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Metabolic Studies with Deuterated Phenobarbital

JOURNAL ARTICLE published May 1967 in Journal of Medicinal Chemistry

Authors: James M. Perel | Peter G. Dayton | Carol L. Tauriello | Leonard. Brand | Lester C. Mark

https://doi.org/10.1021/jm00315a019 Actions

Aminobenzoic acid diuretics. 5. 3-Amino-4-arylmethyl-5-sulfamylbenzoic acid derivatives and related compounds

JOURNAL ARTICLE published October 1973 in Journal of Medicinal Chemistry

Authors: Ole B. Tvaermose Nielsen | Christian Kaergaard Nielsen | Peter W. Feit

https://doi.org/10.1021/jm00268a022 Actions

Expeditious Syntheses of Sugar-Modified Nucleosides and Collections Thereof Exploiting Furan-, Pyrrole-, and Thiophene-Based Siloxy Dienes

JOURNAL ARTICLE published 1 January 1997 in Journal of Medicinal Chemistry

Authors: Gloria Rassu | Franca Zanardi | Lucia Battistini | Enrico Gaetani | Giovanni Casiraghi

https://doi.org/10.1021/jm960400q Actions

R2 C-terminal peptide inhibition of mammalian and yeast ribonucleotide reductase

JOURNAL ARTICLE published November 1993 in Journal of Medicinal Chemistry

Authors: Alison Fisher | Fu De Yang | Harvey Rubin | Barry S. Cooperman

https://doi.org/10.1021/jm00076a015 Actions

Synthesis and Antibacterial Properties of Some Tripeptides1

JOURNAL ARTICLE published November 1963 in Journal of Medicinal Chemistry

Authors: S. Shankman | S. Higa | S. Makineni | W. Noll

https://doi.org/10.1021/jm00342a026 Actions

Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan–Kynurenine Pathway

JOURNAL ARTICLE published 14 January 2021 in Journal of Medicinal Chemistry

Research funded by National Institute of Mental Health (MH107985) | National Institute of General Medical Sciences (GM108988,GM124661)

Authors: Yu Yang | Timothy Borel | Francisco de Azambuja | David Johnson | Jacob P. Sorrentino | Chinedum Udokwu | Ian Davis | Aimin Liu | Ryan A. Altman

https://doi.org/10.1021/acs.jmedchem.0c01762 Actions

1,2-Benzothiazines. IV.1 The Synthesis of 7,8-Dihydropyrido[1,2-b][1,2]benzothiazine-10,11(9H,10aH)-dione 5,5-Dioxides as 1,2-Benzothiazine Analogs of Partial Tetracycline Structures

JOURNAL ARTICLE published March 1967 in Journal of Medicinal Chemistry

Authors: Harold. Zinnes | Roger A. Comes | John. Shavel

https://doi.org/10.1021/jm00314a020 Actions

Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton

JOURNAL ARTICLE published 1 March 2002 in Journal of Medicinal Chemistry

Authors: Stephen Connolly | Colin Bennion | Sarah Botterell | Pamela J. Croshaw | Catherine Hallam | Kim Hardy | Paul Hartopp | Clive G. Jackson | Sarah J. King | Louise Lawrence | Antonio Mete | David Murray | David H. Robinson | Gillian M. Smith | Linda Stein | Iain Walters | Edward Wells | W. John Withnall

https://doi.org/10.1021/jm011050x Actions

Handbook of Chemistry and Physics.

JOURNAL ARTICLE published March 1965 in Journal of Medicinal Chemistry

Authors: Alfred Burger

https://doi.org/10.1021/jm00326a044 Actions

Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors

JOURNAL ARTICLE published 8 June 2023 in Journal of Medicinal Chemistry

Authors: Richard A. Hartz | Vijay T. Ahuja | Guanglin Luo | Ling Chen | Prasanna Sivaprakasam | Hong Xiao | Carol M. Krause | Wendy J. Clarke | Songmei Xu | John S. Tokarski | Kevin Kish | Hal Lewis | Nicolas Szapiel | Ramu Ravirala | Sayali Mutalik | Deepa Nakmode | Devang Shah | Catherine R. Burton | John E. Macor | Gene M. Dubowchik

https://doi.org/10.1021/acs.jmedchem.3c00364 Actions

Synthesis and Evaluation of a Novel Nonsteroidal-Specific Endothelial Cell Proliferation Inhibitor

JOURNAL ARTICLE published 1 April 2003 in Journal of Medicinal Chemistry

Authors: Jonathan M. Schmidt | Gilles B. Tremblay | Martine Pagé | Julie Mercure | Miklos Feher | Robert Dunn-Dufault | Markus G. Peter | Peter R. Redden

https://doi.org/10.1021/jm034007d Actions

Novel, Highly Potent Adenosine Deaminase Inhibitors Containing the Pyrazolo[3,4-d]pyrimidine Ring System. Synthesis, Structure−Activity Relationships, and Molecular Modeling Studies

JOURNAL ARTICLE published 1 August 2005 in Journal of Medicinal Chemistry

Authors: Federico Da Settimo | Giampaolo Primofiore | Concettina La Motta | Sabrina Taliani | Francesca Simorini | Anna Maria Marini | Laura Mugnaini | Antonio Lavecchia | Ettore Novellino | Daniela Tuscano | Claudia Martini

https://doi.org/10.1021/jm050136d Actions

Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors

JOURNAL ARTICLE published 26 February 2009 in Journal of Medicinal Chemistry

Authors: Lihren Chen | Weiheng Wang | Katherine L. Lee | Marina W. H. Shen | Elizabeth A. Murphy | Wen Zhang | Xin Xu | Steve Tam | Cheryl Nickerson-Nutter | Debra G. Goodwin | James D. Clark | John C. McKew

https://doi.org/10.1021/jm8009876 Actions

Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase

JOURNAL ARTICLE published 13 October 2016 in Journal of Medicinal Chemistry

Research funded by Seventh Framework Programme (260872)

Authors: Rosaria Luciani | Puneet Saxena | Sachin Surade | Matteo Santucci | Alberto Venturelli | Chiara Borsari | Gaetano Marverti | Glauco Ponterini | Stefania Ferrari | Tom L. Blundell | Maria Paola Costi

https://doi.org/10.1021/acs.jmedchem.6b00977 Actions

Highly Potent Cyclic Disulfide Antagonists of Somatostatin

JOURNAL ARTICLE published 1 June 1999 in Journal of Medicinal Chemistry

Authors: Simon J. Hocart | Rahul Jain | William A. Murphy | John E. Taylor | David H. Coy

https://doi.org/10.1021/jm9806289 Actions

Redefining the Structure−Activity Relationships of 2,6-Methano-3-benzazocines. 4. Opioid Receptor Binding Properties of 8-[N-(4‘-phenyl)-phenethyl)carboxamido] Analogues of Cyclazocine and Ethylketocycalzocine

JOURNAL ARTICLE published 1 September 2006 in Journal of Medicinal Chemistry

Authors: Mark P. Wentland | Melissa VanAlstine | Robert Kucejko | Rongliang Lou | Dana J. Cohen | Amy L. Parkhill | Jean M. Bidlack

https://doi.org/10.1021/jm060278n Actions

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

JOURNAL ARTICLE published 14 September 2017 in Journal of Medicinal Chemistry

Research funded by European Seventh Framework Program Nanotherapeutics Against Resistant Emerging Bacterial Pathogens (NAREB) (NAREB Project 604237)

Authors: Maria V. Buchieri | Mena Cimino | Sonia Rebollo-Ramirez | Claire Beauvineau | Alessandro Cascioferro | Sandrine Favre-Rochex | Olivier Helynck | Delphine Naud-Martin | Gerald Larrouy-Maumus | Hélène Munier-Lehmann | Brigitte Gicquel

https://doi.org/10.1021/acs.jmedchem.7b00726 Actions

Improving Binding Specificity of Pharmacological Chaperones That Target Mutant Superoxide Dismutase-1 Linked to Familial Amyotrophic Lateral Sclerosis Using Computational Methods

JOURNAL ARTICLE published 8 April 2010 in Journal of Medicinal Chemistry

Authors: Richard J. Nowak | Gregory D. Cuny | Sungwoon Choi | Peter T. Lansbury | Soumya S. Ray

https://doi.org/10.1021/jm901062p Actions

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A

JOURNAL ARTICLE published 8 October 2020 in Journal of Medicinal Chemistry

Research funded by U.S. Department of Health and Human Services (R01 AI149444,R01 AI153298,R21 AI137709) | U.S. Department of Health and Human Services (F32 DA044692) | Government of Canada (PGSD3-502274)

Authors: Lucy Lin | Margaret E. Olson | Takashi Sugane | Lewis D. Turner | Margarita A. Tararina | Alexander L. Nielsen | Elbek K. Kurbanov | Sabine Pellett | Eric A. Johnson | Seth M. Cohen | Karen N. Allen | Kim D. Janda

https://doi.org/10.1021/acs.jmedchem.0c01006 Actions

Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor

JOURNAL ARTICLE published 14 November 2019 in Journal of Medicinal Chemistry

Research funded by Ministry of Science and Technology of the People's Republic of China (2018YFA0507000) | National Natural Science Foundation of China (21502206,21572243)

Authors: Fang Zhou | Kang Ding | Yiqing Zhou | Yang Liu | Xiaoyan Liu | Fei Zhao | Yiran Wu | Xianjun Zhang | Qiwen Tan | Fei Xu | Wenfu Tan | Youli Xiao | Suwen Zhao | Houchao Tao

https://doi.org/10.1021/acs.jmedchem.9b00283 Actions
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