2016) | Agentúra na Podporu Výskumu a Vývoja (APVV-15-0515)

Authors: Rui Liu | Lowell Markley | Patricia A. Miller | Scott Franzblau | Gauri Shetye | Rui Ma | Karin Savková | Katarína Mikušová | Bei Shi Lee | Kevin Pethe | Garrett C. Moraski | Marvin J. Miller

https://doi.org/10.1039/d0md00390e Actions

Front cover

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

https://doi.org/10.1039/d0md90016h Actions

Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by H2020 European Research Council (ERC-2012-StG-311460 DrugE3CRLs) | Innovative Medicines Initiative (875510)

Authors: Nikolai Makukhin | Alessio Ciulli

https://doi.org/10.1039/d0md00272k Actions

Contents list

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

https://doi.org/10.1039/d0md90017f Actions

New insights into ethionamide metabolism: influence of oxidized methionine on its degradation path

JOURNAL ARTICLE published 2020 in RSC Medicinal Chemistry

Authors: Nuno Vale | Diana Duarte | Alexandra Correia | Cláudia Alves | Patrícia Figueiredo | Hélder A. Santos

https://doi.org/10.1039/d0md00253d Actions

Synthesis and biological evaluation of N6 derivatives of 8-azapurine as novel antiplatelet agents

JOURNAL ARTICLE published 2021 in RSC Medicinal Chemistry

Research funded by Natural Science Foundation of Beijing Municipality (2192004)

Authors: Zhichang Zhao | Yeming Wang | Nana Tian | Hong Yan | Juan Wang

https://doi.org/10.1039/d1md00128k Actions

The era of high-quality chemical probes

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Research funded by Wellcome Trust (WT212969/Z/18/Z) | Cancer Research UK (C309/A11566,C2739/A22897,C35696/A23187)

Authors: Marco P. Licciardello | Paul Workman

https://doi.org/10.1039/d2md00291d Actions

Recent advances in the discovery of protein tyrosine phosphatase SHP2 inhibitors

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Research funded by National Natural Science Foundation of China (21772214,81761128022) | National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology (2018ZX09711002-006-004)

Authors: Jiao Kong | Ya-Qiu Long

https://doi.org/10.1039/d1md00386k Actions

Synthesis of a fluorinated pyronin that enables blue light to rapidly depolarize mitochondria

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Research funded by National Institutes of Health (2P20 GM103440) | National Cancer Institute (R01-CA211720) | Ohio State University (2P30-CA016058)

Authors: Zhe Gao | Krishna K. Sharma | Angelo E. Andres | Brandon Walls | Fadel Boumelhem | Zachary R. Woydziak | Blake R. Peterson

https://doi.org/10.1039/d1md00395j Actions

Back cover

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

https://doi.org/10.1039/d2md90027k Actions

FLT3 inhibitors for acute myeloid leukemia: successes, defeats, and emerging paradigms

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Research funded by National Institute of General Medical Sciences (P20GM109005)

Authors: Baku Acharya | Debasmita Saha | Daniel Armstrong | Naga Rajiv Lakkaniga | Brendan Frett

https://doi.org/10.1039/d2md00067a Actions

Design, synthesis and immunological evaluation of monophosphoryl lipid A derivatives as adjuvants for a RBD-hFc based SARS-CoV-2 vaccine

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by Guangdong Science and Technology Department (2022B1111020005) | Department of Education of Guangdong Province (2020KQNCX016)

Authors: Shiwei Su | Liqing Chen | Menglan Yang | Dan Liang | Bixia Ke | Zhongqiu Liu | Changwen Ke | Guochao Liao | Liang Liu | Xiang Luo

https://doi.org/10.1039/d2md00298a Actions

Contents list

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

https://doi.org/10.1039/d2md90028a Actions

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators

JOURNAL ARTICLE published 2023 in RSC Medicinal Chemistry

Research funded by National Natural Science Foundation of China (82173677,82204196) | Natural Science Foundation of Shandong Province (ZR2022QH015) | National Institute of Allergy and Infectious Diseases (R01AI150491)

Authors: Xujie Zhang | Lin Sun | Shujing Xu | Tianguang Huang | Fabao Zhao | Dang Ding | Chuanfeng Liu | Xiangyi Jiang | Yucen Tao | Dongwei Kang | Erik De Clercq | Christophe Pannecouque | Simon Cocklin | Alexej Dick | Xinyong Liu | Peng Zhan

https://doi.org/10.1039/d3md00134b Actions

Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Research funded by British Heart Foundation (FS/19/59/34896)

Authors: Samuel J. Turvey | Martin J. McPhillie | Mark T. Kearney | Stephen P. Muench | Katie J. Simmons | Colin W. G. Fishwick

https://doi.org/10.1039/d1md00300c Actions

Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analogues

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

Research funded by Council of Scientific and Industrial Research, India (F.No. 02(392)/21/EMR II) | Birla Institute of Technology and Science, Pilani (201920-NFST-TEL- 01497)

Authors: Yogesh Mahadu Khetmalis | Surendar Chitti | Anjani Umarani Wunnava | Banoth Karan Kumar | Muthyala Murali Krishna Kumar | Sankaranarayanan Murugesan | Kondapalli Venkata Gowri Chandra Sekhar

https://doi.org/10.1039/d1md00367d Actions

Back cover

JOURNAL ARTICLE published 2022 in RSC Medicinal Chemistry

https://doi.org/10.1039/d2md90005j Actions
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