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ACCELERATING THE DEVELOPMENT OF NOVEL ANTIBODY-DRUG CONJUGATES THROUGH SITE-SPECIFIC CONJUGATION METHODS

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Authors: An Ouyang | Spencer Chiang | Chao Wang

3H-3000, AN FGFR2B-SPECIFIC MONOCLONAL ANTIBODY, SHOWS SUPERIOR TUMOR KILLING IN VIVO

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Authors: You Li | Jianwei Zhang | Ruiqin Wang | Xueying Yin | Susan Liu | Jufang Lin | Shaojing Hu | Mingqing Cai

REVOLUTIONIZING ANTIBODY DISCOVERY INDUSTRY WITH HIGHLY EFFICIENT AND ACCURATE AI-BASED EPITOPE-SPECIFIC ANTIBODY DE NOVO DESIGN WORKFLOW

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Authors: Tianyuan Wang | Xiangrui Gao | Zhe Huai | Zhaohui Gong | Ting Mao | Xuezhe Fan | Xingxing Wu | Zhiyuan Duan | Xiaodong Wang | Jiewen Du | Mengcheng Yao | Xin Li | Min Wu | Zonghu Wang | Lin Zhang | Junjie Zhang | Wenbo Cao | Kai Yan | Yujie Fang | Shixiang Ma | Kun Yang | Lili Wu | Frank An | Yi Yang | Lipeng Lai | Xiaolu Huang

CAMEL NANOBODIES NEUTRALIZE SARS-COV-2 VARIANTS

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Authors: Jessica Hong | Hyung Joon Kwon | Raul Cachau | Kevin John Butay | Zhijian Duan | Dan Li | Hua Ren | Chao-Ming Hsieh | Venkata P Dandey | Mario J Borgnia | Hang Xie | Mitchell Ho

GENERATION OF NOVEL ANTIBODY CANDIDATES USING TRANSFORMER AND GAN-BASED DEEP LEARNING ARTIFICIAL INTELLIGENCE

JOURNAL ARTICLE published 24 July 2023 in Antibody Therapeutics

Authors: Hongyu Zhang | Xiaochen Lyu | Qichao Zhao | Bo Liu

Expert’s views and perspectives: an interview with distinguished investigator Dr. Ira Pastan at the National Cancer Institute at NIH

JOURNAL ARTICLE published 25 July 2020 in Antibody Therapeutics

Authors: Peng Lin | Junpeng Qi | Weijing Liu

The 2018 Nobel Prize in Medicine for breakthroughs in targeting immune checkpoint inhibitors: a brief perspective

JOURNAL ARTICLE published 1 January 2019 in Antibody Therapeutics

Research funded by Cancer Prevention and Research Institute of Texas (RP150551) | Welch Foundation (AU-0042-20030616)

Authors: Adan Rios | Georgina To'a Salazar | Ningyan Zhang | Zhiqiang An

Rapid exploration of the epitope coverage produced by an Ebola survivor to guide the discovery of therapeutic antibody cocktails

JOURNAL ARTICLE published 25 July 2020 in Antibody Therapeutics

Authors: Tom Z Yuan | Ana G Lujan Hernandez | Erica Keane | Qiang Liu | Fumiko Axelrod | Shweta Kailasan | Madeleine Noonan-Shueh | Mohammad Javad Aman | Aaron K Sato | Yasmina N Abdiche

SARS-CoV-2 receptor-binding mutations and antibody contact sites

JOURNAL ARTICLE published 19 July 2021 in Antibody Therapeutics

Research funded by Precision Medicine Initiative (PRMF2020-006)

Authors: Marios Mejdani | Kiandokht Haddadi | Chester Pham | Radhakrishnan Mahadevan

Generation of antibody-based therapeutics targeting the idiotype of B-cell malignancies

JOURNAL ARTICLE published 1 January 2019 in Antibody Therapeutics

Research funded by U.S. Department of Defense (W81XWH-12-1-0548)

Authors: Emily Weiss | Robert Sarnovsky | Mitchell Ho | Evgeny Arons | Robert Kreitman | Evan Angelus | Antonella Antignani | David FitzGerald

Development of a T cell-redirecting bispecific antibody targeting B-cell maturation antigen for the suppression of multiple myeloma cell growth

JOURNAL ARTICLE published 13 April 2022 in Antibody Therapeutics

Authors: Jianxin Huo | Yuhan Huang | Ziying Zheng | Xin Ni Tay | Farouq Bin Mahfut | Wei Zhang | Kong-Peng Lam | Yuansheng Yang | Shengli Xu

Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants

JOURNAL ARTICLE published 18 January 2023 in Antibody Therapeutics

Authors: Neil M Bodie | Rina Hashimoto | David Connolly | Jennifer Chu | Kazuo Takayama | Bruce D Uhal

Development of a novel humanized anti-TSLP monoclonal antibody HZ-1127 with anti-allergic diseases and cancer potential

JOURNAL ARTICLE published 28 March 2024 in Antibody Therapeutics

Authors: Xiaolei Liu | Jianzhong Han | Qian Wang | Peng Wang | Li Li | Kehe Du | Fengchao Jiang | Pei Zhang | Hongjun Liu | Jian Huang

Reforming solid tumor treatment: the emerging potential of smaller format antibody-drug conjugate

JOURNAL ARTICLE published 28 March 2024 in Antibody Therapeutics

Research funded by National Key R&D Program of China (2019YFA0904400) | National Natural Science Foundation of China (32270984) | Science and Technology Commission of Shanghai Municipality (23XD1400800) | Shanghai Municipal Health Commission (GWVI-11.2-YQ46)

Authors: Xiaojie Ma | Mingkai Wang | Tianlei Ying | Yanling Wu

Antibody conjugation and formulation

JOURNAL ARTICLE published 1 January 2019 in Antibody Therapeutics

Authors: Nathan J Alves

Insights into CD47/SIRPα axis-targeting tumor immunotherapy

JOURNAL ARTICLE published 17 September 2018 in Antibody Therapeutics

Research funded by National Key Basic Research Program of China (2015CB931800) | National Natural Science Foundation of China (81573332,81773620) | Shanghai Science and Technology Funds (18431902800)

Authors: Xuyao Zhang | Jiajun Fan | Dianwen Ju

Preclinical development of anti-BCMA immunotoxins targeting multiple myeloma

JOURNAL ARTICLE published 31 August 2018 in Antibody Therapeutics

Research funded by Cancer Research Foundation (BC008753)

Authors: Zoe Shancer | Matthew Williams | Austin Igelman | Satoshi Nagata | Tomoko Ise | Ira Pastan | Tapan K Bera

Ceramic hydroxyapatite chromatography plays a critical role in bispecific antibody purification process for impurity removal

JOURNAL ARTICLE published 18 January 2023 in Antibody Therapeutics

Authors: Jessica A Waller | Ji Zheng | Rachel Dyer | Thomas Slaney | Wei Wu | Li Tao | Sanchayita Ghose

Novel development strategies and challenges for anti-Her2 antibody-drug conjugates

JOURNAL ARTICLE published 1 January 2022 in Antibody Therapeutics

Research funded by Open Project of Shandong Collaborative Innovation Center for Antibody Drug (CIC-AD1803) | Chinese Postdoctoral Science Foundation (2020 M672136,2019 M662443)

Authors: Xinling Zhang | Andrew C Huang | Fahai Chen | Hu Chen | Lele Li | Nana Kong | Wenting Luo | Jianmin Fang

In vitro generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2

JOURNAL ARTICLE published 3 October 2023 in Antibody Therapeutics

Research funded by Horizon 2020 (899670) | European Research Council (834631) | EPSRC Future Vaccine Manufacturing and Research Hub (EP/R013764/1) | EPSRC (EP/M022609/1) | MRC (MR/V027506/1,MR/R020566/1,MR/V027506/1) | United States Food and Drug Administration (HHSF223201510104C) | European Research Council (294852) | University of Bristol (BB/L01386X/1) | BBSRC (BB/R000484/1) | Wellcome Trust (221708/Z/20/Z,206181/Z/17/Z,202904/Z/16/Z)

Authors: Dora Buzas | Adrian H Bunzel | Oskar Staufer | Emily J Milodowski | Grace L Edmunds | Joshua C Bufton | Beatriz V Vidana Mateo | Sathish K N Yadav | Kapil Gupta | Charlotte Fletcher | Maia K Williamson | Alexandra Harrison | Ufuk Borucu | Julien Capin | Ore Francis | Georgia Balchin | Sophie Hall | Mirella V Vega | Fabien Durbesson | Srikanth Lingappa | Renaud Vincentelli | Joe Roe | Linda Wooldridge | Rachel Burt | Ross J L Anderson | Adrian J Mulholland | Jonathan Hare | Mick Bailey | Andrew D Davidson | Adam Finn | David Morgan | Jamie Mann | Joachim Spatz | Frederic Garzoni | Christiane Schaffitzel | Imre Berger