Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

JOURNAL ARTICLE published 19 October 2023 in eLife

Research funded by European Research Council (ERC-AdG-787702) | National Research Foundation of Korea (NRF 2017K1A1A2013124) | China Scholarship Council (201906050019)

Authors: Xiaoxu Li | Jean-David Morel | Giorgia Benegiamo | Johanne Poisson | Alexis Bachmann | Alexis Rapin | Jonathan Sulc | Evan Williams | Alessia Perino | Kristina Schoonjans | Maroun Bou Sleiman | Johan Auwerx

Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer

JOURNAL ARTICLE published 8 November 2023 in eLife

Research funded by National Institute on Drug Abuse (DP1DA039650) | National Institute on Drug Abuse (R01DA053743) | National Institute on Drug Abuse (R01DA054714) | National Institute of Mental Health (R01MH114990) | McKnight Foundation (Neurobiology of Brain Disorders Award) | National Institute of Neurological Disorders and Stroke (T32NS061788)

Authors: Robert A Phillips | Ethan Wan | Jennifer J Tuscher | David Reid | Olivia R Drake | Lara Ianov | Jeremy J Day

Probing ligand selectivity in pathogens

JOURNAL ARTICLE published 21 December 2023 in eLife

Authors: Bryan VanSchouwen | Giuseppe Melacini

Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

JOURNAL ARTICLE published 21 January 2022 in eLife

Research funded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO.STU.018-2.007) | European Research Council (ERC-StG-852880)

Authors: Stefan T Huber | Edin Sarajlic | Roeland Huijink | Felix Weis | Wiel H Evers | Arjen J Jakobi

Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

JOURNAL ARTICLE published 27 June 2022 in eLife

Research funded by Canadian Institutes of Health Research (CIHR FDN 167279)

Authors: Johnny M Tkach | Reuben Philip | Amit Sharma | Jonathan Strecker | Daniel Durocher | Laurence Pelletier

Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

JOURNAL ARTICLE published 8 February 2022 in eLife

Research funded by Ministerio de Economía, Industria y Competitividad, Gobierno de España (BFU2013-44188-P) | Instituto de Salud Carlos III (PI19-00013)

Authors: Gerard Cantero-Recasens | Josune Alonso-Marañón | Teresa Lobo-Jarne | Marta Garrido | Mar Iglesias | Lluis Espinosa | Vivek Malhotra

Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

JOURNAL ARTICLE published 25 January 2022 in eLife

Research funded by European Community's Seventh Framework Programme (308333) | European Union's Horizon 2020 (774548) | National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (R21ES02968) | Instituto de Salud Carlos III (MS16/00128) | Research Council of Norway, under the MILJØFORSK program (268465) | Fundação de Amparo à Pesquisa do Estado de São Paulo (2016/14302-7 and 2018/19820-1) | Instituto de Salud Carlos III (ISCIII) and ERDF (PT17/0019 of the PE I+D+i 2013-2016) | NIH/NIEHS (R01ES029944) | NIH/NIEHS (R01ES030691) | NIH/NIEHS (R01ES030364) | NIH/NIEHS (P30ES007048) | NIH (P01CA196569) | NIH (R01CA140561) | NIH (R01ES016813) | NIH (P30DK048522) | Departament de Salut de la Generalitat de Catalunya (Spanish regional program PERIS (Ref.: SLT017/20/000119))

Authors: Nikos Stratakis | Alexandros P Siskos | Eleni Papadopoulou | Anh N Nguyen | Yinqi Zhao | Katerina Margetaki | Chung-Ho E Lau | Muireann Coen | Lea Maitre | Silvia Fernández-Barrés | Lydiane Agier | Sandra Andrusaityte | Xavier Basagaña | Anne Lise Brantsaeter | Maribel Casas | Serena Fossati | Regina Grazuleviciene | Barbara Heude | Rosemary RC McEachan | Helle Margrete Meltzer | Christopher Millett | Fernanda Rauber | Oliver Robinson | Theano Roumeliotaki | Eva Borras | Eduard Sabidó | Jose Urquiza | Marina Vafeiadi | Paolo Vineis | Trudy Voortman | John Wright | David V Conti | Martine Vrijheid | Hector C Keun | Leda Chatzi

Sleep regularity and mortality: a prospective analysis in the UK Biobank

JOURNAL ARTICLE published 23 November 2023 in eLife

Research funded by National Health and Medical Research Council (GTN2009264) | National Health and Medical Research Council (GTN1158384) | National Institute on Aging (AG062531) | Alzheimer's Association (2018-AARG-591358) | Banting Research Foundation (#454104)

Authors: Lachlan Cribb | Ramon Sha | Stephanie Yiallourou | Natalie A Grima | Marina Cavuoto | Andree-Ann Baril | Matthew P Pase

Exploiting the mediating role of the metabolome to unravel transcript-to-phenotype associations

JOURNAL ARTICLE published 9 March 2023 in eLife

Research funded by Swiss National Science Foundation (310030-189147) | Swiss National Science Foundation (31003A_182632)

Authors: Chiara Auwerx | Marie C Sadler | Tristan Woh | Alexandre Reymond | Zoltán Kutalik | Eleonora Porcu

Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

JOURNAL ARTICLE published 14 November 2023 in eLife

Research funded by National Institute of Health (EY012543) | National Institute of Health (EY032136) | Research to Prevent Blindness (Stein Innovation Award) | Widłak Family (CRX Research Fund)

Authors: Yiqiao Zheng | Chi Sun | Xiaodong Zhang | Philip A Ruzycki | Shiming Chen

A reductionist paradigm for high-throughput behavioural fingerprinting in Drosophila melanogaster

JOURNAL ARTICLE published 8 November 2023 in eLife

Research funded by Biotechnology and Biological Sciences Research Council (BB/M011178/1)

Authors: Hannah Jones | Jenny A Willis | Lucy C Firth | Carlo NG Giachello | Giorgio F Gilestro

Excitatory and inhibitory D-serine binding to the NMDA receptor

JOURNAL ARTICLE published 27 October 2022 in eLife

Research funded by National Institutes of Health (T32GM135131) | National Institutes of Health (NS111745) | National Institutes of Health (MH085926)

Authors: Remy A Yovanno | Tsung Han Chou | Sarah J Brantley | Hiro Furukawa | Albert Y Lau

Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

JOURNAL ARTICLE published 8 September 2022 in eLife

Research funded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (NCCR RNA and Disease) | Howard Hughes Medical Institute (55008735)

Authors: Lena Maria Muckenfuss | Anabel Carmen Migenda Herranz | Franziska Maria Boneberg | Marcello Clerici | Martin Jinek

Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction

JOURNAL ARTICLE published 23 November 2022 in eLife

Research funded by Medical Research Council (MC_UU_12014/12) | Wellcome Trust (217221/Z/19/Z)

Authors: Nardus Mollentze | Deborah Keen | Uuriintuya Munkhbayar | Roman Biek | Daniel G Streicker

Tracing the path of 37,050 studies into practice across 18 specialties of the 2.4 million published between 2011 and 2020

JOURNAL ARTICLE published 28 February 2023 in eLife

Authors: Moustafa Abdalla | Salwa Abdalla | Mohamed Abdalla

Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans

JOURNAL ARTICLE published 1 December 2023 in eLife

Research funded by National Institutes of Health (R01GM121597) | Damon Runyon Cancer Research Foundation (DRR-47-17) | National Institutes of Health (F31HD100091) | Stony Brook University (Presidential Critical Research Funds) | National Institutes of Health (F30CA257383) | Human Frontier Science Program (LTF000127/2016-L) | Howard Hughes Medical Institute (Investigator) | National Institutes of Health (R01GM117406) | National Science Foundation (2217560) | National Institutes of Health (R35GM142880)

Authors: Taylor N Medwig-Kinney | Brian A Kinney | Michael AQ Martinez | Callista Yee | Sydney S Sirota | Angelina A Mullarkey | Neha Somineni | Justin Hippler | Wan Zhang | Kang Shen | Christopher Hammell | Ariel M Pani | David Q Matus

The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice

JOURNAL ARTICLE published 17 February 2023 in eLife

Research funded by Fonds National de la Recherche Luxembourg (AFR PhD ID 10111126) | Fonds National de la Recherche Luxembourg (Next Immune DTU PRIDE ID 11012546)

Authors: Mathieu Amand | Philipp Adams | Rafaela Schober | Gilles Iserentant | Jean-Yves Servais | Michel Moutschen | Carole Seguin-Devaux

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

JOURNAL ARTICLE published 9 December 2022 in eLife

Research funded by National Key Research and Development Program of China (2021YFA1300502) | Natural Science Foundation of China (91942309) | Natural Science Foundation of China (92057210) | Natural Science Foundation of China (82222029) | Natural Science Foundation of China (82071754) | Natural Science Foundation of China (82271793) | Natural Science Foundation of China (81971481) | Natural Science Foundation of China (82173064) | Natural Science Foundation of China (81602205) | Natural Science Foundation of China (82002786) | Natural Science Foundation of China (82003859) | Natural Science Foundation of Guangdong Province (2020A1515011458) | Natural Science Foundation of Guangdong Province (2022B1515020023) | Natural Science Foundation of Guangdong Province (2021A1515010230) | Science and Technology Program of Guangzhou (202103000070) | Science and Technology Program of Guangzhou (202201020467) | Sun Yat-Sen Projects for Clinical Trials (SYS-C-202003) | Fundamental Research Funds for the Central Universities (22ykqb01)

Authors: Jiaqian Li | Di Huang | Bingxi Lei | Jingying Huang | Linbing Yang | Man Nie | Shicheng Su | Qiyi Zhao | Ying Wang

Regional importation and asymmetric within-country spread of SARS-CoV-2 variants of concern in the Netherlands

JOURNAL ARTICLE published 13 September 2022 in eLife

Research funded by European Research Council (ERC NaviFlu (no. 818353)) | National Institutes of Health (5R01AI132362-04) | Nederlandse Organisatie voor Wetenschappelijk Onderzoek (09150182010027)

Authors: Alvin X Han | Eva Kozanli | Jelle Koopsen | Harry Vennema | Karim Hajji | Annelies Kroneman | Ivo van Walle | Don Klinkenberg | Jacco Wallinga | Colin A Russell | Dirk Eggink | Chantal Reusken | RIVM COVID-19 molecular epidemiology group

Unraveling the developmental dynamic of visual exploration of social interactions in autism

JOURNAL ARTICLE published 9 January 2024 in eLife

Research funded by National Centre of Competence in Research (NCCR) SYNAPSY (51NF40-185897) | Swiss National Science Foundation (163859) | Swiss National Science Foundation (190084) | Swiss National Science Foundation (202235) | Swiss National Science Foundation (212653) | ERC Synergy fund BrainPlay - The Self-teaching Brain grant (810580)

Authors: Nada Kojovic | Sezen Cekic | Santiago Herce Castañón | Martina Franchini | Holger Franz Sperdin | Corrado Sandini | Reem Kais Jan | Daniela Zöller | Lylia Ben Hadid | Daphné Bavelier | Marie Schaer