Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 ⁺ T cells drive gastrointestinal acute graft-versus-host disease

JOURNAL ARTICLE published 13 January 2021 in Science Translational Medicine

Research funded by American Cancer Society (129701-MRSG-16-153-01-CCE) | National Heart, Lung, and Blood Institute (NIH 2R01 HL095791) | National Heart, Lung, and Blood Institute (NIH R01 HL56067) | National Heart, Lung, and Blood Institute (NIH 2R01 HL095791) | National Heart, Lung, and Blood Institute (K23HL136900) | National Institute of Allergy and Infectious Diseases (NIH 2U19 AI051731) | Alfred P. Sloan Foundation (Sloan Fellowship in Chemistry) | National Institute of Allergy and Infectious Diseases (NIH R37 AI34495) | Be The Match Foundation (Amy Strelzer Manasevit Research Program Grant) | American Society for Transplantation and Cellular Therapy (New Investigator Award)

Authors: Victor Tkachev | James Kaminski | E. Lake Potter | Scott N. Furlan | Alison Yu | Daniel J. Hunt | Connor McGuckin | Hengqi Zheng | Lucrezia Colonna | Ulrike Gerdemann | Judith Carlson | Michelle Hoffman | Joe Olvera | Chris English | Audrey Baldessari | Angela Panoskaltsis-Mortari | Benjamin Watkins | Muna Qayed | Yvonne Suessmuth | Kayla Betz | Brandi Bratrude | Amelia Langston | John T. Horan | Jose Ordovas-Montanes | Alex K. Shalek | Bruce R. Blazar | Mario Roederer | Leslie S. Kean

TCR-Ligand k _off Rate Correlates with the Protective Capacity of Antigen-Specific CD8 ⁺ T Cells for Adoptive Transfer

JOURNAL ARTICLE published 3 July 2013 in Science Translational Medicine

Authors: Magdalena Nauerth | Bianca Weißbrich | Robert Knall | Tobias Franz | Georg Dössinger | Jeannette Bet | Paulina J. Paszkiewicz | Lukas Pfeifer | Mario Bunse | Wolfgang Uckert | Rafaela Holtappels | Dorothea Gillert-Marien | Michael Neuenhahn | Angela Krackhardt | Matthias J. Reddehase | Stanley R. Riddell | Dirk H. Busch

Multiple roles for HIV broadly neutralizing antibodies

JOURNAL ARTICLE published 30 October 2019 in Science Translational Medicine

Authors: Barton F. Haynes | Dennis R. Burton | John R. Mascola

Denervation suppresses gastric tumorigenesis

JOURNAL ARTICLE published 20 August 2014 in Science Translational Medicine

Authors: Chun-Mei Zhao | Yoku Hayakawa | Yosuke Kodama | Sureshkumar Muthupalani | Christoph B. Westphalen | Gøran T. Andersen | Arnar Flatberg | Helene Johannessen | Richard A. Friedman | Bernhard W. Renz | Arne K. Sandvik | Vidar Beisvag | Hiroyuki Tomita | Akira Hara | Michael Quante | Zhishan Li | Michael D. Gershon | Kazuhiro Kaneko | James G. Fox | Timothy C. Wang | Duan Chen

Human IFNAR2 deficiency: Lessons for antiviral immunity

JOURNAL ARTICLE published 30 September 2015 in Science Translational Medicine

Research funded by Wellcome Trust (101788/Z/13/Z) | Sir Jules Thorn Trust (12/JTA) | Academy of Medical Sciences (AMS-SGCL11)

Authors: Christopher J. A. Duncan | Siti M. B. Mohamad | Dan F. Young | Andrew J. Skelton | T. Ronan Leahy | Diane C. Munday | Karina M. Butler | Sofia Morfopoulou | Julianne R. Brown | Mike Hubank | Jeff Connell | Patrick J. Gavin | Cathy McMahon | Eugene Dempsey | Niamh E. Lynch | Thomas S. Jacques | Manoj Valappil | Andrew J. Cant | Judith Breuer | Karin R. Engelhardt | Richard E. Randall | Sophie Hambleton

Intratumoral CD8 ⁺ T cells with stem cell–like properties: Implications for cancer immunotherapy

JOURNAL ARTICLE published 23 October 2019 in Science Translational Medicine

Research funded by Swiss National Science Foundation (310030B_179570) | Swiss National Science Foundation (310030-179459 and CRSII3-160708) | Swiss Cancer League (KFS-4407-02-2018) | Swiss Cancer League (KFS-3971-08-2016)

Authors: Werner Held | Imran Siddiqui | Karin Schaeuble | Daniel E. Speiser

Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors

JOURNAL ARTICLE published 16 February 2022 in Science Translational Medicine

Authors: Diana Tavares-Ferreira | Stephanie Shiers | Pradipta R. Ray | Andi Wangzhou | Vivekanand Jeevakumar | Ishwarya Sankaranarayanan | Anna M. Cervantes | Jeffrey C. Reese | Alexander Chamessian | Bryan A. Copits | Patrick M. Dougherty | Robert W. Gereau | Michael D. Burton | Gregory Dussor | Theodore J. Price

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

JOURNAL ARTICLE published 17 August 2022 in Science Translational Medicine

Authors: Stephanie N. Langel | Susan Johnson | Clarissa I. Martinez | Sarah N. Tedjakusuma | Nadine Peinovich | Emery G. Dora | Philip J. Kuehl | Hammad Irshad | Edward G. Barrett | Adam D. Werts | Sean N. Tucker

Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

JOURNAL ARTICLE published January 2020 in Science Translational Medicine

Research funded by National Institute on Aging (R01-AG045611) | National Institute on Aging (R01-AG034570) | National Institute on Aging (P50-AG023501) | Alzheimer’s Association (AARF-16-443577)

Authors: Renaud La Joie | Adrienne V. Visani | Suzanne L. Baker | Jesse A. Brown | Viktoriya Bourakova | Jungho Cha | Kiran Chaudhary | Lauren Edwards | Leonardo Iaccarino | Mustafa Janabi | Orit H. Lesman-Segev | Zachary A. Miller | David C. Perry | James P. O’Neil | Julie Pham | Julio C. Rojas | Howard J. Rosen | William W. Seeley | Richard M. Tsai | Bruce L. Miller | William J. Jagust | Gil D. Rabinovici

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

JOURNAL ARTICLE published 12 November 2014 in Science Translational Medicine

Authors: Antonio DiGiandomenico | Ashley E. Keller | Cuihua Gao | Godfrey J. Rainey | Paul Warrener | Mareia M. Camara | Jessica Bonnell | Ryan Fleming | Binyam Bezabeh | Nazzareno Dimasi | Bret R. Sellman | Jamese Hilliard | Caitlin M. Guenther | Vivekananda Datta | Wei Zhao | Changshou Gao | Xiang-Qing Yu | JoAnn A. Suzich | C. Kendall Stover

Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics

JOURNAL ARTICLE published 22 December 2021 in Science Translational Medicine

Authors: Jay-Hyun Jo | Catriona P. Harkins | Nicole H. Schwardt | Jessica A. Portillo | Matthew D. Zimmerman | Claire L. Carter | Md Amir Hossen | Cody J. Peer | Eric C. Polley | Véronique Dartois | William D. Figg | Niki M. Moutsopoulos | Julia A. Segre | Heidi H. Kong | NISC Comparative Sequencing Program

Tmc gene therapy restores auditory function in deaf mice

JOURNAL ARTICLE published 8 July 2015 in Science Translational Medicine

Authors: Charles Askew | Cylia Rochat | Bifeng Pan | Yukako Asai | Hena Ahmed | Erin Child | Bernard L. Schneider | Patrick Aebischer | Jeffrey R. Holt

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

JOURNAL ARTICLE published 8 June 2016 in Science Translational Medicine

Research funded by NIH (NS095387,NS059806,ES022644,ES020718,ES020327,NS065789,AG026389,P50AG005133) | U.S. Department of Veterans Affairs (1I01BX000548)

Authors: Roberto Di Maio | Paul J. Barrett | Eric K. Hoffman | Caitlyn W. Barrett | Alevtina Zharikov | Anupom Borah | Xiaoping Hu | Jennifer McCoy | Charleen T. Chu | Edward A. Burton | Teresa G. Hastings | J. Timothy Greenamyre

A once-a-month oral contraceptive

JOURNAL ARTICLE published 4 December 2019 in Science Translational Medicine

Research funded by Bill and Melinda Gates Foundation (OPP1139927)

Authors: Ameya R. Kirtane | Tiffany Hua | Alison Hayward | Ambika Bajpayee | Aniket Wahane | Aaron Lopes | Taylor Bensel | Lihong Ma | Frank Z. Stanczyk | Sierra Brooks | Declan Gwynne | Jacob Wainer | Joy Collins | Siddartha M. Tamang | Robert Langer | Giovanni Traverso

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

JOURNAL ARTICLE published 3 April 2013 in Science Translational Medicine

Authors: Ken-ichi Matsuoka | John Koreth | Haesook T. Kim | Gregory Bascug | Sean McDonough | Yutaka Kawano | Kazuyuki Murase | Corey Cutler | Vincent T. Ho | Edwin P. Alyea | Philippe Armand | Bruce R. Blazar | Joseph H. Antin | Robert J. Soiffer | Jerome Ritz

Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans

JOURNAL ARTICLE published 25 November 2020 in Science Translational Medicine

Research funded by National Institutes of Health (R01AG034618) | National Institutes of Health (R01AG035015) | National Institutes of Health (P50AG008702)

Authors: Sabrina Simoes | Jessica L. Neufeld | Gallen Triana-Baltzer | Setareh Moughadam | Emily I. Chen | Milankumar Kothiya | Yasir H. Qureshi | Vivek Patel | Lawrence S. Honig | Hartmuth Kolb | Scott A. Small

High-throughput pairing of T cell receptor α and β sequences

JOURNAL ARTICLE published 19 August 2015 in Science Translational Medicine

Authors: Bryan Howie | Anna M. Sherwood | Ashley D. Berkebile | Jan Berka | Ryan O. Emerson | David W. Williamson | Ilan Kirsch | Marissa Vignali | Mark J. Rieder | Christopher S. Carlson | Harlan S. Robins

Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis

JOURNAL ARTICLE published 30 September 2020 in Science Translational Medicine

Authors: Debomita Chakraborty | Honglin Zhu | Astrid Jüngel | Lena Summa | Yi-Nan Li | Alexandru-Emil Matei | Xiang Zhou | Jingang Huang | Thuong Trinh-Minh | Chih-Wei Chen | Robert Lafyatis | Clara Dees | Christina Bergmann | Alina Soare | Hui Luo | Andreas Ramming | Georg Schett | Oliver Distler | Jörg H. W. Distler

Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration

JOURNAL ARTICLE published 7 June 2023 in Science Translational Medicine

Authors: Yu Mikami | Barbara R. Grubb | Troy D. Rogers | Hong Dang | Takanori Asakura | Pradeep Kota | Rodney C. Gilmore | Kenichi Okuda | Lisa C. Morton | Ling Sun | Gang Chen | Jason A. Wykoff | Camille Ehre | Juan Vilar | Catharina van Heusden | Alessandra Livraghi-Butrico | Martina Gentzsch | Brian Button | M. Jackson Stutts | Scott H. Randell | Wanda K. O’Neal | Richard C. Boucher

Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis

JOURNAL ARTICLE published 2 September 2020 in Science Translational Medicine

Research funded by Medical Research Council (MR/L022893/1) | Medical Research Council (MR/N010973/1) | Medical Research Council (MR/P026362/1) | Rosetrees Trust (A1205) | Rosetrees Trust (A2575) | Versus Arthritis (19667) | Versus Arthritis (21515) | Versus Arthritis (20886) | Versus Arthritis (21621)

Authors: Suzanne E. Eldridge | Aida Barawi | Hui Wang | Anke J. Roelofs | Magdalena Kaneva | Zeyu Guan | Helen Lydon | Bethan L. Thomas | Anne-Sophie Thorup | Beatriz F. Fernandez | Sara Caxaria | Danielle Strachan | Ahmed Ali | Kanatheepan Shanmuganathan | Costantino Pitzalis | James R. Whiteford | Frances Henson | Andrew W. McCaskie | Cosimo De Bari | Francesco Dell’Accio