Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

JOURNAL ARTICLE published 16 June 2022 in eLife

Research funded by National Institutes of Health (R01-GM057391) | National Institutes of Health (R01-GM098894) | Government of Canada (Natural Science and Engineering Research Council of Canada NSERC-2020-04241) | Michael Smith Foundation for Health Research (Scholar Award 17686) | National Science Foundation (DGE-1650116)

Authors: Edhriz Siraliev-Perez | Jordan TB Stariha | Reece M Hoffmann | Brenda RS Temple | Qisheng Zhang | Nicole Hajicek | Meredith L Jenkins | John E Burke | John Sondek

XAB2 dynamics during DNA damage-dependent transcription inhibition

JOURNAL ARTICLE published 26 July 2022 in eLife

Research funded by Agence Nationale de la Recherche (ANR-14-CE10-0009) | Institut National Du Cancer (PLBIO17-043) | Institut National Du Cancer (PLBIO19-126) | Ligue Contre le Cancer (218398) | Electricité de France (218398)

Authors: Lise-Marie Donnio | Elena Cerutti | Charlene Magnani | Damien Neuillet | Pierre-Olivier Mari | Giuseppina Giglia-Mari

Unbiased mosaic variant assessment in sperm: a cohort study to test predictability of transmission

JOURNAL ARTICLE published 5 July 2022 in eLife

Authors: Martin W Breuss | Xiaoxu Yang | Valentina Stanley | Jennifer McEvoy-Venneri | Xin Xu | Arlene J Morales | Joseph G Gleeson

Neuronal origins of reduced accuracy and biases in economic choices under sequential offers

JOURNAL ARTICLE published 13 April 2022 in eLife

Research funded by National Institute of Mental Health (R01-MH104494) | McDonnell Center for Systems Neuroscience (CCSN Fellowship)

Authors: Weikang Shi | Sebastien Ballesta | Camillo Padoa-Schioppa

Environmental response in gene expression and DNA methylation reveals factors influencing the adaptive potential of Arabidopsis lyrata

JOURNAL ARTICLE published 28 October 2022 in eLife

Research funded by Academy of Finland (132611) | Academy of Finland (339702)

Authors: Tuomas Hämälä | Weixuan Ning | Helmi Kuittinen | Nader Aryamanesh | Outi Savolainen

MorphoFeatures for unsupervised exploration of cell types, tissues, and organs in volume electron microscopy

JOURNAL ARTICLE published 16 February 2023 in eLife

Research funded by European Research Council (788921)

Authors: Valentyna Zinchenko | Johannes Hugger | Virginie Uhlmann | Detlev Arendt | Anna Kreshuk

Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs

JOURNAL ARTICLE published 13 June 2022 in eLife

Research funded by National Cancer Institute (R01CA177786) | National Cancer Institute (P30CA056036)

Authors: Ramkrishna Mitra | Clare M Adams | Christine M Eischen

Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

JOURNAL ARTICLE published 11 October 2022 in eLife

Research funded by Deutsche Forschungsgemeinschaft (SA 3349/3-1) | DFG Research Grant (432439166)

Authors: Camilo Riquelme-Guzmán | Stephanie L Tsai | Karen Carreon Paz | Congtin Nguyen | David Oriola | Maritta Schuez | Jan Brugués | Joshua D Currie | Tatiana Sandoval-Guzmán

Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation

JOURNAL ARTICLE published 19 April 2022 in eLife

Research funded by Canadian Institutes of Health Research (MOP126158)

Authors: Corson Areshenkoff | Daniel J Gale | Dominic Standage | Joseph Y Nashed | J Randall Flanagan | Jason P Gallivan

Uncertainty alters the balance between incremental learning and episodic memory

JOURNAL ARTICLE published 2 December 2022 in eLife

Research funded by National Science Foundation (1644869) | National Science Foundation (1822619) | National Institutes of Health (MH121093) | John Templeton Foundation (60844)

Authors: Jonathan Nicholas | Nathaniel D Daw | Daphna Shohamy

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

JOURNAL ARTICLE published 2 December 2022 in eLife

Research funded by National Eye Institute (R01-EY013760) | National Eye Institute (P30-EY014800) | National Eye Institute (P30-EY008216) | National Eye Institute (R01-EY020560) | National Eye Institute (T32-EY007315) | Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-007491) | Eunice Kennedy Shriver National Institute of Child Health and Human Development (R00-HD087532)

Authors: Xiaodong Li | Patrick J Gordon | John A Gaynes | Alexandra W Fuller | Randy Ringuette | Clayton P Santiago | Valerie Wallace | Seth Blackshaw | Pulin Li | Edward M Levine

Short-term plasticity in the human visual thalamus

JOURNAL ARTICLE published 6 April 2022 in eLife

Research funded by H2020 European Research Council (PUPILTRAITS) | H2020 European Research Council (GENPERCEPT) | Ministero dell'Istruzione, dell'Università e della Ricerca (PRIN2017-MISMATCH) | Ministero dell'Istruzione, dell'Università e della Ricerca (FARE2-SMILY) | Ministero della Salute (RC and 5x1000)

Authors: Jan W Kurzawski | Claudia Lunghi | Laura Biagi | Michela Tosetti | Maria Concetta Morrone | Paola Binda

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

JOURNAL ARTICLE published 31 May 2022 in eLife

Research funded by NSF Graduate Research Fellowship Program (1938105) | NCI CSHL Cancer Center Support Grant (5P30CA045508) | NIH Shared Instrumentation Grant (S10 OD016234)

Authors: Brianna Bibel | Elad Elkayam | Steve Silletti | Elizabeth A Komives | Leemor Joshua-Tor

Using adopted individuals to partition indirect maternal genetic effects into prenatal and postnatal effects on offspring phenotypes

JOURNAL ARTICLE published 13 July 2022 in eLife

Research funded by National Health and Medical Research Council (APP1137714) | National Health and Medical Research Council (GNT1157714) | National Health and Medical Research Council (GNT1183074) | Norwegian Research Council (287198)

Authors: Liang-Dar Hwang | Gunn-Helen Moen | David M Evans

Mechanotransduction events at the physiological site of touch detection

JOURNAL ARTICLE published 6 January 2023 in eLife

Research funded by National Science Foundation (1923127) | National Science Foundation (2114084) | National Science Foundation (1754286) | National Institutes of Health (R01NS097547) | National Institutes of Health (R01NS126277)

Authors: Luke H Ziolkowski | Elena O Gracheva | Sviatoslav N Bagriantsev

DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness

JOURNAL ARTICLE published 20 September 2022 in eLife

Research funded by Centre National de la Recherche Scientifique (ATIP) | Centre National de la Recherche Scientifique (Region Midi Pyrenees - Equipe d'excellence) | Centre National de la Recherche Scientifique (Region Midi Pyrenees - FEDER) | Fondation InnaBioSante (EpAM)

Authors: Arnaud Carrier | Cécile Desjobert | Loic Ponger | Laurence Lamant | Matias Bustos | Jorge Torres-Ferreira | Rui Henrique | Carmen Jeronimo | Luisa Lanfrancone | Audrey Delmas | Gilles Favre | Antoine Daunay | Florence Busato | Dave SB Hoon | Jorg Tost | Chantal Etievant | Joëlle Riond | Paola B Arimondo

Gasotransmitter modulation of hypoglossal motoneuron activity

JOURNAL ARTICLE published 19 January 2023 in eLife

Research funded by National Heart, Lung, and Blood Institute (P01 HL144454) | National Institute of Neurological Disorders and Stroke (R01NS107421) | National Institute on Drug Abuse (R01DA057767) | National Heart, Lung, and Blood Institute (R01HL163965)

Authors: Brigitte M Browe | Ying-Jie Peng | Jayasri Nanduri | Nanduri R Prabhakar | Alfredo J Garcia

A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

JOURNAL ARTICLE published 22 April 2022 in eLife

Research funded by Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0427) | Biotechnology and Biological Sciences Research Council (BBS/E/B/000C0428) | Wellcome Trust (200823/Z/16/Z) | Biotechnology and Biological Sciences Research Council (BB/L016745/1) | European Molecular Biology Organization (ALTF 880-2018) | Cancer Research UK (C29967/A26787)

Authors: David J Turner | Alexander Saveliev | Fiamma Salerno | Louise S Matheson | Michael Screen | Hannah Lawson | David Wotherspoon | Kamil R Kranc | Martin Turner

Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys

JOURNAL ARTICLE published 13 December 2022 in eLife

Research funded by Japan Society for the Promotion of Science (KAKENHI 18H05287) | Japan Society for the Promotion of Science (KAKENHI 18H04038) | Japan Society for the Promotion of Science (KAKENHI 20H05489) | Japan Society for the Promotion of Science (KAKENHI 20H05713) | Japan Society for the Promotion of Science (KAKENHI JP18J11771) | Japan Society for the Promotion of Science (KAKENHI 20K19377) | Moonshot Research and Development Program (JPMJMS2012)

Authors: Miki Kaneshige | Kei Obara | Michiaki Suzuki | Toshiki Tazoe | Yukio Nishimura

Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context

JOURNAL ARTICLE published 28 June 2022 in eLife

Research funded by Centre National de la Recherche Scientifique (IR-RMN-THC FR3050) | University of California, San Francisco (Sanghvi-Agarwal Innovation Award)

Authors: Atanas Radkov | Anne L Sapiro | Sebastian Flores | Corey Henderson | Hayden Saunders | Rachel Kim | Steven Massa | Samuel Thompson | Chase Mateusiak | Jacob Biboy | Ziyi Zhao | Lea M Starita | William L Hatleberg | Waldemar Vollmer | Alistair B Russell | Jean-Pierre Simorre | Spencer Anthony-Cahill | Peter Brzovic | Beth Hayes | Seemay Chou