Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell–dependent regression of glioblastoma

JOURNAL ARTICLE published 24 May 2023 in Science Translational Medicine

Authors: Thomas Look | Emanuele Puca | Marcel Bühler | Daniel Kirschenbaum | Roberto De Luca | Riccardo Stucchi | Domenico Ravazza | Cesare Di Nitto | Patrick Roth | Yonatan Katzenelenbogen | Assaf Weiner | Lukas Rindlisbacher | Burkhard Becher | Ido Amit | Michael Weller | Dario Neri | Teresa Hemmerle | Tobias Weiss

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

JOURNAL ARTICLE published 23 February 2022 in Science Translational Medicine

Authors: Meghan S. Vermillion | Eisuke Murakami | Bin Ma | Jared Pitts | Adrian Tomkinson | Davin Rautiola | Darius Babusis | Hammad Irshad | Dustin Seigel | Cynthia Kim | Xiaofeng Zhao | Congrong Niu | Jesse Yang | Andrew Gigliotti | Nani Kadrichu | John P. Bilello | Scott Ellis | Roy Bannister | Raju Subramanian | Bill Smith | Richard L. Mackman | William A. Lee | Philip J. Kuehl | Jim Hartke | Tomas Cihlar | Danielle P. Porter

HIV-Specific Cytolytic CD4 T Cell Responses During Acute HIV Infection Predict Disease Outcome

JOURNAL ARTICLE published 29 February 2012 in Science Translational Medicine

Authors: Damien Z. Soghoian | Heiko Jessen | Michael Flanders | Kailan Sierra-Davidson | Sam Cutler | Thomas Pertel | Srinika Ranasinghe | Madelene Lindqvist | Isaiah Davis | Kimberly Lane | Jenna Rychert | Eric S. Rosenberg | Alicja Piechocka-Trocha | Abraham L. Brass | Jason M. Brenchley | Bruce D. Walker | Hendrik Streeck

Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function

JOURNAL ARTICLE published 8 May 2024 in Science Translational Medicine

Authors: Benjamin P. Hurrell | Yoshihiro Sakano | Stephen Shen | Doumet Georges Helou | Meng Li | Pedram Shafiei-Jahani | Mohammad Hossein Kazemi | Kei Sakano | Xin Li | Christine Quach | Richard Barbers | Omid Akbari

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA _B Receptors with Arbaclofen

JOURNAL ARTICLE published 19 September 2012 in Science Translational Medicine

Authors: Christina Henderson | Lasani Wijetunge | Mika Nakamoto Kinoshita | Matthew Shumway | Rebecca S. Hammond | Friso R. Postma | Christopher Brynczka | Roger Rush | Alexia Thomas | Richard Paylor | Stephen T. Warren | Peter W. Vanderklish | Peter C. Kind | Randall L. Carpenter | Mark F. Bear | Aileen M. Healy

Navigating regulatory pathways for translation of biologic cartilage repair products

JOURNAL ARTICLE published 24 August 2022 in Science Translational Medicine

Authors: Rachel C. Nordberg | Gaston A. Otarola | Dean Wang | Jerry C. Hu | Kyriacos A. Athanasiou

PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

JOURNAL ARTICLE published 11 December 2019 in Science Translational Medicine

Research funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32 AR007016)

Authors: Xue Han | Matthew D. Vesely | Wendy Yang | Miguel F. Sanmamed | Ti Badri | Jude Alawa | Francesc López-Giráldez | Patricia Gaule | Sang Won Lee | Jian-Ping Zhang | Xinxin Nie | Ala Nassar | Agedi Boto | Dallas B. Flies | Linghua Zheng | Tae Kon Kim | Gilbert W. Moeckel | Jennifer M. McNiff | Lieping Chen

Engineering Approaches to Immunotherapy

JOURNAL ARTICLE published 22 August 2012 in Science Translational Medicine

Authors: Melody A. Swartz | Sachiko Hirosue | Jeffrey A. Hubbell

Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

JOURNAL ARTICLE published 26 February 2020 in Science Translational Medicine

Research funded by American Association for Cancer Research (Judah Folkman Award) | National Institute of Neurological Disorders and Stroke (R01NS094533) | National Institute of Neurological Disorders and Stroke (R01NS106108)

Authors: Menggui Huang | Duo Zhang | Janet Y. Wu | Kun Xing | Eujin Yeo | Chunsheng Li | Lin Zhang | Eric Holland | Lutian Yao | Ling Qin | Zev A. Binder | Donald M. O’Rourke | Steven Brem | Constantinos Koumenis | Yanqing Gong | Yi Fan

Aging as a driver of leukemogenesis

JOURNAL ARTICLE published 23 September 2015 in Science Translational Medicine

Research funded by Wellcome Trust Clinician Scientist Fellowship (WT098051) | Wellcome Trust Senior Fellowship in Clinical Science (WT095663MA)

Authors: Thomas McKerrell | George S. Vassiliou

Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis

JOURNAL ARTICLE published 30 November 2016 in Science Translational Medicine

Research funded by Deutsche Forschungsgemeinschaft (SFB 1123,SFB 914)

Authors: Tobias Petzold | Manuela Thienel | Ildiko Konrad | Irene Schubert | Ron Regenauer | Boj Hoppe | Michael Lorenz | Annekathrin Eckart | Sue Chandraratne | Carsten Lennerz | Christof Kolb | Daniel Braun | Janina Jamasbi | Richard Brandl | Siegmund Braun | Wolfgang Siess | Christian Schulz | Steffen Massberg

Digital Genomic Quantification of Tumor-Infiltrating Lymphocytes

JOURNAL ARTICLE published 4 December 2013 in Science Translational Medicine

Authors: Harlan S. Robins | Nolan G. Ericson | Jamie Guenthoer | Kathy C. O’Briant | Muneesh Tewari | Charles W. Drescher | Jason H. Bielas

Structure-based drug design identifies polythiophenes as antiprion compounds

JOURNAL ARTICLE published 5 August 2015 in Science Translational Medicine

Research funded by European Union Seventh Framework Program (Bio-NMR 261863) | Agence Nationale de la Recherche (ANR-11-BSV-8021-01,ANR-12-BS08-0013-01) | Swiss National Science Foundation (200020_146757,315230_149897)

Authors: Uli S. Herrmann | Anne K. Schütz | Hamid Shirani | Danzhi Huang | Dino Saban | Mario Nuvolone | Bei Li | Boris Ballmer | Andreas K. O. Åslund | Jeffrey J. Mason | Elisabeth Rushing | Herbert Budka | Sofie Nyström | Per Hammarström | Anja Böckmann | Amedeo Caflisch | Beat H. Meier | K. Peter R. Nilsson | Simone Hornemann | Adriano Aguzzi

RNAi Therapies: Drugging the Undruggable

JOURNAL ARTICLE published 11 June 2014 in Science Translational Medicine

Authors: Sherry Y. Wu | Gabriel Lopez-Berestein | George A. Calin | Anil K. Sood

Applying What We Know to Accelerate Cancer Prevention

JOURNAL ARTICLE published 28 March 2012 in Science Translational Medicine

Authors: Graham A. Colditz | Kathleen Y. Wolin | Sarah Gehlert

How to know when physicians are ready for genomic medicine

JOURNAL ARTICLE published 13 May 2015 in Science Translational Medicine

Research funded by U. S. National Institutes of Health (KL2-TR001100,L30-DK089597,R01-HG005092,U01-HG006500,U19-HD077671)

Authors: Jason L. Vassy | Bruce R. Korf | Robert C. Green

Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression

JOURNAL ARTICLE published 23 October 2013 in Science Translational Medicine

Authors: Raffit Hassan | Andrew C. Miller | Elad Sharon | Anish Thomas | James C. Reynolds | Alexander Ling | Robert J. Kreitman | Markku M. Miettinen | Seth M. Steinberg | Daniel H. Fowler | Ira Pastan

Efficacy and costs of spinal muscular atrophy drugs

JOURNAL ARTICLE published 11 November 2020 in Science Translational Medicine

Authors: Jonathan J. Darrow | Monica Sharma | Mansa Shroff | Anita K. Wagner

Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study

JOURNAL ARTICLE published 7 October 2020 in Science Translational Medicine

Authors: Brendan Conlon | Berthold Langguth | Caroline Hamilton | Stephen Hughes | Emma Meade | Ciara O Connor | Martin Schecklmann | Deborah A. Hall | Sven Vanneste | Sook Ling Leong | Thavakumar Subramaniam | Shona D’Arcy | Hubert H. Lim

Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms

JOURNAL ARTICLE published 14 June 2023 in Science Translational Medicine

Authors: Yasuyuki Shima | Shota Sasagawa | Nakao Ota | Rieko Oyama | Minoru Tanaka | Mie Kubota-Sakashita | Hirochika Kawakami | Mika Kobayashi | Naoko Takubo | Atsuko Nakanishi Ozeki | Xiaoning Sun | Yeon-Jeong Kim | Yoichiro Kamatani | Koichi Matsuda | Kazuhiro Maejima | Masashi Fujita | Kosumo Noda | Hiroyasu Kamiyama | Rokuya Tanikawa | Motoo Nagane | Junji Shibahara | Toru Tanaka | Yoshiyuki Rikitake | Nobuko Mataga | Satoru Takahashi | Kenjiro Kosaki | Hideyuki Okano | Tomomi Furihata | Ryo Nakaki | Nobuyoshi Akimitsu | Youichiro Wada | Toshihisa Ohtsuka | Hiroki Kurihara | Hiroyuki Kamiguchi | Shigeo Okabe | Masato Nakafuku | Tadafumi Kato | Hidewaki Nakagawa | Nobuhito Saito | Hirofumi Nakatomi