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Showing results for ISSN matching 0022-2623

Discovery of Orally Bioavailable 1,3,4-Trisubstituted 2-Oxopiperazine-Based Melanocortin-4 Receptor Agonists as Potential Antiobesity Agents

JOURNAL ARTICLE published 9 October 2008 in Journal of Medicinal Chemistry

Authors: Xinrong Tian | Adrian G. Switzer | Steve A. Derose | Rajesh K. Mishra | Mark G. Solinsky | Rashid N. Mumin | Frank H. Ebetino | Lalith R. Jayasinghe | Mark E. Webster | Anny-Odile Colson | Doreen Crossdoersen | Beth B. Pinney | Julie A. Farmer | Martin E. Dowty | Cindy M. Obringer | Charles A. Cruze | Melissa L. Burklow | Paula M. Suchanek | Lily Dong | Mary Kay Dirr | Russell J. Sheldon | John A. Wos

https://doi.org/10.1021/jm800525p Actions

Novel Bis(1H-indol-2-yl)methanones as Potent Inhibitors of FLT3 and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

JOURNAL ARTICLE published 1 June 2006 in Journal of Medicinal Chemistry

Authors: Siavosh Mahboobi | Andrea Uecker | Andreas Sellmer | Christophe Cénac | Heymo Höcher | Herwig Pongratz | Emerich Eichhorn | Harald Hufsky | Antje Trümpler | Marit Sicker | Florian Heidel | Thomas Fischer | Carol Stocking | Sigurd Elz | Frank-D. Böhmer | Stefan Dove

https://doi.org/10.1021/jm058033i Actions

(+)-cis-N-(para-, meta-, and ortho-substituted benzyl)-N-normetazocines: Synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (.sigma.1) site and quantitative structure-affinity relationship studies

JOURNAL ARTICLE published February 1995 in Journal of Medicinal Chemistry

Authors: S. Wayne Mascarella | Xu Bai | Wanda Williams | Bethel Sine | Wayne D. Bowen | F. Ivy Carroll

https://doi.org/10.1021/jm00003a019 Actions

Iodinated 2-Aminotetralins and 3-Amino-1-benzopyrans: Ligands for Dopamine D2 and D3 Receptors

JOURNAL ARTICLE published November 1994 in Journal of Medicinal Chemistry

Authors: Sumalee Chumpradit | Mei-Ping Kung | Janet Vessotskie | Catherine Foulon | Mu Mu | Hank F. Kung

https://doi.org/10.1021/jm00050a021 Actions

Novel Ligands Rationally Designed for Characterizing I2−Imidazoline Binding Sites Nature and Functions

JOURNAL ARTICLE published 1 August 2008 in Journal of Medicinal Chemistry

Authors: Francesco Gentili | Claudia Cardinaletti | Cristian Vesprini | Francesca Ghelfi | Aniket Farande | Mario Giannella | Alessandro Piergentili | Wilma Quaglia | Laura Mattioli | Marina Perfumi | Alan Hudson | Maria Pigini

https://doi.org/10.1021/jm800400k Actions

Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of .gamma.-aminobutyric acid-related biological properties in vitro and in vivo

JOURNAL ARTICLE published January 1986 in Journal of Medicinal Chemistry

Authors: Donald T. Witiak | Raymond J. Patch | S. J. Enna | Yiu K. Fung

https://doi.org/10.1021/jm00151a001 Actions

Potent angiotensin II antagonists with non-.beta.-branched amino acids in position 5

JOURNAL ARTICLE published February 1989 in Journal of Medicinal Chemistry

Authors: J. Samanen | D. Narindray | T. Cash | E. Brandeis | W. Adams | T. Yellin | D. Eggleston | C. DeBrosse | D. Regoli

https://doi.org/10.1021/jm00122a030 Actions

Rigid amino acids related to .alpha.-methyldopa

JOURNAL ARTICLE published May 1974 in Journal of Medicinal Chemistry

Authors: Joseph G. Cannon | John P. O'Donnell | John P. Rosazza | Charles R. Hoppin

https://doi.org/10.1021/jm00251a029 Actions

Probes for narcotic receptor mediated phenomena. 18. Epimeric 6.alpha.- and 6.beta.-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5.alpha.-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6.beta.-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5.alpha.-epoxymorphinan

JOURNAL ARTICLE published July 1992 in Journal of Medicinal Chemistry

Authors: Brian R. De Costa | Michael J. Iadarola | Richard B. Rothman | Karen F. Berman | Clifford George | Amy H. Newman | Artin Mahboubi | Arthur E. Jacobson | Kenner C. Rice

https://doi.org/10.1021/jm00093a016 Actions

Conformational Analysis of Ketolide, Conformations of RU 004 in Solution and Bound to Bacterial Ribosomes

JOURNAL ARTICLE published 1 August 1998 in Journal of Medicinal Chemistry

Authors: Gildas Bertho | Josyane Gharbi-Benarous | Marcel Delaforge | Catherine Lang | Annick Parent | Jean-Pierre Girault

https://doi.org/10.1021/jm970852i Actions

Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

JOURNAL ARTICLE published September 1990 in Journal of Medicinal Chemistry

Authors: Michael S. Allen | Yun C. Tan | Mark L. Trudell | Kris Narayanan | Liesl R. Schindler | Michael J. Martin | Christopher Schultz | Timothy J. Hagen | Konrad F. Koehler

https://doi.org/10.1021/jm00171a007 Actions

Determining Cysteines Available for Covalent Inhibition Across the Human Kinome

JOURNAL ARTICLE published 13 April 2017 in Journal of Medicinal Chemistry

Research funded by U.S. National Library of Medicine (R01 LM011986) | National Institute on Minority Health and Health Disparities (G12 MD007599)

Authors: Zheng Zhao | Qingsong Liu | Spencer Bliven | Lei Xie | Philip E. Bourne

https://doi.org/10.1021/acs.jmedchem.6b01815 Actions

Effects of Bisphosphonates on the Growth of Entamoeba histolytica and Plasmodium Species in Vitro and in Vivo

JOURNAL ARTICLE published 1 January 2004 in Journal of Medicinal Chemistry

Authors: Subhash Ghosh | Julian M. W. Chan | Christopher R. Lea | Gary A. Meints | Jared C. Lewis | Zev S. Tovian | Ryan M. Flessner | Timothy C. Loftus | Iris Bruchhaus | Howard Kendrick | Simon L. Croft | Robert G. Kemp | Seiki Kobayashi | Tomoyoshi Nozaki | Eric Oldfield

https://doi.org/10.1021/jm030084x Actions

Metabolism of 1,3-bis(2-chloroethyl)-1-nitrosourea by rat hepatic microsomes

JOURNAL ARTICLE published June 1981 in Journal of Medicinal Chemistry

Authors: Huey-Shin Lin | Robert J. Weinkam

https://doi.org/10.1021/jm00138a025 Actions

The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

JOURNAL ARTICLE published 28 March 2013 in Journal of Medicinal Chemistry

Authors: Edwige Lorthiois | Werner Breitenstein | Frederic Cumin | Claus Ehrhardt | Eric Francotte | Edgar Jacoby | Nils Ostermann | Holger Sellner | Takatoshi Kosaka | Randy L. Webb | Dean F. Rigel | Ulrich Hassiepen | Paul Richert | Trixie Wagner | Jürgen Maibaum

https://doi.org/10.1021/jm3017078 Actions

Design and Synthesis of Brefeldin A Sulfide Derivatives as Prodrug Candidates with Enhanced Aqueous Solubilities

JOURNAL ARTICLE published 1 August 1998 in Journal of Medicinal Chemistry

Authors: Ankush B. Argade | Rajesh Devraj | Jeffrey A. Vroman | Rudiger D. Haugwitz | Melinda Hollingshead | Mark Cushman

https://doi.org/10.1021/jm970746g Actions

Bis-cycloSal-d4T-monophosphates:  Drugs That Deliver Two Molecules of Bioactive Nucleotides

JOURNAL ARTICLE published 1 March 2007 in Journal of Medicinal Chemistry

Authors: Christian Ducho | Ulf Görbig | Sönke Jessel | Nicolas Gisch | Jan Balzarini | Chris Meier

https://doi.org/10.1021/jm0611713 Actions

Synthesis and Anticonvulsant Activities of (R)-N-(4′-Substituted)benzyl 2-Acetamido-3-methoxypropionamides

JOURNAL ARTICLE published 11 February 2010 in Journal of Medicinal Chemistry

Authors: Christophe Salomé | Elise Salomé-Grosjean | Ki Duk Park | Pierre Morieux | Robert Swendiman | Erica DeMarco | James P. Stables | Harold Kohn

https://doi.org/10.1021/jm901563p Actions

Discovery of Benzocycloalkane Derivatives Efficiently Blocking Bacterial Virulence for the Treatment of Methicillin-Resistant S. aureus (MRSA) Infections by Targeting Diapophytoene Desaturase (CrtN)

JOURNAL ARTICLE published 26 May 2016 in Journal of Medicinal Chemistry

Research funded by Program for New Century Excellent Talents in University (NCET-12-0853) | Shanghai Municipal Education Commission (14SG28) | National Natural Science Foundation of China (21222211,21372001,21472207)

Authors: Youxin Wang | Hongxia Di | Feifei Chen | Yong Xu | Qiang Xiao | Xuehai Wang | Hanwen Wei | Yanli Lu | Lingling Zhang | Jin Zhu | Lefu Lan | Jian Li

https://doi.org/10.1021/acs.jmedchem.6b00122 Actions

Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities

JOURNAL ARTICLE published 14 October 2021 in Journal of Medicinal Chemistry

Research funded by Medical Research Council (MR/K000179/1,MR/R009066/1) | European Regional Development Fund (CZ.02.1.01/0.0/0.0/16_019/0000729)

Authors: Terezie Páníková | Katarína Mitrová | Tereza Halamová | Karolína Mrzílková | Jan Pícha | Martina Chrudinová | Andrii Kurochka | Irena Selicharová | Lenka Žáková | Jiří Jiráček

https://doi.org/10.1021/acs.jmedchem.1c01388 Actions
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