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Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers

JOURNAL ARTICLE published 21 June 2017 in Science Translational Medicine

Research funded by Bill and Melinda Gates Foundation (award292759,opp1080385) | Top Institute Pharma (award292760,T4-102)

Authors: Matthew B. B. McCall | Linda J. Wammes | Marijke C. C. Langenberg | Geert-Jan van Gemert | Jona Walk | Cornelus C. Hermsen | Wouter Graumans | Rob Koelewijn | Jean-François Franetich | Sandra Chishimba | Max Gerdsen | Audrey Lorthiois | Marga van de Vegte | Dominique Mazier | Else M. Bijker | Jaap J. van Hellemond | Perry J. J. van Genderen | Robert W. Sauerwein

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

JOURNAL ARTICLE published 22 June 2022 in Science Translational Medicine

Authors: Naoto Fujiwara | Naoto Kubota | Emilie Crouchet | Bhuvaneswari Koneru | Cesia A. Marquez | Arun K. Jajoriya | Gayatri Panda | Tongqi Qian | Shijia Zhu | Nicolas Goossens | Xiaochen Wang | Shuang Liang | Zhenyu Zhong | Sara Lewis | Bachir Taouli | Myron E. Schwartz | Maria Isabel Fiel | Amit G. Singal | Jorge A. Marrero | Austin J. Fobar | Neehar D. Parikh | Indu Raman | Quan-Zhen Li | Masataka Taguri | Atsushi Ono | Hiroshi Aikata | Takashi Nakahara | Hayato Nakagawa | Yuki Matsushita | Ryosuke Tateishi | Kazuhiko Koike | Masahiro Kobayashi | Takaaki Higashi | Shigeki Nakagawa | Yo-ichi Yamashita | Toru Beppu | Hideo Baba | Hiromitsu Kumada | Kazuaki Chayama | Thomas F. Baumert | Yujin Hoshida

Human T H 17 Cells Are Long-Lived Effector Memory Cells

JOURNAL ARTICLE published 12 October 2011 in Science Translational Medicine

Authors: Ilona Kryczek | Ende Zhao | Yan Liu | Yin Wang | Linhua Vatan | Wojciech Szeliga | Jeffrey Moyer | Aleksandra Klimczak | Andrzej Lange | Weiping Zou

Acetyl-CoA carboxylase 1 controls a lipid droplet–peroxisome axis and is a vulnerability of endocrine-resistant ER + breast cancer

JOURNAL ARTICLE published 28 February 2024 in Science Translational Medicine

Authors: Marina Bacci | Nicla Lorito | Alfredo Smiriglia | Angela Subbiani | Francesca Bonechi | Giuseppina Comito | Ludivine Morriset | Rania El Botty | Matteo Benelli | Joanna I. López-Velazco | Maria M. Caffarel | Ander Urruticoechea | George Sflomos | Luca Malorni | Michela Corsini | Luigi Ippolito | Elisa Giannoni | Icro Meattini | Vittoria Matafora | Kristina Havas | Angela Bachi | Paola Chiarugi | Elisabetta Marangoni | Andrea Morandi

An Alphavirus -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

JOURNAL ARTICLE published 5 August 2020 in Science Translational Medicine

Research funded by National Institute of General Medical Sciences (R01GM120553) | National Institute of Allergy and Infectious Diseases (P51OD010425) | National Institute of Allergy and Infectious Diseases (27220140006C) | National Institute of Allergy and Infectious Diseases (75N93019C00037) | National Institute of Allergy and Infectious Diseases (HHSN272201700059C) | National Institute of Allergy and Infectious Diseases (1F32AI136371) | Burroughs Wellcome Fund (Investigators in the pathogenesis of infectious disease award) | Pew Charitable Trusts (Pew Biomedical Scholars Award) | Washington Research Foundation (WRF Postdoctoral Fellowship)

Authors: Jesse H. Erasmus | Amit P. Khandhar | Megan A. O’Connor | Alexandra C. Walls | Emily A. Hemann | Patience Murapa | Jacob Archer | Shanna Leventhal | James T. Fuller | Thomas B. Lewis | Kevin E. Draves | Samantha Randall | Kathryn A. Guerriero | Malcolm S. Duthie | Darrick Carter | Steven G. Reed | David W. Hawman | Heinz Feldmann | Michael Gale | David Veesler | Peter Berglund | Deborah Heydenburg Fuller

Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes

JOURNAL ARTICLE published 10 August 2022 in Science Translational Medicine

Authors: Hiroki Kobayashi | Helen C. Looker | Eiichiro Satake | Francesca D’Addio | Jonathan M. Wilson | Pierre Jean Saulnier | Zaipul I. Md Dom | Kristina O’Neil | Katsuhito Ihara | Bozena Krolewski | Hannah S. Badger | Adriana Petrazzuolo | Domenico Corradi | Andrzej Galecki | Parker C. Wilson | Behzad Najafian | Michael Mauer | Monika A. Niewczas | Alessandro Doria | Benjamin D. Humphreys | Kevin L. Duffin | Paolo Fiorina | Robert G. Nelson | Andrzej S. Krolewski

Vaccination with S pan , an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice

JOURNAL ARTICLE published 4 January 2023 in Science Translational Medicine

Authors: Yongliang Zhao | Wenjia Ni | Simeng Liang | Lianghui Dong | Min Xiang | Zeng Cai | Danping Niu | Qiuhan Zhang | Dehe Wang | Yucheng Zheng | Zhen Zhang | Dan Zhou | Wenhua Guo | Yongbing Pan | Xiaoli Wu | Yimin Yang | Zhaofei Jing | Yongzhong Jiang | Yu Chen | Huan Yan | Yu Zhou | Ke Xu | Ke Lan

Immune correlates of tuberculosis disease and risk translate across species

JOURNAL ARTICLE published 29 January 2020 in Science Translational Medicine

Research funded by National Institutes of Health (HL105427) | National Institutes of Health (AI111914-02) | National Institutes of Health (AI123780) | National Institutes of Health (AI134236-02)

Authors: Mushtaq Ahmed | Shyamala Thirunavukkarasu | Bruce A. Rosa | Kimberly A. Thomas | Shibali Das | Javier Rangel-Moreno | Lan Lu | Smriti Mehra | Stanley Kimbung Mbandi | Larissa B. Thackray | Michael S. Diamond | Kenneth M. Murphy | Terry Means | John Martin | Deepak Kaushal | Thomas J. Scriba | Makedonka Mitreva | Shabaana A. Khader

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

JOURNAL ARTICLE published 9 January 2019 in Science Translational Medicine

Research funded by National Health and Medical Research Council (1092789) | National Health and Medical Research Council (1132975) | National Health and Medical Research Council (SRF) | National Health and Medical Research Council (CDF)

Authors: James G. Beeson | Liriye Kurtovic | Carlota Dobaño | D. Herbert Opi | Jo-Anne Chan | Gaoqian Feng | Michael F. Good | Linda Reiling | Michelle J. Boyle

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus

JOURNAL ARTICLE published 10 January 2024 in Science Translational Medicine

Authors: Francesco Andreata | Kelly D. Moynihan | Valeria Fumagalli | Pietro Di Lucia | Danielle C. Pappas | Keigo Kawashima | Irene Ni | Paul H. Bessette | Chiara Perucchini | Elisa Bono | Leonardo Giustini | Henry C. Nguyen | S. Michael Chin | Yik Andy Yeung | Craig S. Gibbs | Ivana Djuretic | Matteo Iannacone

Impaired cortical plasticity in drug abuse

JOURNAL ARTICLE published 13 July 2016 in Science Translational Medicine

Authors: Amit Etkin

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

JOURNAL ARTICLE published 20 May 2020 in Science Translational Medicine

Research funded by National Institutes of Health (RO1MH106469) | National Institute of Mental Health (T32MH074249) | Simons Foundation (SFARI #240559)

Authors: Patrick K. McCamphill | Laura J. Stoppel | Rebecca K. Senter | Michael C. Lewis | Arnold J. Heynen | David C. Stoppel | Vinay Sridhar | Katie A. Collins | Xi Shi | Jen Q. Pan | Jon Madison | Jeffrey R. Cottrell | Kimberly M. Huber | Edward M. Scolnick | Edward B. Holson | Florence F. Wagner | Mark F. Bear

Cardioprotective effects of autophagy: Eat your heart out, heart failure!

JOURNAL ARTICLE published 30 May 2018 in Science Translational Medicine

Authors: Gaetano Santulli

A Critical Subset Model Provides a Conceptual Basis for the High Antiviral Activity of Major HIV Drugs

JOURNAL ARTICLE published 13 July 2011 in Science Translational Medicine

Authors: Lin Shen | S. Alireza Rabi | Ahmad R. Sedaghat | Liang Shan | Jun Lai | Sifei Xing | Robert F. Siliciano

Breaking Down Translation Barriers: Investigator’s Perspective

JOURNAL ARTICLE published 3 September 2014 in Science Translational Medicine

Authors: Nathan P. Staff | Bethany Kinseth Runge | Anthony J. Windebank

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

JOURNAL ARTICLE published 12 February 2020 in Science Translational Medicine

Research funded by Eli Lilly and Company (Not applicable) | Pfizer (Not applicable) | European Research Council (ERC StG 640087 – SOS) | European Research Council (ERC 4D NanoScope) | Deutsche Forschungsgemeinschaft (FG 2886 (Project No. B01/A03)) | Deutsche Forschungsgemeinschaft (DFG-SFB 1181 (Project No. A01/A03/A05)) | Deutsche Forschungsgemeinschaft (Project SCHE 1583/14-1) | Deutsche Forschungsgemeinschaft (HA 8163/1-1) | Bundesministerium für Bildung und Forschung (METARTHROS) | Innovative Medicines Initiative (777357) | Interdisciplinary Center for Clinical Research (IZKF) Universitätsklinikum Erlangen (Not applicable)

Authors: Susanne Adam | Nils Simon | Ulrike Steffen | Fabian T. Andes | Carina Scholtysek | Dorothea I. H. Müller | Daniela Weidner | Darja Andreev | Arnd Kleyer | Stephan Culemann | Madelaine Hahn | Georg Schett | Gerhard Krönke | Silke Frey | Axel J. Hueber

Understanding respiratory microbiome–immune system interactions in health and disease

JOURNAL ARTICLE published 11 January 2023 in Science Translational Medicine

Authors: Sara K. Di Simone | Ina Rudloff | Claudia A. Nold-Petry | Samuel C. Forster | Marcel F. Nold

Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis

JOURNAL ARTICLE published 6 March 2013 in Science Translational Medicine

Authors: Rosa Ferriero | Giuseppe Manco | Eleonora Lamantea | Edoardo Nusco | Maria I. Ferrante | Paolo Sordino | Peter W. Stacpoole | Brendan Lee | Massimo Zeviani | Nicola Brunetti-Pierri

Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis

JOURNAL ARTICLE published 9 February 2011 in Science Translational Medicine

Authors: Tuomas Tammela | Anne Saaristo | Tanja Holopainen | Seppo Ylä-Herttuala | Leif C. Andersson | Susanna Virolainen | Ilkka Immonen | Kari Alitalo

Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice

JOURNAL ARTICLE published 25 July 2018 in Science Translational Medicine

Research funded by National Eye Institute (R01EY021798) | National Eye Institute (P30EY005722) | National Eye Institute (F32EY025557) | National Institute of Allergy and Infectious Diseases (R21AI128727) | National Institute of Arthritis and Musculoskeletal and Skin Diseases (K08AR063729) | Research to Prevent Blindness (Unrestricted (Duke Eye Center)) | Duke University (Duke Physician-Scientist Strong Start Award)

Authors: Nancy J. Reyes | Chen Yu | Rose Mathew | Carolina M. Kunnen | Joan Kalnitsky | Rachel L. Redfern | Andrea Leonardi | Victor L. Perez | Amanda S. MacLeod | Preeya K. Gupta | Daniel R. Saban