What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic?

JOURNAL ARTICLE published 14 November 2012 in Science Translational Medicine

Authors: Glenn D. Prestwich | Sangeeta Bhatia | Christopher K. Breuer | Shannon L. M. Dahl | Chris Mason | Richard McFarland | David J. McQuillan | Jonathan Sackner-Bernstein | Jeffrey Schox | William E. Tente | Alan Trounson

Complexities of the Uniquely Human Vagina

JOURNAL ARTICLE published 2 May 2012 in Science Translational Medicine

Authors: Steven S. Witkin | William J. Ledger

Comment on “Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast”

JOURNAL ARTICLE published 11 December 2013 in Science Translational Medicine

Authors: Jun Wang | Akash Gupta | Hong Hu | Robert T. Chatterton | Charles V. Clevenger | Seema A. Khan

A tale of two cells: Regulatory T cell–microglia cross-talk in the ischemic brain

JOURNAL ARTICLE published 8 November 2023 in Science Translational Medicine

Authors: Alessio Ricci | Arthur Liesz

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism

JOURNAL ARTICLE published 19 May 2021 in Science Translational Medicine

Research funded by Wellcome Trust (WT098524MA) | Wellcome Trust (090532/Z/09/Z) | Wellcome (210774/Z18/Z) | Wellcome (204841/Z/16/Z) | Medical Research Council (MR/K02342X/1) | Medical Research Council (MR/N026101/1) | Medical Research Council (MR/R015325/1) | Medical Research Council (MR/P026494/1) | Medical Research Council (MR/T008024/1) | Medical Research Council (MR/N019075/1) | LifeArc (P2020-0008) | Medical Research Council (MR/T044853/1) | Medical Research Council (MR/R025134/1) | Medical Research Council (MR/S009434/1) | Medical Research Council (MR/S036784/1) | Medical Research Council (G0900747 91070) | National Institute for Health Research (WT098524MA) | National Institute for Health Research (MR/K02342X/1) | National Institute for Health Research (MR/R015325/1) | National Institute for Health Research (V1284) | National Institute for Health Research (NIHR-RP-2016-07-019) | Department of Health, Australian Government (608381) | Department of Health, Australian Government (UK F1701 M) | Department of Health, Australian Government (658418) | Department of Health, Australian Government (544454) | Department of Health, Australian Government (MR/P026494/1) | Department of Health, Australian Government (17UCL01) | Department of Health, Australian Government (P2020-0008) | Department of Health, Australian Government (V4720) | Department of Health, Australian Government (MR/N019075/1) | Epilepsy Research UK (F1701) | Great Ormond Street Hospital Charity (V1284) | Royal Society (UF140596) | Rosetrees Trust (M576) | Austrian Science Fund (P31255-B27) | Wellbeing of Women (RT-414) | Parkinson’s UK (J-1403) | Action Medical Research (GN2137) | Austrian Science Fund (SFB35-10) | Sparks (17UCL01) | Great Ormond Street Hospital Charity (V4720) | Action Medical Research (GN2485) | Department of Health, Australian Government (GN2137) | Department of Health, Australian Government (MRC MR/T008024/1) | Department of Health, Australian Government (72160294) | Department of Health, Australian Government (P2020-0008) | Department of Health, Australian Government (UF140596) | Department of Health, Australian Government (21552) | Department of Health, Australian Government (21593) | Department of Health, Australian Government (P31255-B27) | Department of Health, Australian Government (SFB35-10) | Department of Health, Australian Government (LSC17-026) | Department of Health, Australian Government (21077/Z/18/Z) | Department of Health, Australian Government (19507) | Department of Health, Australian Government (22946) | Department of Health, Australian Government (MR/N026101/1) | Department of Health, Australian Government (MR/R025134/1) | Department of Health, Australian Government (MR/S009434/1) | Department of Health, Australian Government (MR/S036784/1) | Department of Health, Australian Government (MR/T044853/1) | Department of Health, Australian Government (NC/L001780/1) | Department of Health, Australian Government (204841/Z/16/Z) | Department of Health, Australian Government (666918) | Department of Health, Australian Government (GN2485) | Marie Curie Fellowship (658418) | NIHR (NIHR-RP-2016-07-019) | Versus Arthritis (21552) | CONICYT Becas Chile Doctoral Fellowship Program (7216029) | Association Française contre les Myopathies (19507 and 22946) | NC3Rs (NC/L001780/1) | European Union’s Horizon 2020 (666918) | Marie Skłodowska-Curie Actions European Union’s Seventh Framework Programme FP7 (608381)

Authors: Joanne Ng | Serena Barral | Carmen De La Fuente Barrigon | Gabriele Lignani | Fatma A. Erdem | Rebecca Wallings | Riccardo Privolizzi | Giada Rossignoli | Haya Alrashidi | Sonja Heasman | Esther Meyer | Adeline Ngoh | Simon Pope | Rajvinder Karda | Dany Perocheau | Julien Baruteau | Natalie Suff | Juan Antinao Diaz | Stephanie Schorge | Jane Vowles | Lucy R. Marshall | Sally A. Cowley | Sonja Sucic | Michael Freissmuth | John R. Counsell | Richard Wade-Martins | Simon J. R. Heales | Ahad A. Rahim | Maximilien Bencze | Simon N. Waddington | Manju A. Kurian

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

JOURNAL ARTICLE published 2 February 2022 in Science Translational Medicine

Authors: Baoling Ying | Bradley Whitener | Laura A. VanBlargan | Ahmed O. Hassan | Swathi Shrihari | Chieh-Yu Liang | Courtney E. Karl | Samantha Mackin | Rita E. Chen | Natasha M. Kafai | Samuel H. Wilks | Derek J. Smith | Juan Manuel Carreño | Gagandeep Singh | Florian Krammer | Andrea Carfi | Sayda M. Elbashir | Darin K. Edwards | Larissa B. Thackray | Michael S. Diamond

The tumor microenvironment state associates with response to HPV therapeutic vaccination in patients with respiratory papillomatosis

JOURNAL ARTICLE published 25 October 2023 in Science Translational Medicine

Authors: Scott M. Norberg | Ke Bai | Cem Sievers | Yvette Robbins | Jay Friedman | Xinping Yang | Meg Kenyon | Elizabeth Ward | Jeffrey Schlom | James Gulley | Amy Lankford | Roshanak Semnani | Helen Sabzevari | Douglas E. Brough | Clint T. Allen

CpG ODN Nanorings Induce IFNα from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

JOURNAL ARTICLE published 7 May 2014 in Science Translational Medicine

Authors: Bilgi Gungor | Fuat Cem Yagci | Gizem Tincer | Banu Bayyurt | Esin Alpdundar | Soner Yildiz | Mine Ozcan | Ihsan Gursel | Mayda Gursel

Stronger regulation of AI in biomedicine

JOURNAL ARTICLE published 13 September 2023 in Science Translational Medicine

Authors: Artem A. Trotsyuk | Carole A. Federico | Mildred K. Cho | Russ B. Altman | David Magnus

Pathophysiology of Dyt1- Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction

JOURNAL ARTICLE published 3 May 2023 in Science Translational Medicine

Authors: Amanda M. Pocratsky | Filipe Nascimento | M. Görkem Özyurt | Ian J. White | Roisin Sullivan | Benjamin J. O’Callaghan | Calvin C. Smith | Sunaina Surana | Marco Beato | Robert M. Brownstone

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

JOURNAL ARTICLE published 6 January 2016 in Science Translational Medicine

Research funded by NIH (#T32GM007171) | National Cancer Institute Small Business Innovation Research (#1U43CA165024) | National Center for Advancing Translational Science (#UL1TR001117) | Duke Comprehensive Cancer Center Support (5P30-CA-014236-38)

Authors: Melodi Javid Whitley | Diana M. Cardona | Alexander L. Lazarides | Ivan Spasojevic | Jorge M. Ferrer | Joan Cahill | Chang-Lung Lee | Matija Snuderl | Dan G. Blazer | E. Shelley Hwang | Rachel A. Greenup | Paul J. Mosca | Jeffrey K. Mito | Kyle C. Cuneo | Nicole A. Larrier | Erin K. O’Reilly | Richard F. Riedel | William C. Eward | David B. Strasfeld | Dai Fukumura | Rakesh K. Jain | W. David Lee | Linda G. Griffith | Moungi G. Bawendi | David G. Kirsch | Brian E. Brigman

Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta

JOURNAL ARTICLE published 3 July 2013 in Science Translational Medicine

Authors: Elinor K. Karlsson | Jason B. Harris | Shervin Tabrizi | Atiqur Rahman | Ilya Shlyakhter | Nick Patterson | Colm O’Dushlaine | Stephen F. Schaffner | Sameer Gupta | Fahima Chowdhury | Alaullah Sheikh | Ok Sarah Shin | Crystal Ellis | Christine E. Becker | Lynda M. Stuart | Stephen B. Calderwood | Edward T. Ryan | Firdausi Qadri | Pardis C. Sabeti | Regina C. LaRocque

A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates

JOURNAL ARTICLE published 15 May 2019 in Science Translational Medicine

Authors: Sung-Youl Ko | Wataru Akahata | Eun Sung Yang | Wing-Pui Kong | Crystal W. Burke | Shelley P. Honnold | Donald K. Nichols | Yan-Jang S. Huang | Gretchen L. Schieber | Kevin Carlton | Luis DaSilva | Vicki Traina-Dorge | Dana L. Vanlandingham | Yaroslav Tsybovsky | Tyler Stephens | Ulrich Baxa | Stephen Higgs | Chad J. Roy | Pamela J. Glass | John R. Mascola | Gary J. Nabel | Srinivas S. Rao

Donor Myocardial Infarction Impairs the Therapeutic Potential of Bone Marrow Cells by an Interleukin-1–Mediated Inflammatory Response

JOURNAL ARTICLE published 14 September 2011 in Science Translational Medicine

Authors: Xiaoyin Wang | Junya Takagawa | Viola C. Lam | Daniel J. Haddad | Diana L. Tobler | Pamela Y. Mok | Yan Zhang | Brian T. Clifford | Kranthi Pinnamaneni | Shereen A. Saini | Robert Su | Maya J. Bartel | Richard E. Sievers | Larry Carbone | Scott Kogan | Yerem Yeghiazarians | Michelle L. Hermiston | Matthew L. Springer

Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community

JOURNAL ARTICLE published 25 October 2017 in Science Translational Medicine

Research funded by Wellcome Trust (award307774,201344/Z/16/Z) | Wellcome Trust (award307775,Wellcome Trust Clinical PhD fellow) | Medical Research Council (award307772,G1000803) | UKCRC Translational Infection Research (TIR) Initiative (award307771) | Academy of Medical Sciences and the Health Foundation (award307776) | NIHR Cambridge Biomedical Research Centre (award307777)

Authors: Francesc Coll | Ewan M. Harrison | Michelle S. Toleman | Sandra Reuter | Kathy E. Raven | Beth Blane | Beverley Palmer | A. Ruth M. Kappeler | Nicholas M. Brown | M. Estée Török | Julian Parkhill | Sharon J. Peacock

Selective activation of TWIK-related acid-sensitive K ⁺ 3 subunit–containing channels is analgesic in rodent models

JOURNAL ARTICLE published 20 November 2019 in Science Translational Medicine

Authors: Ping Liao | Yunguang Qiu | Yiqing Mo | Jie Fu | Zhenpeng Song | Lu Huang | Suwen Bai | Yang Wang | Jia-Jie Zhu | Fuyun Tian | Zhuo Chen | Nanfang Pan | Er-Yi Sun | Linghui Yang | Xi Lan | Yinbin Chen | Dongping Huang | Peihua Sun | Lifen Zhao | Dehua Yang | Weiqiang Lu | Tingting Yang | Junjie Xiao | Wei-Guang Li | Zhaobing Gao | Bing Shen | Qiansen Zhang | Jin Liu | Hualiang Jiang | Ruotian Jiang | Huaiyu Yang

Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance

JOURNAL ARTICLE published 18 February 2015 in Science Translational Medicine

Research funded by Agence Nationale de la Recherche (ANR-10-BLAN-1118) | Fondation Recherche Medicale (PLP20071010956)

Authors: Nimesh Gupta | Slobodan Culina | Yann Meslier | Jordan Dimitrov | Christophe Arnoult | Sandrine Delignat | Bagirath Gangadharan | Maxime Lecerf | Sune Justesen | Valérie Gouilleux-Gruart | Benoit L. Salomon | David W. Scott | Srinivas V. Kaveri | Roberto Mallone | Sébastien Lacroix-Desmazes

Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM -Defective Tumors

JOURNAL ARTICLE published 12 June 2013 in Science Translational Medicine

Authors: Arina Riabinska | Mathias Daheim | Grit S. Herter-Sprie | Johannes Winkler | Christian Fritz | Michael Hallek | Roman K. Thomas | Karl-Anton Kreuzer | Lukas P. Frenzel | Parisa Monfared | Jorge Martins-Boucas | Shuhua Chen | Hans Christian Reinhardt

Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors

JOURNAL ARTICLE published 14 October 2020 in Science Translational Medicine

Research funded by CDTI (IDI-20170635)

Authors: Iván Márquez-Rodas | Federico Longo | Maria E. Rodriguez-Ruiz | Antonio Calles | Santiago Ponce | Maria Jove | Belén Rubio-Viqueira | Jose Luis Perez-Gracia | Ana Gómez-Rueda | Sara López-Tarruella | Mariano Ponz-Sarvise | Rosa Álvarez | Ainara Soria-Rivas | Enrique de Miguel | Rocío Ramos-Medina | Eduardo Castañon | Pablo Gajate | Cayetano Sempere-Ortega | Elisabeth Jiménez-Aguilar | M. Angela Aznar | Aitana Calvo | Pedro P. Lopez-Casas | Salvador Martín-Algarra | Miguel Martín | Dominique Tersago | Marisol Quintero | Ignacio Melero

Passive monitoring by smart toilets for precision health

JOURNAL ARTICLE published February 2023 in Science Translational Medicine

Authors: T. Jessie Ge | Vasiliki Nataly Rahimzadeh | Kevin Mintz | Walter G. Park | Nicole Martinez-Martin | Joseph C. Liao | Seung-min Park