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Showing results for ISSN matching 0022-2623

Design, Synthesis, and Preliminary Pharmacological Evaluation of a Set of Small Molecules That Directly Activate Gi Proteins

JOURNAL ARTICLE published 1 October 2005 in Journal of Medicinal Chemistry

Authors: Dina Manetti | Lorenzo Di Cesare Mannelli | Silvia Dei | Nicoletta Galeotti | Carla Ghelardini | Maria Novella Romanelli | Serena Scapecchi | Elisabetta Teodori | Alessandra Pacini | Alessandro Bartolini | Fulvio Gualtieri

https://doi.org/10.1021/jm050498l Actions

Antimalarial compounds related to diaminodiphenyl sulfone

JOURNAL ARTICLE published July 1969 in Journal of Medicinal Chemistry

Authors: Henry Bader | John F. Hoops | John H. Biel | Harlen H. Koelling | Robert G. Stein | Tara Singh

https://doi.org/10.1021/jm00304a043 Actions

Synthesis and chemical carcinogen inhibitory activity of 2-tert-butyl-4-hydroxyanisole

JOURNAL ARTICLE published May 1979 in Journal of Medicinal Chemistry

Authors: Luke K. T. Lam | Ramdas P. Pai | Lee W. Wattenberg

https://doi.org/10.1021/jm00191a020 Actions

Calculation of the .pi.-electron "ring current" properties of some carcinogenic, heptacyclic, condensed, benzenoid hydrocarbons

JOURNAL ARTICLE published September 1971 in Journal of Medicinal Chemistry

Authors: Roger B. Mallion

https://doi.org/10.1021/jm00291a012 Actions

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

JOURNAL ARTICLE published 10 June 2021 in Journal of Medicinal Chemistry

Research funded by National Cancer Institute (Z01 BC 006150-19) | Guangdong Provincial Key Laboratory of Construction Foundation (2017B030314030) | Guangdong Basic and Applied Basic Research Foundation (2019A1515011317) | Guangzhou Basic and Applied Basic Research Project (202002030312)

Authors: De-Xuan Hu | Wen-Lin Tang | Yu Zhang | Hao Yang | Wenjie Wang | Keli Agama | Yves Pommier | Lin-Kun An

https://doi.org/10.1021/acs.jmedchem.1c00318 Actions

Antitumor agents. 113. New 4.beta.-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

JOURNAL ARTICLE published September 1990 in Journal of Medicinal Chemistry

Authors: Zhe Qing Wang | Yao Haur Kuo | Dora Schnur | J. Phillip Bowen | Su Ying Liu | Fu Sheng Han | Jang Yang Chang | Yung Chi Cheng | Kuo Hsiung Lee

https://doi.org/10.1021/jm00171a050 Actions

Arylcyanoguanidines as Activators of Kir6.2/SUR1KATP Channels and Inhibitors of Insulin Release

JOURNAL ARTICLE published 1 June 2004 in Journal of Medicinal Chemistry

Authors: Tina M. Tagmose | Søren C. Schou | John P. Mogensen | Flemming E. Nielsen | Per O. G. Arkhammar | Philip Wahl | Birgit S. Hansen | Anne Worsaae | Harrie C. M. Boonen | Marie-Hélène Antoine | Philippe Lebrun | John Bondo Hansen

https://doi.org/10.1021/jm031018y Actions

Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators

JOURNAL ARTICLE published 26 December 2019 in Journal of Medicinal Chemistry

Research funded by National Institute on Drug Abuse (DA024022,DA044855,DA050311)

Authors: Hongguang Ma | Samuel Obeng | Huiqun Wang | Yi Zheng | Mengchu Li | Abdulmajeed M. Jali | David L. Stevens | William L. Dewey | Dana E. Selley | Yan Zhang

https://doi.org/10.1021/acs.jmedchem.9b01767 Actions

Efficient Inhibition of Iron Superoxide Dismutase and of Trypanosoma cruzi Growth by Benzo[g]phthalazine Derivatives Functionalized with One or Two Imidazole Rings

JOURNAL ARTICLE published 1 March 2008 in Journal of Medicinal Chemistry

Authors: Ana M. Sanz | Fernando Gómez-Contreras | Pilar Navarro | Manuel Sánchez-Moreno | Samira Boutaleb-Charki | Jose Campuzano | Mercedes Pardo | Antonio Osuna | Carmen Cano | María J. R. Yunta | Lucrecia Campayo

https://doi.org/10.1021/jm701179m Actions

4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

JOURNAL ARTICLE published 14 April 2022 in Journal of Medicinal Chemistry

Research funded by National Institute of Allergy and Infectious Diseases (R01AI136982) | National Institute of General Medical Sciences (R35 GM118047)

Authors: Tianyu He | Tiffany C. Edwards | Jiashu Xie | Hideki Aihara | Robert J. Geraghty | Zhengqiang Wang

https://doi.org/10.1021/acs.jmedchem.2c00203 Actions

Synthesis and Anti-HIV Activity of Novel N-1 Side Chain-Modified Analogs of 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

JOURNAL ARTICLE published 1 June 1997 in Journal of Medicinal Chemistry

Authors: Renée Pontikis | Rachid Benhida | Anne-Marie Aubertin | David S. Grierson | Claude Monneret

https://doi.org/10.1021/jm960765a Actions

N-Substituent Effects in the Selective Delivery of Polyamine Conjugates into Cells Containing Active Polyamine Transporters

JOURNAL ARTICLE published 1 November 2004 in Journal of Medicinal Chemistry

Authors: Richard Andrew Gardner | Jean-Guy Delcros | Fanta Konate | Fred Breitbeil | Bénédicte Martin | Michael Sigman | Min Huang

https://doi.org/10.1021/jm0497040 Actions

Synthesis and Antiviral Activity of 3-Formyl- and 3-Cyano-2,5,6-trichloroindole Nucleoside Derivatives

JOURNAL ARTICLE published 1 November 2004 in Journal of Medicinal Chemistry

Authors: John D. Williams | Jiong J. Chen | John C. Drach | Leroy B. Townsend

https://doi.org/10.1021/jm040032n Actions

Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors

JOURNAL ARTICLE published 26 November 2009 in Journal of Medicinal Chemistry

Authors: Coco N. Kapanda | Giulio G. Muccioli | Geoffray Labar | Jacques H. Poupaert | Didier M. Lambert

https://doi.org/10.1021/jm901323s Actions

Flavonoid Derivatives as Adenosine Receptor Antagonists:  A Comparison of the Hypothetical Receptor Binding Site Based on a Comparative Molecular Field Analysis Model

JOURNAL ARTICLE published 1 January 1998 in Journal of Medicinal Chemistry

Authors: Stefano Moro | A. Michiel van Rhee | Lawrence H. Sanders | Kenneth A. Jacobson

https://doi.org/10.1021/jm970446z Actions

Synthesis, Molecular Pharmacology, and Structure–Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinoid Type 2 Receptor Antagonists

JOURNAL ARTICLE published 13 May 2021 in Journal of Medicinal Chemistry

Research funded by National Institute on Drug Abuse (R01 DA039143) | National Institute of General Medical Sciences (P20 GM130456)

Authors: Harvey F. Fulo | Amal Shoeib | Christian V. Cabanlong | Alexander H. Williams | Chang-Guo Zhan | Paul L. Prather | Gregory B. Dudley

https://doi.org/10.1021/acs.jmedchem.1c00442 Actions

Portage transport of sulfanilamide and sulfanilic acid

JOURNAL ARTICLE published March 1989 in Journal of Medicinal Chemistry

Authors: Se Young Hwang | David A. Berges | John J. Taggart | Charles Gilvarg

https://doi.org/10.1021/jm00123a034 Actions

Synthesis and Biological Activity of 2,22-Dimethylene Analogues of 19-Norcalcitriol and Related Compounds

JOURNAL ARTICLE published 9 July 2020 in Journal of Medicinal Chemistry

Authors: Izabela K. Sibilska-Kaminski | Rafal R. Sicinski | Lori A. Plum | Hector F. DeLuca

https://doi.org/10.1021/acs.jmedchem.0c00580 Actions

Chemistry and Pharmacological Characterization of Novel Nitrogen Analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(Azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-Nicotinic Acetylcholine Receptor-Selective Partial Agonists

JOURNAL ARTICLE published 14 October 2010 in Journal of Medicinal Chemistry

Authors: Jianhua Liu | J. Brek Eaton | Barbara Caldarone | Ronald J. Lukas | Alan P. Kozikowski

https://doi.org/10.1021/jm100765u Actions

Design, Synthesis, and in Vitro and in Vivo Evaluation of High Affinity and Specificity Near-Infrared Fluorescent Bombesin Antagonists for Tumor Imaging

JOURNAL ARTICLE published 13 September 2018 in Journal of Medicinal Chemistry

Research funded by U.S. Department of Veterans Affairs (1I01BX003392) | Medical Research and Materiel Command (W91ZSQ8335N612) | U.S. Department of Defense (W81XWH0920176)

Authors: Hang Xu | Rajendra P. Bandari | Li Lee | Ran Li | Ping Yu | Charles J. Smith | Lixin Ma

https://doi.org/10.1021/acs.jmedchem.8b00614 Actions
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